SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-07-14

AUTHORS

Tyler N. Starr, Nadine Czudnochowski, Zhuoming Liu, Fabrizia Zatta, Young-Jun Park, Amin Addetia, Dora Pinto, Martina Beltramello, Patrick Hernandez, Allison J. Greaney, Roberta Marzi, William G. Glass, Ivy Zhang, Adam S. Dingens, John E. Bowen, M. Alejandra Tortorici, Alexandra C. Walls, Jason A. Wojcechowskyj, Anna De Marco, Laura E. Rosen, Jiayi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, Josh R. Dillen, Heather Tucker, Jessica Bassi, Chiara Silacci-Fregni, Michael P. Housley, Julia di Iulio, Gloria Lombardo, Maria Agostini, Nicole Sprugasci, Katja Culap, Stefano Jaconi, Marcel Meury, Exequiel Dellota Jr, Rana Abdelnabi, Shi-Yan Caroline Foo, Elisabetta Cameroni, Spencer Stumpf, Tristan I. Croll, Jay C. Nix, Colin Havenar-Daughton, Luca Piccoli, Fabio Benigni, Johan Neyts, Amalio Telenti, Florian A. Lempp, Matteo S. Pizzuto, John D. Chodera, Christy M. Hebner, Herbert W. Virgin, Sean P. J. Whelan, David Veesler, Davide Corti, Jesse D. Bloom, Gyorgy Snell

ABSTRACT

An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape1–3, have activity against diverse sarbecoviruses4–7, and be highly protective through viral neutralization8–11 and effector functions12,13. Understanding how these properties relate to each other and vary across epitopes would aid the development of therapeutic antibodies and guide vaccine design. Here we comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD). Despite a trade-off between in vitro neutralization potency and breadth of sarbecovirus binding, we identify neutralizing antibodies with exceptional sarbecovirus breadth and a corresponding resistance to SARS-CoV-2 escape. One of these antibodies, S2H97, binds with high affinity across all sarbecovirus clades to a cryptic epitope and prophylactically protects hamsters from viral challenge. Antibodies that target the angiotensin-converting enzyme 2 (ACE2) receptor-binding motif (RBM) typically have poor breadth and are readily escaped by mutations despite high neutralization potency. Nevertheless, we also characterize a potent RBM antibody (S2E128) with breadth across sarbecoviruses related to SARS-CoV-2 and a high barrier to viral escape. These data highlight principles underlying variation in escape, breadth and potency among antibodies that target the RBD, and identify epitopes and features to prioritize for therapeutic development against the current and potential future pandemics. More... »

PAGES

97-102

References to SciGraph publications

  • 2021-05-24. SARS-CoV-2 Simulations Go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the Proteome in NATURE CHEMISTRY
  • 2020-10-12. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies in NATURE
  • 2019-10-07. Real-time cryo–EM data pre-processing with Warp in NATURE METHODS
  • 2020-03-26. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins in NATURE
  • 2021-03-04. Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies in NATURE MEDICINE
  • 2015-11-09. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence in NATURE MEDICINE
  • 2021-03-09. Detection of a SARS-CoV-2 variant of concern in South Africa in NATURE
  • 2020-05-26. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 in NATURE
  • 2020-02-24. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses in NATURE MICROBIOLOGY
  • 2020-11-17. STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters in NATURE COMMUNICATIONS
  • 2021-03-08. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 in NATURE
  • 2021-03-11. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies in NATURE
  • 2021-05-12. Structural basis for broad coronavirus neutralization in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2020-10-15. A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19 in NATURE COMMUNICATIONS
  • 2020-07-15. Potently neutralizing and protective human antibodies against SARS-CoV-2 in NATURE
  • 2020-11-30. Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction in NATURE METHODS
  • 2017-02-06. cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination in NATURE METHODS
  • 2021-07-19. Broad sarbecovirus neutralization by a human monoclonal antibody in NATURE
  • 2021-05-10. Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses in NATURE
  • 2020-05-18. Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody in NATURE
  • 2020-12-01. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate in NATURE
  • 2020-03-30. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    7874

    VOLUME

    597

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41586-021-03807-6

    DOI

    http://dx.doi.org/10.1038/s41586-021-03807-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1139689054

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34261126


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