Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, João A. G. Duarte, Arndt A. Schmitz, Patrick Steigemann, Mustapha Najimi, Andrea Hägebarth, Jo A. Van Ginderachter, Etienne Sokal, Naohiro Gotoh, Kwok-Kin Wong, Catherine Verfaillie, Rita Derua, Sebastian Munck, Mariia Yuneva, Laura Beretta, Ralph J. DeBerardinis, Johannes V. Swinnen, Leanne Hodson, David Cassiman, Chris Verslype, Sven Christian, Sylvia Grünewald, Thomas G. P. Grünewald, Sarah-Maria Fendt

ABSTRACT

Most tumours have an aberrantly activated lipid metabolism1,2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation3. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Here we show that some cancer cells can exploit an alternative fatty acid desaturation pathway. We identify various cancer cell lines, mouse hepatocellular carcinomas, and primary human liver and lung carcinomas that desaturate palmitate to the unusual fatty acid sapienate to support membrane biosynthesis during proliferation. Accordingly, we found that sapienate biosynthesis enables cancer cells to bypass the known fatty acid desaturation pathway that is dependent on stearoyl-CoA desaturase. Thus, only by targeting both desaturation pathways is the in vitro and in vivo proliferation of cancer cells that synthesize sapienate impaired. Our discovery explains metabolic plasticity in fatty acid desaturation and constitutes an unexplored metabolic rewiring in cancers. More... »

PAGES

403-406

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41586-019-0904-1

DOI

http://dx.doi.org/10.1038/s41586-019-0904-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111950410

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30728499


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vriens", 
        "givenName": "Kim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christen", 
        "givenName": "Stefan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vrije Universiteit Brussel", 
          "id": "https://www.grid.ac/institutes/grid.8767.e", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium", 
            "Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium", 
            "Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parik", 
        "givenName": "Sweta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broekaert", 
        "givenName": "Dorien", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fukushima University", 
          "id": "https://www.grid.ac/institutes/grid.443549.b", 
          "name": [
            "Tsukishima Foods Industry, Tokyo, Japan", 
            "Cluster of Agricultural Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshinaga", 
        "givenName": "Kazuaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Talebi", 
        "givenName": "Ali", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dehairs", 
        "givenName": "Jonas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Escalona-Noguero", 
        "givenName": "Carmen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmieder", 
        "givenName": "Roberta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cornfield", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charlton", 
        "givenName": "Catriona", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero-P\u00e9rez", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossi", 
        "givenName": "Matteo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rinaldi", 
        "givenName": "Gianmarco", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orth", 
        "givenName": "Martin F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boon", 
        "givenName": "Ruben", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium", 
            "Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerstens", 
        "givenName": "Axelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwan", 
        "givenName": "Suet Ying", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Children\u2019s Medical Center Research Institute, UT Southwestern, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faubert", 
        "givenName": "Brandon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00e9ndez-Lucas", 
        "givenName": "Andr\u00e9s", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bayer (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420044.6", 
          "name": [
            "Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kopitz", 
        "givenName": "Charlotte C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University Langone Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Ting", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez-Garcia", 
        "givenName": "Juan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duarte", 
        "givenName": "Jo\u00e3o A. G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bayer (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420044.6", 
          "name": [
            "Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmitz", 
        "givenName": "Arndt A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bayer (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420044.6", 
          "name": [
            "Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steigemann", 
        "givenName": "Patrick", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cliniques Universitaires Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.48769.34", 
          "name": [
            "Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Najimi", 
        "givenName": "Mustapha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bayer (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420044.6", 
          "name": [
            "Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00e4gebarth", 
        "givenName": "Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vrije Universiteit Brussel", 
          "id": "https://www.grid.ac/institutes/grid.8767.e", 
          "name": [
            "Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium", 
            "Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Ginderachter", 
        "givenName": "Jo A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cliniques Universitaires Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.48769.34", 
          "name": [
            "Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sokal", 
        "givenName": "Etienne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo University of Marine Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.412785.d", 
          "name": [
            "Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gotoh", 
        "givenName": "Naohiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University Langone Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Kwok-Kin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verfaillie", 
        "givenName": "Catherine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Derua", 
        "givenName": "Rita", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium", 
            "Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Munck", 
        "givenName": "Sebastian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuneva", 
        "givenName": "Mariia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beretta", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Children\u2019s Medical Center Research Institute, UT Southwestern, Dallas, TX, USA", 
