Genomic encoding of transcriptional burst kinetics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-02

AUTHORS

Anton J. M. Larsson, Per Johnsson, Michael Hagemann-Jensen, Leonard Hartmanis, Omid R. Faridani, Björn Reinius, Åsa Segerstolpe, Chloe M. Rivera, Bing Ren, Rickard Sandberg

ABSTRACT

Mammalian gene expression is inherently stochastic1,2, and results in discrete bursts of RNA molecules that are synthesized from each allele3-7. Although transcription is known to be regulated by promoters and enhancers, it is unclear how cis-regulatory sequences encode transcriptional burst kinetics. Characterization of transcriptional bursting, including the burst size and frequency, has mainly relied on live-cell4,6,8 or single-molecule RNA fluorescence in situ hybridization3,5,8,9 recordings of selected loci. Here we determine transcriptome-wide burst frequencies and sizes for endogenous mouse and human genes using allele-sensitive single-cell RNA sequencing. We show that core promoter elements affect burst size and uncover synergistic effects between TATA and initiator elements, which were masked at mean expression levels. Notably, we provide transcriptome-wide evidence that enhancers control burst frequencies, and demonstrate that cell-type-specific gene expression is primarily shaped by changes in burst frequencies. Together, our data show that burst frequency is primarily encoded in enhancers and burst size in core promoters, and that allelic single-cell RNA sequencing is a powerful model for investigating transcriptional kinetics. More... »

PAGES

1-4

Journal

TITLE

Nature

ISSUE

N/A

VOLUME

N/A

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41586-018-0836-1

DOI

http://dx.doi.org/10.1038/s41586-018-0836-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110854883

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30602787


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larsson", 
        "givenName": "Anton J. M.", 
        "id": "sg:person.013531172751.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013531172751.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden", 
            "Ludwig Institute for Cancer Research, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnsson", 
        "givenName": "Per", 
        "id": "sg:person.01266744024.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266744024.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagemann-Jensen", 
        "givenName": "Michael", 
        "id": "sg:person.0724157441.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724157441.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hartmanis", 
        "givenName": "Leonard", 
        "id": "sg:person.011077757523.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011077757523.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden", 
            "Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Faridani", 
        "givenName": "Omid R.", 
        "id": "sg:person.01052340131.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052340131.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden", 
            "Ludwig Institute for Cancer Research, Stockholm, Sweden", 
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinius", 
        "givenName": "Bj\u00f6rn", 
        "id": "sg:person.01227500470.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227500470.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden", 
            "Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Stockholm, Sweden", 
            "Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Segerstolpe", 
        "givenName": "\u00c5sa", 
        "id": "sg:person.0764725411.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764725411.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.1052.6", 
          "name": [
            "Ludwig Institute for Cancer Research, San Diego, CA, USA", 
            "Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rivera", 
        "givenName": "Chloe M.", 
        "id": "sg:person.0771225751.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771225751.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.1052.6", 
          "name": [
            "Ludwig Institute for Cancer Research, San Diego, CA, USA", 
            "Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ren", 
        "givenName": "Bing", 
        "id": "sg:person.01174702157.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174702157.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden", 
            "Ludwig Institute for Cancer Research, Stockholm, Sweden", 
            "Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sandberg", 
        "givenName": "Rickard", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m702776200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001982264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1228186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010384793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1198817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011656336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013616167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1213530109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015322861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017148160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018209341", 
          "https://doi.org/10.1038/nrm3953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018463905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022270616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022512355", 
          "https://doi.org/10.1038/ncomms12248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.03.092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025966713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/tpbi.1995.1027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027444563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.15.7125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027808269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029201144", 
          "https://doi.org/10.1038/nrg3888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0040309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031857499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033819095", 
          "https://doi.org/10.1038/nature13994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1245316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035294760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(96)10050-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035467098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(03)00140-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037985676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(03)00140-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037985676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0114485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041700241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.139378.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042482558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.05.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043138868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2013-14-1-r7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043158487", 
          "https://doi.org/10.1186/gb-2013-14-1-r7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044330050", 
          "https://doi.org/10.1038/ng.3678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052601820", 
          "https://doi.org/10.1038/nature01763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052601820", 
          "https://doi.org/10.1038/nature01763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-017-1200-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084955750", 
          "https://doi.org/10.1186/s13059-017-1200-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-017-1200-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084955750", 
          "https://doi.org/10.1186/s13059-017-1200-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2017.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085206475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c7mb00154a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085743976"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-02", 
    "datePublishedReg": "2019-01-02", 
    "description": "Mammalian gene expression is inherently stochastic1,2, and results in discrete bursts of RNA molecules that are synthesized from each allele3-7. Although transcription is known to be regulated by promoters and enhancers, it is unclear how cis-regulatory sequences encode transcriptional burst kinetics. Characterization of transcriptional bursting, including the burst size and frequency, has mainly relied on live-cell4,6,8 or single-molecule RNA fluorescence in situ hybridization3,5,8,9 recordings of selected loci. Here we determine transcriptome-wide burst frequencies and sizes for endogenous mouse and human genes using allele-sensitive single-cell RNA sequencing. We show that core promoter elements affect burst size and uncover synergistic effects between TATA and initiator elements, which were masked at mean expression levels. Notably, we provide transcriptome-wide evidence that enhancers control burst frequencies, and demonstrate that cell-type-specific gene expression is primarily shaped by changes in burst frequencies. Together, our data show that burst frequency is primarily encoded in enhancers and burst size in core promoters, and that allelic single-cell RNA sequencing is a powerful model for investigating transcriptional kinetics.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41586-018-0836-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }
    ], 
    "name": "Genomic encoding of transcriptional burst kinetics", 
    "pagination": "1-4", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a936d4af8037f635f5cbd1dba6e63fd3b086850714607dd68a0a17d11c2d2e9e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30602787"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41586-018-0836-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110854883"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41586-018-0836-1", 
      "https://app.dimensions.ai/details/publication/pub.1110854883"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000310_0000000310/records_90755_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41586-018-0836-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0836-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0836-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0836-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0836-1'


