Structural basis of Notch recognition by human γ-secretase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-31

AUTHORS

Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi

ABSTRACT

Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-secretase recognizes its substrate remains unknown. Here we report the cryo-electron microscopy structure of human γ-secretase in complex with a Notch fragment at a resolution of 2.7 Å. The transmembrane helix of Notch is surrounded by three transmembrane domains of PS1, and the carboxyl-terminal β-strand of the Notch fragment forms a β-sheet with two substrate-induced β-strands of PS1 on the intracellular side. Formation of the hybrid β-sheet is essential for substrate cleavage, which occurs at the carboxyl-terminal end of the Notch transmembrane helix. PS1 undergoes pronounced conformational rearrangement upon substrate binding. These features reveal the structural basis of Notch recognition and have implications for the recruitment of the amyloid precursor protein by γ-secretase. More... »

PAGES

1-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41586-018-0813-8

DOI

http://dx.doi.org/10.1038/s41586-018-0813-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110837773

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30598546


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Guanghui", 
        "id": "sg:person.01025133004.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025133004.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Rui", 
        "id": "sg:person.01141361404.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141361404.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westlake Institute for Advanced Study", 
          "id": "https://www.grid.ac/institutes/grid.494629.4", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China", 
            "Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Qiang", 
        "id": "sg:person.01105627715.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105627715.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Xuefei", 
        "id": "sg:person.015161062103.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015161062103.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Chuangye", 
        "id": "sg:person.01274436253.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274436253.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ke", 
        "givenName": "Meng", 
        "id": "sg:person.01135225171.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135225171.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China", 
            "Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Jianlin", 
        "id": "sg:person.0777074713.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777074713.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westlake Institute for Advanced Study", 
          "id": "https://www.grid.ac/institutes/grid.494629.4", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China", 
            "Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Yigong", 
        "id": "sg:person.012705321277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705321277.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ultramic.2013.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000304364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471250953.bi0506s47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000988724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0700814104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003555146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004359799", 
          "https://doi.org/10.1038/19077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004359799", 
          "https://doi.org/10.1038/19077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/375754a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007185513", 
          "https://doi.org/10.1038/375754a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.18722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009291458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.06980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010948956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011214574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011351216", 
          "https://doi.org/10.1038/nsmb1179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011351216", 
          "https://doi.org/10.1038/nsmb1179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1210951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013757649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013833540", 
          "https://doi.org/10.1038/nature13567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015026428", 
          "https://doi.org/10.1038/nature14892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.110126897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015370546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1506242112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017267804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80675-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017347922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1033.2002.03271.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019515950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2012.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019988217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909052925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020777046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.03.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021056409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.11182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023050774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/nbdi.2001.0470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023139084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.17578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023241073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1512952113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025278633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aab1576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026142402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1618657114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028066108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2005.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029507842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2014.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031002456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pharmtox-010814-124309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031705508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1102160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033243130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2010.243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034167926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036332384", 
