Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-05-29

AUTHORS

Jason Lloyd-Price, Cesar Arze, Ashwin N. Ananthakrishnan, Melanie Schirmer, Julian Avila-Pacheco, Tiffany W. Poon, Elizabeth Andrews, Nadim J. Ajami, Kevin S. Bonham, Colin J. Brislawn, David Casero, Holly Courtney, Antonio Gonzalez, Thomas G. Graeber, A. Brantley Hall, Kathleen Lake, Carol J. Landers, Himel Mallick, Damian R. Plichta, Mahadev Prasad, Gholamali Rahnavard, Jenny Sauk, Dmitry Shungin, Yoshiki Vázquez-Baeza, Richard A. White, Jonathan Braun, Lee A. Denson, Janet K. Jansson, Rob Knight, Subra Kugathasan, Dermot P. B. McGovern, Joseph F. Petrosino, Thaddeus S. Stappenbeck, Harland S. Winter, Clary B. Clish, Eric A. Franzosa, Hera Vlamakis, Ramnik J. Xavier, Curtis Huttenhower

ABSTRACT

Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect several million individuals worldwide. Crohn’s disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study’s infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi’omics Database (http://ibdmdb.org), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases. More... »

PAGES

655-662

References to SciGraph publications

  • 2017-11-28. A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients in GENOME MEDICINE
  • 2007-06-28. Virus detection and identification using random multiplex (RT)-PCR with 3'-locked random primers in VIROLOGY JOURNAL
  • 2014-11-17. Fast and sensitive protein alignment using DIAMOND in NATURE METHODS
  • 1993-09. Multiple vitamin status in Crohn's disease in DIGESTIVE DISEASES AND SCIENCES
  • 2012-06-13. Structure, function and diversity of the healthy human microbiome in NATURE
  • 2001-10-01. The short inflammatory bowel disease questionnaire is reliable and responsive to clinically important change in ulcerative colitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2015-04-08. Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease in GENOME BIOLOGY
  • 2015-07-20. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations in NATURE GENETICS
  • 2015-09-29. MetaPhlAn2 for enhanced metagenomic taxonomic profiling in NATURE METHODS
  • 2012-09-26. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment in GENOME BIOLOGY
  • 2002-01-14. Identification of a variant associated with adult-type hypolactasia in NATURE GENETICS
  • 2017-06-28. Fine-mapping inflammatory bowel disease loci to single-variant resolution in NATURE
  • 2015-09-01. The global burden of IBD: from 2015 to 2025 in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2014-09-10. Environmental Risk Factors for Inflammatory Bowel Diseases: A Review in DIGESTIVE DISEASES AND SCIENCES
  • 2015-04-08. Temporal and technical variability of human gut metagenomes in GENOME BIOLOGY
  • 2018-01-08. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome in NATURE MICROBIOLOGY
  • 2016. ggplot2, Elegant Graphics for Data Analysis in NONE
  • 2015-09-30. A global reference for human genetic variation in NATURE
  • 2007-06. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2016-05-23. Complement in disease: a defence system turning offensive in NATURE REVIEWS NEPHROLOGY
  • 2010-11-10. Intestinal Epithelial Serum Amyloid A Modulates Bacterial Growth In Vitro and Pro-Inflammatory Responses in Mouse Experimental Colitis in BMC GASTROENTEROLOGY
  • 2018-08-10. Maximal viral information recovery from sequence data using VirMAP in NATURE COMMUNICATIONS
  • 2013-08-18. UPARSE: highly accurate OTU sequences from microbial amplicon reads in NATURE METHODS
  • 2014-10-31. MS-GF+ makes progress towards a universal database search tool for proteomics in NATURE COMMUNICATIONS
  • 2001-05. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease in NATURE
  • 1972-03. Species identity of insect cell lines in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY
  • 2017-08-21. Human genetic variation and the gut microbiome in disease in NATURE REVIEWS GENETICS
  • 2015-03-02. Simultaneous generation of many RNA-seq libraries in a single reaction in NATURE METHODS
  • 2017-02-13. Dynamics of the human gut microbiome in inflammatory bowel disease in NATURE MICROBIOLOGY
  • 2018-10-01. Qiita: rapid, web-enabled microbiome meta-analysis in NATURE METHODS
  • 2012-06-13. A framework for human microbiome research in NATURE
  • 2011-01-04. A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries in GENOME BIOLOGY
  • 2018-10-30. Species-level functional profiling of metagenomes and metatranscriptomes in NATURE METHODS
  • 2017-11-01. A communal catalogue reveals Earth’s multiscale microbial diversity in NATURE
  • 2012-03-08. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2011-03-18. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling in NATURE PROTOCOLS
  • 2014-12-02. Complex host genetics influence the microbiome in inflammatory bowel disease in GENOME MEDICINE
  • 2012-10-31. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease in NATURE
  • 2017-11-16. Novel mechanisms and functions of complement in NATURE IMMUNOLOGY
  • 2018-01-15. Metatranscriptome of human faecal microbial communities in a cohort of adult men in NATURE MICROBIOLOGY
  • 2017-09-20. Strains, functions and dynamics in the expanded Human Microbiome Project in NATURE
  • 1985-12. Growth rate-dependent regulation of RNA polymerase synthesis in Escherichia coli in MOLECULAR GENETICS AND GENOMICS
  • Journal

    TITLE

    Nature

    ISSUE

    7758

    VOLUME

    569

    Author Affiliations

  • Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA
  • Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
  • Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  • Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  • Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
  • Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA
  • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
  • Department of Pediatrics, University of California San Diego, La Jolla, CA, USA
  • Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA
  • Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
  • F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  • Department of Pediatrics, Emory University, Atlanta, GA, USA
  • Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA
  • Department of Odontology, Umeå University, Umeå, Sweden
  • Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
  • Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA
  • Department of Pathology & Immunology, Washington University, St. Louis, MO, USA
  • Department of Pediatrics, Harvard Medical School, Boston, MA, USA
  • Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA
  • Clinical Trials linked to this publication

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41586-019-1237-9

    DOI

    http://dx.doi.org/10.1038/s41586-019-1237-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1115981538

