Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Shun He, Florian Kahles, Sara Rattik, Manfred Nairz, Cameron S. McAlpine, Atsushi Anzai, Daniel Selgrade, Ashley M. Fenn, Christopher T. Chan, John E. Mindur, Colin Valet, Wolfram C. Poller, Lennard Halle, Noemi Rotllan, Yoshiko Iwamoto, Gregory R. Wojtkiewicz, Ralph Weissleder, Peter Libby, Carlos Fernández-Hernando, Daniel J. Drucker, Matthias Nahrendorf, Filip K. Swirski

ABSTRACT

The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metabolism. Here we describe a subset of immune cells-integrin β7+ natural gut intraepithelial T lymphocytes (natural IELs)-that is dispersed throughout the enterocyte layer of the small intestine and that modulates systemic metabolism. Integrin β7- mice that lack natural IELs are metabolically hyperactive and, when fed a high-fat and high-sugar diet, are resistant to obesity, hypercholesterolaemia, hypertension, diabetes and atherosclerosis. Furthermore, we show that protection from cardiovascular disease in the absence of natural IELs depends on the enteroendocrine-derived incretin GLP-12, which is normally controlled by IELs through expression of the GLP-1 receptor. In this metabolic control system, IELs modulate enteroendocrine activity by acting as gatekeepers that limit the bioavailability of GLP-1. Although the function of IELs may prove advantageous when food is scarce, present-day overabundance of diets high in fat and sugar renders this metabolic checkpoint detrimental to health. More... »

PAGES

115-119

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41586-018-0849-9

DOI

http://dx.doi.org/10.1038/s41586-018-0849-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111780480

