Relatedness disequilibrium regression estimates heritability without environmental bias View Full Text


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Article Info

DATE

2018-09

AUTHORS

Alexander I. Young, Michael L. Frigge, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Gyda Bjornsdottir, Patrick Sulem, Gisli Masson, Unnur Thorsteinsdottir, Kari Stefansson, Augustine Kong

ABSTRACT

Heritability measures the proportion of trait variation that is due to genetic inheritance. Measurement of heritability is important in the nature-versus-nurture debate. However, existing estimates of heritability may be biased by environmental effects. Here, we introduce relatedness disequilibrium regression (RDR), a novel method for estimating heritability. RDR avoids most sources of environmental bias by exploiting variation in relatedness due to random Mendelian segregation. We used a sample of 54,888 Icelanders who had both parents genotyped to estimate the heritability of 14 traits, including height (55.4%, s.e. 4.4%) and educational attainment (17.0%, s.e. 9.4%). Our results suggest that some other estimates of heritability may be inflated by environmental effects. More... »

PAGES

1304-1310

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0178-9

    DOI

    http://dx.doi.org/10.1038/s41588-018-0178-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106100348

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30104764


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