 

This table displays all metadata directly associated to this object as RDF triples.

229 TRIPLES      21 PREDICATES      54 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41586-018-0836-1 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N7ed047c331ba483ca178820b2890c2ba
4 schema:citation sg:pub.10.1038/nature01763
5 sg:pub.10.1038/nature13994
6 sg:pub.10.1038/ncomms12248
7 sg:pub.10.1038/ng.3678
8 sg:pub.10.1038/nrg3888
9 sg:pub.10.1038/nrm3953
10 sg:pub.10.1186/gb-2013-14-1-r7
11 sg:pub.10.1186/s13059-017-1200-8
12 https://doi.org/10.1006/tpbi.1995.1027
13 https://doi.org/10.1016/j.cell.2008.09.050
14 https://doi.org/10.1016/j.cell.2016.05.025
15 https://doi.org/10.1016/j.cub.2006.03.092
16 https://doi.org/10.1016/j.molcel.2015.03.005
17 https://doi.org/10.1016/j.molcel.2016.03.007
18 https://doi.org/10.1016/j.sbi.2017.03.013
19 https://doi.org/10.1016/s0168-9525(03)00140-9
20 https://doi.org/10.1016/s0968-0004(96)10050-5
21 https://doi.org/10.1039/c7mb00154a
22 https://doi.org/10.1073/pnas.1213530109
23 https://doi.org/10.1073/pnas.92.15.7125
24 https://doi.org/10.1074/jbc.m702776200
25 https://doi.org/10.1101/gr.139378.112
26 https://doi.org/10.1126/science.1072241
27 https://doi.org/10.1126/science.1198817
28 https://doi.org/10.1126/science.1228186
29 https://doi.org/10.1126/science.1245316
30 https://doi.org/10.1371/journal.pbio.0040309
31 https://doi.org/10.1371/journal.pone.0114485
32 schema:datePublished 2019-01-02
33 schema:datePublishedReg 2019-01-02
34 schema:description Mammalian gene expression is inherently stochastic<sup>1,2</sup>, and results in discrete bursts of RNA molecules that are synthesized from each allele<sup>3-7</sup>. Although transcription is known to be regulated by promoters and enhancers, it is unclear how cis-regulatory sequences encode transcriptional burst kinetics. Characterization of transcriptional bursting, including the burst size and frequency, has mainly relied on live-cell<sup>4,6,8</sup> or single-molecule RNA fluorescence in situ hybridization<sup>3,5,8,9</sup> recordings of selected loci. Here we determine transcriptome-wide burst frequencies and sizes for endogenous mouse and human genes using allele-sensitive single-cell RNA sequencing. We show that core promoter elements affect burst size and uncover synergistic effects between TATA and initiator elements, which were masked at mean expression levels. Notably, we provide transcriptome-wide evidence that enhancers control burst frequencies, and demonstrate that cell-type-specific gene expression is primarily shaped by changes in burst frequencies. Together, our data show that burst frequency is primarily encoded in enhancers and burst size in core promoters, and that allelic single-cell RNA sequencing is a powerful model for investigating transcriptional kinetics.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf sg:journal.1018957
39 schema:name Genomic encoding of transcriptional burst kinetics
40 schema:pagination 1-4
41 schema:productId N3bf99b98757f4ed5bf7cbd77b5b755cb
42 N66fd470830394c8a9de7853dcbff3e83
43 N751fadf8a04a4302ba1db2ac4b7b5400
44 N7e8501eceaa14edcbad649c2e7da0c2b
45 Ne9c2303478904642aed58ff956c94805
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110854883
47 https://doi.org/10.1038/s41586-018-0836-1
48 schema:sdDatePublished 2019-04-11T08:34
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher N4307d8344b7c4b8babeefb63cdbb7398
51 schema:url https://www.nature.com/articles/s41586-018-0836-1
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N0b8b74ebaf7743e096f8f80f0c39ad22 rdf:first sg:person.01266744024.31
56 rdf:rest N99e4acba6ebc4a989610702196ab75d2
57 N3bf99b98757f4ed5bf7cbd77b5b755cb schema:name dimensions_id
58 schema:value pub.1110854883
59 rdf:type schema:PropertyValue
60 N4307d8344b7c4b8babeefb63cdbb7398 schema:name Springer Nature - SN SciGraph project
61 rdf:type schema:Organization
62 N5b5eec4ec006411a9b74560d71ef0fab rdf:first N85cb3b465eda4eeca2dbbbd8f3b11254
63 rdf:rest rdf:nil
64 N66fd470830394c8a9de7853dcbff3e83 schema:name nlm_unique_id
65 schema:value 0410462
66 rdf:type schema:PropertyValue
67 N751fadf8a04a4302ba1db2ac4b7b5400 schema:name readcube_id
68 schema:value a936d4af8037f635f5cbd1dba6e63fd3b086850714607dd68a0a17d11c2d2e9e
69 rdf:type schema:PropertyValue
70 N7e8501eceaa14edcbad649c2e7da0c2b schema:name doi