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30700910


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1111", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nutrition and Dietetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Shun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kahles", 
        "givenName": "Florian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rattik", 
        "givenName": "Sara", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nairz", 
        "givenName": "Manfred", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McAlpine", 
        "givenName": "Cameron S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anzai", 
        "givenName": "Atsushi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selgrade", 
        "givenName": "Daniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fenn", 
        "givenName": "Ashley M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Christopher T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mindur", 
        "givenName": "John E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valet", 
        "givenName": "Colin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poller", 
        "givenName": "Wolfram C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halle", 
        "givenName": "Lennard", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Vascular Biology and Therapeutics Program, Department of Comparative Medicine and Pathology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rotllan", 
        "givenName": "Noemi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwamoto", 
        "givenName": "Yoshiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.483004.b", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wojtkiewicz", 
        "givenName": "Gregory R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
            "Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
            "Department of Systems Biology, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weissleder", 
        "givenName": "Ralph", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Libby", 
        "givenName": "Peter", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Vascular Biology and Therapeutics Program, Department of Comparative Medicine and Pathology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fern\u00e1ndez-Hernando", 
        "givenName": "Carlos", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drucker", 
        "givenName": "Daniel J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
            "Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nahrendorf", 
        "givenName": "Matthias", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA", 
            "Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Swirski", 
        "givenName": "Filip K.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4049/jimmunol.168.6.2811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000274365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1607141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001940001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2241-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002028227", 
          "https://doi.org/10.1007/s00125-011-2241-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2241-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002028227", 
          "https://doi.org/10.1007/s00125-011-2241-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.5.1924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003334868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006612589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci57132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006731651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007041154", 
          "https://doi.org/10.1038/nri3007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008440265", 
          "https://doi.org/10.1038/nri982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008440265", 
          "https://doi.org/10.1038/nri982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1603827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010225149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci29950", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011464063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012231291", 
          "https://doi.org/10.1038/nm.3128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-1694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012779387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90981-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015369739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2013.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017205359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382366a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022036577", 
          "https://doi.org/10.1038/382366a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11883-012-0274-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023119853", 
          "https://doi.org/10.1007/s11883-012-0274-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2013.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024724990", 
          "https://doi.org/10.1038/nrendo.2013.136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830220140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024782613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db14-0100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031791887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.03.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032750609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.01.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040414535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90305-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044449566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db14-1577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044882302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2016.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051656989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1230719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062467744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156652409789105525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069186044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074469631", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1989.tb03566.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079200066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085172837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085172837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2017.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090900420", 