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31142855


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fungi", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammatory Bowel Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phylogeny", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Species Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Viruses", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lloyd-Price", 
            "givenName": "Jason", 
            "id": "sg:person.01305635227.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305635227.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arze", 
            "givenName": "Cesar", 
            "id": "sg:person.01117132167.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117132167.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ananthakrishnan", 
            "givenName": "Ashwin N.", 
            "id": "sg:person.01162263474.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162263474.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schirmer", 
            "givenName": "Melanie", 
            "id": "sg:person.0735243706.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735243706.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Avila-Pacheco", 
            "givenName": "Julian", 
            "id": "sg:person.013015545665.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013015545665.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poon", 
            "givenName": "Tiffany W.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andrews", 
            "givenName": "Elizabeth", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ajami", 
            "givenName": "Nadim J.", 
            "id": "sg:person.01115634232.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115634232.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonham", 
            "givenName": "Kevin S.", 
            "id": "sg:person.01025747646.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025747646.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.451303.0", 
              "name": [
                "Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brislawn", 
            "givenName": "Colin J.", 
            "id": "sg:person.01061722456.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061722456.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Casero", 
            "givenName": "David", 
            "id": "sg:person.01250633146.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250633146.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Courtney", 
            "givenName": "Holly", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, University of California San Diego, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pediatrics, University of California San Diego, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonzalez", 
            "givenName": "Antonio", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Graeber", 
            "givenName": "Thomas G.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hall", 
            "givenName": "A. Brantley", 
            "id": "sg:person.01024545742.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024545742.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239573.9", 
              "name": [
                "Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lake", 
            "givenName": "Kathleen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.50956.3f", 
              "name": [
                "F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Landers", 
            "givenName": "Carol J.", 
            "id": "sg:person.01352161553.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352161553.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mallick", 
            "givenName": "Himel", 
            "id": "sg:person.01356136132.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356136132.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plichta", 
            "givenName": "Damian R.", 
            "id": "sg:person.012337212065.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012337212065.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Emory University, Atlanta, GA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Pediatrics, Emory University, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prasad", 
            "givenName": "Mahadev", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rahnavard", 
            "givenName": "Gholamali", 
            "id": "sg:person.01325533721.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325533721.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sauk", 
            "givenName": "Jenny", 
            "id": "sg:person.0734646245.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734646245.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Odontology, Ume\u00e5 University, Ume\u00e5, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.12650.30", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Department of Odontology, Ume\u00e5 University, Ume\u00e5, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shungin", 
            "givenName": "Dmitry", 
            "id": "sg:person.01121546365.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121546365.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA", 
                "Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "V\u00e1zquez-Baeza", 
            "givenName": "Yoshiki", 
            "id": "sg:person.01113460501.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113460501.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.451303.0", 
              "name": [
                "Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "White", 
            "givenName": "Richard A.", 
            "id": "sg:person.01243031357.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243031357.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Braun", 
            "givenName": "Jonathan", 
            "id": "sg:person.01157070417.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157070417.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.24827.3b", 
              "name": [
                "Department of Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH, USA", 
                "Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Denson", 
            "givenName": "Lee A.", 
            "id": "sg:person.01066161527.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066161527.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.451303.0", 
              "name": [
                "Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jansson", 
            "givenName": "Janet K.", 
            "id": "sg:person.0777235637.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777235637.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pediatrics, University of California San Diego, La Jolla, CA, USA", 
                "Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA", 
                "Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knight", 
            "givenName": "Rob", 
            "id": "sg:person.016311745377.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016311745377.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Emory University, Atlanta, GA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Pediatrics, Emory University, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kugathasan", 
            "givenName": "Subra", 
            "id": "sg:person.01147172155.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147172155.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.50956.3f", 
              "name": [
                "F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McGovern", 
            "givenName": "Dermot P. B.", 
            "id": "sg:person.016421317744.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016421317744.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petrosino", 
            "givenName": "Joseph F.", 