            "Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DeBerardinis", 
        "givenName": "Ralph J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Swinnen", 
        "givenName": "Johannes V.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hodson", 
        "givenName": "Leanne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Department of Hepatology, KU Leuven, Leuven, Belgium", 
            "Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cassiman", 
        "givenName": "David", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Department of Hepatology, KU Leuven, Leuven, Belgium", 
            "Department of Digestive Oncology, KU Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verslype", 
        "givenName": "Chris", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bayer (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420044.6", 
          "name": [
            "Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christian", 
        "givenName": "Sven", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bayer (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420044.6", 
          "name": [
            "Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00fcnewald", 
        "givenName": "Sylvia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany", 
            "Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany", 
            "German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany", 
            "German Cancer Research Center (DKFZ), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00fcnewald", 
        "givenName": "Thomas G. P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flanders Institute for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.11486.3a", 
          "name": [
            "Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium", 
            "Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fendt", 
        "givenName": "Sarah-Maria", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ymben.2016.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003213929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(87)41071-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003799314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2003.12123.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014094170", 
          "https://doi.org/10.1046/j.1523-1747.2003.12123.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2010.01.083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016086668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017218108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019353586", 
          "https://doi.org/10.1038/ng1555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019353586", 
          "https://doi.org/10.1038/ng1555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0009-8981(02)00100-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019924354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2011.419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020810197", 
          "https://doi.org/10.1038/nprot.2011.419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.13681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021318836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2012.10.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024268011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.d300020-jlr200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024380680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.09.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026482132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4889(85)90202-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029330847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4889(85)90202-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029330847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2014.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029778168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.29517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031023948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032287924", 
          "https://doi.org/10.1038/ncb3272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc.2016.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046768702", 
          "https://doi.org/10.1038/nrc.2016.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2013.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049833315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075727656", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1992.263.4.e667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076301467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-8769-6_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107589303", 
          "https://doi.org/10.1007/978-1-4939-8769-6_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-8769-6_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107589303", 
          "https://doi.org/10.1007/978-1-4939-8769-6_14"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Most tumours have an aberrantly activated lipid metabolism1,2 that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation3. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Here we show that some cancer cells can exploit an alternative fatty acid desaturation pathway. We identify various cancer cell lines, mouse hepatocellular carcinomas, and primary human liver and lung carcinomas that desaturate palmitate to the unusual fatty acid sapienate to support membrane biosynthesis during proliferation. Accordingly, we found that sapienate biosynthesis enables cancer cells to bypass the known fatty acid desaturation pathway that is dependent on stearoyl-CoA desaturase. Thus, only by targeting both desaturation pathways is the in vitro and in vivo proliferation of cancer cells that synthesize sapienate impaired. Our discovery explains metabolic plasticity in fatty acid desaturation and constitutes an unexplored metabolic rewiring in cancers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41586-019-0904-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7744", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "566"
      }
    ], 
    "name": "Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity", 
    "pagination": "403-406", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8f448c3608e2fed9f74cb618e34aab4ce6789fd6a4171b680fb2ff608641969c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30728499"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41586-019-0904-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111950410"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41586-019-0904-1", 
      "https://app.dimensions.ai/details/publication/pub.1111950410"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130801_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41586-019-0904-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-0904-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-0904-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-0904-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-019-0904-1'


 

This table displays all metadata directly associated to this object as RDF triples.