71 schema:value 10.1038/s41586-018-0836-1
72 rdf:type schema:PropertyValue
73 N7ed047c331ba483ca178820b2890c2ba rdf:first sg:person.013531172751.66
74 rdf:rest N0b8b74ebaf7743e096f8f80f0c39ad22
75 N83ee13074592454db791da39c253adc2 rdf:first sg:person.0771225751.42
76 rdf:rest Nea8cf7dbcc694d99a6435188224315e8
77 N85cb3b465eda4eeca2dbbbd8f3b11254 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
78 schema:familyName Sandberg
79 schema:givenName Rickard
80 rdf:type schema:Person
81 N86b746c2ea8d4b6289c2dee872edb8ae rdf:first sg:person.011077757523.33
82 rdf:rest Ndad9232ad9ac431aafed5b02192e92f6
83 N99e4acba6ebc4a989610702196ab75d2 rdf:first sg:person.0724157441.36
84 rdf:rest N86b746c2ea8d4b6289c2dee872edb8ae
85 Ndad9232ad9ac431aafed5b02192e92f6 rdf:first sg:person.01052340131.35
86 rdf:rest Nf09b8eb2e4994e5ea81182bcb29e32b3
87 Ndc3543445085477d83aa56670e966b21 rdf:first sg:person.0764725411.14
88 rdf:rest N83ee13074592454db791da39c253adc2
89 Ne9c2303478904642aed58ff956c94805 schema:name pubmed_id
90 schema:value 30602787
91 rdf:type schema:PropertyValue
92 Nea8cf7dbcc694d99a6435188224315e8 rdf:first sg:person.01174702157.48
93 rdf:rest N5b5eec4ec006411a9b74560d71ef0fab
94 Nf09b8eb2e4994e5ea81182bcb29e32b3 rdf:first sg:person.01227500470.21
95 rdf:rest Ndc3543445085477d83aa56670e966b21
96 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
97 schema:name Biological Sciences
98 rdf:type schema:DefinedTerm
99 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
100 schema:name Genetics
101 rdf:type schema:DefinedTerm
102 sg:journal.1018957 schema:issn 0090-0028
103 1476-4687
104 schema:name Nature
105 rdf:type schema:Periodical
106 sg:person.01052340131.35 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
107 schema:familyName Faridani
108 schema:givenName Omid R.
109 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052340131.35
110 rdf:type schema:Person
111 sg:person.011077757523.33 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
112 schema:familyName Hartmanis
113 schema:givenName Leonard
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011077757523.33
115 rdf:type schema:Person
116 sg:person.01174702157.48 schema:affiliation https://www.grid.ac/institutes/grid.1052.6
117 schema:familyName Ren
118 schema:givenName Bing
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174702157.48
120 rdf:type schema:Person
121 sg:person.01227500470.21 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
122 schema:familyName Reinius
123 schema:givenName Björn
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227500470.21
125 rdf:type schema:Person
126 sg:person.01266744024.31 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
127 schema:familyName Johnsson
128 schema:givenName Per
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266744024.31
130 rdf:type schema:Person
131 sg:person.013531172751.66 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
132 schema:familyName Larsson
133 schema:givenName Anton J. M.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013531172751.66
135 rdf:type schema:Person
136 sg:person.0724157441.36 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
137 schema:familyName Hagemann-Jensen
138 schema:givenName Michael
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724157441.36
140 rdf:type schema:Person
141 sg:person.0764725411.14 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
142 schema:familyName Segerstolpe
143 schema:givenName Åsa
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764725411.14
145 rdf:type schema:Person
146 sg:person.0771225751.42 schema:affiliation https://www.grid.ac/institutes/grid.1052.6
147 schema:familyName Rivera
148 schema:givenName Chloe M.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771225751.42
150 rdf:type schema:Person
151 sg:pub.10.1038/nature01763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052601820
152 https://doi.org/10.1038/nature01763
153 rdf:type schema:CreativeWork
154 sg:pub.10.1038/nature13994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033819095
155 https://doi.org/10.1038/nature13994
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/ncomms12248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022512355
158 https://doi.org/10.1038/ncomms12248
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/ng.3678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044330050
