Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11

AUTHORS

Derek Klarin, Scott M. Damrauer, Kelly Cho, Yan V. Sun, Tanya M. Teslovich, Jacqueline Honerlaw, David R. Gagnon, Scott L. DuVall, Jin Li, Gina M. Peloso, Mark Chaffin, Aeron M. Small, Jie Huang, Hua Tang, Julie A. Lynch, Yuk-Lam Ho, Dajiang J. Liu, Connor A. Emdin, Alexander H. Li, Jennifer E. Huffman, Jennifer S. Lee, Pradeep Natarajan, Rajiv Chowdhury, Danish Saleheen, Marijana Vujkovic, Aris Baras, Saiju Pyarajan, Emanuele Di Angelantonio, Benjamin M. Neale, Aliya Naheed, Amit V. Khera, John Danesh, Kyong-Mi Chang, Gonçalo Abecasis, Cristen Willer, Frederick E. Dewey, David J. Carey, John Concato, J. Michael Gaziano, Christopher J. O’Donnell, Philip S. Tsao, Sekar Kathiresan, Daniel J. Rader, Peter W. F. Wilson, Themistocles L. Assimes

ABSTRACT

The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical phenotypes extracted from electronic health records covering a median of 10.0 years of follow-up. Among 297,626 veterans with at least one blood lipid measurement, including 57,332 black and 24,743 Hispanic participants, we tested up to around 32 million variants for association with lipid levels and identified 118 novel genome-wide significant loci after meta-analysis with data from the Global Lipids Genetics Consortium (total n > 600,000). Through a focus on mutations predicted to result in a loss of gene function and a phenome-wide association study, we propose novel indications for pharmaceutical inhibitors targeting PCSK9 (abdominal aortic aneurysm), ANGPTL4 (type 2 diabetes) and PDE3B (triglycerides and coronary disease). More... »

PAGES

1514-1523

References to SciGraph publications

  • 2012-08. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing in NATURE GENETICS
  • 2013-11. Common variants associated with plasma triglycerides and risk for coronary artery disease in NATURE GENETICS
  • 2017-12. T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders in SCIENTIFIC REPORTS
  • 2017-12. Exome chip meta-analysis identifies novel loci and East Asian–specific coding variants that contribute to lipid levels and coronary artery disease in NATURE GENETICS
  • 2015-11. Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers in NATURE GENETICS
  • 2013-11. Discovery and refinement of loci associated with lipid levels in NATURE GENETICS
  • 2016-07. Fast and accurate long-range phasing in a UK Biobank cohort in NATURE GENETICS
  • 2016-09. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue in SCIENTIFIC REPORTS
  • 2016-08. Analysis of protein-coding genetic variation in 60,706 humans in NATURE
  • 2014-05. Heritability and genomics of gene expression in peripheral blood in NATURE GENETICS
  • 2016-05. Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs in SCIENTIFIC REPORTS
  • 2010-08. Biological, clinical and population relevance of 95 loci for blood lipids in NATURE
  • 2015-10. A global reference for human genetic variation in NATURE
  • 2015-06. PDE3A mutations cause autosomal dominant hypertension with brachydactyly in NATURE GENETICS
  • 2018-04. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes in NATURE GENETICS
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 2017-12. Exome-wide association study of plasma lipids in >300,000 individuals in NATURE GENETICS
  • 2017-09. Association analyses based on false discovery rate implicate new loci for coronary artery disease in NATURE GENETICS
  • 2017-09. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease in NATURE GENETICS
  • 2014-02. A polygenic burden of rare disruptive mutations in schizophrenia in NATURE
  • 2013-12. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data in NATURE BIOTECHNOLOGY
  • 2013-02. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes in DIABETOLOGIA
  • 2016-03. Integrative approaches for large-scale transcriptome-wide association studies in NATURE GENETICS
  • 2017-10. Genetic effects on gene expression across human tissues in NATURE
  • 2017-02-01. Rare and low-frequency coding variants alter human adult height in NATURE
  • 2014-05. Quality control and conduct of genome-wide association meta-analyses in NATURE PROTOCOLS
  • 2016-09. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0222-9

    DOI

    http://dx.doi.org/10.1038/s41588-018-0222-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107327384

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30275531


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