            "id": "sg:person.013161563737.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013161563737.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology & Immunology, Washington University, St. Louis, MO, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Pathology & Immunology, Washington University, St. Louis, MO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stappenbeck", 
            "givenName": "Thaddeus S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA, USA", 
                "Department of Pediatrics, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winter", 
            "givenName": "Harland S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clish", 
            "givenName": "Clary B.", 
            "id": "sg:person.0764632420.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franzosa", 
            "givenName": "Eric A.", 
            "id": "sg:person.0772302366.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772302366.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vlamakis", 
            "givenName": "Hera", 
            "id": "sg:person.0773476547.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773476547.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Gastroenterology, Massachusetts General Hospital, Boston, MA, USA", 
                "Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xavier", 
            "givenName": "Ramnik J.", 
            "id": "sg:person.0717130066.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA", 
                "Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huttenhower", 
            "givenName": "Curtis", 
            "id": "sg:person.01214462502.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214462502.85"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature11234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007740093", 
              "https://doi.org/10.1038/nature11234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023901695", 
              "https://doi.org/10.1038/nmeth.3176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0637-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019300544", 
              "https://doi.org/10.1186/s13059-015-0637-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2001.04682.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044975615", 
              "https://doi.org/10.1111/j.1572-0241.2001.04682.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2015.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003936311", 
              "https://doi.org/10.1038/nrgastro.2015.150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41592-018-0141-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107129414", 
              "https://doi.org/10.1038/s41592-018-0141-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-230x-10-133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017543259", 
              "https://doi.org/10.1186/1471-230x-10-133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027248000", 
              "https://doi.org/10.1038/nature11209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41564-017-0084-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100404462", 
              "https://doi.org/10.1038/s41564-017-0084-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-422x-4-65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019382915", 
              "https://doi.org/10.1186/1743-422x-4-65"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02661721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045384998", 
              "https://doi.org/10.1007/bf02661721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031360950", 
              "https://doi.org/10.1038/35079107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010070877", 
              "https://doi.org/10.1038/ncomms6277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41564-017-0089-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099939086", 
              "https://doi.org/10.1038/s41564-017-0089-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004556449", 
              "https://doi.org/10.1038/nature05911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090278096", 
              "https://doi.org/10.1038/nature22969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10620-014-3350-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016753411", 
              "https://doi.org/10.1007/s10620-014-3350-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019843926", 
              "https://doi.org/10.1038/ng.3359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2012.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038992953", 
              "https://doi.org/10.1038/ismej.2012.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00331327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021908537", 
              "https://doi.org/10.1007/bf00331327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2012-13-9-r79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029450096", 
              "https://doi.org/10.1186/gb-2012-13-9-r79"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41592-018-0176-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107804224", 
              "https://doi.org/10.1038/s41592-018-0176-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046541188", 
              "https://doi.org/10.1038/nature11582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812064", 
              "https://doi.org/10.1038/nature15393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027743851", 
              "https://doi.org/10.1038/nmeth.2604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-05658-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106026165", 
              "https://doi.org/10.1038/s41467-018-05658-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092706083", 
              "https://doi.org/10.1038/ni.3858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028162909", 
              "https://doi.org/10.1038/nmeth.3589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-017-0490-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093054943", 
              "https://doi.org/10.1186/s13073-017-0490-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008272701", 
              "https://doi.org/10.1038/nmeth.3313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2010.190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034558482", 
              "https://doi.org/10.1038/nprot.2010.190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01303168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018880364", 
              "https://doi.org/10.1007/bf01303168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-1-r1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045286538", 
              "https://doi.org/10.1186/gb-2011-12-1-r1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg.2017.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091280737", 
              "https://doi.org/10.1038/nrg.2017.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature24621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092446313", 
              "https://doi.org/10.1038/nature24621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2017.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083801915", 
              "https://doi.org/10.1038/nmicrobiol.2017.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051591016", 
              "https://doi.org/10.1038/ng826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature23889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091863851", 
              "https://doi.org/10.1038/nature23889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneph.2016.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030964110", 
              "https://doi.org/10.1038/nrneph.2016.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-24277-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028525626", 
              "https://doi.org/10.1007/978-3-319-24277-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-014-0107-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006350078", 
