Precancerous neoplastic cells can move through the pancreatic ductal system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Alvin P. Makohon-Moore, Karen Matsukuma, Ming Zhang, Johannes G. Reiter, Jeffrey M. Gerold, Yuchen Jiao, Lisa Sikkema, Marc A. Attiyeh, Shinichi Yachida, Corinne Sandone, Ralph H. Hruban, David S. Klimstra, Nickolas Papadopoulos, Martin A. Nowak, Kenneth W. Kinzler, Bert Vogelstein, Christine A. Iacobuzio-Donahue

ABSTRACT

Most adult carcinomas develop from noninvasive precursor lesions, a progression that is supported by genetic analysis. However, the evolutionary and genetic relationships among co-existing lesions are unclear. Here we analysed the somatic variants of pancreatic cancers and precursor lesions sampled from distinct regions of the same pancreas. After inferring evolutionary relationships, we found that the ancestral cell had initiated and clonally expanded to form one or more lesions, and that subsequent driver gene mutations eventually led to invasive pancreatic cancer. We estimate that this multi-step progression generally spans many years. These new data reframe the step-wise progression model of pancreatic cancer by illustrating that independent, high-grade pancreatic precursor lesions observed in a single pancreas often represent a single neoplasm that has colonized the ductal system, accumulating spatial and genetic divergence over time. More... »

PAGES

201-205

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41586-018-0481-8

    DOI

    http://dx.doi.org/10.1038/s41586-018-0481-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106521550

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30177826


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