Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04

AUTHORS

Eleni Zengini, Konstantinos Hatzikotoulas, Ioanna Tachmazidou, Julia Steinberg, Fernando P. Hartwig, Lorraine Southam, Sophie Hackinger, Cindy G. Boer, Unnur Styrkarsdottir, Arthur Gilly, Daniel Suveges, Britt Killian, Thorvaldur Ingvarsson, Helgi Jonsson, George C. Babis, Andrew McCaskie, Andre G. Uitterlinden, Joyce B. J. van Meurs, Unnur Thorsteinsdottir, Kari Stefansson, George Davey Smith, Jeremy M. Wilkinson, Eleftheria Zeggini

ABSTRACT

Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After performing replication and meta-analysis in up to 30,727 cases and 297,191 controls, we identified nine new osteoarthritis loci, in all of which the most likely causal variant was noncoding. For three loci, we detected association with biologically relevant radiographic endophenotypes, and in five signals we identified genes that were differentially expressed in degraded compared with intact articular cartilage from patients with osteoarthritis. We established causal effects on osteoarthritis for higher body mass index but not for triglyceride levels or genetic predisposition to type 2 diabetes. More... »

PAGES

549-558

References to SciGraph publications

  • 2010-06. Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study in ARTHRITIS RESEARCH & THERAPY
  • 2007-04. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis in NATURE GENETICS
  • 2016-02. Protein prenylation: unique fats make their mark on biology in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2016-11. Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps in NATURE GENETICS
  • 2007-07. A new multipoint method for genome-wide association studies by imputation of genotypes in NATURE GENETICS
  • 2017-04. Salmon provides fast and bias-aware quantification of transcript expression in NATURE METHODS
  • 2014-12. biobambam: tools for read pair collation based algorithms on BAM files in SOURCE CODE FOR BIOLOGY AND MEDICINE
  • 2015-10. A global reference for human genetic variation in NATURE
  • 2006-04. CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase in ARTHRITIS RESEARCH & THERAPY
  • 2016-02. A spectral approach integrating functional genomic annotations for coding and noncoding variants in NATURE GENETICS
  • 2016-12. Genome-wide analysis identifies 12 loci influencing human reproductive behavior in NATURE GENETICS
  • 2017-12. Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis in SCIENTIFIC REPORTS
  • 1999-05. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure in NATURE GENETICS
  • 2013-07. Plectin–intermediate filament partnership in skin, skeletal muscle, and peripheral nerve in HISTOCHEMISTRY AND CELL BIOLOGY
  • 2014-03. A general framework for estimating the relative pathogenicity of human genetic variants in NATURE GENETICS
  • 2017-08. Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk in NATURE GENETICS
  • 2014-12. A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration in CELL AND TISSUE RESEARCH
  • 2017-05. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis in NATURE GENETICS
  • 2015-10. The UK10K project identifies rare variants in health and disease in NATURE
  • 2014-02. voom: precision weights unlock linear model analysis tools for RNA-seq read counts in GENOME BIOLOGY
  • 2016-09. Context-specific protection of TGFα null mice from osteoarthritis in SCIENTIFIC REPORTS
  • 2015-12. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1 in ARTHRITIS RESEARCH & THERAPY
  • 2010-01. Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation in LABORATORY INVESTIGATION
  • 2011-10. Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project in ARTHRITIS RESEARCH & THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-018-0079-y

    DOI

    http://dx.doi.org/10.1038/s41588-018-0079-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101630922

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29559693


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Sheffield", 
              "id": "https://www.grid.ac/institutes/grid.11835.3e", 
              "name": [
                "Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK", 
                "Psychiatric Department, Dromokaiteio Psychiatric Hospital, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zengini", 
            "givenName": "Eleni", 
            "id": "sg:person.01267231076.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267231076.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatzikotoulas", 
            "givenName": "Konstantinos", 
            "id": "sg:person.01002374162.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002374162.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United Kingdom)", 
              "id": "https://www.grid.ac/institutes/grid.418236.a", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK", 
                "GSK, R&D Target Sciences, Medicines Research Centre, Stevenage, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tachmazidou", 
            "givenName": "Ioanna", 
            "id": "sg:person.01317561105.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317561105.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Council New South Wales", 
              "id": "https://www.grid.ac/institutes/grid.420082.c", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK", 
                "Cancer Research Division, Cancer Council NSW, Sydney, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steinberg", 
            "givenName": "Julia", 
            "id": "sg:person.011213112067.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011213112067.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bristol", 
              "id": "https://www.grid.ac/institutes/grid.5337.2", 
              "name": [
                "Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil", 
                "Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hartwig", 
            "givenName": "Fernando P.", 
            "id": "sg:person.01236154630.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236154630.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Centre for Human Genetics", 
              "id": "https://www.grid.ac/institutes/grid.270683.8", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK", 
                "Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Southam", 
            "givenName": "Lorraine", 
            "id": "sg:person.01036127203.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036127203.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hackinger", 
            "givenName": "Sophie", 
            "id": "sg:person.01064454741.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064454741.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Departments of Internal Medicine and Epidemiology, Erasmus MC, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boer", 
