Ontology type: schema:ScholarlyArticle Open Access: True
2020-05-18
AUTHORSDora Pinto, Young-Jun Park, Martina Beltramello, Alexandra C. Walls, M. Alejandra Tortorici, Siro Bianchi, Stefano Jaconi, Katja Culap, Fabrizia Zatta, Anna De Marco, Alessia Peter, Barbara Guarino, Roberto Spreafico, Elisabetta Cameroni, James Brett Case, Rita E. Chen, Colin Havenar-Daughton, Gyorgy Snell, Amalio Telenti, Herbert W. Virgin, Antonio Lanzavecchia, Michael S. Diamond, Katja Fink, David Veesler, Davide Corti
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), which has resulted in more than 3.7 million infections and 260,000 deaths as of 6 May 20201,2. Vaccine and therapeutic discovery efforts are paramount to curb the pandemic spread of this zoonotic virus. The SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is the main target of neutralizing antibodies. Here we describe several monoclonal antibodies that target the S glycoprotein of SARS-CoV-2, which we identified from memory B cells of an individual who was infected with severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. One antibody (named S309) potently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2, by engaging the receptor-binding domain of the S glycoprotein. Using cryo-electron microscopy and binding assays, we show that S309 recognizes an epitope containing a glycan that is conserved within the Sarbecovirus subgenus, without competing with receptor attachment. Antibody cocktails that include S309 in combination with other antibodies that we identified further enhanced SARS-CoV-2 neutralization, and may limit the emergence of neutralization-escape mutants. These results pave the way for using S309 and antibody cocktails containing S309 for prophylaxis in individuals at a high risk of exposure or as a post-exposure therapy to limit or treat severe disease. More... »
PAGES290-295
http://scigraph.springernature.com/pub.10.1038/s41586-020-2349-y
DOIhttp://dx.doi.org/10.1038/s41586-020-2349-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1127684942
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/32422645
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Microbiology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Angiotensin-Converting Enzyme 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Monoclonal",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Neutralizing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibodies, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antibody-Dependent Cell Cytotoxicity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Betacoronavirus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "COVID-19",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chlorocebus aethiops",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coronavirus Infections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cross Reactions",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cryoelectron Microscopy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epitopes, B-Lymphocyte",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HEK293 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immune Evasion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunoglobulin Fab Fragments",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunologic Memory",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Killer Cells, Natural",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Molecular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neutralization Tests",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pandemics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peptidyl-Dipeptidase A",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pneumonia, Viral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "SARS Virus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "SARS-CoV-2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Severe Acute Respiratory Syndrome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spike Glycoprotein, Coronavirus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vero Cells",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Pinto",
"givenName": "Dora",
"id": "sg:person.01116527452.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116527452.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry, University of Washington, Seattle, WA, USA",
"id": "http://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Biochemistry, University of Washington, Seattle, WA, USA"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Young-Jun",
"id": "sg:person.015020273740.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015020273740.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Beltramello",
"givenName": "Martina",
"id": "sg:person.01161036612.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161036612.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry, University of Washington, Seattle, WA, USA",
"id": "http://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Biochemistry, University of Washington, Seattle, WA, USA"
],
"type": "Organization"
},
"familyName": "Walls",
"givenName": "Alexandra C.",
"id": "sg:person.0600455253.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600455253.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institut Pasteur and CNRS UMR 3569, Unit\u00e9 de Virologie Structurale, Paris, France",
"id": "http://www.grid.ac/institutes/grid.428999.7",
"name": [
"Department of Biochemistry, University of Washington, Seattle, WA, USA",
"Institut Pasteur and CNRS UMR 3569, Unit\u00e9 de Virologie Structurale, Paris, France"
],
"type": "Organization"
},
"familyName": "Tortorici",
"givenName": "M. Alejandra",
"id": "sg:person.01314262545.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314262545.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Bianchi",
"givenName": "Siro",
"id": "sg:person.0614660436.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614660436.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Jaconi",
"givenName": "Stefano",
"id": "sg:person.014167254733.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014167254733.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Culap",
"givenName": "Katja",
"id": "sg:person.012020760021.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012020760021.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Zatta",
"givenName": "Fabrizia",
"id": "sg:person.010067474113.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010067474113.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "De Marco",
"givenName": "Anna",
"id": "sg:person.014507234055.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014507234055.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Peter",