466 TRIPLES      21 PREDICATES      50 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41586-019-0904-1 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author Nd9ca8d7cc58443dd94bb4c7634bc014a
4 schema:citation sg:pub.10.1007/978-1-4939-8769-6_14
5 sg:pub.10.1038/ncb3272
6 sg:pub.10.1038/ng1555
7 sg:pub.10.1038/nprot.2011.419
8 sg:pub.10.1038/nrc.2016.89
9 sg:pub.10.1046/j.1523-1747.2003.12123.x
10 https://app.dimensions.ai/details/publication/pub.1075727656
11 https://doi.org/10.1002/ijc.29517
12 https://doi.org/10.1016/0076-6879(87)41071-9
13 https://doi.org/10.1016/0167-4889(85)90202-2
14 https://doi.org/10.1016/j.bmcl.2010.01.083
15 https://doi.org/10.1016/j.celrep.2016.09.042
16 https://doi.org/10.1016/j.cmet.2013.05.017
17 https://doi.org/10.1016/j.cub.2012.10.041
18 https://doi.org/10.1016/j.tcb.2014.06.001
19 https://doi.org/10.1016/j.ymben.2016.11.005
20 https://doi.org/10.1016/s0009-8981(02)00100-6
21 https://doi.org/10.1111/febs.13681
22 https://doi.org/10.1152/ajpendo.1992.263.4.e667
23 https://doi.org/10.1158/0008-5472.can-09-3871
24 https://doi.org/10.1194/jlr.d300020-jlr200
25 schema:datePublished 2019-02
26 schema:datePublishedReg 2019-02-01
27 schema:description Most tumours have an aberrantly activated lipid metabolism<sup>1,2</sup> that enables them to synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular subsets of cancer cells are sensitive to approaches that target fatty acid metabolism and, in particular, fatty acid desaturation<sup>3</sup>. This suggests that many cancer cells contain an unexplored plasticity in their fatty acid metabolism. Here we show that some cancer cells can exploit an alternative fatty acid desaturation pathway. We identify various cancer cell lines, mouse hepatocellular carcinomas, and primary human liver and lung carcinomas that desaturate palmitate to the unusual fatty acid sapienate to support membrane biosynthesis during proliferation. Accordingly, we found that sapienate biosynthesis enables cancer cells to bypass the known fatty acid desaturation pathway that is dependent on stearoyl-CoA desaturase. Thus, only by targeting both desaturation pathways is the in vitro and in vivo proliferation of cancer cells that synthesize sapienate impaired. Our discovery explains metabolic plasticity in fatty acid desaturation and constitutes an unexplored metabolic rewiring in cancers.
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf N076e65093f894b1b933f54377a5b927f
32 N6959d814bd11470d938ad63b32bb87e5
33 sg:journal.1018957
34 schema:name Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
35 schema:pagination 403-406
36 schema:productId N07fcdf5295cd4c2c8a09df1bd4f7a390
37 N658a08bb55e94fa2b8f20af67d302b15
38 Nd5ed6bce3a75400cb7dcb338081eba0a
39 Ndbc33a4d91e6400a9204fed7ea3c0285
40 Nfacb35a2ba1b40088d885d7c88348826
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111950410
42 https://doi.org/10.1038/s41586-019-0904-1
43 schema:sdDatePublished 2019-04-11T13:52
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher N7ee3d71a3ac2449282bf6bfd80b2561d
46 schema:url https://www.nature.com/articles/s41586-019-0904-1
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N00b37a4fa51a477792cd8a16e9a43ffe rdf:first Nf2fbbf2def8348188d1df9a635f9fc80
51 rdf:rest Na6943141631e40d8ad77ee4d994fcdba
52 N00bfca1050d3451695cd4308e88fe95c schema:affiliation https://www.grid.ac/institutes/grid.420044.6
53 schema:familyName Hägebarth
54 schema:givenName Andrea
55 rdf:type schema:Person
56 N0208895e803644b286cd301f9694a98d rdf:first N88b61bf57b2f40748f3098ab4b2e4d54
57 rdf:rest N7ed1f794af254e40b00f5016c9603fed
58 N05d5ea993420481482f86f4495f7ae4d rdf:first N8f2bb39fca514478a75d798010f878b1
59 rdf:rest N88af9b3ce34043989e07873a2a7c573a
60 N076e65093f894b1b933f54377a5b927f schema:volumeNumber 566
61 rdf:type schema:PublicationVolume
62 N07b19469d77f4e7f860ffaad9dd13df2 rdf:first N440d60a8831d466b9c345c65e53851f2
63 rdf:rest N0ef30a4aa5be4c498974db0ea9659d53
64 N07fcdf5295cd4c2c8a09df1bd4f7a390 schema:name pubmed_id
65 schema:value 30728499
66 rdf:type schema:PropertyValue
67 N0ef30a4aa5be4c498974db0ea9659d53 rdf:first N103d1f6e32774ae3a9d631dcc04c5be8
68 rdf:rest N0ff8ca7b73c345848c5d46b608fbd547
69 N0ff8ca7b73c345848c5d46b608fbd547 rdf:first N68ab093fe3cc46fd9edc4add0267ed33
70 rdf:rest N8503302c7606456cb7608724c011f05b
71 N103d1f6e32774ae3a9d631dcc04c5be8 schema:affiliation https://www.grid.ac/institutes/grid.8767.e
72 schema:familyName Parik
73 schema:givenName Sweta
74 rdf:type schema:Person
75 N106a70858e254393835584b9eaa7463d schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
76 schema:familyName Duarte
77 schema:givenName João A. G.