            "givenName": "Cindy G.", 
            "id": "sg:person.010250330042.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010250330042.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CODE genetics/Amgen, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Styrkarsdottir", 
            "givenName": "Unnur", 
            "id": "sg:person.01205523707.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205523707.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gilly", 
            "givenName": "Arthur", 
            "id": "sg:person.01162064062.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162064062.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suveges", 
            "givenName": "Daniel", 
            "id": "sg:person.0647271714.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647271714.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Killian", 
            "givenName": "Britt", 
            "id": "sg:person.011130356551.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011130356551.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Akureyri", 
              "id": "https://www.grid.ac/institutes/grid.16977.3e", 
              "name": [
                "Department of Orthopaedic Surgery, Akureyri Hospital, Akureyri, Iceland", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland", 
                "Institution of Health Science, University of Akureyri, Akureyri, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ingvarsson", 
            "givenName": "Thorvaldur", 
            "id": "sg:person.01256544557.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256544557.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University Hospital of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.410540.4", 
              "name": [
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland", 
                "Department of Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jonsson", 
            "givenName": "Helgi", 
            "id": "sg:person.0575412557.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575412557.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National and Kapodistrian University of Athens", 
              "id": "https://www.grid.ac/institutes/grid.5216.0", 
              "name": [
                "Department of Orthopaedic Surgery, Konstantopouleio General Hospital, National and Kapodistrian University of Athens, Athens, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Babis", 
            "givenName": "George C.", 
            "id": "sg:person.01212557541.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212557541.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Division of Trauma & Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCaskie", 
            "givenName": "Andrew", 
            "id": "sg:person.01126765414.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126765414.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Departments of Internal Medicine and Epidemiology, Erasmus MC, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uitterlinden", 
            "givenName": "Andre G.", 
            "id": "sg:person.01174076626.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174076626.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Erasmus University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Departments of Internal Medicine and Epidemiology, Erasmus MC, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Meurs", 
            "givenName": "Joyce B. J.", 
            "id": "sg:person.013254715244.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013254715244.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "CODE genetics/Amgen, Reykjavik, Iceland", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thorsteinsdottir", 
            "givenName": "Unnur", 
            "id": "sg:person.01277776417.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277776417.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Iceland", 
              "id": "https://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "CODE genetics/Amgen, Reykjavik, Iceland", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stefansson", 
            "givenName": "Kari", 
            "id": "sg:person.0723426172.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723426172.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospitals Bristol NHS Foundation Trust", 
              "id": "https://www.grid.ac/institutes/grid.410421.2", 
              "name": [
                "Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK", 
                "Population Health Sciences, University of Bristol, Bristol, UK", 
                "National Institute for Health Research, Bristol Biomedical Research Centre, University Hospitals Bristol, NHS Foundation Trust and University of Bristol, Bristol, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "George Davey", 
            "id": "sg:person.010663343457.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010663343457.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Sheffield", 
              "id": "https://www.grid.ac/institutes/grid.11835.3e", 
              "name": [
                "Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilkinson", 
            "givenName": "Jeremy M.", 
            "id": "sg:person.01037341220.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037341220.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Sanger Institute", 
              "id": "https://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zeggini", 
            "givenName": "Eleftheria", 
            "id": "sg:person.01220453202.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220453202.22"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000291747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.115.176107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000783574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.115.176107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000783574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/ker360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003641583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0507979103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005959955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-013-1102-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006527541", 
              "https://doi.org/10.1007/s00418-013-1102-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-013-1102-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006527541", 
              "https://doi.org/10.1007/s00418-013-1102-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007003574", 