"givenName": "Alessia",
"id": "sg:person.014211301421.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014211301421.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Guarino",
"givenName": "Barbara",
"id": "sg:person.01113450636.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113450636.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vir Biotechnology, San Francisco, CA, USA",
"id": "http://www.grid.ac/institutes/grid.507173.7",
"name": [
"Vir Biotechnology, San Francisco, CA, USA"
],
"type": "Organization"
},
"familyName": "Spreafico",
"givenName": "Roberto",
"id": "sg:person.01015054532.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015054532.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Cameroni",
"givenName": "Elisabetta",
"id": "sg:person.010645354037.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010645354037.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medicine, Washington University School of Medicine, St Louis, MO, USA",
"id": "http://www.grid.ac/institutes/grid.4367.6",
"name": [
"Department of Medicine, Washington University School of Medicine, St Louis, MO, USA"
],
"type": "Organization"
},
"familyName": "Case",
"givenName": "James Brett",
"id": "sg:person.01206633375.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206633375.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA",
"id": "http://www.grid.ac/institutes/grid.4367.6",
"name": [
"Department of Medicine, Washington University School of Medicine, St Louis, MO, USA",
"Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA"
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Rita E.",
"id": "sg:person.01164430641.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164430641.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vir Biotechnology, San Francisco, CA, USA",
"id": "http://www.grid.ac/institutes/grid.507173.7",
"name": [
"Vir Biotechnology, San Francisco, CA, USA"
],
"type": "Organization"
},
"familyName": "Havenar-Daughton",
"givenName": "Colin",
"id": "sg:person.01170166465.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170166465.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vir Biotechnology, San Francisco, CA, USA",
"id": "http://www.grid.ac/institutes/grid.507173.7",
"name": [
"Vir Biotechnology, San Francisco, CA, USA"
],
"type": "Organization"
},
"familyName": "Snell",
"givenName": "Gyorgy",
"id": "sg:person.012067073221.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012067073221.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vir Biotechnology, San Francisco, CA, USA",
"id": "http://www.grid.ac/institutes/grid.507173.7",
"name": [
"Vir Biotechnology, San Francisco, CA, USA"
],
"type": "Organization"
},
"familyName": "Telenti",
"givenName": "Amalio",
"id": "sg:person.01162002733.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162002733.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vir Biotechnology, San Francisco, CA, USA",
"id": "http://www.grid.ac/institutes/grid.507173.7",
"name": [
"Vir Biotechnology, San Francisco, CA, USA"
],
"type": "Organization"
},
"familyName": "Virgin",
"givenName": "Herbert W.",
"id": "sg:person.01252531616.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252531616.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute for Research in Biomedicine, Universit\u00e0 della Svizzera Italiana, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.29078.34",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera Italiana, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Lanzavecchia",
"givenName": "Antonio",
"id": "sg:person.01215457533.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215457533.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA",
"id": "http://www.grid.ac/institutes/grid.4367.6",
"name": [
"Department of Medicine, Washington University School of Medicine, St Louis, MO, USA",
"Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA",
"Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA"
],
"type": "Organization"
},
"familyName": "Diamond",
"givenName": "Michael S.",
"id": "sg:person.0757052535.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757052535.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Fink",
"givenName": "Katja",
"id": "sg:person.015652355621.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015652355621.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry, University of Washington, Seattle, WA, USA",
"id": "http://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Biochemistry, University of Washington, Seattle, WA, USA"
],
"type": "Organization"
},
"familyName": "Veesler",
"givenName": "David",
"id": "sg:person.01002414777.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002414777.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland",
"id": "http://www.grid.ac/institutes/grid.498378.9",
"name": [
"Humabs BioMed SA, Vir Biotechnology, Bellinzona, Switzerland"
],
"type": "Organization"
},
"familyName": "Corti",
"givenName": "Davide",
"id": "sg:person.01340264536.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340264536.63"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/s41586-020-2380-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1127872932",
"https://doi.org/10.1038/s41586-020-2380-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.3541",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004871597",
"https://doi.org/10.1038/nmeth.3541"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-017-00928-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092092286",
"https://doi.org/10.1038/s41467-017-00928-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41586-020-2012-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1124545162",
"https://doi.org/10.1038/s41586-020-2012-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12711",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034803318",
"https://doi.org/10.1038/nature12711"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41467-020-16256-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1127347639",
"https://doi.org/10.1038/s41467-020-16256-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.2115",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041024070",
"https://doi.org/10.1038/nmeth.2115"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41586-020-2180-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1125975734",
"https://doi.org/10.1038/s41586-020-2180-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41577-020-0321-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1126837604",
"https://doi.org/10.1038/s41577-020-0321-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41586-020-2169-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1125900810",
