Genome doubling shapes the evolution and prognosis of advanced cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-16

AUTHORS

Craig M. Bielski, Ahmet Zehir, Alexander V. Penson, Mark T. A. Donoghue, Walid Chatila, Joshua Armenia, Matthew T. Chang, Alison M. Schram, Philip Jonsson, Chaitanya Bandlamudi, Pedram Razavi, Gopa Iyer, Mark E. Robson, Zsofia K. Stadler, Nikolaus Schultz, Jose Baselga, David B. Solit, David M. Hyman, Michael F. Berger, Barry S. Taylor

ABSTRACT

Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied by tumor lineage and molecular subtype, and arose early in carcinogenesis after an antecedent transforming driver mutation. While associated with TP53 mutations, 46% of all WGD arose in TP53-wild-type tumors and in such cases was associated with an E2F-mediated G1 arrest defect, although neither aberration was obligate in WGD tumors. The variability of WGD across cancer types can be explained in part by cancer cell proliferation rates. WGD predicted for increased morbidity across cancer types, including KRAS-mutant colorectal cancers and estrogen receptor-positive breast cancers, independently of established clinical prognostic factors. We conclude that WGD is highly common in cancer and is a macro-evolutionary event associated with poor prognosis across cancer types. More... »

PAGES

1189-1195

References to SciGraph publications

  • 2013-11-03. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer in NATURE GENETICS
  • 2015-05-26. Challenges in the management of advanced, ER-positive, HER2-negative breast cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2017-05-15. The evolutionary significance of polyploidy in NATURE REVIEWS GENETICS
  • 2013-09-26. Pan-cancer patterns of somatic copy number alteration in NATURE GENETICS
  • 2015-04-21. Clinical management of breast cancer heterogeneity in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2005-10. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells in NATURE
  • 2018-04-02. The long tail of oncogenic drivers in prostate cancer in NATURE GENETICS
  • 2004-01. From polyploidy to aneuploidy, genome instability and cancer in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-05-08. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients in NATURE MEDICINE
  • 2016-12-06. From tumour heterogeneity to advances in precision treatment of colorectal cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2017-04-11. Toil enables reproducible, open source, big biomedical data analyses in NATURE BIOTECHNOLOGY
  • 2017-01-30. Systematic analysis of telomere length and somatic alterations in 31 cancer types in NATURE GENETICS
  • 2015-11-30. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity in NATURE BIOTECHNOLOGY
  • 2012-04-29. Absolute quantification of somatic DNA alterations in human cancer in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0165-1

    DOI

    http://dx.doi.org/10.1038/s41588-018-0165-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105584566

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30013179


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