              "https://doi.org/10.1186/ar3033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/8773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007114189", 
              "https://doi.org/10.1038/8773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/8773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007114189", 
              "https://doi.org/10.1038/8773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar1891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007210775", 
              "https://doi.org/10.1186/ar1891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-014-2010-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010078962", 
              "https://doi.org/10.1007/s00441-014-2010-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-014-2010-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010078962", 
              "https://doi.org/10.1007/s00441-014-2010-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13075-015-0792-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011010684", 
              "https://doi.org/10.1186/s13075-015-0792-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.21742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011752531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2008.096164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012096480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2008.096164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012096480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyg070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014851183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016098431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.23999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016666267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2008040406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017865516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2008040406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017865516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812819106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017903498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellbi.2008.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018699083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar3492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019028396", 
              "https://doi.org/10.1186/ar3492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.27397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020927392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812064", 
              "https://doi.org/10.1038/nature15393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.22968", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024050632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1751-0473-9-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029431008", 
              "https://doi.org/10.1186/1751-0473-9-13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029709383", 
              "https://doi.org/10.1038/ng.3698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031965116", 
              "https://doi.org/10.1038/2005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwm165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033364676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddm174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035231809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bone.2009.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040493483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042669977", 
              "https://doi.org/10.1038/ng.3668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043158715", 
              "https://doi.org/10.1038/ng.3477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2014-15-2-r29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045312009", 
              "https://doi.org/10.1186/gb-2014-15-2-r29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2015.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045794129", 
              "https://doi.org/10.1038/nrm.2015.11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046979341", 
              "https://doi.org/10.1038/ng2088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047276303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03008207.2015.1125480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047781955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep30434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047886250", 
              "https://doi.org/10.1038/srep30434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.acthis.2014.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048999754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcell.2016.00040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049306923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049666571", 
              "https://doi.org/10.1038/nature14962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050728268", 
              "https://doi.org/10.1038/ng.2892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bone.2012.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051337699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2009.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051549392", 
              "https://doi.org/10.1038/labinvest.2009.111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jor.20579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051903243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2010.134619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052135489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.34453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052578912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/annrheumdis-2012-201451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053125291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btw613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059414984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-133-8-200010170-00016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073704442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.15246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083843584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.joca.2017.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084090345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129154", 
              "https://doi.org/10.1038/ng.3816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129154", 
              "https://doi.org/10.1038/ng.3816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.4197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084129290", 
