Genome doubling shapes the evolution and prognosis of advanced cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-16

AUTHORS

Craig M. Bielski, Ahmet Zehir, Alexander V. Penson, Mark T. A. Donoghue, Walid Chatila, Joshua Armenia, Matthew T. Chang, Alison M. Schram, Philip Jonsson, Chaitanya Bandlamudi, Pedram Razavi, Gopa Iyer, Mark E. Robson, Zsofia K. Stadler, Nikolaus Schultz, Jose Baselga, David B. Solit, David M. Hyman, Michael F. Berger, Barry S. Taylor

ABSTRACT

Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospectively sequenced advanced cancer patients. WGD varied by tumor lineage and molecular subtype, and arose early in carcinogenesis after an antecedent transforming driver mutation. While associated with TP53 mutations, 46% of all WGD arose in TP53-wild-type tumors and in such cases was associated with an E2F-mediated G1 arrest defect, although neither aberration was obligate in WGD tumors. The variability of WGD across cancer types can be explained in part by cancer cell proliferation rates. WGD predicted for increased morbidity across cancer types, including KRAS-mutant colorectal cancers and estrogen receptor-positive breast cancers, independently of established clinical prognostic factors. We conclude that WGD is highly common in cancer and is a macro-evolutionary event associated with poor prognosis across cancer types. More... »

PAGES

1189-1195

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0165-1

    DOI

    http://dx.doi.org/10.1038/s41588-018-0165-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105584566

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30013179


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