              "https://doi.org/10.1186/s13073-014-0107-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-015-0639-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039645572", 
              "https://doi.org/10.1186/s13059-015-0639-8"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-05-29", 
        "datePublishedReg": "2019-05-29", 
        "description": "Inflammatory bowel diseases, which include Crohn\u2019s disease and ulcerative colitis, affect several million individuals worldwide. Crohn\u2019s disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study\u2019s infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi\u2019omics Database (http://ibdmdb.org), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41586-019-1237-9", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2690017", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5475480", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439002", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3806830", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2690320", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2436126", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3121390", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7099396", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438997", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7072454", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439042", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2529416", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699180", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7758", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "569"
          }
        ], 
        "keywords": [
          "inflammatory bowel disease", 
          "bowel disease", 
          "disease activity", 
          "ulcerative colitis", 
          "Crohn's disease", 
          "inflammatory bowel disease activity", 
          "bowel disease activity", 
          "levels of antibodies", 
          "gut microbial ecosystem", 
          "Integrative Human Microbiome Project", 
          "functional dysbiosis", 
          "host serum", 
          "gut microbiome", 
          "disease", 
          "host factors", 
          "molecular profile", 
          "colitis", 
          "Human Microbiome Project", 
          "biochemical shifts", 
          "molecular disruption", 
          "complex diseases", 
          "obligate anaerobes", 
          "characteristic increase", 
          "Microbiome Project", 
          "anaerobes", 
          "dysbiosis", 
          "activity", 
          "serum", 
          "antibodies", 
          "integrative analysis", 
          "dysregulation", 
          "levels", 
          "factors", 
          "facultative anaerobes", 
          "subjects", 
          "increase", 
          "microbiome", 
          "host", 
          "years", 
          "microbial levels", 
          "extensive research", 
          "individuals", 
          "disruption", 
          "microbial ecosystem", 
          "period", 
          "database", 
          "metabolite pools", 
          "comprehensive description", 
          "date", 
          "transcription", 
          "profile", 
          "results", 
          "data", 
          "microbial activity", 
          "pool", 
          "comprehensive view", 
          "variability", 
          "analysis", 
          "microbial transcription", 
          "focus", 
          "part", 
          "research", 
          "expense", 
          "view", 
          "shift", 
          "taxonomic", 
          "ecosystems", 
          "description", 
          "resources", 
          "project", 
          "temporal variability", 
          "infrastructure resources"
        ], 
        "name": "Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases", 
        "pagination": "655-662", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1115981538"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41586-019-1237-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31142855"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41586-019-1237-9", 
          "https://app.dimensions.ai/details/publication/pub.1115981538"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_811.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41586-019-1237-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-1237-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-1237-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-1237-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-1237-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    683 TRIPLES      21 PREDICATES      149 URIs      99 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41586-019-1237-9 schema:about N685459bb0fb649f5894b99d67e375e12
    2 N71f98aafc43e482ca5854d2c1b306405
    3 N78245bd0162242d1832262d1ea10ad42
    4 N825d6e3af2d8486c95f183b0b329f702
    5 N93ce8dd81fb64f7793256fbb33963a54
    6 Naef6f12cda48472898c10c8653019b1c
    7 Nc95e6d0f660a4215b446c83b9d53fddc
    8 Nd2b0c16b308347f08130288d9973734d
    9 Nd733e584081540b1aab6eea94ae1bbc6
    10 Nfe50efc2be374dc4b3acb87536403356
    11 anzsrc-for:06
    12 anzsrc-for:0605
    13 schema:author Na774878d42904934830d6105b6180b1a
    14 schema:citation sg:pub.10.1007/978-3-319-24277-4
    15 sg:pub.10.1007/bf00331327
    16 sg:pub.10.1007/bf01303168
    17 sg:pub.10.1007/bf02661721
    18 sg:pub.10.1007/s10620-014-3350-9
    19 sg:pub.10.1038/35079107
    20 sg:pub.10.1038/ismej.2012.8
    21 sg:pub.10.1038/nature05911
    22 sg:pub.10.1038/nature11209
    23 sg:pub.10.1038/nature11234
    24 sg:pub.10.1038/nature11582
    25 sg:pub.10.1038/nature15393
    26 sg:pub.10.1038/nature22969
    27 sg:pub.10.1038/nature23889
    28 sg:pub.10.1038/nature24621
    29 sg:pub.10.1038/ncomms6277
    30 sg:pub.10.1038/ng.3359
    31 sg:pub.10.1038/ng826
    32 sg:pub.10.1038/ni.3858
    33 sg:pub.10.1038/nmeth.2604
    34 sg:pub.10.1038/nmeth.3176
    35 sg:pub.10.1038/nmeth.3313
    36 sg:pub.10.1038/nmeth.3589
    37 sg:pub.10.1038/nmicrobiol.2017.4
    38 sg:pub.10.1038/nprot.2010.190
    39 sg:pub.10.1038/nrg.2017.63
    40 sg:pub.10.1038/nrgastro.2015.150
    41 sg:pub.10.1038/nrneph.2016.70
    42 sg:pub.10.1038/s41467-018-05658-8
    43 sg:pub.10.1038/s41564-017-0084-4
    44 sg:pub.10.1038/s41564-017-0089-z
    45 sg:pub.10.1038/s41592-018-0141-9
    46 sg:pub.10.1038/s41592-018-0176-y
    47 sg:pub.10.1111/j.1572-0241.2001.04682.x
    48 sg:pub.10.1186/1471-230x-10-133
    49 sg:pub.10.1186/1743-422x-4-65
    50 sg:pub.10.1186/gb-2011-12-1-r1
    51 sg:pub.10.1186/gb-2012-13-9-r79
    52 sg:pub.10.1186/s13059-015-0637-x
    53 sg:pub.10.1186/s13059-015-0639-8
    54 sg:pub.10.1186/s13073-014-0107-1
    55 sg:pub.10.1186/s13073-017-0490-5
    56 schema:datePublished 2019-05-29
    57 schema:datePublishedReg 2019-05-29
    58 schema:description Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect several million individuals worldwide. Crohn’s disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study’s infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi’omics Database (http://ibdmdb.org), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases.
    59 schema:genre article
    60 schema:isAccessibleForFree true
    61 schema:isPartOf Nab7cd8ca1e184c819a872f8625c5f0ed
    62 Nf5278deb29874ae7a018ab1b7b72e711
    63 sg:journal.1018957
    64 schema:keywords Crohn's disease
    65 Human Microbiome Project
    66 Integrative Human Microbiome Project
    67 Microbiome Project
    68 activity
    69 anaerobes
    70 analysis
    71 antibodies
    72 biochemical shifts
    73 bowel disease
    74 bowel disease activity
    75 characteristic increase
    76 colitis
    77 complex diseases
    78 comprehensive description
    79 comprehensive view
    80 data
    81 database
    82 date
    83 description
    84 disease
    85 disease activity
    86 disruption
    87 dysbiosis
    88 dysregulation
    89 ecosystems
