Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-05-18

AUTHORS

Dora Pinto, Young-Jun Park, Martina Beltramello, Alexandra C. Walls, M. Alejandra Tortorici, Siro Bianchi, Stefano Jaconi, Katja Culap, Fabrizia Zatta, Anna De Marco, Alessia Peter, Barbara Guarino, Roberto Spreafico, Elisabetta Cameroni, James Brett Case, Rita E. Chen, Colin Havenar-Daughton, Gyorgy Snell, Amalio Telenti, Herbert W. Virgin, Antonio Lanzavecchia, Michael S. Diamond, Katja Fink, David Veesler, Davide Corti

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), which has resulted in more than 3.7 million infections and 260,000 deaths as of 6 May 20201,2. Vaccine and therapeutic discovery efforts are paramount to curb the pandemic spread of this zoonotic virus. The SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is the main target of neutralizing antibodies. Here we describe several monoclonal antibodies that target the S glycoprotein of SARS-CoV-2, which we identified from memory B cells of an individual who was infected with severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. One antibody (named S309) potently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2, by engaging the receptor-binding domain of the S glycoprotein. Using cryo-electron microscopy and binding assays, we show that S309 recognizes an epitope containing a glycan that is conserved within the Sarbecovirus subgenus, without competing with receptor attachment. Antibody cocktails that include S309 in combination with other antibodies that we identified further enhanced SARS-CoV-2 neutralization, and may limit the emergence of neutralization-escape mutants. These results pave the way for using S309 and antibody cocktails containing S309 for prophylaxis in individuals at a high risk of exposure or as a post-exposure therapy to limit or treat severe disease. More... »

PAGES

290-295

References to SciGraph publications

  • 2020-04-21. Developing therapeutic monoclonal antibodies at pandemic pace in NATURE BIOTECHNOLOGY
  • 2019-10-07. Real-time cryo-electron microscopy data preprocessing with Warp in NATURE METHODS
  • 2020-03-26. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins in NATURE
  • 2010-01-17. Enhanced antibody half-life improves in vivo activity in NATURE BIOTECHNOLOGY
  • 2020-02-03. A pneumonia outbreak associated with a new coronavirus of probable bat origin in NATURE
  • 2020-05-26. Human neutralizing antibodies elicited by SARS-CoV-2 infection in NATURE
  • 2020-04-21. The potential danger of suboptimal antibody responses in COVID-19 in NATURE REVIEWS IMMUNOLOGY
  • 2013-10-30. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor in NATURE
  • 2020-05-04. A human monoclonal antibody blocking SARS-CoV-2 infection in NATURE COMMUNICATIONS
  • 2019-06-03. Structural basis for human coronavirus attachment to sialic acid receptors in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2020-02-24. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses in NATURE MICROBIOLOGY
  • 2016-09-12. Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2019-12-02. Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-07-11. An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus in NATURE MEDICINE
  • 2015-11-04. Privateer: software for the conformational validation of carbohydrate structures in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-07-29. Prevention of overfitting in cryo-EM structure determination in NATURE METHODS
  • 2017-02-06. cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination in NATURE METHODS
  • 2017-10-06. IgG Fc engineering to modulate antibody effector functions in PROTEIN & CELL
  • 2007-09. Fc receptor but not complement binding is important in antibody protection against HIV in NATURE
  • 2017-07-03. Addressing preferred specimen orientation in single-particle cryo-EM through tilting in NATURE METHODS
  • 2016-02-08. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer in NATURE
  • 2020-03-30. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor in NATURE
  • 2017-10-10. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice in NATURE COMMUNICATIONS
  • 2015-08-17. EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy in NATURE METHODS
  • 2020-03-30. Structural basis of receptor recognition by SARS-CoV-2 in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    7815

    VOLUME

    583

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41586-020-2349-y

    DOI

    http://dx.doi.org/10.1038/s41586-020-2349-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1127684942

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32422645


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