The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-22

AUTHORS

Jeramiah J. Smith, Nataliya Timoshevskaya, Chengxi Ye, Carson Holt, Melissa C. Keinath, Hugo J. Parker, Malcolm E. Cook, Jon E. Hess, Shawn R. Narum, Francesco Lamanna, Henrik Kaessmann, Vladimir A. Timoshevskiy, Courtney K. M. Waterbury, Cody Saraceno, Leanne M. Wiedemann, Sofia M. C. Robb, Carl Baker, Evan E. Eichler, Dorit Hockman, Tatjana Sauka-Spengler, Mark Yandell, Robb Krumlauf, Greg Elgar, Chris T. Amemiya

ABSTRACT

The sea lamprey (Petromyzon marinus) serves as a comparative model for reconstructing vertebrate evolution. To enable more informed analyses, we developed a new assembly of the lamprey germline genome that integrates several complementary data sets. Analysis of this highly contiguous (chromosome-scale) assembly shows that both chromosomal and whole-genome duplications have played significant roles in the evolution of ancestral vertebrate and lamprey genomes, including chromosomes that carry the six lamprey HOX clusters. The assembly also contains several hundred genes that are reproducibly eliminated from somatic cells during early development in lamprey. Comparative analyses show that gnathostome (mouse) homologs of these genes are frequently marked by polycomb repressive complexes (PRCs) in embryonic stem cells, suggesting overlaps in the regulatory logic of somatic DNA elimination and bivalent states that are regulated by early embryonic PRCs. This new assembly will enhance diverse studies that are informed by lampreys' unique biology and evolutionary/comparative perspective. More... »

PAGES

270-277

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41588-017-0036-1

    DOI

    http://dx.doi.org/10.1038/s41588-017-0036-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100523005

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29358652


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