78 rdf:type schema:Person
79 N188284306aeb4c3e9e5ba465b18a1e31 schema:affiliation https://www.grid.ac/institutes/grid.443549.b
80 schema:familyName Yoshinaga
81 schema:givenName Kazuaki
82 rdf:type schema:Person
83 N1f0ec21aee474c7095a12227ecb924e1 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
84 schema:familyName Vriens
85 schema:givenName Kim
86 rdf:type schema:Person
87 N1fb9e981f4c94e5db447a550efdbf548 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
88 schema:familyName DeBerardinis
89 schema:givenName Ralph J.
90 rdf:type schema:Person
91 N204fb223586a43f3969a02f9e4d3b7f0 rdf:first N238c3d39ba4d4153919fd1df6f2a85a8
92 rdf:rest Nf413450d40e84915b750f7412b5763f3
93 N238c3d39ba4d4153919fd1df6f2a85a8 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
94 schema:familyName Kerstens
95 schema:givenName Axelle
96 rdf:type schema:Person
97 N23ca494670874cc4b9bae971e500f36a rdf:first N3562e7a135964e8880e4dd833c942fbb
98 rdf:rest N7d64a8a291a44ab99427a494287169e4
99 N2bb2d18b3c794ca6be48c2c78a107c6c schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
100 schema:familyName Schmieder
101 schema:givenName Roberta
102 rdf:type schema:Person
103 N2d370425bd2b4e6d8c51b9e7e9edc0fb schema:affiliation https://www.grid.ac/institutes/grid.240324.3
104 schema:familyName Wong
105 schema:givenName Kwok-Kin
106 rdf:type schema:Person
107 N2ef399b25a174585a815166030310934 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
108 schema:familyName Escalona-Noguero
109 schema:givenName Carmen
110 rdf:type schema:Person
111 N2ff4d42725a24cd49cc37be5a660c30c schema:affiliation https://www.grid.ac/institutes/grid.5596.f
112 schema:familyName Verslype
113 schema:givenName Chris
114 rdf:type schema:Person
115 N3562e7a135964e8880e4dd833c942fbb schema:affiliation https://www.grid.ac/institutes/grid.420044.6
116 schema:familyName Kopitz
117 schema:givenName Charlotte C.
118 rdf:type schema:Person
119 N3baa2e5b28fc48e3a198c2bf3cb4fa3b rdf:first Nfba5e6d50f174e85b57c4e2e48f7bb24
120 rdf:rest N84028559dae04e39bdc47a9ab4ee3e45
121 N3d79d9950c1841d7a60d6f5ad4ec2682 rdf:first Nd31fc8e2a4904345bcc8db139fdcd151
122 rdf:rest N23ca494670874cc4b9bae971e500f36a
123 N4067aa5fbb1e470aa86100629b426d98 schema:affiliation Na9d568068bc34adf98c6aeabace31b20
124 schema:familyName Dehairs
125 schema:givenName Jonas
126 rdf:type schema:Person
127 N40a599b10c464e0e852c34f42dcf8f4e rdf:first Nfee7aad6a2bc495898c3ffe963396a0d
128 rdf:rest N5bb4f0012d1844319309752a25d96ef1
129 N440d60a8831d466b9c345c65e53851f2 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
130 schema:familyName Christen
131 schema:givenName Stefan
132 rdf:type schema:Person
133 N448fae2cd7324059b6be60bb7881d9d4 rdf:first N5cb03fc7eb7b46cfb60a6bb0738259c8
134 rdf:rest N05d5ea993420481482f86f4495f7ae4d
135 N465878808161448a8025d0949f13df1d rdf:first N4d79d0e18a8445daa9a05567e6348f43
136 rdf:rest N7002894148914f22ac90cbb3c4581405
137 N48eee4f78ddf45878a74c4e631235e03 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
138 schema:familyName Cassiman
139 schema:givenName David
140 rdf:type schema:Person
141 N4c4a43292ce94c75adcd395e0835380b rdf:first Na022e43f1b1a44a99ccceb99c7747ba0