          "https://doi.org/10.1038/mi.2017.62"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways1, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metabolism. Here we describe a subset of immune cells-integrin \u03b27+ natural gut intraepithelial T lymphocytes (natural IELs)-that is dispersed throughout the enterocyte layer of the small intestine and that modulates systemic metabolism. Integrin \u03b27- mice that lack natural IELs are metabolically hyperactive and, when fed a high-fat and high-sugar diet, are resistant to obesity, hypercholesterolaemia, hypertension, diabetes and atherosclerosis. Furthermore, we show that protection from cardiovascular disease in the absence of natural IELs depends on the enteroendocrine-derived incretin GLP-12, which is normally controlled by IELs through expression of the GLP-1 receptor. In this metabolic control system, IELs modulate enteroendocrine activity by acting as gatekeepers that limit the bioavailability of GLP-1. Although the function of IELs may prove advantageous when food is scarce, present-day\u00a0overabundance of diets high in fat and sugar renders this metabolic checkpoint detrimental to health.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41586-018-0849-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4102174", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4241723", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6617574", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6617620", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7742", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "566"
      }
    ], 
    "name": "Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease", 
    "pagination": "115-119", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f504faf310aa0bfd04c0eb472a2120e50a2a93face76a30eae58deb44ee1167f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30700910"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41586-018-0849-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111780480"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41586-018-0849-9", 
      "https://app.dimensions.ai/details/publication/pub.1111780480"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000365_0000000365/records_71712_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41586-018-0849-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0849-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0849-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0849-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0849-9'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      59 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41586-018-0849-9 schema:about anzsrc-for:11
2 anzsrc-for:1111
3 schema:author Nef8c342d079248db9c8610fd07093cf3
4 schema:citation sg:pub.10.1007/s00125-011-2241-2
5 sg:pub.10.1007/s11883-012-0274-8
6 sg:pub.10.1038/382366a0
7 sg:pub.10.1038/mi.2017.62
8 sg:pub.10.1038/nm.3128
9 sg:pub.10.1038/nrendo.2013.136
10 sg:pub.10.1038/nri3007
11 sg:pub.10.1038/nri982
12 https://app.dimensions.ai/details/publication/pub.1074469631
13 https://doi.org/10.1002/eji.1830220140
14 https://doi.org/10.1002/j.1460-2075.1989.tb03566.x
15 https://doi.org/10.1016/0092-8674(89)90981-1
16 https://doi.org/10.1016/0092-8674(93)90305-a
17 https://doi.org/10.1016/j.cell.2013.01.041
18 https://doi.org/10.1016/j.cell.2017.04.004
19 https://doi.org/10.1016/j.cmet.2016.06.009
20 https://doi.org/10.1016/j.immuni.2013.04.001
21 https://doi.org/10.1053/j.gastro.2007.03.054
22 https://doi.org/10.1056/nejmoa1603827
23 https://doi.org/10.1056/nejmoa1607141
24 https://doi.org/10.1073/pnas.89.5.1924
25 https://doi.org/10.1126/science.1230719
26 https://doi.org/10.1172/jci29950
27 https://doi.org/10.1172/jci42497
28 https://doi.org/10.1172/jci57132
29 https://doi.org/10.2174/156652409789105525
30 https://doi.org/10.2337/db09-1694
31 https://doi.org/10.2337/db14-0100
32 https://doi.org/10.2337/db14-1577
33 https://doi.org/10.4049/jimmunol.168.6.2811
34 schema:datePublished 2019-02
35 schema:datePublishedReg 2019-02-01
36 schema:description The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways<sup>1</sup>, how our bodies handle nutrients depends on strategically positioned metabolic sensors that link the intrinsic nutritional value of a meal with intermediary metabolism. Here we describe a subset of immune cells-integrin β7<sup>+</sup> natural gut intraepithelial T lymphocytes (natural IELs)-that is dispersed throughout the enterocyte layer of the small intestine and that modulates systemic metabolism. Integrin β7<sup>-</sup> mice that lack natural IELs are metabolically hyperactive and, when fed a high-fat and high-sugar diet, are resistant to obesity, hypercholesterolaemia, hypertension, diabetes and atherosclerosis. Furthermore, we show that protection from cardiovascular disease in the absence of natural IELs depends on the enteroendocrine-derived incretin GLP-1<sup>2</sup>, which is normally controlled by IELs through expression of the GLP-1 receptor. In this metabolic control system, IELs modulate enteroendocrine activity by acting as gatekeepers that limit the bioavailability of GLP-1. Although the function of IELs may prove advantageous when food is scarce, present-day overabundance of diets high in fat and sugar renders this metabolic checkpoint detrimental to health.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N3bd157014b634e458807fcdd5f4ab449
41 Naa163b147fa447febf3705a8a00a9c9b
42 sg:journal.1018957
43 schema:name Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease
44 schema:pagination 115-119
45 schema:productId N46524c41f92c466295486d61487092b9
46 N4df0bd6f34f3405c8c6c1c8d510e3eeb
47 N4f54d362946443609d04e7eb2fa91699
48 N86dfafa0cba0475bb26561293a738f00
49 Ned69b67a2aaa42bbab5f8955bd17c90d
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111780480
51 https://doi.org/10.1038/s41586-018-0849-9
52 schema:sdDatePublished 2019-04-11T13:01
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N98c5a66ba6394c17a059e472a40af745
55 schema:url https://www.nature.com/articles/s41586-018-0849-9
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N047a23c01f254604a58ada336ae97bb5 rdf:first Nd674e4b0c08749a2b91380e0553774f1
60 rdf:rest Nf3b93c57ade04b10a54a521649367263
61 N079b6f5c7bdd4084a6e36f5abbd4d382 rdf:first N3005a10c46fb406c94504dd09ebfca81
62 rdf:rest N162019a35af24fa1b945c261e102a2ce
