Discoveries in structure and physiology of mechanically activated ion channels View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-25

AUTHORS

J. M. Kefauver, A. B. Ward, A. Patapoutian

ABSTRACT

The ability to sense physical forces is conserved across all organisms. Cells convert mechanical stimuli into electrical or chemical signals via mechanically activated ion channels. In recent years, the identification of new families of mechanosensitive ion channels—such as PIEZO and OSCA/TMEM63 channels—along with surprising insights into well-studied mechanosensitive channels have driven further developments in the mechanotransduction field. Several well-characterized mechanosensory roles such as touch, blood-pressure sensing and hearing are now linked with primary mechanotransducers. Unanticipated roles of mechanical force sensing continue to be uncovered. Furthermore, high-resolution structures representative of nearly every family of mechanically activated channel described so far have underscored their diversity while advancing our understanding of the biophysical mechanisms of pressure sensing. Here we summarize recent discoveries in the physiology and structures of known mechanically activated ion channel families and discuss their implications for understanding the mechanisms of mechanical force sensing. More... »

PAGES

567-576

References to SciGraph publications

  • 1991-02. The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration in NATURE
  • 2014-03-24. Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch in NATURE COMMUNICATIONS
  • 2018-09-04. Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile in BIOPHYSICAL REVIEWS
  • 2015-11-09. The role of lipids in mechanosensation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-01-15. Nanospring behaviour of ankyrin repeats in NATURE
  • 1990-11. Mechanosensitive ion channels of E. coli activated by amphipaths in NATURE
  • 2019-08-21. Force-induced conformational changes in PIEZO1 in NATURE
  • 2017-12-20. Structure of the mechanically activated ion channel Piezo1 in NATURE
  • 2019-08-21. Structure and mechanogating of the mammalian tactile channel PIEZO2 in NATURE
  • 2014-02-07. DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes in CELL RESEARCH
  • 2015-09-21. Architecture of the mammalian mechanosensitive Piezo1 channel in NATURE
  • 2020-07-23. Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance in NATURE COMMUNICATIONS
  • 2016-10-03. Localized force application reveals mechanically sensitive domains of Piezo1 in NATURE COMMUNICATIONS
  • 2014-12-03. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel in NATURE
  • 2016-12-15. Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D in NATURE COMMUNICATIONS
  • 2018-02-07. Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel in NATURE
  • 2016-05-10. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors in NATURE COMMUNICATIONS
  • 2018-04-03. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel in NATURE COMMUNICATIONS
  • 2014-08-27. OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis in NATURE
  • 2013-07-10. Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states in NATURE COMMUNICATIONS
  • 2009-01. Neurosensory mechanotransduction in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-12-09. Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation in NATURE
  • 2018-11-29. Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2 in NATURE COMMUNICATIONS
  • 2002-08-12. A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2002-08-12. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2018-05-23. Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1 in NATURE COMMUNICATIONS
  • 2015-05-26. Piezo1 ion channel pore properties are dictated by C-terminal region in NATURE COMMUNICATIONS
  • 2015-10-07. Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons in NATURE COMMUNICATIONS
  • 2017-07-10. K2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site in NATURE
  • 2017-10-04. Piezos thrive under pressure: mechanically activated ion channels in health and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-06-26. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC in NATURE
  • 2018-02-26. Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2019-08-21. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity in NATURE
  • 2018-01-22. Structure and mechanogating mechanism of the Piezo1 channel in NATURE
  • 2016-06-22. The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels in NATURE COMMUNICATIONS
  • 2019-08-07. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers in COMMUNICATIONS BIOLOGY
  • 2018-09-06. Structure of the mechanosensitive OSCA channels in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2017-12-12. Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41586-020-2933-1

    DOI

    http://dx.doi.org/10.1038/s41586-020-2933-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132922400