              "https://doi.org/10.1038/nmeth.4197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/078972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085114261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/078972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085114261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/078972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085114261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3899/jrheum.151384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085301321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090341838", 
              "https://doi.org/10.1038/ng.3911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090341838", 
              "https://doi.org/10.1038/ng.3911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddx302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090972791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-09335-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091255946", 
              "https://doi.org/10.1038/s41598-017-09335-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-09335-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091255946", 
              "https://doi.org/10.1038/s41598-017-09335-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-09335-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091255946", 
              "https://doi.org/10.1038/s41598-017-09335-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-04", 
        "datePublishedReg": "2018-04-01", 
        "description": "Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After performing replication and meta-analysis in up to 30,727 cases and 297,191 controls, we identified nine new osteoarthritis loci, in all of which the most likely causal variant was noncoding. For three loci, we detected association with biologically relevant radiographic endophenotypes, and in five signals we identified genes that were differentially expressed in degraded compared with intact articular cartilage from patients with osteoarthritis. We established causal effects on osteoarthritis for higher body mass index but not for triglyceride levels or genetic predisposition to type 2 diabetes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41588-018-0079-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2786773", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3498582", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "50"
          }
        ], 
        "name": "Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis", 
        "pagination": "549-558", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "34cc860744ab575b43e10eafa6bfc037967f2775c85930a8dc10b94e7ef88f4e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29559693"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41588-018-0079-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101630922"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41588-018-0079-y", 
          "https://app.dimensions.ai/details/publication/pub.1101630922"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78964_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41588-018-0079-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0079-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0079-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0079-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41588-018-0079-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    474 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41588-018-0079-y schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N2065807368674fd082cc63e75520a90f
    4 schema:citation sg:pub.10.1007/s00418-013-1102-0
    5 sg:pub.10.1007/s00441-014-2010-x
    6 sg:pub.10.1038/2005
    7 sg:pub.10.1038/8773
    8 sg:pub.10.1038/labinvest.2009.111
    9 sg:pub.10.1038/nature14962
    10 sg:pub.10.1038/nature15393
    11 sg:pub.10.1038/ng.2892
    12 sg:pub.10.1038/ng.3477
    13 sg:pub.10.1038/ng.3668
    14 sg:pub.10.1038/ng.3698
    15 sg:pub.10.1038/ng.3816
    16 sg:pub.10.1038/ng.3911
    17 sg:pub.10.1038/ng2088
    18 sg:pub.10.1038/nmeth.4197
    19 sg:pub.10.1038/nrm.2015.11
    20 sg:pub.10.1038/s41598-017-09335-6
    21 sg:pub.10.1038/srep30434
    22 sg:pub.10.1186/1751-0473-9-13
    23 sg:pub.10.1186/ar1891
    24 sg:pub.10.1186/ar3033
    25 sg:pub.10.1186/ar3492
    26 sg:pub.10.1186/gb-2014-15-2-r29
    27 sg:pub.10.1186/s13075-015-0792-1
    28 https://doi.org/10.1002/art.22968
    29 https://doi.org/10.1002/art.23999
    30 https://doi.org/10.1002/art.27397
    31 https://doi.org/10.1002/art.34453
    32 https://doi.org/10.1002/gepi.21742
    33 https://doi.org/10.1002/jor.20579
    34 https://doi.org/10.1016/j.acthis.2014.10.010
    35 https://doi.org/10.1016/j.bone.2009.10.014
    36 https://doi.org/10.1016/j.bone.2012.04.012
    37 https://doi.org/10.1016/j.cellbi.2008.02.003
    38 https://doi.org/10.1016/j.joca.2017.03.007
    39 https://doi.org/10.1073/pnas.0507979103
    40 https://doi.org/10.1073/pnas.0812819106
    41 https://doi.org/10.1093/aje/kwm165
    42 https://doi.org/10.1093/bioinformatics/btp352
    43 https://doi.org/10.1093/bioinformatics/btq340
    44 https://doi.org/10.1093/bioinformatics/btw613
    45 https://doi.org/10.1093/hmg/ddm174
    46 https://doi.org/10.1093/hmg/ddx302
    47 https://doi.org/10.1093/ije/dyg070
    48 https://doi.org/10.1093/nar/gkv007
    49 https://doi.org/10.1093/rheumatology/ker360
    50 https://doi.org/10.1101/078972
    51 https://doi.org/10.1136/annrheumdis-2012-201451
    52 https://doi.org/10.1136/ard.2008.096164
    53 https://doi.org/10.1136/ard.2010.134619
    54 https://doi.org/10.1371/journal.pgen.1006260
    55 https://doi.org/10.1534/genetics.115.176107
    56 https://doi.org/10.1681/asn.2008040406
    57 https://doi.org/10.18632/oncotarget.15246
    58 https://doi.org/10.3109/03008207.2015.1125480
    59 https://doi.org/10.3389/fcell.2016.00040
    60 https://doi.org/10.3899/jrheum.151384
    61 https://doi.org/10.7326/0003-4819-133-8-200010170-00016
    62 schema:datePublished 2018-04
    63 schema:datePublishedReg 2018-04-01
    64 schema:description Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After performing replication and meta-analysis in up to 30,727 cases and 297,191 controls, we identified nine new osteoarthritis loci, in all of which the most likely causal variant was noncoding. For three loci, we detected association with biologically relevant radiographic endophenotypes, and in five signals we identified genes that were differentially expressed in degraded compared with intact articular cartilage from patients with osteoarthritis. We established causal effects on osteoarthritis for higher body mass index but not for triglyceride levels or genetic predisposition to type 2 diabetes.