63 N0db1eb8177d249129f49a239cd2de9d2 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
64 schema:familyName Selgrade
65 schema:givenName Daniel
66 rdf:type schema:Person
67 N162019a35af24fa1b945c261e102a2ce rdf:first N8a391e4e9c264427a2e7a68bfb105519
68 rdf:rest N9532ae9e6d1b4e64bb70e899ab18364f
69 N228a89e87b414e519eaba2f28efaf432 rdf:first Nce80ace78eec4c72979b61d43babe22a
70 rdf:rest Nc2b08efcb84146f689705b395bec864a
71 N3005a10c46fb406c94504dd09ebfca81 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
72 schema:familyName Fernández-Hernando
73 schema:givenName Carlos
74 rdf:type schema:Person
75 N33960eb310364e70ad8b2000de2a9262 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
76 schema:familyName Valet
77 schema:givenName Colin
78 rdf:type schema:Person
79 N358761bd11794fac99f489dc46b412a2 rdf:first N698c89f9816f4e59847d0a932b839fb7
80 rdf:rest N228a89e87b414e519eaba2f28efaf432
81 N3a032f9f4be64a468d3845b9f10e75dd rdf:first Nc2af0082a51f4c82837394b973beaab1
82 rdf:rest N358761bd11794fac99f489dc46b412a2
83 N3bd157014b634e458807fcdd5f4ab449 schema:volumeNumber 566
84 rdf:type schema:PublicationVolume
85 N46524c41f92c466295486d61487092b9 schema:name readcube_id
86 schema:value f504faf310aa0bfd04c0eb472a2120e50a2a93face76a30eae58deb44ee1167f
87 rdf:type schema:PropertyValue
88 N4ce9f1b010f44821b925911c223e9aea rdf:first N9d70844dd1ad4199bc581d0583488571
89 rdf:rest Ndd1f44a797a84cdf84d357811e22d94a
90 N4d44852c409d46c89b6fd2eaefaac3ef rdf:first Ne58ab92650bc423ebc993bdfb514c18e
91 rdf:rest N7f764b496e054dce93cc0a7cd643a201
92 N4df0bd6f34f3405c8c6c1c8d510e3eeb schema:name pubmed_id
93 schema:value 30700910
94 rdf:type schema:PropertyValue
95 N4df74a070aa44aa3884c2fa72bad4fc1 rdf:first N8b352796a97f4c62b36c854632c3962d
96 rdf:rest N079b6f5c7bdd4084a6e36f5abbd4d382
97 N4f54d362946443609d04e7eb2fa91699 schema:name dimensions_id
98 schema:value pub.1111780480
99 rdf:type schema:PropertyValue
100 N672ebd24300340f38556ad7db526e753 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
101 schema:familyName Swirski
102 schema:givenName Filip K.
103 rdf:type schema:Person
104 N69755773035a4f31ad6915e328695cf2 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
105 schema:familyName He
106 schema:givenName Shun
107 rdf:type schema:Person
108 N698c89f9816f4e59847d0a932b839fb7 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
109 schema:familyName Rotllan
110 schema:givenName Noemi
111 rdf:type schema:Person
112 N7218f21efa7342d398ea2c4c2eab69c7 rdf:first N8ed5627f846e440aabcf91ca97de7ba3
113 rdf:rest N047a23c01f254604a58ada336ae97bb5
114 N728b978f9f1f41ae8eaf475f37ed8815 rdf:first Ne027c0381579493db8e09032b9e3c24d
115 rdf:rest N4df74a070aa44aa3884c2fa72bad4fc1
116 N72a80f45c69d4ffdaca0deb41d398528 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
117 schema:familyName Wojtkiewicz
118 schema:givenName Gregory R.
119 rdf:type schema:Person
120 N7f764b496e054dce93cc0a7cd643a201 rdf:first Nd4718fc9fc57411c91e2af13b014b41f
121 rdf:rest N7218f21efa7342d398ea2c4c2eab69c7
122 N8045b2aa0afb4ff2af6981337fb922b6 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
123 schema:familyName Poller
124 schema:givenName Wolfram C.
125 rdf:type schema:Person
126 N8132049790ec4e10a540d244c137c6b4 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
127 schema:familyName Fenn
128 schema:givenName Ashley M.
129 rdf:type schema:Person
130 N86dfafa0cba0475bb26561293a738f00 schema:name doi
131 schema:value 10.1038/s41586-018-0849-9
132 rdf:type schema:PropertyValue
133 N8a391e4e9c264427a2e7a68bfb105519 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
134 schema:familyName Drucker
135 schema:givenName Daniel J.
136 rdf:type schema:Person
137 N8a6e378c20464fbc97d808b602b21d80 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
138 schema:familyName Kahles
139 schema:givenName Florian
140 rdf:type schema:Person
141 N8b352796a97f4c62b36c854632c3962d schema:affiliation https://www.grid.ac/institutes/grid.62560.37
142 schema:familyName Libby
143 schema:givenName Peter
144 rdf:type schema:Person
145 N8ed5627f846e440aabcf91ca97de7ba3 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
146 schema:familyName McAlpine
147 schema:givenName Cameron S.
148 rdf:type schema:Person
149 N9532ae9e6d1b4e64bb70e899ab18364f rdf:first Nccb07a9b95844e569885ad500c8acf5f
150 rdf:rest N9b01897f38894fc8b0e56b4774b839c2
151 N98c5a66ba6394c17a059e472a40af745 schema:name Springer Nature - SN SciGraph project
152 rdf:type schema:Organization
153 N999e4edf55b641d188b4ffc6f996511e schema:affiliation https://www.grid.ac/institutes/grid.483004.b
154 schema:familyName Chan
155 schema:givenName Christopher T.
156 rdf:type schema:Person
157 N9b01897f38894fc8b0e56b4774b839c2 rdf:first N672ebd24300340f38556ad7db526e753
158 rdf:rest rdf:nil
159 N9d70844dd1ad4199bc581d0583488571 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
160 schema:familyName Mindur
161 schema:givenName John E.
162 rdf:type schema:Person
163 N9d7277d6fa5e4fdb9165b33e92c46816 rdf:first N999e4edf55b641d188b4ffc6f996511e
164 rdf:rest N4ce9f1b010f44821b925911c223e9aea
165 Naa163b147fa447febf3705a8a00a9c9b schema:issueNumber 7742
166 rdf:type schema:PublicationIssue
167 Nbbb9f33db7ba42418f38aa554b6af94e rdf:first N8045b2aa0afb4ff2af6981337fb922b6
168 rdf:rest N3a032f9f4be64a468d3845b9f10e75dd
169 Nc2af0082a51f4c82837394b973beaab1 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
170 schema:familyName Halle
171 schema:givenName Lennard
172 rdf:type schema:Person
173 Nc2b08efcb84146f689705b395bec864a rdf:first N72a80f45c69d4ffdaca0deb41d398528
174 rdf:rest N728b978f9f1f41ae8eaf475f37ed8815
175 Nccb07a9b95844e569885ad500c8acf5f schema:affiliation https://www.grid.ac/institutes/grid.32224.35
176 schema:familyName Nahrendorf
177 schema:givenName Matthias
178 rdf:type schema:Person
179 Nce80ace78eec4c72979b61d43babe22a schema:affiliation https://www.grid.ac/institutes/grid.483004.b
180 schema:familyName Iwamoto
181 schema:givenName Yoshiko
182 rdf:type schema:Person
183 Nd4718fc9fc57411c91e2af13b014b41f schema:affiliation https://www.grid.ac/institutes/grid.483004.b
184 schema:familyName Nairz
185 schema:givenName Manfred
186 rdf:type schema:Person
187 Nd674e4b0c08749a2b91380e0553774f1 schema:affiliation https://www.grid.ac/institutes/grid.483004.b
188 schema:familyName Anzai
189 schema:givenName Atsushi
190 rdf:type schema:Person
191 Ndd1f44a797a84cdf84d357811e22d94a rdf:first N33960eb310364e70ad8b2000de2a9262
192 rdf:rest Nbbb9f33db7ba42418f38aa554b6af94e
193 Ndf47e3ee612646378ee2b9ae57cc5fa4 rdf:first N8a6e378c20464fbc97d808b602b21d80
194 rdf:rest N4d44852c409d46c89b6fd2eaefaac3ef