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33239794


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Other Physical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ion Channel Gating", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ion Channels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mechanotransduction, Cellular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Quaternary", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, University of Geneva, Geneva, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.8591.5", 
              "name": [
                "Howard Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA", 
                "Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA", 
                "Department of Molecular Biology, University of Geneva, Geneva, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kefauver", 
            "givenName": "J. M.", 
            "id": "sg:person.01366140353.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366140353.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.214007.0", 
              "name": [
                "Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ward", 
            "givenName": "A. B.", 
            "id": "sg:person.0640074731.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640074731.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.214007.0", 
              "name": [
                "Howard Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patapoutian", 
            "givenName": "A.", 
            "id": "sg:person.01367225306.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367225306.34"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature13593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007620365", 
              "https://doi.org/10.1038/nature13593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-04405-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104045475", 
              "https://doi.org/10.1038/s41467-018-04405-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099723544", 
              "https://doi.org/10.1038/nature25453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-019-1499-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120437512", 
              "https://doi.org/10.1038/s41586-019-1499-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-019-1485-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120437747", 
              "https://doi.org/10.1038/s41586-019-1485-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-16540-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099597360", 
              "https://doi.org/10.1038/s41598-017-16540-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025607863", 
              "https://doi.org/10.1038/ncomms9512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034712359", 
              "https://doi.org/10.1038/nsb827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-07564-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110155349", 
              "https://doi.org/10.1038/s41467-018-07564-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41594-018-0037-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101201696", 
              "https://doi.org/10.1038/s41594-018-0037-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017828067", 
              "https://doi.org/10.1038/ncomms12939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014291838", 
              "https://doi.org/10.1038/nrm2595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019832816", 
              "https://doi.org/10.1038/ncomms4520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s42003-019-0514-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120182518", 
              "https://doi.org/10.1038/s42003-019-0514-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046908618", 
              "https://doi.org/10.1038/ncomms3137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028933618", 
              "https://doi.org/10.1038/nature04437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100861940", 
              "https://doi.org/10.1038/nature25744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-03570-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101897331", 
              "https://doi.org/10.1038/s41467-018-03570-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-020-17538-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1129561560", 
              "https://doi.org/10.1038/s41467-020-17538-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024237845", 
              "https://doi.org/10.1038/nsb828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41586-019-1505-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120442720", 
              "https://doi.org/10.1038/s41586-019-1505-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015658277", 
              "https://doi.org/10.1038/nature14013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41594-018-0117-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106545343", 
              "https://doi.org/10.1038/s41594-018-0117-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms13873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025263207", 
              "https://doi.org/10.1038/ncomms13873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022597181", 
              "https://doi.org/10.1038/ncomms11460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2014.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044349449", 