    65 schema:genre research_article
    66 schema:inLanguage en
    67 schema:isAccessibleForFree true
    68 schema:isPartOf N72caee30d6074484b12acb5b074cf00d
    69 N961c4bc4975a42cfbbf74dedc7cbdb48
    70 sg:journal.1103138
    71 schema:name Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
    72 schema:pagination 549-558
    73 schema:productId N4affa57201c840b7b8282f9061eee477
    74 N54470073f01c4177a98c0e769f1d6763
    75 N6880ab7290754867a6b8d80e5190f5e7
    76 N80c3791cb34744d79ca9083d1cc578f5
    77 N96172c9afa144e2692a810d8d47d2316
    78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101630922
    79 https://doi.org/10.1038/s41588-018-0079-y
    80 schema:sdDatePublished 2019-04-11T13:19
    81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    82 schema:sdPublisher N06a983b64e594176a9c606fcd8e296fd
    83 schema:url https://www.nature.com/articles/s41588-018-0079-y
    84 sgo:license sg:explorer/license/
    85 sgo:sdDataset articles
    86 rdf:type schema:ScholarlyArticle
    87 N06a983b64e594176a9c606fcd8e296fd schema:name Springer Nature - SN SciGraph project
    88 rdf:type schema:Organization
    89 N1527a51dd6c5467798cae4666dba4fe7 rdf:first sg:person.01126765414.68
    90 rdf:rest N22e724cd3d41447aaf66aaa069bd7231
    91 N18aea50aa73b454a82f1335f7201a3a5 rdf:first sg:person.013254715244.15
    92 rdf:rest Nedc8a39ab92a4d23b49100d40c9ba15d
    93 N2065807368674fd082cc63e75520a90f rdf:first sg:person.01267231076.59
    94 rdf:rest N47929bdd7b534f80b393849cb579ab3c
    95 N212f50abae344e978088d9098cb93a42 rdf:first sg:person.01037341220.14
    96 rdf:rest N7779d9a640554208bf890da624a9859d
    97 N22e724cd3d41447aaf66aaa069bd7231 rdf:first sg:person.01174076626.46
    98 rdf:rest N18aea50aa73b454a82f1335f7201a3a5
    99 N3e2591175d1d4a19b91ae7de52a06f32 rdf:first sg:person.010250330042.12
    100 rdf:rest N6eb80d59d25c44e4b0bf3b2a09b41ea1
    101 N43d7c2f9d78045c7850d7b96ebc8b80c rdf:first sg:person.01036127203.64
    102 rdf:rest N88ae87af9f834471a1ae2f22dbf9cab2
    103 N47929bdd7b534f80b393849cb579ab3c rdf:first sg:person.01002374162.44
    104 rdf:rest Nbe78ad94516d46f3872e20de12c50e49
    105 N4affa57201c840b7b8282f9061eee477 schema:name readcube_id
    106 schema:value 34cc860744ab575b43e10eafa6bfc037967f2775c85930a8dc10b94e7ef88f4e
    107 rdf:type schema:PropertyValue
    108 N4e50196f8c184deb976746d0c01b78e1 rdf:first sg:person.011213112067.15
    109 rdf:rest N51aef6f268e145a7bdda11bed49d5761
    110 N4e82e79bcfdf4fe8a52f4007c14274b4 rdf:first sg:person.0575412557.89
    111 rdf:rest Nd9b7e7f8b574469e89bcd4251156e0d9
    112 N51aef6f268e145a7bdda11bed49d5761 rdf:first sg:person.01236154630.21
    113 rdf:rest N43d7c2f9d78045c7850d7b96ebc8b80c
    114 N54470073f01c4177a98c0e769f1d6763 schema:name doi
    115 schema:value 10.1038/s41588-018-0079-y
    116 rdf:type schema:PropertyValue
    117 N6269f0738b0d479fad4d01e73abd3202 rdf:first sg:person.010663343457.34
    118 rdf:rest N212f50abae344e978088d9098cb93a42
    119 N6880ab7290754867a6b8d80e5190f5e7 schema:name pubmed_id
    120 schema:value 29559693
    121 rdf:type schema:PropertyValue
    122 N6eb80d59d25c44e4b0bf3b2a09b41ea1 rdf:first sg:person.01205523707.73
    123 rdf:rest N935d88be26f642dbb3102c125475353c
    124 N6f6933a47bf94ec0b4f6fee8d2e77d54 rdf:first sg:person.0647271714.33
    125 rdf:rest N88682dc1d75a4fa09dd81c92896d4490
    126 N72caee30d6074484b12acb5b074cf00d schema:volumeNumber 50
    127 rdf:type schema:PublicationVolume
    128 N7779d9a640554208bf890da624a9859d rdf:first sg:person.01220453202.22
    129 rdf:rest rdf:nil
    130 N80c3791cb34744d79ca9083d1cc578f5 schema:name dimensions_id
    131 schema:value pub.1101630922
    132 rdf:type schema:PropertyValue
    133 N88682dc1d75a4fa09dd81c92896d4490 rdf:first sg:person.011130356551.40
    134 rdf:rest Nbdce420f139142528af229819babcaf3
    135 N88ae87af9f834471a1ae2f22dbf9cab2 rdf:first sg:person.01064454741.63
    136 rdf:rest N3e2591175d1d4a19b91ae7de52a06f32
    137 N935d88be26f642dbb3102c125475353c rdf:first sg:person.01162064062.22
    138 rdf:rest N6f6933a47bf94ec0b4f6fee8d2e77d54
    139 N96172c9afa144e2692a810d8d47d2316 schema:name nlm_unique_id
    140 schema:value 9216904