    90 expense
    91 extensive research
    92 factors
    93 facultative anaerobes
    94 focus
    95 functional dysbiosis
    96 gut microbial ecosystem
    97 gut microbiome
    98 host
    99 host factors
    100 host serum
    101 increase
    102 individuals
    103 inflammatory bowel disease
    104 inflammatory bowel disease activity
    105 infrastructure resources
    106 integrative analysis
    107 levels
    108 levels of antibodies
    109 metabolite pools
    110 microbial activity
    111 microbial ecosystem
    112 microbial levels
    113 microbial transcription
    114 microbiome
    115 molecular disruption
    116 molecular profile
    117 obligate anaerobes
    118 part
    119 period
    120 pool
    121 profile
    122 project
    123 research
    124 resources
    125 results
    126 serum
    127 shift
    128 subjects
    129 taxonomic
    130 temporal variability
    131 transcription
    132 ulcerative colitis
    133 variability
    134 view
    135 years
    136 schema:name Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
    137 schema:pagination 655-662
    138 schema:productId N61c3f791362d4e10885795270f2ae711
    139 N8d8be3be170f4aa2bc6a73c371f8671c
    140 Nc77b2325c4724ebf98b889c8170baad7
    141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1115981538
    142 https://doi.org/10.1038/s41586-019-1237-9
    143 schema:sdDatePublished 2022-08-04T17:07
    144 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    145 schema:sdPublisher N339570a08e8c488fa09041b160ae9fa2
    146 schema:url https://doi.org/10.1038/s41586-019-1237-9
    147 sgo:license sg:explorer/license/
    148 sgo:sdDataset articles
    149 rdf:type schema:ScholarlyArticle
    150 N014235ee773f4a83ac9f1c7d0d750389 rdf:first sg:person.01115634232.85
    151 rdf:rest Na838346558ab4682bb04ad5350b6afcb
    152 N0360689af67e4ca2bb7361fcc8850cf1 rdf:first sg:person.01352161553.31
    153 rdf:rest Nb5cc9f90ba3e461dacf5413b412d6621
    154 N08540b90d6474c6b94e89e227a568373 schema:affiliation grid-institutes:grid.189967.8
    155 schema:familyName Prasad
    156 schema:givenName Mahadev
    157 rdf:type schema:Person
    158 N113d83cc3ec24a568e5fb1100b96b78c rdf:first sg:person.01250633146.03
    159 rdf:rest Nde54cc48d72f4e30b1499a318beccc80
    160 N1144e6560836412cb203cbb47570d5af rdf:first sg:person.01243031357.24
    161 rdf:rest Nfd567427b3444cf59ccacdc9f17557a9
    162 N15531f3e3d984999a54748a4780c93d2 rdf:first sg:person.01061722456.58
    163 rdf:rest N113d83cc3ec24a568e5fb1100b96b78c
    164 N224776314d7141ae999fc420eeafed8c rdf:first N3bcea7d306704d87a9ec2cf52452e229
    165 rdf:rest N0360689af67e4ca2bb7361fcc8850cf1
    166 N23564c9ff4644ca7b0a7fbc3fb02f176 rdf:first N59776f1e4bff406980f8333bff3a2ccb
    167 rdf:rest Nf4710fb390514e29aac20c49798991c3
    168 N2f77ee62f1064b6e8c2c564a445e4f61 schema:affiliation grid-institutes:grid.32224.35
    169 schema:familyName Andrews
    170 schema:givenName Elizabeth
    171 rdf:type schema:Person
    172 N339570a08e8c488fa09041b160ae9fa2 schema:name Springer Nature - SN SciGraph project
    173 rdf:type schema:Organization
    174 N352c0d9578ea4af3a23211a996215c2a rdf:first sg:person.0777235637.90
    175 rdf:rest Nb07b805974d9463ba5c02c08e7a13dbb
    176 N377b489ed22e457a9f99dd2ff6f79beb rdf:first sg:person.013161563737.99
    177 rdf:rest N23564c9ff4644ca7b0a7fbc3fb02f176
    178 N388d214fc83c4cf8a56d60644203a8c7 schema:affiliation grid-institutes:grid.266100.3
    179 schema:familyName Gonzalez
    180 schema:givenName Antonio
    181 rdf:type schema:Person
    182 N3bcea7d306704d87a9ec2cf52452e229 schema:affiliation grid-institutes:grid.239573.9
    183 schema:familyName Lake
    184 schema:givenName Kathleen
    185 rdf:type schema:Person
    186 N3d307a85668142a89e389719f5b2b2fb rdf:first sg:person.01024545742.89
    187 rdf:rest N224776314d7141ae999fc420eeafed8c
    188 N42a9a137e32a4458aab1e85c48ef810c rdf:first sg:person.0772302366.11
    189 rdf:rest Nc54354ce4ab848c7b59c10014ac2397a
    190 N4488f64fc1754f709a7790076ca64dc2 rdf:first sg:person.01214462502.85
    191 rdf:rest rdf:nil
    192 N59776f1e4bff406980f8333bff3a2ccb schema:affiliation grid-institutes:grid.4367.6
    193 schema:familyName Stappenbeck
    194 schema:givenName Thaddeus S.
    195 rdf:type schema:Person
    196 N5b014947f976486eb1dca5fb421109a4 rdf:first Nb0365383f84a476b9170c46c0b69b733
    197 rdf:rest Nc6de7593a0214636ae280f0d7822e729
    198 N5b9e07719833410a9a1940ed21f35950 rdf:first sg:person.01113460501.49
    199 rdf:rest N1144e6560836412cb203cbb47570d5af
    200 N61c3f791362d4e10885795270f2ae711 schema:name doi
    201 schema:value 10.1038/s41586-019-1237-9
    202 rdf:type schema:PropertyValue
    203 N653ed175b0de421ab5ea272bf0ad3083 rdf:first sg:person.0717130066.82
    204 rdf:rest N4488f64fc1754f709a7790076ca64dc2
    205 N685459bb0fb649f5894b99d67e375e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Health
    207 rdf:type schema:DefinedTerm
    208 N696a47cc0cff4643a68bc7a5364d7bd3 rdf:first sg:person.0764632420.16
    209 rdf:rest N42a9a137e32a4458aab1e85c48ef810c
    210 N6b10a16bf9724c97a980258124c6e315 schema:affiliation grid-institutes:grid.38142.3c
    211 schema:familyName Winter
    212 schema:givenName Harland S.
    213 rdf:type schema:Person
    214 N71f98aafc43e482ca5854d2c1b306405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Humans
    216 rdf:type schema:DefinedTerm
    217 N78245bd0162242d1832262d1ea10ad42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Species Specificity
    219 rdf:type schema:DefinedTerm
    220 N79de489064fe4b2888805463a8ab9245 rdf:first sg:person.0735243706.58
    221 rdf:rest Nae0b6d43ccc44e258fd51a82bb5a52fa
    222 N7aca85243e284feca02c1161e1908314 rdf:first sg:person.01325533721.33
    223 rdf:rest N84db5ede504e427ca448b3dfb5d39250
    224 N7cdef2314dda4a1c91a1240382df496f rdf:first sg:person.016421317744.47
    225 rdf:rest N377b489ed22e457a9f99dd2ff6f79beb
    226 N81a0cd26c04f4054bbb33f8d7ee80cc4 rdf:first sg:person.01117132167.66
    227 rdf:rest Nc59b481008794c7faac720c3acca46ed
    228 N825d6e3af2d8486c95f183b0b329f702 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Inflammatory Bowel Diseases
    230 rdf:type schema:DefinedTerm
    231 N84db5ede504e427ca448b3dfb5d39250 rdf:first sg:person.0734646245.51
    232 rdf:rest Na19a8b17e66340f5921357b62ab2fc7d
    233 N88fd3d3ff7f34282bd9cade67d738add rdf:first sg:person.01066161527.57
    234 rdf:rest N352c0d9578ea4af3a23211a996215c2a
    235 N8d8be3be170f4aa2bc6a73c371f8671c schema:name pubmed_id
    236 schema:value 31142855
    237 rdf:type schema:PropertyValue
    238 N93ce8dd81fb64f7793256fbb33963a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Transcriptome
    240 rdf:type schema:DefinedTerm
    241 N9b4fcd65790b40ffad0b2eaa7630f715 rdf:first sg:person.01147172155.49
    242 rdf:rest N7cdef2314dda4a1c91a1240382df496f
    243 N9d8780a088fb484c86467f6249a3d49e rdf:first sg:person.012337212065.71
    244 rdf:rest N9f10f8011b074ac595ec269f423fcb82
    245 N9f10f8011b074ac595ec269f423fcb82 rdf:first N08540b90d6474c6b94e89e227a568373
    246 rdf:rest N7aca85243e284feca02c1161e1908314
    247 Na19a8b17e66340f5921357b62ab2fc7d rdf:first sg:person.01121546365.80
    248 rdf:rest N5b9e07719833410a9a1940ed21f35950
    249 Na774878d42904934830d6105b6180b1a rdf:first sg:person.01305635227.39
    250 rdf:rest N81a0cd26c04f4054bbb33f8d7ee80cc4
    251 Na838346558ab4682bb04ad5350b6afcb rdf:first sg:person.01025747646.29
    252 rdf:rest N15531f3e3d984999a54748a4780c93d2
    253 Na84f42966a094f719c585fcc32ea19a5 schema:affiliation grid-institutes:grid.19006.3e
    254 schema:familyName Graeber
    255 schema:givenName Thomas G.
    256 rdf:type schema:Person
    257 Na8f75007db0f42ad87a3d6163212e331 rdf:first Na84f42966a094f719c585fcc32ea19a5
    258 rdf:rest N3d307a85668142a89e389719f5b2b2fb
    259 Nab7cd8ca1e184c819a872f8625c5f0ed schema:issueNumber 7758
    260 rdf:type schema:PublicationIssue
    261 Nae0b6d43ccc44e258fd51a82bb5a52fa rdf:first sg:person.013015545665.52