              "https://doi.org/10.1038/cr.2014.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086240605", 
              "https://doi.org/10.1038/nature22981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/348261a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039500507", 
              "https://doi.org/10.1038/348261a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/349588a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040819912", 
              "https://doi.org/10.1038/349588a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008354936", 
              "https://doi.org/10.1038/ncomms11984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.3120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025168606", 
              "https://doi.org/10.1038/nsmb.3120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022470462", 
              "https://doi.org/10.1038/nature11685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100554377", 
              "https://doi.org/10.1038/nature25743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090546578", 
              "https://doi.org/10.1038/nature22988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018560485", 
              "https://doi.org/10.1038/ncomms8223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010081089", 
              "https://doi.org/10.1038/nature15247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2017.92", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092059811", 
              "https://doi.org/10.1038/nrm.2017.92"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12551-018-0450-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106650236", 
              "https://doi.org/10.1007/s12551-018-0450-3"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-11-25", 
        "datePublishedReg": "2020-11-25", 
        "description": "The ability to sense physical forces is conserved across all organisms. Cells convert mechanical stimuli into electrical or chemical signals via mechanically activated ion channels. In recent years, the identification of new families of mechanosensitive ion channels\u2014such as PIEZO and OSCA/TMEM63 channels\u2014along with surprising insights into well-studied mechanosensitive channels have driven further developments in the mechanotransduction field. Several well-characterized mechanosensory roles such as touch, blood-pressure sensing and hearing are now linked with primary mechanotransducers. Unanticipated roles of mechanical force sensing continue to be uncovered. Furthermore, high-resolution structures representative of nearly every family of mechanically activated channel described so far have underscored their diversity while advancing our understanding of the biophysical mechanisms of pressure sensing. Here we summarize recent discoveries in the physiology and structures of known mechanically activated ion channel families and discuss their implications for understanding the mechanisms of mechanical force sensing.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41586-020-2933-1", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8388781", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7171861", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7835", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "587"
          }
        ], 
        "keywords": [
          "ion channels", 
          "ion channel family", 
          "mechanosensitive channels", 
          "unanticipated role", 
          "chemical signals", 
          "mechanosensory role", 
          "channel family", 
          "recent discovery", 
          "biophysical mechanisms", 
          "surprising insights", 
          "physiology", 
          "physical forces", 
          "family", 
          "mechanical stimuli", 
          "mechanotransducers", 
          "discovery", 
          "organisms", 
          "new family", 
          "diversity", 
          "mechanism", 
          "role", 
          "cells", 
          "identification", 
          "insights", 
          "structure", 
          "structure representative", 
          "channels", 
          "representatives", 
          "understanding", 
          "ability", 
          "signals", 
          "force sensing", 
          "recent years", 
          "development", 
          "sensing", 
          "further development", 
          "stimuli", 
          "implications", 
          "ions", 
          "piezo", 
          "field", 
          "years", 
          "force", 
          "hearing", 
          "pressure", 
          "touch", 
          "mechanosensitive ion", 
          "OSCA/TMEM63 channels", 
          "TMEM63 channels", 
          "mechanotransduction field", 
          "blood-pressure sensing", 
          "primary mechanotransducers", 
          "mechanical force sensing", 
          "high-resolution structures representative"
        ], 
        "name": "Discoveries in structure and physiology of mechanically activated ion channels", 
        "pagination": "567-576", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1132922400"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41586-020-2933-1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33239794"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41586-020-2933-1", 