    141 rdf:type schema:PropertyValue
    142 N961c4bc4975a42cfbbf74dedc7cbdb48 schema:issueNumber 4
    143 rdf:type schema:PublicationIssue
    144 Na9dd8115c5a84d1a9a92ff203457238d rdf:first sg:person.0723426172.10
    145 rdf:rest N6269f0738b0d479fad4d01e73abd3202
    146 Nbdce420f139142528af229819babcaf3 rdf:first sg:person.01256544557.44
    147 rdf:rest N4e82e79bcfdf4fe8a52f4007c14274b4
    148 Nbe78ad94516d46f3872e20de12c50e49 rdf:first sg:person.01317561105.02
    149 rdf:rest N4e50196f8c184deb976746d0c01b78e1
    150 Nbf7e53ceb31c41278fbfc79e96d0c48c schema:name CODE genetics/Amgen, Reykjavik, Iceland
    151 rdf:type schema:Organization
    152 Nd9b7e7f8b574469e89bcd4251156e0d9 rdf:first sg:person.01212557541.60
    153 rdf:rest N1527a51dd6c5467798cae4666dba4fe7
    154 Nedc8a39ab92a4d23b49100d40c9ba15d rdf:first sg:person.01277776417.51
    155 rdf:rest Na9dd8115c5a84d1a9a92ff203457238d
    156 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Biological Sciences
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Genetics
    161 rdf:type schema:DefinedTerm
    162 sg:grant.2786773 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-018-0079-y
    163 rdf:type schema:MonetaryGrant
    164 sg:grant.3498582 http://pending.schema.org/fundedItem sg:pub.10.1038/s41588-018-0079-y
    165 rdf:type schema:MonetaryGrant
    166 sg:journal.1103138 schema:issn 1061-4036
    167 1546-1718
    168 schema:name Nature Genetics
    169 rdf:type schema:Periodical
    170 sg:person.01002374162.44 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    171 schema:familyName Hatzikotoulas
    172 schema:givenName Konstantinos
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002374162.44
    174 rdf:type schema:Person
    175 sg:person.010250330042.12 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    176 schema:familyName Boer
    177 schema:givenName Cindy G.
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010250330042.12
    179 rdf:type schema:Person
    180 sg:person.01036127203.64 schema:affiliation https://www.grid.ac/institutes/grid.270683.8
    181 schema:familyName Southam
    182 schema:givenName Lorraine
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036127203.64
    184 rdf:type schema:Person
    185 sg:person.01037341220.14 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
    186 schema:familyName Wilkinson
    187 schema:givenName Jeremy M.
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037341220.14
    189 rdf:type schema:Person
    190 sg:person.01064454741.63 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    191 schema:familyName Hackinger
    192 schema:givenName Sophie
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064454741.63
    194 rdf:type schema:Person
    195 sg:person.010663343457.34 schema:affiliation https://www.grid.ac/institutes/grid.410421.2
    196 schema:familyName Smith
    197 schema:givenName George Davey
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010663343457.34
    199 rdf:type schema:Person
    200 sg:person.011130356551.40 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    201 schema:familyName Killian
    202 schema:givenName Britt
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011130356551.40
    204 rdf:type schema:Person
    205 sg:person.011213112067.15 schema:affiliation https://www.grid.ac/institutes/grid.420082.c
    206 schema:familyName Steinberg
    207 schema:givenName Julia
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011213112067.15
    209 rdf:type schema:Person
    210 sg:person.01126765414.68 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    211 schema:familyName McCaskie
    212 schema:givenName Andrew
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126765414.68
    214 rdf:type schema:Person
    215 sg:person.01162064062.22 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    216 schema:familyName Gilly
    217 schema:givenName Arthur
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162064062.22
    219 rdf:type schema:Person
    220 sg:person.01174076626.46 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    221 schema:familyName Uitterlinden
    222 schema:givenName Andre G.