    262 rdf:rest N5b014947f976486eb1dca5fb421109a4
    263 Naef6f12cda48472898c10c8653019b1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Phylogeny
    265 rdf:type schema:DefinedTerm
    266 Nb0365383f84a476b9170c46c0b69b733 schema:affiliation grid-institutes:grid.66859.34
    267 schema:familyName Poon
    268 schema:givenName Tiffany W.
    269 rdf:type schema:Person
    270 Nb07b805974d9463ba5c02c08e7a13dbb rdf:first sg:person.016311745377.96
    271 rdf:rest N9b4fcd65790b40ffad0b2eaa7630f715
    272 Nb5cc9f90ba3e461dacf5413b412d6621 rdf:first sg:person.01356136132.18
    273 rdf:rest N9d8780a088fb484c86467f6249a3d49e
    274 Nc54354ce4ab848c7b59c10014ac2397a rdf:first sg:person.0773476547.34
    275 rdf:rest N653ed175b0de421ab5ea272bf0ad3083
    276 Nc59b481008794c7faac720c3acca46ed rdf:first sg:person.01162263474.10
    277 rdf:rest N79de489064fe4b2888805463a8ab9245
    278 Nc6de7593a0214636ae280f0d7822e729 rdf:first N2f77ee62f1064b6e8c2c564a445e4f61
    279 rdf:rest N014235ee773f4a83ac9f1c7d0d750389
    280 Nc77b2325c4724ebf98b889c8170baad7 schema:name dimensions_id
    281 schema:value pub.1115981538
    282 rdf:type schema:PropertyValue
    283 Nc95e6d0f660a4215b446c83b9d53fddc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    284 schema:name Animals
    285 rdf:type schema:DefinedTerm
    286 Nd2b0c16b308347f08130288d9973734d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    287 schema:name Gastrointestinal Microbiome
    288 rdf:type schema:DefinedTerm
    289 Nd35df9b689be41fcae0bc500f125c289 rdf:first N388d214fc83c4cf8a56d60644203a8c7
    290 rdf:rest Na8f75007db0f42ad87a3d6163212e331
    291 Nd733e584081540b1aab6eea94ae1bbc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    292 schema:name Viruses
    293 rdf:type schema:DefinedTerm
    294 Nde54cc48d72f4e30b1499a318beccc80 rdf:first Nf2dd36953d1c47e9a4335b8a14f04baf
    295 rdf:rest Nd35df9b689be41fcae0bc500f125c289
    296 Nf2dd36953d1c47e9a4335b8a14f04baf schema:affiliation grid-institutes:grid.32224.35
    297 schema:familyName Courtney
    298 schema:givenName Holly
    299 rdf:type schema:Person
    300 Nf4710fb390514e29aac20c49798991c3 rdf:first N6b10a16bf9724c97a980258124c6e315
    301 rdf:rest N696a47cc0cff4643a68bc7a5364d7bd3
    302 Nf5278deb29874ae7a018ab1b7b72e711 schema:volumeNumber 569
    303 rdf:type schema:PublicationVolume
    304 Nfd567427b3444cf59ccacdc9f17557a9 rdf:first sg:person.01157070417.56
    305 rdf:rest N88fd3d3ff7f34282bd9cade67d738add
    306 Nfe50efc2be374dc4b3acb87536403356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    307 schema:name Fungi
    308 rdf:type schema:DefinedTerm
    309 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    310 schema:name Biological Sciences
    311 rdf:type schema:DefinedTerm
    312 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    313 schema:name Microbiology
    314 rdf:type schema:DefinedTerm
    315 sg:grant.2436126 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    316 rdf:type schema:MonetaryGrant
    317 sg:grant.2438997 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    318 rdf:type schema:MonetaryGrant
    319 sg:grant.2439002 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    320 rdf:type schema:MonetaryGrant
    321 sg:grant.2439042 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    322 rdf:type schema:MonetaryGrant
    323 sg:grant.2529416 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    324 rdf:type schema:MonetaryGrant
    325 sg:grant.2690017 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    326 rdf:type schema:MonetaryGrant
    327 sg:grant.2690320 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    328 rdf:type schema:MonetaryGrant
    329 sg:grant.2699180 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    330 rdf:type schema:MonetaryGrant
    331 sg:grant.3121390 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    332 rdf:type schema:MonetaryGrant
    333 sg:grant.3806830 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    334 rdf:type schema:MonetaryGrant
    335 sg:grant.5475480 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    336 rdf:type schema:MonetaryGrant
    337 sg:grant.7072454 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    338 rdf:type schema:MonetaryGrant
    339 sg:grant.7099396 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-019-1237-9
    340 rdf:type schema:MonetaryGrant
    341 sg:journal.1018957 schema:issn 0028-0836
    342 1476-4687
    343 schema:name Nature
    344 schema:publisher Springer Nature
    345 rdf:type schema:Periodical
    346 sg:person.01024545742.89 schema:affiliation grid-institutes:grid.66859.34
    347 schema:familyName Hall
    348 schema:givenName A. Brantley
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024545742.89
    350 rdf:type schema:Person
    351 sg:person.01025747646.29 schema:affiliation grid-institutes:grid.38142.3c
    352 schema:familyName Bonham
    353 schema:givenName Kevin S.
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025747646.29
    355 rdf:type schema:Person
    356 sg:person.01061722456.58 schema:affiliation grid-institutes:grid.451303.0
    357 schema:familyName Brislawn
    358 schema:givenName Colin J.
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061722456.58
    360 rdf:type schema:Person
    361 sg:person.01066161527.57 schema:affiliation grid-institutes:grid.24827.3b
    362 schema:familyName Denson
    363 schema:givenName Lee A.
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066161527.57
    365 rdf:type schema:Person
    366 sg:person.01113460501.49 schema:affiliation grid-institutes:grid.266100.3
    367 schema:familyName Vázquez-Baeza
    368 schema:givenName Yoshiki
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113460501.49
    370 rdf:type schema:Person
    371 sg:person.01115634232.85 schema:affiliation grid-institutes:grid.39382.33
    372 schema:familyName Ajami
    373 schema:givenName Nadim J.
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115634232.85
    375 rdf:type schema:Person
    376 sg:person.01117132167.66 schema:affiliation grid-institutes:grid.38142.3c
    377 schema:familyName Arze
    378 schema:givenName Cesar
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117132167.66
    380 rdf:type schema:Person
    381 sg:person.01121546365.80 schema:affiliation grid-institutes:grid.12650.30
    382 schema:familyName Shungin
    383 schema:givenName Dmitry
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121546365.80
    385 rdf:type schema:Person
    386 sg:person.01147172155.49 schema:affiliation grid-institutes:grid.189967.8
    387 schema:familyName Kugathasan
    388 schema:givenName Subra
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147172155.49
    390 rdf:type schema:Person
    391 sg:person.01157070417.56 schema:affiliation grid-institutes:grid.19006.3e
    392 schema:familyName Braun
    393 schema:givenName Jonathan
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157070417.56
    395 rdf:type schema:Person
    396 sg:person.01162263474.10 schema:affiliation grid-institutes:grid.32224.35
    397 schema:familyName Ananthakrishnan
    398 schema:givenName Ashwin N.
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162263474.10
    400 rdf:type schema:Person
    401 sg:person.01214462502.85 schema:affiliation grid-institutes:grid.38142.3c
    402 schema:familyName Huttenhower
    403 schema:givenName Curtis
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214462502.85
    405 rdf:type schema:Person
    406 sg:person.012337212065.71 schema:affiliation grid-institutes:grid.66859.34
    407 schema:familyName Plichta
    408 schema:givenName Damian R.
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012337212065.71
    410 rdf:type schema:Person
    411 sg:person.01243031357.24 schema:affiliation grid-institutes:grid.451303.0
    412 schema:familyName White
    413 schema:givenName Richard A.
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243031357.24
    415 rdf:type schema:Person