          "https://app.dimensions.ai/details/publication/pub.1132922400"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_853.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41586-020-2933-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2933-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2933-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2933-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2933-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    329 TRIPLES      22 PREDICATES      127 URIs      79 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41586-020-2933-1 schema:about N372505188f624201b0aac855386a4a04
    2 N9f1eeb74f2c24c748daea8a692dc8505
    3 Nc2845e527ae8486c9d222b4ad5d59e54
    4 Nce0f8884bf044aad83e29548ff49073a
    5 Nd1593c84ccfa47968cfcc56bf4990d9b
    6 Ne98e1f1105e24d7bafb6316a53927734
    7 Nffd3b9be73f949b084840a1dbdd5d732
    8 anzsrc-for:02
    9 anzsrc-for:0299
    10 anzsrc-for:06
    11 anzsrc-for:0601
    12 schema:author Nd715434f355a494cbedca872696531d6
    13 schema:citation sg:pub.10.1007/s12551-018-0450-3
    14 sg:pub.10.1038/348261a0
    15 sg:pub.10.1038/349588a0
    16 sg:pub.10.1038/cr.2014.14
    17 sg:pub.10.1038/nature04437
    18 sg:pub.10.1038/nature11685
    19 sg:pub.10.1038/nature13593
    20 sg:pub.10.1038/nature14013
    21 sg:pub.10.1038/nature15247
    22 sg:pub.10.1038/nature22981
    23 sg:pub.10.1038/nature22988
    24 sg:pub.10.1038/nature25453
    25 sg:pub.10.1038/nature25743
    26 sg:pub.10.1038/nature25744
    27 sg:pub.10.1038/ncomms11460
    28 sg:pub.10.1038/ncomms11984
    29 sg:pub.10.1038/ncomms12939
    30 sg:pub.10.1038/ncomms13873
    31 sg:pub.10.1038/ncomms3137
    32 sg:pub.10.1038/ncomms4520
    33 sg:pub.10.1038/ncomms8223
    34 sg:pub.10.1038/ncomms9512
    35 sg:pub.10.1038/nrm.2017.92
    36 sg:pub.10.1038/nrm2595
    37 sg:pub.10.1038/nsb827
    38 sg:pub.10.1038/nsb828
    39 sg:pub.10.1038/nsmb.3120
    40 sg:pub.10.1038/s41467-018-03570-9
    41 sg:pub.10.1038/s41467-018-04405-3
    42 sg:pub.10.1038/s41467-018-07564-5
    43 sg:pub.10.1038/s41467-020-17538-1
    44 sg:pub.10.1038/s41586-019-1485-8
    45 sg:pub.10.1038/s41586-019-1499-2
    46 sg:pub.10.1038/s41586-019-1505-8
    47 sg:pub.10.1038/s41594-018-0037-5
    48 sg:pub.10.1038/s41594-018-0117-6
    49 sg:pub.10.1038/s41598-017-16540-w
    50 sg:pub.10.1038/s42003-019-0514-3
    51 schema:datePublished 2020-11-25
    52 schema:datePublishedReg 2020-11-25
    53 schema:description The ability to sense physical forces is conserved across all organisms. Cells convert mechanical stimuli into electrical or chemical signals via mechanically activated ion channels. In recent years, the identification of new families of mechanosensitive ion channels—such as PIEZO and OSCA/TMEM63 channels—along with surprising insights into well-studied mechanosensitive channels have driven further developments in the mechanotransduction field. Several well-characterized mechanosensory roles such as touch, blood-pressure sensing and hearing are now linked with primary mechanotransducers. Unanticipated roles of mechanical force sensing continue to be uncovered. Furthermore, high-resolution structures representative of nearly every family of mechanically activated channel described so far have underscored their diversity while advancing our understanding of the biophysical mechanisms of pressure sensing. Here we summarize recent discoveries in the physiology and structures of known mechanically activated ion channel families and discuss their implications for understanding the mechanisms of mechanical force sensing.
    54 schema:genre article
    55 schema:inLanguage en
    56 schema:isAccessibleForFree true
    57 schema:isPartOf N15812708920f43db943dcfda2f36963f
    58 Ne43467fcbf51445abe2e159526c142fe
    59 sg:journal.1018957
    60 schema:keywords OSCA/TMEM63 channels
    61 TMEM63 channels
    62 ability
    63 biophysical mechanisms
    64 blood-pressure sensing
    65 cells
    66 channel family
    67 channels
    68 chemical signals
    69 development
    70 discovery
    71 diversity
    72 family
    73 field
    74 force
    75 force sensing
    76 further development
    77 hearing
    78 high-resolution structures representative
    79 identification
    80 implications
    81 insights
    82 ion channel family
    83 ion channels
    84 ions
    85 mechanical force sensing
    86 mechanical stimuli
    87 mechanism
    88 mechanosensitive channels
    89 mechanosensitive ion
    90 mechanosensory role
    91 mechanotransducers
    92 mechanotransduction field
    93 new family
    94 organisms
    95 physical forces
    96 physiology
    97 piezo
    98 pressure
    99 primary mechanotransducers
    100 recent discovery
    101 recent years
    102 representatives
    103 role
    104 sensing
    105 signals
    106 stimuli
    107 structure
    108 structure representative
    109 surprising insights
    110 touch
    111 unanticipated role
    112 understanding
    113 years
    114 schema:name Discoveries in structure and physiology of mechanically activated ion channels
    115 schema:pagination 567-576
    116 schema:productId N1ce45b7134644ed68c85bc8cce718342
    117 N3f1e0e4291c04b36a0ff3430523b5944
    118 N99eb6ca70a964982903fc187dfac5e55
    119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132922400
    120 https://doi.org/10.1038/s41586-020-2933-1
    121 schema:sdDatePublished 2022-01-01T18:56
    122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    123 schema:sdPublisher N608ef2c64da64aa38f763ebc41971e90
    124 schema:url https://doi.org/10.1038/s41586-020-2933-1