142 rdf:rest Ndb59831e24774f11b8d2b1e45efea9af
143 N4d79d0e18a8445daa9a05567e6348f43 schema:affiliation N7feab97b17c046be9bc10f45809a7ce9
144 schema:familyName Talebi
145 schema:givenName Ali
146 rdf:type schema:Person
147 N4ebf1ff574114372a3ba43eba4a4807a schema:affiliation https://www.grid.ac/institutes/grid.5596.f
148 schema:familyName Boon
149 schema:givenName Ruben
150 rdf:type schema:Person
151 N596a35eb08064ffa9ea16059f882d1ff rdf:first N4ebf1ff574114372a3ba43eba4a4807a
152 rdf:rest N204fb223586a43f3969a02f9e4d3b7f0
153 N5bb4f0012d1844319309752a25d96ef1 rdf:first Nbcafc58a5d3a4f518bdc2f6bf3b45276
154 rdf:rest Necdc26392d3f4a848ff6ad78513324a8
155 N5cb03fc7eb7b46cfb60a6bb0738259c8 schema:affiliation https://www.grid.ac/institutes/grid.420044.6
156 schema:familyName Steigemann
157 schema:givenName Patrick
158 rdf:type schema:Person
159 N5da4dbbc62a34ff6bbc159255a043e74 rdf:first N6a04dd2e79ca4b1a8b696cea6fae1c55
160 rdf:rest N448fae2cd7324059b6be60bb7881d9d4
161 N60b4cbef000a450faf0a23ae2857ed6b rdf:first Nc09b63a60a3b45c1ba7a79b3b388c8aa
162 rdf:rest Ncc67b2c312b74dcfa55db01de3745984
163 N63a98a30f6d0457b96c514c0bb75d730 schema:affiliation https://www.grid.ac/institutes/grid.420044.6
164 schema:familyName Grünewald
165 schema:givenName Sylvia
166 rdf:type schema:Person
167 N643db1eab71f46af9f74f0e206714534 rdf:first Nf17d56e4071e47efad8350db586aff9a
168 rdf:rest N3d79d9950c1841d7a60d6f5ad4ec2682
169 N658a08bb55e94fa2b8f20af67d302b15 schema:name nlm_unique_id
170 schema:value 0410462
171 rdf:type schema:PropertyValue
172 N6601775ad68c4329a40ce70f6cd435fd rdf:first N7e8112f4d82a4f4c9b6141cf10f1fa9f
173 rdf:rest N0208895e803644b286cd301f9694a98d
174 N68ab093fe3cc46fd9edc4add0267ed33 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
175 schema:familyName Broekaert
176 schema:givenName Dorien
177 rdf:type schema:Person
178 N6959d814bd11470d938ad63b32bb87e5 schema:issueNumber 7744
179 rdf:type schema:PublicationIssue
180 N6a04dd2e79ca4b1a8b696cea6fae1c55 schema:affiliation https://www.grid.ac/institutes/grid.420044.6
181 schema:familyName Schmitz
182 schema:givenName Arndt A.
183 rdf:type schema:Person
184 N6b9c3e140f4c4252a7a61a93a15683ea rdf:first Need2e594e177405aa9982a9172d213cf
185 rdf:rest N6ebe80003ce44345a7b728a3c5d4f933
186 N6ebe80003ce44345a7b728a3c5d4f933 rdf:first N2d370425bd2b4e6d8c51b9e7e9edc0fb
187 rdf:rest Nd921b71c1335457182e6312806add4ea
188 N6f176d8de4134743bbf4d73fec988b5f schema:affiliation https://www.grid.ac/institutes/grid.420044.6
189 schema:familyName Christian
190 schema:givenName Sven
191 rdf:type schema:Person
192 N7002894148914f22ac90cbb3c4581405 rdf:first N4067aa5fbb1e470aa86100629b426d98
193 rdf:rest N8ec1982a3adb46db96a3192697afc6c0
194 N7503ec0b96fd4abca5f8d02623ec4f7f schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
195 schema:familyName Rossi
196 schema:givenName Matteo
197 rdf:type schema:Person
198 N7d64a8a291a44ab99427a494287169e4 rdf:first Nd795ff757623414e8b0318d0741b03f4
199 rdf:rest N3baa2e5b28fc48e3a198c2bf3cb4fa3b
200 N7e8112f4d82a4f4c9b6141cf10f1fa9f schema:affiliation N897dac3c5b474d6cbac5246ed80a3df1
201 schema:familyName Swinnen
202 schema:givenName Johannes V.