          "https://doi.org/10.1038/nature12754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1163-08.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037116875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00525-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038235605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2362-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038480534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2013.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039746431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi400377p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040449107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1215076110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043435152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3164-14.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046937063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embj.201489367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047271537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.12.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048387940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.12.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048387940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.12.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048387940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048748829", 
          "https://doi.org/10.1038/19083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048748829", 
          "https://doi.org/10.1038/19083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2015.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049504602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35015085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050813076", 
          "https://doi.org/10.1038/35015085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35015085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050813076", 
          "https://doi.org/10.1038/35015085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444902016657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051282549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2011.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052958331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1037392100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052993691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053079917", 
          "https://doi.org/10.1038/34910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/34910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053079917", 
          "https://doi.org/10.1038/34910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90424-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053122375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi300303g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055205014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1070925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1150755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1196284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062462805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1566067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062491586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1738847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062503577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5415.770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062565091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8191290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078570798", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129286", 
          "https://doi.org/10.1038/nmeth.4193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a024067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084197347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/sciadv.1602794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084846294"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12-31", 
    "datePublishedReg": "2018-12-31", 
    "description": "Aberrant cleavage of Notch by \u03b3-secretase leads to several types of cancer, but how \u03b3-secretase recognizes its substrate remains unknown. Here we report the cryo-electron microscopy structure of human \u03b3-secretase in complex with a Notch fragment at a resolution of 2.7\u00a0\u00c5. The transmembrane helix of Notch is surrounded by three transmembrane domains of PS1, and the carboxyl-terminal \u03b2-strand of the Notch fragment forms a \u03b2-sheet with two substrate-induced \u03b2-strands of PS1 on the intracellular side. Formation of the hybrid \u03b2-sheet is essential for substrate cleavage, which occurs at the carboxyl-terminal end of the Notch transmembrane helix. PS1 undergoes pronounced conformational rearrangement upon substrate binding. These features reveal the structural basis of Notch recognition and have implications for the recruitment of the amyloid precursor protein by \u03b3-secretase.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41586-018-0813-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }
    ], 
    "name": "Structural basis of Notch recognition by human \u03b3-secretase", 
    "pagination": "1-6", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ca55a33bb7dabafed64bde7018c4c2c65f637058d58f98e3e3d23277cab61f4f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30598546"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41586-018-0813-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110837773"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41586-018-0813-8", 
      "https://app.dimensions.ai/details/publication/pub.1110837773"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106289_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41586-018-0813-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0813-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0813-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0813-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0813-8'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      21 PREDICATES      88 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41586-018-0813-8 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N1876bd22583b4d36ab17df7f7d3a58a4
4 schema:citation sg:pub.10.1038/19077
5 sg:pub.10.1038/19083
6 sg:pub.10.1038/34910
7 sg:pub.10.1038/35015085
8 sg:pub.10.1038/375754a0
9 sg:pub.10.1038/nature12754
10 sg:pub.10.1038/nature13567
11 sg:pub.10.1038/nature14892
12 sg:pub.10.1038/nmeth.4193
13 sg:pub.10.1038/nsmb1179
14 https://app.dimensions.ai/details/publication/pub.1078570798
15 https://doi.org/10.1002/0471250953.bi0506s47
16 https://doi.org/10.1006/nbdi.2001.0470
17 https://doi.org/10.1016/0092-8674(93)90424-o
18 https://doi.org/10.1016/j.cell.2009.03.045
19 https://doi.org/10.1016/j.jmb.2011.11.010
20 https://doi.org/10.1016/j.jsb.2005.01.002
21 https://doi.org/10.1016/j.jsb.2012.09.006
22 https://doi.org/10.1016/j.jsb.2014.11.010
23 https://doi.org/10.1016/j.jsb.2015.11.003
24 https://doi.org/10.1016/j.molcel.2015.12.022
25 https://doi.org/10.1016/j.str.2013.03.013
26 https://doi.org/10.1016/j.ultramic.2013.06.004
27 https://doi.org/10.1016/s0092-8674(00)80675-3
28 https://doi.org/10.1016/s0092-8674(01)00525-6
29 https://doi.org/10.1016/s1097-2765(00)80006-4
30 https://doi.org/10.1021/bi300303g
31 https://doi.org/10.1021/bi400377p
32 https://doi.org/10.1038/emboj.2010.243
33 https://doi.org/10.1046/j.1432-1033.2002.03271.x
34 https://doi.org/10.1056/nejmoa1210951
35 https://doi.org/10.1073/pnas.0700814104
36 https://doi.org/10.1073/pnas.1037392100
37 https://doi.org/10.1073/pnas.110126897
38 https://doi.org/10.1073/pnas.1215076110
39 https://doi.org/10.1073/pnas.1506242112
40 https://doi.org/10.1073/pnas.1512952113
41 https://doi.org/10.1073/pnas.1618657114
42 https://doi.org/10.1101/cshperspect.a024067
43 https://doi.org/10.1107/s0907444902016657
44 https://doi.org/10.1107/s0907444904019158