"https://doi.org/10.1038/s41586-020-2169-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41564-020-0688-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1125089278",
"https://doi.org/10.1038/s41564-020-0688-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41586-020-2179-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1125975630",
"https://doi.org/10.1038/s41586-020-2179-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41587-020-0512-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1126840322",
"https://doi.org/10.1038/s41587-020-0512-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.4347",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090326400",
"https://doi.org/10.1038/nmeth.4347"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13238-017-0473-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092115732",
"https://doi.org/10.1007/s13238-017-0473-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.3293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018950972",
"https://doi.org/10.1038/nsmb.3293"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41592-019-0580-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1121550754",
"https://doi.org/10.1038/s41592-019-0580-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.3115",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010755414",
"https://doi.org/10.1038/nsmb.3115"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature16988",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050236601",
"https://doi.org/10.1038/nature16988"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003318475",
"https://doi.org/10.1038/nature06106"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41594-019-0233-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1116577957",
"https://doi.org/10.1038/s41594-019-0233-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1080",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000767164",
"https://doi.org/10.1038/nm1080"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41594-019-0334-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1123050653",
"https://doi.org/10.1038/s41594-019-0334-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.4169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083686092",
"https://doi.org/10.1038/nmeth.4169"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.1601",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019620179",
"https://doi.org/10.1038/nbt.1601"
],
"type": "CreativeWork"
}
],
"datePublished": "2020-05-18",
"datePublishedReg": "2020-05-18",
"description": "Severe acute respiratory syndrome coronavirus\u00a02 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), which has resulted in more than 3.7\u00a0million infections and 260,000\u00a0deaths as of 6\u00a0May 20201,2. Vaccine and therapeutic discovery efforts are paramount to curb the pandemic spread of this zoonotic virus. The SARS-CoV-2 spike (S) glycoprotein promotes entry into host cells and is the main target of neutralizing antibodies. Here we describe several monoclonal antibodies that target the S\u00a0glycoprotein of SARS-CoV-2, which we identified from memory B\u00a0cells of an individual who was infected with severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. One antibody (named S309) potently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2, by engaging the receptor-binding domain of the S\u00a0glycoprotein. Using cryo-electron microscopy and binding assays, we show that S309 recognizes an epitope containing a glycan that is conserved within the Sarbecovirus subgenus, without competing with receptor attachment. Antibody cocktails that include S309 in combination with other antibodies that we identified further enhanced SARS-CoV-2 neutralization, and may limit the emergence of neutralization-escape mutants. These results pave the way for using S309 and antibody cocktails containing S309 for prophylaxis in individuals at a high risk of exposure or as a post-exposure therapy to limit or treat severe disease.",
"genre": "article",
"id": "sg:pub.10.1038/s41586-020-2349-y",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6803473",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7169995",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5503638",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7815",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "583"
}
],
"keywords": [
"SARS-CoV-2",
"severe acute respiratory syndrome coronavirus",
"acute respiratory syndrome coronavirus",
"authentic SARS-CoV-2",
"SARS-CoV-2 neutralization",
"SARS-CoV-2 spike glycoprotein",
"post-exposure therapy",
"coronavirus disease 2019",
"SARS-CoV pseudovirus",
"neutralization escape mutants",
"SARS-CoV antibody",
"disease 2019",
"memory B",
"receptor-binding domain",
"severe disease",
"high risk",
"monoclonal antibodies",
"antibodies",
"zoonotic viruses",
"pandemic spread",
"spike glycoprotein",
"current pandemic",
"coronavirus",
"S309",
"host cells",
"Sarbecovirus subgenus",
"receptor attachment",
"glycoprotein",
"discovery efforts",
"prophylaxis",
"cells",
"therapy",
"vaccine",
"pseudoviruses",
"infection",
"main target",
"disease",
"individuals",
"death",
"epitopes",
"virus",
"risk",
"pandemic",
"exposure",
"assays",
"neutralization",
"target",
"spread",
"entry",
"combination",
"glycans",
"attachment",
"results",
"efforts",
"emergence",
"mutants",
"microscopy",
"domain",
"cryo-electron microscopy",
"way",
"subgenera",
"respiratory syndrome coronavirus",
"syndrome coronavirus",
"therapeutic discovery efforts",
"human monoclonal SARS-CoV antibody",
"monoclonal SARS-CoV antibody"
],
"name": "Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody",
"pagination": "290-295",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1127684942"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41586-020-2349-y"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"32422645"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41586-020-2349-y",
"https://app.dimensions.ai/details/publication/pub.1127684942"
],
"sdDataset": "articles",
"sdDatePublished": "2022-01-01T18:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_853.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41586-020-2349-y"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2349-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2349-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2349-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-020-2349-y'
This table displays all metadata directly associated to this object as RDF triples.
547 TRIPLES
22 PREDICATES
148 URIs
114 LITERALS
37 BLANK NODES