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174076626.46
    224 rdf:type schema:Person
    225 sg:person.01205523707.73 schema:affiliation Nbf7e53ceb31c41278fbfc79e96d0c48c
    226 schema:familyName Styrkarsdottir
    227 schema:givenName Unnur
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205523707.73
    229 rdf:type schema:Person
    230 sg:person.01212557541.60 schema:affiliation https://www.grid.ac/institutes/grid.5216.0
    231 schema:familyName Babis
    232 schema:givenName George C.
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212557541.60
    234 rdf:type schema:Person
    235 sg:person.01220453202.22 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    236 schema:familyName Zeggini
    237 schema:givenName Eleftheria
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220453202.22
    239 rdf:type schema:Person
    240 sg:person.01236154630.21 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
    241 schema:familyName Hartwig
    242 schema:givenName Fernando P.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236154630.21
    244 rdf:type schema:Person
    245 sg:person.01256544557.44 schema:affiliation https://www.grid.ac/institutes/grid.16977.3e
    246 schema:familyName Ingvarsson
    247 schema:givenName Thorvaldur
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256544557.44
    249 rdf:type schema:Person
    250 sg:person.01267231076.59 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
    251 schema:familyName Zengini
    252 schema:givenName Eleni
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267231076.59
    254 rdf:type schema:Person
    255 sg:person.01277776417.51 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    256 schema:familyName Thorsteinsdottir
    257 schema:givenName Unnur
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277776417.51
    259 rdf:type schema:Person
    260 sg:person.01317561105.02 schema:affiliation https://www.grid.ac/institutes/grid.418236.a
    261 schema:familyName Tachmazidou
    262 schema:givenName Ioanna
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317561105.02
    264 rdf:type schema:Person
    265 sg:person.013254715244.15 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
    266 schema:familyName van Meurs
    267 schema:givenName Joyce B. J.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013254715244.15
    269 rdf:type schema:Person
    270 sg:person.0575412557.89 schema:affiliation https://www.grid.ac/institutes/grid.410540.4
    271 schema:familyName Jonsson
    272 schema:givenName Helgi
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575412557.89
    274 rdf:type schema:Person
    275 sg:person.0647271714.33 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
    276 schema:familyName Suveges
    277 schema:givenName Daniel
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647271714.33
    279 rdf:type schema:Person
    280 sg:person.0723426172.10 schema:affiliation https://www.grid.ac/institutes/grid.14013.37
    281 schema:familyName Stefansson
    282 schema:givenName Kari
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723426172.10
    284 rdf:type schema:Person
    285 sg:pub.10.1007/s00418-013-1102-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006527541
    286 https://doi.org/10.1007/s00418-013-1102-0
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1007/s00441-014-2010-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010078962
    289 https://doi.org/10.1007/s00441-014-2010-x
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031965116
    292 https://doi.org/10.1038/2005
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/8773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007114189
    295 https://doi.org/10.1038/8773
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/labinvest.2009.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051549392
    298 https://doi.org/10.1038/labinvest.2009.111
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nature14962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049666571
    301 https://doi.org/10.1038/nature14962
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nature15393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812064
    304 https://doi.org/10.1038/nature15393
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/ng.2892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050728268
    307 https://doi.org/10.1038/ng.2892
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/ng.3477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043158715
    310 https://doi.org/10.1038/ng.3477
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/ng.3668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042669977
    313 https://doi.org/10.1038/ng.3668
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/ng.3698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029709383
    316 https://doi.org/10.1038/ng.3698
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/ng.3816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129154
    319 https://doi.org/10.1038/ng.3816
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/ng.3911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090341838
    322 https://doi.org/10.1038/ng.3911
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/ng2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046979341
    325 https://doi.org/10.1038/ng2088
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nmeth.4197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129290
    328 https://doi.org/10.1038/nmeth.4197
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nrm.2015.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045794129
    331 https://doi.org/10.1038/nrm.2015.11
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/s41598-017-09335-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091255946
    334 https://doi.org/10.1038/s41598-017-09335-6
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/srep30434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047886250
    337 https://doi.org/10.1038/srep30434
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1186/1751-0473-9-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029431008
    340 https://doi.org/10.1186/1751-0473-9-13
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1186/ar1891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007210775
    343 https://doi.org/10.1186/ar1891
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1186/ar3033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007003574
    346 https://doi.org/10.1186/ar3033
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1186/ar3492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019028396
    349 https://doi.org/10.1186/ar3492
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1186/gb-2014-15-2-r29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045312009
    352 https://doi.org/10.1186/gb-2014-15-2-r29
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1186/s13075-015-0792-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011010684
    355 https://doi.org/10.1186/s13075-015-0792-1
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1002/art.22968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024050632
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1002/art.23999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016666267
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1002/art.27397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020927392
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1002/art.34453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052578912