45 https://doi.org/10.1107/s0907444909042073
46 https://doi.org/10.1107/s0907444909052925
47 https://doi.org/10.1126/sciadv.1602794
48 https://doi.org/10.1126/science.1070925
49 https://doi.org/10.1126/science.1102160
50 https://doi.org/10.1126/science.1150755
51 https://doi.org/10.1126/science.1196284
52 https://doi.org/10.1126/science.1566067
53 https://doi.org/10.1126/science.1738847
54 https://doi.org/10.1126/science.284.5415.770
55 https://doi.org/10.1126/science.8191290
56 https://doi.org/10.1126/science.aab1576
57 https://doi.org/10.1146/annurev-pharmtox-010814-124309
58 https://doi.org/10.1523/jneurosci.1163-08.2008
59 https://doi.org/10.1523/jneurosci.2362-09.2009
60 https://doi.org/10.1523/jneurosci.3164-14.2015
61 https://doi.org/10.15252/embj.201489367
62 https://doi.org/10.7554/elife.06980
63 https://doi.org/10.7554/elife.11182
64 https://doi.org/10.7554/elife.17578
65 https://doi.org/10.7554/elife.18722
66 schema:datePublished 2018-12-31
67 schema:datePublishedReg 2018-12-31
68 schema:description Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-secretase recognizes its substrate remains unknown. Here we report the cryo-electron microscopy structure of human γ-secretase in complex with a Notch fragment at a resolution of 2.7 Å. The transmembrane helix of Notch is surrounded by three transmembrane domains of PS1, and the carboxyl-terminal β-strand of the Notch fragment forms a β-sheet with two substrate-induced β-strands of PS1 on the intracellular side. Formation of the hybrid β-sheet is essential for substrate cleavage, which occurs at the carboxyl-terminal end of the Notch transmembrane helix. PS1 undergoes pronounced conformational rearrangement upon substrate binding. These features reveal the structural basis of Notch recognition and have implications for the recruitment of the amyloid precursor protein by γ-secretase.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf sg:journal.1018957
73 schema:name Structural basis of Notch recognition by human γ-secretase
74 schema:pagination 1-6
75 schema:productId N0937fc9db41a4fd4bceed91321263c6d
76 N4ae428d740fb4579ae90ed838b6eb028
77 N51980250152e4f72b9b177abad32d4f5
78 N803300a5f19547bfa7e47ea9319fe61e
79 N94186db6923943c3923550f8781754bb
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110837773
81 https://doi.org/10.1038/s41586-018-0813-8
82 schema:sdDatePublished 2019-04-11T08:32
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Ne68bba7626dc4b048143017821e426d6
85 schema:url https://www.nature.com/articles/s41586-018-0813-8
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0937fc9db41a4fd4bceed91321263c6d schema:name nlm_unique_id
90 schema:value 0410462
91 rdf:type schema:PropertyValue
92 N1876bd22583b4d36ab17df7f7d3a58a4 rdf:first sg:person.01025133004.48
93 rdf:rest N73adc1ed9f3f4cc48d486092c58958d9
94 N4ae428d740fb4579ae90ed838b6eb028 schema:name dimensions_id
95 schema:value pub.1110837773
96 rdf:type schema:PropertyValue
97 N51980250152e4f72b9b177abad32d4f5 schema:name readcube_id
98 schema:value ca55a33bb7dabafed64bde7018c4c2c65f637058d58f98e3e3d23277cab61f4f
99 rdf:type schema:PropertyValue
100 N73adc1ed9f3f4cc48d486092c58958d9 rdf:first sg:person.01141361404.76
101 rdf:rest Nc71d414b3d17410aa8ac22c8068142bd
102 N7aaddda6414245ad9d0a2eec1fdaf65e rdf:first sg:person.015161062103.30
103 rdf:rest Nefc628f4d797429bb1d3433651e200b5
104 N7c57b95737954a65816da71aff972008 rdf:first sg:person.012705321277.28
105 rdf:rest rdf:nil
106 N803300a5f19547bfa7e47ea9319fe61e schema:name doi
107 schema:value 10.1038/s41586-018-0813-8
108 rdf:type schema:PropertyValue
109 N94186db6923943c3923550f8781754bb schema:name pubmed_id
110 schema:value 30598546
111 rdf:type schema:PropertyValue
112 N9980321483a84334a29a975ae942bef8 rdf:first sg:person.0777074713.06
113 rdf:rest N7c57b95737954a65816da71aff972008
114 Nc71d414b3d17410aa8ac22c8068142bd rdf:first sg:person.01105627715.04
115 rdf:rest N7aaddda6414245ad9d0a2eec1fdaf65e
116 Nd3886b307342452abdb90aead927fd19 rdf:first sg:person.01135225171.18
117 rdf:rest N9980321483a84334a29a975ae942bef8
118 Ne68bba7626dc4b048143017821e426d6 schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 Nefc628f4d797429bb1d3433651e200b5 rdf:first sg:person.01274436253.23
121 rdf:rest Nd3886b307342452abdb90aead927fd19
122 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biological Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
126 schema:name Biochemistry and Cell Biology
127 rdf:type schema:DefinedTerm
128 sg:journal.1018957 schema:issn 0090-0028
129 1476-4687
130 schema:name Nature
131 rdf:type schema:Periodical
132 sg:person.01025133004.48 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
133 schema:familyName Yang
134 schema:givenName Guanghui
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025133004.48
136 rdf:type schema:Person
137 sg:person.01105627715.04 schema:affiliation https://www.grid.ac/institutes/grid.494629.4
138 schema:familyName Zhou
139 schema:givenName Qiang
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105627715.04
141 rdf:type schema:Person
142 sg:person.01135225171.18 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
143 schema:familyName Ke
144 schema:givenName Meng
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135225171.18
146 rdf:type schema:Person
147 sg:person.01141361404.76 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
148 schema:familyName Zhou
149 schema:givenName Rui
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141361404.76
151 rdf:type schema:Person
152 sg:person.012705321277.28 schema:affiliation https://www.grid.ac/institutes/grid.494629.4
153 schema:familyName Shi
154 schema:givenName Yigong
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705321277.28
156 rdf:type schema:Person
157 sg:person.01274436253.23 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
158 schema:familyName Yan
159 schema:givenName Chuangye
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274436253.23
161 rdf:type schema:Person
162 sg:person.015161062103.30 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
163 schema:familyName Guo
164 schema:givenName Xuefei
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015161062103.30
166 rdf:type schema:Person
167 sg:person.0777074713.06 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
168 schema:familyName Lei
169 schema:givenName Jianlin
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777074713.06
171 rdf:type schema:Person
172 sg:pub.10.1038/19077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004359799
173 https://doi.org/10.1038/19077
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/19083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048748829
176 https://doi.org/10.1038/19083
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/34910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053079917
179 https://doi.org/10.1038/34910
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/35015085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050813076
182 https://doi.org/10.1038/35015085
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/375754a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007185513
185 https://doi.org/10.1038/375754a0
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nature12754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036332384
188 https://doi.org/10.1038/nature12754
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nature13567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013833540
191 https://doi.org/10.1038/nature13567