203 rdf:type schema:Person
204 N7ed1f794af254e40b00f5016c9603fed rdf:first N48eee4f78ddf45878a74c4e631235e03
205 rdf:rest Nf0595e14db4f4806b80ce936195872d8
206 N7ee3d71a3ac2449282bf6bfd80b2561d schema:name Springer Nature - SN SciGraph project
207 rdf:type schema:Organization
208 N7fa54fe810954ddbadb134ab61132745 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
209 schema:familyName Fendt
210 schema:givenName Sarah-Maria
211 rdf:type schema:Person
212 N7feab97b17c046be9bc10f45809a7ce9 schema:name Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium
213 rdf:type schema:Organization
214 N7ff9e3cf812940288ee51da954cad1f6 schema:affiliation https://www.grid.ac/institutes/grid.8767.e
215 schema:familyName Van Ginderachter
216 schema:givenName Jo A.
217 rdf:type schema:Person
218 N8323411862f14fc9ab44231a39273023 rdf:first Na845a67b6e53493aa79f439a398bf432
219 rdf:rest N596a35eb08064ffa9ea16059f882d1ff
220 N84028559dae04e39bdc47a9ab4ee3e45 rdf:first N106a70858e254393835584b9eaa7463d
221 rdf:rest N5da4dbbc62a34ff6bbc159255a043e74
222 N8503302c7606456cb7608724c011f05b rdf:first N188284306aeb4c3e9e5ba465b18a1e31
223 rdf:rest N465878808161448a8025d0949f13df1d
224 N8710787d5a3f45069e1226ccd3bfc33a schema:affiliation https://www.grid.ac/institutes/grid.451388.3
225 schema:familyName Yuneva
226 schema:givenName Mariia
227 rdf:type schema:Person
228 N88a75c503da140b799bf774b5f2715c8 rdf:first N6f176d8de4134743bbf4d73fec988b5f
229 rdf:rest Na59c148d628f41458ecd3696cf741b97
230 N88af9b3ce34043989e07873a2a7c573a rdf:first N00bfca1050d3451695cd4308e88fe95c
231 rdf:rest Nfc697298238b4b23aa220eb1dc850b45
232 N88b61bf57b2f40748f3098ab4b2e4d54 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
233 schema:familyName Hodson
234 schema:givenName Leanne
235 rdf:type schema:Person
236 N897dac3c5b474d6cbac5246ed80a3df1 schema:name Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium
237 rdf:type schema:Organization
238 N89c0d9c04b3f4c56b0518a55e7675f24 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
239 schema:familyName Verfaillie
240 schema:givenName Catherine
241 rdf:type schema:Person
242 N8afc597727ac487f91a3c4771b0d770a rdf:first Nc5b8d05ab9f74a09bd145c53e71b4024
243 rdf:rest N8323411862f14fc9ab44231a39273023
244 N8ea345477025484db8c57f2ae58a31f1 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
245 schema:familyName Sokal
246 schema:givenName Etienne
247 rdf:type schema:Person
248 N8ec1982a3adb46db96a3192697afc6c0 rdf:first N2ef399b25a174585a815166030310934
249 rdf:rest Nf2a6e68e3f8f40da9b8e01ae766dbf4d
250 N8f2bb39fca514478a75d798010f878b1 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
251 schema:familyName Najimi
252 schema:givenName Mustapha
253 rdf:type schema:Person
254 N9e409e09b8434ee2adcab7ff0bb60723 rdf:first N8ea345477025484db8c57f2ae58a31f1
255 rdf:rest N6b9c3e140f4c4252a7a61a93a15683ea
256 Na022e43f1b1a44a99ccceb99c7747ba0 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
257 schema:familyName Beretta
258 schema:givenName Laura
259 rdf:type schema:Person
260 Na59c148d628f41458ecd3696cf741b97 rdf:first N63a98a30f6d0457b96c514c0bb75d730
261 rdf:rest Nf2121aebe6f44cf398d6ae1707bf7203
262 Na6943141631e40d8ad77ee4d994fcdba rdf:first N7503ec0b96fd4abca5f8d02623ec4f7f
263 rdf:rest N8afc597727ac487f91a3c4771b0d770a
264 Na845a67b6e53493aa79f439a398bf432 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
265 schema:familyName Orth
266 schema:givenName Martin F.