161 https://doi.org/10.1038/ng.3678
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nrg3888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029201144
164 https://doi.org/10.1038/nrg3888
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/nrm3953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018209341
167 https://doi.org/10.1038/nrm3953
168 rdf:type schema:CreativeWork
169 sg:pub.10.1186/gb-2013-14-1-r7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043158487
170 https://doi.org/10.1186/gb-2013-14-1-r7
171 rdf:type schema:CreativeWork
172 sg:pub.10.1186/s13059-017-1200-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084955750
173 https://doi.org/10.1186/s13059-017-1200-8
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1006/tpbi.1995.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027444563
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.cell.2008.09.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018463905
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.cell.2016.05.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043138868
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.cub.2006.03.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025966713
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.molcel.2015.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022270616
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.molcel.2016.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017148160
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.sbi.2017.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085206475
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/s0168-9525(03)00140-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037985676
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0968-0004(96)10050-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035467098
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1039/c7mb00154a schema:sameAs https://app.dimensions.ai/details/publication/pub.1085743976
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1073/pnas.1213530109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015322861
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1073/pnas.92.15.7125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027808269
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1074/jbc.m702776200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001982264
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1101/gr.139378.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042482558
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1126/science.1072241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013616167
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1126/science.1198817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011656336
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1126/science.1228186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010384793
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1126/science.1245316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035294760
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1371/journal.pbio.0040309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031857499
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1371/journal.pone.0114485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041700241
214 rdf:type schema:CreativeWork
215 https://www.grid.ac/institutes/grid.1052.6 schema:alternateName Ludwig Cancer Research
216 schema:name Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
217 Ludwig Institute for Cancer Research, San Diego, CA, USA
218 rdf:type schema:Organization
219 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
220 schema:name Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
221 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
222 Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Stockholm, Sweden
223 Ludwig Institute for Cancer Research, Stockholm, Sweden
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
226 schema:name Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
227 Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Stockholm, Sweden
228 Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
229 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...