    125 sgo:license sg:explorer/license/
    126 sgo:sdDataset articles
    127 rdf:type schema:ScholarlyArticle
    128 N15812708920f43db943dcfda2f36963f schema:volumeNumber 587
    129 rdf:type schema:PublicationVolume
    130 N1ce45b7134644ed68c85bc8cce718342 schema:name dimensions_id
    131 schema:value pub.1132922400
    132 rdf:type schema:PropertyValue
    133 N372505188f624201b0aac855386a4a04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Mechanotransduction, Cellular
    135 rdf:type schema:DefinedTerm
    136 N3f1e0e4291c04b36a0ff3430523b5944 schema:name pubmed_id
    137 schema:value 33239794
    138 rdf:type schema:PropertyValue
    139 N608ef2c64da64aa38f763ebc41971e90 schema:name Springer Nature - SN SciGraph project
    140 rdf:type schema:Organization
    141 N99eb6ca70a964982903fc187dfac5e55 schema:name doi
    142 schema:value 10.1038/s41586-020-2933-1
    143 rdf:type schema:PropertyValue
    144 N9f1eeb74f2c24c748daea8a692dc8505 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Humans
    146 rdf:type schema:DefinedTerm
    147 Nc2845e527ae8486c9d222b4ad5d59e54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Ion Channels
    149 rdf:type schema:DefinedTerm
    150 Nce0f8884bf044aad83e29548ff49073a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Models, Molecular
    152 rdf:type schema:DefinedTerm
    153 Nd1593c84ccfa47968cfcc56bf4990d9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Animals
    155 rdf:type schema:DefinedTerm
    156 Nd715434f355a494cbedca872696531d6 rdf:first sg:person.01366140353.50
    157 rdf:rest Nf66f09bf59524667a11c1572fb1b414b
    158 Nd767aba9bd7d49ca953e55f366ca792c rdf:first sg:person.01367225306.34
    159 rdf:rest rdf:nil
    160 Ne43467fcbf51445abe2e159526c142fe schema:issueNumber 7835
    161 rdf:type schema:PublicationIssue
    162 Ne98e1f1105e24d7bafb6316a53927734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Ion Channel Gating
    164 rdf:type schema:DefinedTerm
    165 Nf66f09bf59524667a11c1572fb1b414b rdf:first sg:person.0640074731.29
    166 rdf:rest Nd767aba9bd7d49ca953e55f366ca792c
    167 Nffd3b9be73f949b084840a1dbdd5d732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Protein Structure, Quaternary
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Physical Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Other Physical Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Biological Sciences
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Biochemistry and Cell Biology
    181 rdf:type schema:DefinedTerm
    182 sg:grant.7171861 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-020-2933-1
    183 rdf:type schema:MonetaryGrant
    184 sg:grant.8388781 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-020-2933-1
    185 rdf:type schema:MonetaryGrant
    186 sg:journal.1018957 schema:issn 0028-0836
    187 1476-4687
    188 schema:name Nature
    189 schema:publisher Springer Nature
    190 rdf:type schema:Periodical
    191 sg:person.01366140353.50 schema:affiliation grid-institutes:grid.8591.5
    192 schema:familyName Kefauver
    193 schema:givenName J. M.
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366140353.50
    195 rdf:type schema:Person
    196 sg:person.01367225306.34 schema:affiliation grid-institutes:grid.214007.0
    197 schema:familyName Patapoutian
    198 schema:givenName A.
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367225306.34
    200 rdf:type schema:Person
    201 sg:person.0640074731.29 schema:affiliation grid-institutes:grid.214007.0
    202 schema:familyName Ward
    203 schema:givenName A. B.
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640074731.29
    205 rdf:type schema:Person
    206 sg:pub.10.1007/s12551-018-0450-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106650236
    207 https://doi.org/10.1007/s12551-018-0450-3
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/348261a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039500507
    210 https://doi.org/10.1038/348261a0
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/349588a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040819912
    213 https://doi.org/10.1038/349588a0
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/cr.2014.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044349449
    216 https://doi.org/10.1038/cr.2014.14
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nature04437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028933618
    219 https://doi.org/10.1038/nature04437
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nature11685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022470462
    222 https://doi.org/10.1038/nature11685
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature13593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007620365
    225 https://doi.org/10.1038/nature13593
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature14013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015658277
    228 https://doi.org/10.1038/nature14013
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature15247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010081089
    231 https://doi.org/10.1038/nature15247
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature22981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086240605
    234 https://doi.org/10.1038/nature22981
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature22988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090546578
    237 https://doi.org/10.1038/nature22988