    416 sg:person.01250633146.03 schema:affiliation grid-institutes:grid.19006.3e
    417 schema:familyName Casero
    418 schema:givenName David
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250633146.03
    420 rdf:type schema:Person
    421 sg:person.013015545665.52 schema:affiliation grid-institutes:grid.66859.34
    422 schema:familyName Avila-Pacheco
    423 schema:givenName Julian
    424 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013015545665.52
    425 rdf:type schema:Person
    426 sg:person.01305635227.39 schema:affiliation grid-institutes:grid.38142.3c
    427 schema:familyName Lloyd-Price
    428 schema:givenName Jason
    429 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305635227.39
    430 rdf:type schema:Person
    431 sg:person.013161563737.99 schema:affiliation grid-institutes:grid.39382.33
    432 schema:familyName Petrosino
    433 schema:givenName Joseph F.
    434 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013161563737.99
    435 rdf:type schema:Person
    436 sg:person.01325533721.33 schema:affiliation grid-institutes:grid.38142.3c
    437 schema:familyName Rahnavard
    438 schema:givenName Gholamali
    439 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325533721.33
    440 rdf:type schema:Person
    441 sg:person.01352161553.31 schema:affiliation grid-institutes:grid.50956.3f
    442 schema:familyName Landers
    443 schema:givenName Carol J.
    444 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352161553.31
    445 rdf:type schema:Person
    446 sg:person.01356136132.18 schema:affiliation grid-institutes:grid.38142.3c
    447 schema:familyName Mallick
    448 schema:givenName Himel
    449 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356136132.18
    450 rdf:type schema:Person
    451 sg:person.016311745377.96 schema:affiliation grid-institutes:grid.266100.3
    452 schema:familyName Knight
    453 schema:givenName Rob
    454 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016311745377.96
    455 rdf:type schema:Person
    456 sg:person.016421317744.47 schema:affiliation grid-institutes:grid.50956.3f
    457 schema:familyName McGovern
    458 schema:givenName Dermot P. B.
    459 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016421317744.47
    460 rdf:type schema:Person
    461 sg:person.0717130066.82 schema:affiliation grid-institutes:grid.116068.8
    462 schema:familyName Xavier
    463 schema:givenName Ramnik J.
    464 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82
    465 rdf:type schema:Person
    466 sg:person.0734646245.51 schema:affiliation grid-institutes:grid.19006.3e
    467 schema:familyName Sauk
    468 schema:givenName Jenny
    469 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734646245.51
    470 rdf:type schema:Person
    471 sg:person.0735243706.58 schema:affiliation grid-institutes:grid.32224.35
    472 schema:familyName Schirmer
    473 schema:givenName Melanie
    474 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735243706.58
    475 rdf:type schema:Person
    476 sg:person.0764632420.16 schema:affiliation grid-institutes:grid.66859.34
    477 schema:familyName Clish
    478 schema:givenName Clary B.
    479 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16
    480 rdf:type schema:Person
    481 sg:person.0772302366.11 schema:affiliation grid-institutes:grid.38142.3c
    482 schema:familyName Franzosa
    483 schema:givenName Eric A.
    484 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772302366.11
    485 rdf:type schema:Person
    486 sg:person.0773476547.34 schema:affiliation grid-institutes:grid.66859.34
    487 schema:familyName Vlamakis
    488 schema:givenName Hera
    489 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773476547.34
    490 rdf:type schema:Person
    491 sg:person.0777235637.90 schema:affiliation grid-institutes:grid.451303.0
    492 schema:familyName Jansson
    493 schema:givenName Janet K.
    494 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777235637.90
    495 rdf:type schema:Person
    496 sg:pub.10.1007/978-3-319-24277-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028525626
    497 https://doi.org/10.1007/978-3-319-24277-4
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1007/bf00331327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021908537
    500 https://doi.org/10.1007/bf00331327
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1007/bf01303168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018880364
    503 https://doi.org/10.1007/bf01303168
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1007/bf02661721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045384998
    506 https://doi.org/10.1007/bf02661721
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1007/s10620-014-3350-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016753411
    509 https://doi.org/10.1007/s10620-014-3350-9
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
    512 https://doi.org/10.1038/35079107
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1038/ismej.2012.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038992953
    515 https://doi.org/10.1038/ismej.2012.8
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1038/nature05911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004556449
    518 https://doi.org/10.1038/nature05911
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1038/nature11209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027248000
    521 https://doi.org/10.1038/nature11209
    522 rdf:type schema:CreativeWork
    523 sg:pub.10.1038/nature11234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007740093
    524 https://doi.org/10.1038/nature11234
    525 rdf:type schema:CreativeWork
    526 sg:pub.10.1038/nature11582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046541188
    527 https://doi.org/10.1038/nature11582
    528 rdf:type schema:CreativeWork
    529 sg:pub.10.1038/nature15393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812064
    530 https://doi.org/10.1038/nature15393
    531 rdf:type schema:CreativeWork
    532 sg:pub.10.1038/nature22969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090278096
    533 https://doi.org/10.1038/nature22969
    534 rdf:type schema:CreativeWork
    535 sg:pub.10.1038/nature23889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091863851
    536 https://doi.org/10.1038/nature23889
    537 rdf:type schema:CreativeWork
    538 sg:pub.10.1038/nature24621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092446313
    539 https://doi.org/10.1038/nature24621
    540 rdf:type schema:CreativeWork
    541 sg:pub.10.1038/ncomms6277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010070877
    542 https://doi.org/10.1038/ncomms6277
    543 rdf:type schema:CreativeWork
    544 sg:pub.10.1038/ng.3359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019843926
    545 https://doi.org/10.1038/ng.3359
    546 rdf:type schema:CreativeWork
    547 sg:pub.10.1038/ng826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051591016
    548 https://doi.org/10.1038/ng826
    549 rdf:type schema:CreativeWork
    550 sg:pub.10.1038/ni.3858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092706083
    551 https://doi.org/10.1038/ni.3858
    552 rdf:type schema:CreativeWork
    553 sg:pub.10.1038/nmeth.2604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027743851
    554 https://doi.org/10.1038/nmeth.2604
    555 rdf:type schema:CreativeWork
    556 sg:pub.10.1038/nmeth.3176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023901695
    557 https://doi.org/10.1038/nmeth.3176
    558 rdf:type schema:CreativeWork
    559 sg:pub.10.1038/nmeth.3313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008272701
    560 https://doi.org/10.1038/nmeth.3313
    561 rdf:type schema:CreativeWork
    562 sg:pub.10.1038/nmeth.3589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028162909
    563 https://doi.org/10.1038/nmeth.3589
    564 rdf:type schema:CreativeWork
    565 sg:pub.10.1038/nmicrobiol.2017.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083801915