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nature14892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015026428
194 https://doi.org/10.1038/nature14892
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nmeth.4193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129286
197 https://doi.org/10.1038/nmeth.4193
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nsmb1179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011351216
200 https://doi.org/10.1038/nsmb1179
201 rdf:type schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1078570798 schema:CreativeWork
203 https://doi.org/10.1002/0471250953.bi0506s47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000988724
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1006/nbdi.2001.0470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023139084
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0092-8674(93)90424-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1053122375
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.cell.2009.03.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021056409
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jmb.2011.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052958331
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.jsb.2005.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029507842
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.jsb.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019988217
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.jsb.2014.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031002456
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.jsb.2015.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049504602
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.molcel.2015.12.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048387940
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.str.2013.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039746431
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.ultramic.2013.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000304364
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0092-8674(00)80675-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017347922
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0092-8674(01)00525-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038235605
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1097-2765(00)80006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011214574
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1021/bi300303g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055205014
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1021/bi400377p schema:sameAs https://app.dimensions.ai/details/publication/pub.1040449107
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1038/emboj.2010.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034167926
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1046/j.1432-1033.2002.03271.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019515950
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejmoa1210951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013757649
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.0700814104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003555146
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1073/pnas.1037392100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052993691
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1073/pnas.110126897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015370546
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1073/pnas.1215076110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043435152
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1073/pnas.1506242112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017267804
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1073/pnas.1512952113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025278633
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1073/pnas.1618657114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028066108
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1101/cshperspect.a024067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084197347
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1107/s0907444902016657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051282549
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1107/s0907444909042073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458004
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1126/sciadv.1602794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084846294
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1126/science.1070925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446459
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1126/science.1102160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033243130
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1126/science.1150755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457156
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1126/science.1196284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062462805
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1126/science.1566067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062491586
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.1738847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062503577
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1126/science.284.5415.770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565091
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.8191290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653078
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1126/science.aab1576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026142402
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1146/annurev-pharmtox-010814-124309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031705508
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1523/jneurosci.1163-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037116875
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1523/jneurosci.2362-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038480534
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1523/jneurosci.3164-14.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046937063
294 rdf:type schema:CreativeWork
295 https://doi.org/10.15252/embj.201489367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047271537
296 rdf:type schema:CreativeWork
297 https://doi.org/10.7554/elife.06980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010948956
298 rdf:type schema:CreativeWork
299 https://doi.org/10.7554/elife.11182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023050774
300 rdf:type schema:CreativeWork
301 https://doi.org/10.7554/elife.17578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023241073
302 rdf:type schema:CreativeWork
303 https://doi.org/10.7554/elife.18722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009291458
304 rdf:type schema:CreativeWork
305 https://www.grid.ac/institutes/grid.12527.33 schema:alternateName Tsinghua University
306 schema:name Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
307 Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, China
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.494629.4 schema:alternateName Westlake Institute for Advanced Study
310 schema:name Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
311 Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...