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature25453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099723544
    240 https://doi.org/10.1038/nature25453
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature25743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100554377
    243 https://doi.org/10.1038/nature25743
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nature25744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100861940
    246 https://doi.org/10.1038/nature25744
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/ncomms11460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022597181
    249 https://doi.org/10.1038/ncomms11460
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ncomms11984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008354936
    252 https://doi.org/10.1038/ncomms11984
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ncomms12939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017828067
    255 https://doi.org/10.1038/ncomms12939
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/ncomms13873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025263207
    258 https://doi.org/10.1038/ncomms13873
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/ncomms3137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046908618
    261 https://doi.org/10.1038/ncomms3137
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/ncomms4520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019832816
    264 https://doi.org/10.1038/ncomms4520
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ncomms8223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018560485
    267 https://doi.org/10.1038/ncomms8223
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/ncomms9512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025607863
    270 https://doi.org/10.1038/ncomms9512
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nrm.2017.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092059811
    273 https://doi.org/10.1038/nrm.2017.92
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nrm2595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014291838
    276 https://doi.org/10.1038/nrm2595
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nsb827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034712359
    279 https://doi.org/10.1038/nsb827
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nsb828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024237845
    282 https://doi.org/10.1038/nsb828
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nsmb.3120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025168606
    285 https://doi.org/10.1038/nsmb.3120
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/s41467-018-03570-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101897331
    288 https://doi.org/10.1038/s41467-018-03570-9
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/s41467-018-04405-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104045475
    291 https://doi.org/10.1038/s41467-018-04405-3
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/s41467-018-07564-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110155349
    294 https://doi.org/10.1038/s41467-018-07564-5
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/s41467-020-17538-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1129561560
    297 https://doi.org/10.1038/s41467-020-17538-1
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/s41586-019-1485-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120437747
    300 https://doi.org/10.1038/s41586-019-1485-8
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/s41586-019-1499-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120437512
    303 https://doi.org/10.1038/s41586-019-1499-2
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/s41586-019-1505-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120442720
    306 https://doi.org/10.1038/s41586-019-1505-8
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/s41594-018-0037-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101201696
    309 https://doi.org/10.1038/s41594-018-0037-5
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/s41594-018-0117-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106545343
    312 https://doi.org/10.1038/s41594-018-0117-6
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/s41598-017-16540-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1099597360
    315 https://doi.org/10.1038/s41598-017-16540-w
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/s42003-019-0514-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120182518
    318 https://doi.org/10.1038/s42003-019-0514-3
    319 rdf:type schema:CreativeWork
    320 grid-institutes:grid.214007.0 schema:alternateName Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA
    321 Howard Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA
    322 schema:name Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA
    323 Howard Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA
    324 rdf:type schema:Organization
    325 grid-institutes:grid.8591.5 schema:alternateName Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    326 schema:name Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA
    327 Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    328 Howard Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA
    329 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...