267 rdf:type schema:Person
268 Na9d568068bc34adf98c6aeabace31b20 schema:name Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium
269 rdf:type schema:Organization
270 Nbcafc58a5d3a4f518bdc2f6bf3b45276 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
271 schema:familyName Munck
272 schema:givenName Sebastian
273 rdf:type schema:Person
274 Nc09b63a60a3b45c1ba7a79b3b388c8aa schema:affiliation https://www.grid.ac/institutes/grid.4991.5
275 schema:familyName Cornfield
276 schema:givenName Thomas
277 rdf:type schema:Person
278 Nc5b8d05ab9f74a09bd145c53e71b4024 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
279 schema:familyName Rinaldi
280 schema:givenName Gianmarco
281 rdf:type schema:Person
282 Ncc67b2c312b74dcfa55db01de3745984 rdf:first Ncfae423d151548d5b86be3f767504fc8
283 rdf:rest N00b37a4fa51a477792cd8a16e9a43ffe
284 Ncfae423d151548d5b86be3f767504fc8 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
285 schema:familyName Charlton
286 schema:givenName Catriona
287 rdf:type schema:Person
288 Nd166d0ad6aa6438294ae5a8b3d36028b rdf:first N7fa54fe810954ddbadb134ab61132745
289 rdf:rest rdf:nil
290 Nd31fc8e2a4904345bcc8db139fdcd151 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
291 schema:familyName Méndez-Lucas
292 schema:givenName Andrés
293 rdf:type schema:Person
294 Nd5ed6bce3a75400cb7dcb338081eba0a schema:name dimensions_id
295 schema:value pub.1111950410
296 rdf:type schema:PropertyValue
297 Nd795ff757623414e8b0318d0741b03f4 schema:affiliation https://www.grid.ac/institutes/grid.240324.3
298 schema:familyName Chen
299 schema:givenName Ting
300 rdf:type schema:Person
301 Nd921b71c1335457182e6312806add4ea rdf:first N89c0d9c04b3f4c56b0518a55e7675f24
302 rdf:rest N40a599b10c464e0e852c34f42dcf8f4e
303 Nd9ca8d7cc58443dd94bb4c7634bc014a rdf:first N1f0ec21aee474c7095a12227ecb924e1
304 rdf:rest N07b19469d77f4e7f860ffaad9dd13df2
305 Ndb59831e24774f11b8d2b1e45efea9af rdf:first N1fb9e981f4c94e5db447a550efdbf548
306 rdf:rest N6601775ad68c4329a40ce70f6cd435fd
307 Ndbc33a4d91e6400a9204fed7ea3c0285 schema:name readcube_id
308 schema:value 8f448c3608e2fed9f74cb618e34aab4ce6789fd6a4171b680fb2ff608641969c
309 rdf:type schema:PropertyValue
310 Ne282aedd4356457883d893605e0575c8 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
311 schema:familyName Kwan
312 schema:givenName Suet Ying
313 rdf:type schema:Person
314 Necdc26392d3f4a848ff6ad78513324a8 rdf:first N8710787d5a3f45069e1226ccd3bfc33a
315 rdf:rest N4c4a43292ce94c75adcd395e0835380b
316 Need2e594e177405aa9982a9172d213cf schema:affiliation https://www.grid.ac/institutes/grid.412785.d
317 schema:familyName Gotoh
318 schema:givenName Naohiro
319 rdf:type schema:Person
320 Nf0595e14db4f4806b80ce936195872d8 rdf:first N2ff4d42725a24cd49cc37be5a660c30c
321 rdf:rest N88a75c503da140b799bf774b5f2715c8
322 Nf17d56e4071e47efad8350db586aff9a schema:affiliation https://www.grid.ac/institutes/grid.267313.2
323 schema:familyName Faubert
324 schema:givenName Brandon
325 rdf:type schema:Person
326 Nf2121aebe6f44cf398d6ae1707bf7203 rdf:first Nff906057d4474ab8bb176c8ff70619b1
327 rdf:rest Nd166d0ad6aa6438294ae5a8b3d36028b
328 Nf2a6e68e3f8f40da9b8e01ae766dbf4d rdf:first N2bb2d18b3c794ca6be48c2c78a107c6c
329 rdf:rest N60b4cbef000a450faf0a23ae2857ed6b
330 Nf2fbbf2def8348188d1df9a635f9fc80 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
331 schema:familyName Romero-Pérez
332 schema:givenName Laura
333 rdf:type schema:Person
334 Nf413450d40e84915b750f7412b5763f3 rdf:first Ne282aedd4356457883d893605e0575c8
335 rdf:rest N643db1eab71f46af9f74f0e206714534
336 Nfacb35a2ba1b40088d885d7c88348826 schema:name doi
337 schema:value 10.1038/s41586-019-0904-1
338 rdf:type schema:PropertyValue
339 Nfba5e6d50f174e85b57c4e2e48f7bb24 schema:affiliation https://www.grid.ac/institutes/grid.11486.3a
340 schema:familyName Fernandez-Garcia
341 schema:givenName Juan
342 rdf:type schema:Person
343 Nfc697298238b4b23aa220eb1dc850b45 rdf:first N7ff9e3cf812940288ee51da954cad1f6
344 rdf:rest N9e409e09b8434ee2adcab7ff0bb60723
345 Nfee7aad6a2bc495898c3ffe963396a0d schema:affiliation https://www.grid.ac/institutes/grid.5596.f
346 schema:familyName Derua
347 schema:givenName Rita
348 rdf:type schema:Person
349 Nff906057d4474ab8bb176c8ff70619b1 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
350 schema:familyName Grünewald
351 schema:givenName Thomas G. P.