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1002/gepi.21742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011752531
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1002/jor.20579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051903243
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.acthis.2014.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048999754
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/j.bone.2009.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040493483
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/j.bone.2012.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051337699
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/j.cellbi.2008.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018699083
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.joca.2017.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084090345
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1073/pnas.0507979103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005959955
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1073/pnas.0812819106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017903498
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1093/aje/kwm165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033364676
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1093/bioinformatics/btq340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047276303
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1093/bioinformatics/btw613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059414984
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1093/hmg/ddm174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035231809
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1093/hmg/ddx302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090972791
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1093/ije/dyg070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014851183
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1093/nar/gkv007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016098431
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1093/rheumatology/ker360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003641583
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1101/078972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085114261
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1136/annrheumdis-2012-201451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053125291
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1136/ard.2008.096164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012096480
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1136/ard.2010.134619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052135489
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1371/journal.pgen.1006260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000291747
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1534/genetics.115.176107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000783574
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1681/asn.2008040406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017865516
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.18632/oncotarget.15246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083843584
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.3109/03008207.2015.1125480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047781955
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.3389/fcell.2016.00040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049306923
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.3899/jrheum.151384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085301321
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.7326/0003-4819-133-8-200010170-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073704442
    424 rdf:type schema:CreativeWork
    425 https://www.grid.ac/institutes/grid.10306.34 schema:alternateName Wellcome Sanger Institute
    426 schema:name Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    427 rdf:type schema:Organization
    428 https://www.grid.ac/institutes/grid.11835.3e schema:alternateName University of Sheffield
    429 schema:name Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
    430 Psychiatric Department, Dromokaiteio Psychiatric Hospital, Athens, Greece
    431 rdf:type schema:Organization
    432 https://www.grid.ac/institutes/grid.14013.37 schema:alternateName University of Iceland
    433 schema:name CODE genetics/Amgen, Reykjavik, Iceland
    434 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    435 rdf:type schema:Organization
    436 https://www.grid.ac/institutes/grid.16977.3e schema:alternateName University of Akureyri
    437 schema:name Department of Orthopaedic Surgery, Akureyri Hospital, Akureyri, Iceland
    438 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    439 Institution of Health Science, University of Akureyri, Akureyri, Iceland
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.270683.8 schema:alternateName Wellcome Centre for Human Genetics
    442 schema:name Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    443 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    444 rdf:type schema:Organization
    445 https://www.grid.ac/institutes/grid.410421.2 schema:alternateName University Hospitals Bristol NHS Foundation Trust
    446 schema:name Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK
    447 National Institute for Health Research, Bristol Biomedical Research Centre, University Hospitals Bristol, NHS Foundation Trust and University of Bristol, Bristol, UK
    448 Population Health Sciences, University of Bristol, Bristol, UK
    449 rdf:type schema:Organization
    450 https://www.grid.ac/institutes/grid.410540.4 schema:alternateName National University Hospital of Iceland
    451 schema:name Department of Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland
    452 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    453 rdf:type schema:Organization
    454 https://www.grid.ac/institutes/grid.418236.a schema:alternateName GlaxoSmithKline (United Kingdom)
    455 schema:name GSK, R&D Target Sciences, Medicines Research Centre, Stevenage, UK
    456 Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    457 rdf:type schema:Organization
    458 https://www.grid.ac/institutes/grid.420082.c schema:alternateName Cancer Council New South Wales
    459 schema:name Cancer Research Division, Cancer Council NSW, Sydney, New South Wales, Australia
    460 Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK
    461 rdf:type schema:Organization
    462 https://www.grid.ac/institutes/grid.5216.0 schema:alternateName National and Kapodistrian University of Athens
    463 schema:name Department of Orthopaedic Surgery, Konstantopouleio General Hospital, National and Kapodistrian University of Athens, Athens, Greece
    464 rdf:type schema:Organization
    465 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
    466 schema:name Division of Trauma & Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
    467 rdf:type schema:Organization
    468 https://www.grid.ac/institutes/grid.5337.2 schema:alternateName University of Bristol
    469 schema:name Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK
    470 Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
    471 rdf:type schema:Organization
    472 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
    473 schema:name Departments of Internal Medicine and Epidemiology, Erasmus MC, Rotterdam, the Netherlands
    474 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...