    566 https://doi.org/10.1038/nmicrobiol.2017.4
    567 rdf:type schema:CreativeWork
    568 sg:pub.10.1038/nprot.2010.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034558482
    569 https://doi.org/10.1038/nprot.2010.190
    570 rdf:type schema:CreativeWork
    571 sg:pub.10.1038/nrg.2017.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091280737
    572 https://doi.org/10.1038/nrg.2017.63
    573 rdf:type schema:CreativeWork
    574 sg:pub.10.1038/nrgastro.2015.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003936311
    575 https://doi.org/10.1038/nrgastro.2015.150
    576 rdf:type schema:CreativeWork
    577 sg:pub.10.1038/nrneph.2016.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030964110
    578 https://doi.org/10.1038/nrneph.2016.70
    579 rdf:type schema:CreativeWork
    580 sg:pub.10.1038/s41467-018-05658-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106026165
    581 https://doi.org/10.1038/s41467-018-05658-8
    582 rdf:type schema:CreativeWork
    583 sg:pub.10.1038/s41564-017-0084-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100404462
    584 https://doi.org/10.1038/s41564-017-0084-4
    585 rdf:type schema:CreativeWork
    586 sg:pub.10.1038/s41564-017-0089-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1099939086
    587 https://doi.org/10.1038/s41564-017-0089-z
    588 rdf:type schema:CreativeWork
    589 sg:pub.10.1038/s41592-018-0141-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107129414
    590 https://doi.org/10.1038/s41592-018-0141-9
    591 rdf:type schema:CreativeWork
    592 sg:pub.10.1038/s41592-018-0176-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1107804224
    593 https://doi.org/10.1038/s41592-018-0176-y
    594 rdf:type schema:CreativeWork
    595 sg:pub.10.1111/j.1572-0241.2001.04682.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044975615
    596 https://doi.org/10.1111/j.1572-0241.2001.04682.x
    597 rdf:type schema:CreativeWork
    598 sg:pub.10.1186/1471-230x-10-133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017543259
    599 https://doi.org/10.1186/1471-230x-10-133
    600 rdf:type schema:CreativeWork
    601 sg:pub.10.1186/1743-422x-4-65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019382915
    602 https://doi.org/10.1186/1743-422x-4-65
    603 rdf:type schema:CreativeWork
    604 sg:pub.10.1186/gb-2011-12-1-r1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045286538
    605 https://doi.org/10.1186/gb-2011-12-1-r1
    606 rdf:type schema:CreativeWork
    607 sg:pub.10.1186/gb-2012-13-9-r79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029450096
    608 https://doi.org/10.1186/gb-2012-13-9-r79
    609 rdf:type schema:CreativeWork
    610 sg:pub.10.1186/s13059-015-0637-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019300544
    611 https://doi.org/10.1186/s13059-015-0637-x
    612 rdf:type schema:CreativeWork
    613 sg:pub.10.1186/s13059-015-0639-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039645572
    614 https://doi.org/10.1186/s13059-015-0639-8
    615 rdf:type schema:CreativeWork
    616 sg:pub.10.1186/s13073-014-0107-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006350078
    617 https://doi.org/10.1186/s13073-014-0107-1
    618 rdf:type schema:CreativeWork
    619 sg:pub.10.1186/s13073-017-0490-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093054943
    620 https://doi.org/10.1186/s13073-017-0490-5
    621 rdf:type schema:CreativeWork
    622 grid-institutes:grid.116068.8 schema:alternateName Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA
    623 schema:name Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA
    624 Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    625 Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    626 rdf:type schema:Organization
    627 grid-institutes:grid.12650.30 schema:alternateName Department of Odontology, Umeå University, Umeå, Sweden
    628 schema:name Department of Odontology, Umeå University, Umeå, Sweden
    629 Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    630 rdf:type schema:Organization
    631 grid-institutes:grid.189967.8 schema:alternateName Department of Pediatrics, Emory University, Atlanta, GA, USA
    632 schema:name Department of Pediatrics, Emory University, Atlanta, GA, USA
    633 rdf:type schema:Organization
    634 grid-institutes:grid.19006.3e schema:alternateName Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    635 Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA
    636 Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA
    637 schema:name Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    638 Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA
    639 Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA
    640 rdf:type schema:Organization
    641 grid-institutes:grid.239573.9 schema:alternateName Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
    642 schema:name Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
    643 rdf:type schema:Organization
    644 grid-institutes:grid.24827.3b schema:alternateName Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    645 schema:name Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
    646 Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    647 rdf:type schema:Organization
    648 grid-institutes:grid.266100.3 schema:alternateName Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
    649 Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA
    650 Department of Pediatrics, University of California San Diego, La Jolla, CA, USA
    651 schema:name Center for Microbiome Innovation, University of California San Diego, La Jolla, CA, USA
    652 Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA
    653 Department of Pediatrics, University of California San Diego, La Jolla, CA, USA
    654 Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA
    655 rdf:type schema:Organization
    656 grid-institutes:grid.32224.35 schema:alternateName Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    657 schema:name Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    658 Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    659 rdf:type schema:Organization
    660 grid-institutes:grid.38142.3c schema:alternateName Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA
    661 Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    662 schema:name Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA
    663 Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    664 Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA, USA
    665 Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    666 rdf:type schema:Organization
    667 grid-institutes:grid.39382.33 schema:alternateName Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    668 schema:name Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
    669 rdf:type schema:Organization
    670 grid-institutes:grid.4367.6 schema:alternateName Department of Pathology & Immunology, Washington University, St. Louis, MO, USA
    671 schema:name Department of Pathology & Immunology, Washington University, St. Louis, MO, USA
    672 rdf:type schema:Organization
    673 grid-institutes:grid.451303.0 schema:alternateName Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA
    674 schema:name Earth and Biological Sciences Directorate, Pacific Northwest National Lab, Richland, WA, USA
    675 rdf:type schema:Organization
    676 grid-institutes:grid.50956.3f schema:alternateName F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
    677 schema:name F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
    678 rdf:type schema:Organization
    679 grid-institutes:grid.66859.34 schema:alternateName Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    680 Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    681 schema:name Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    682 Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    683 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...