352 rdf:type schema:Person
353 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
354 schema:name Biological Sciences
355 rdf:type schema:DefinedTerm
356 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
357 schema:name Biochemistry and Cell Biology
358 rdf:type schema:DefinedTerm
359 sg:journal.1018957 schema:issn 0090-0028
360 1476-4687
361 schema:name Nature
362 rdf:type schema:Periodical
363 sg:pub.10.1007/978-1-4939-8769-6_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107589303
364 https://doi.org/10.1007/978-1-4939-8769-6_14
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/ncb3272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032287924
367 https://doi.org/10.1038/ncb3272
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/ng1555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019353586
370 https://doi.org/10.1038/ng1555
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/nprot.2011.419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020810197
373 https://doi.org/10.1038/nprot.2011.419
374 rdf:type schema:CreativeWork
375 sg:pub.10.1038/nrc.2016.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046768702
376 https://doi.org/10.1038/nrc.2016.89
377 rdf:type schema:CreativeWork
378 sg:pub.10.1046/j.1523-1747.2003.12123.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014094170
379 https://doi.org/10.1046/j.1523-1747.2003.12123.x
380 rdf:type schema:CreativeWork
381 https://app.dimensions.ai/details/publication/pub.1075727656 schema:CreativeWork
382 https://doi.org/10.1002/ijc.29517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031023948
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1016/0076-6879(87)41071-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003799314
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1016/0167-4889(85)90202-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029330847
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1016/j.bmcl.2010.01.083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016086668
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1016/j.celrep.2016.09.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026482132
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1016/j.cmet.2013.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049833315
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1016/j.cub.2012.10.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024268011
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1016/j.tcb.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029778168
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1016/j.ymben.2016.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003213929
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1016/s0009-8981(02)00100-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019924354
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1111/febs.13681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021318836
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1152/ajpendo.1992.263.4.e667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076301467
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1158/0008-5472.can-09-3871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017218108
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1194/jlr.d300020-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024380680
409 rdf:type schema:CreativeWork
410 https://www.grid.ac/institutes/grid.11486.3a schema:alternateName Flanders Institute for Biotechnology
411 schema:name Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium
412 Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium
413 rdf:type schema:Organization
414 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
415 schema:name Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.240324.3 schema:alternateName New York University Langone Medical Center
418 schema:name Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
421 schema:name Children’s Medical Center Research Institute, UT Southwestern, Dallas, TX, USA
422 Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA
423 rdf:type schema:Organization
424 https://www.grid.ac/institutes/grid.412785.d schema:alternateName Tokyo University of Marine Science and Technology
425 schema:name Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.420044.6 schema:alternateName Bayer (Germany)
428 schema:name Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany
429 rdf:type schema:Organization
430 https://www.grid.ac/institutes/grid.443549.b schema:alternateName Fukushima University
431 schema:name Cluster of Agricultural Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan
432 Tsukishima Foods Industry, Tokyo, Japan
433 rdf:type schema:Organization
434 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
435 schema:name The Francis Crick Institute, London, UK
436 rdf:type schema:Organization
437 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
438 schema:name Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium
439 rdf:type schema:Organization
440 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
441 schema:name The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
444 schema:name Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany
445 rdf:type schema:Organization
446 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
447 schema:name Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium
448 Department of Digestive Oncology, KU Leuven, Leuven, Belgium
449 Department of Hepatology, KU Leuven, Leuven, Belgium
450 Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
451 Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium
452 Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
453 VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium
454 rdf:type schema:Organization
455 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
456 schema:name German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany
457 German Cancer Research Center (DKFZ), Heidelberg, Germany
458 Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany
459 Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany
460 rdf:type schema:Organization
461 https://www.grid.ac/institutes/grid.8767.e schema:alternateName Vrije Universiteit Brussel
462 schema:name Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium
463 Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium
464 Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
465 Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium
466 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...