195 Ne027c0381579493db8e09032b9e3c24d schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
196 schema:familyName Weissleder
197 schema:givenName Ralph
198 rdf:type schema:Person
199 Ne58ab92650bc423ebc993bdfb514c18e schema:affiliation https://www.grid.ac/institutes/grid.483004.b
200 schema:familyName Rattik
201 schema:givenName Sara
202 rdf:type schema:Person
203 Ned69b67a2aaa42bbab5f8955bd17c90d schema:name nlm_unique_id
204 schema:value 0410462
205 rdf:type schema:PropertyValue
206 Nef8c342d079248db9c8610fd07093cf3 rdf:first N69755773035a4f31ad6915e328695cf2
207 rdf:rest Ndf47e3ee612646378ee2b9ae57cc5fa4
208 Nf3b93c57ade04b10a54a521649367263 rdf:first N0db1eb8177d249129f49a239cd2de9d2
209 rdf:rest Nfc9f1fa7e4b3447dbdc07a3abb34f051
210 Nfc9f1fa7e4b3447dbdc07a3abb34f051 rdf:first N8132049790ec4e10a540d244c137c6b4
211 rdf:rest N9d7277d6fa5e4fdb9165b33e92c46816
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1111 schema:inDefinedTermSet anzsrc-for:
216 schema:name Nutrition and Dietetics
217 rdf:type schema:DefinedTerm
218 sg:grant.4102174 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0849-9
219 rdf:type schema:MonetaryGrant
220 sg:grant.4241723 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0849-9
221 rdf:type schema:MonetaryGrant
222 sg:grant.6617574 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0849-9
223 rdf:type schema:MonetaryGrant
224 sg:grant.6617620 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0849-9
225 rdf:type schema:MonetaryGrant
226 sg:journal.1018957 schema:issn 0090-0028
227 1476-4687
228 schema:name Nature
229 rdf:type schema:Periodical
230 sg:pub.10.1007/s00125-011-2241-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002028227
231 https://doi.org/10.1007/s00125-011-2241-2
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s11883-012-0274-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023119853
234 https://doi.org/10.1007/s11883-012-0274-8
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/382366a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022036577
237 https://doi.org/10.1038/382366a0
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/mi.2017.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090900420
240 https://doi.org/10.1038/mi.2017.62
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nm.3128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012231291
243 https://doi.org/10.1038/nm.3128
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nrendo.2013.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024724990
246 https://doi.org/10.1038/nrendo.2013.136
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nri3007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007041154
249 https://doi.org/10.1038/nri3007
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nri982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008440265
252 https://doi.org/10.1038/nri982
253 rdf:type schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1074469631 schema:CreativeWork
255 https://doi.org/10.1002/eji.1830220140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024782613
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/j.1460-2075.1989.tb03566.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079200066
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/0092-8674(89)90981-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015369739
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/0092-8674(93)90305-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044449566
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.cell.2013.01.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040414535
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.cell.2017.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085172837
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.cmet.2016.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051656989
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.immuni.2013.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017205359
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1053/j.gastro.2007.03.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032750609
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1056/nejmoa1603827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010225149
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1056/nejmoa1607141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001940001
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1073/pnas.89.5.1924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003334868
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.1230719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467744
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1172/jci29950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011464063
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1172/jci42497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006612589
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1172/jci57132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006731651
286 rdf:type schema:CreativeWork
287 https://doi.org/10.2174/156652409789105525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069186044
288 rdf:type schema:CreativeWork
289 https://doi.org/10.2337/db09-1694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012779387
290 rdf:type schema:CreativeWork
291 https://doi.org/10.2337/db14-0100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031791887
292 rdf:type schema:CreativeWork
293 https://doi.org/10.2337/db14-1577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044882302
294 rdf:type schema:CreativeWork
295 https://doi.org/10.4049/jimmunol.168.6.2811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000274365
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
298 schema:name Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
301 schema:name Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
302 Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
305 schema:name Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
306 Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
307 Department of Systems Biology, Harvard Medical School, Boston, MA, USA
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
310 schema:name Vascular Biology and Therapeutics Program, Department of Comparative Medicine and Pathology, Yale University School of Medicine, New Haven, CT, USA
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.483004.b schema:alternateName Center for Systems Biology
313 schema:name Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
316 schema:name Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...