RNA velocity of single cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08

AUTHORS

Gioele La Manno, Ruslan Soldatov, Amit Zeisel, Emelie Braun, Hannah Hochgerner, Viktor Petukhov, Katja Lidschreiber, Maria E. Kastriti, Peter Lönnerberg, Alessandro Furlan, Jean Fan, Lars E. Borm, Zehua Liu, David van Bruggen, Jimin Guo, Xiaoling He, Roger Barker, Erik Sundström, Gonçalo Castelo-Branco, Patrick Cramer, Igor Adameyko, Sten Linnarsson, Peter V. Kharchenko

ABSTRACT

RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and throughput1. However, this approach captures only a static snapshot at a point in time, posing a challenge for the analysis of time-resolved phenomena such as embryogenesis or tissue regeneration. Here we show that RNA velocity-the time derivative of the gene expression state-can be directly estimated by distinguishing between unspliced and spliced mRNAs in common single-cell RNA sequencing protocols. RNA velocity is a high-dimensional vector that predicts the future state of individual cells on a timescale of hours. We validate its accuracy in the neural crest lineage, demonstrate its use on multiple published datasets and technical platforms, reveal the branching lineage tree of the developing mouse hippocampus, and examine the kinetics of transcription in human embryonic brain. We expect RNA velocity to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans. More... »

PAGES

494-498

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41586-018-0414-6

DOI

http://dx.doi.org/10.1038/s41586-018-0414-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106054982

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30089906


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Lineage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromaffin Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Datasets as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Crest", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Splicing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Cell Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "La Manno", 
        "givenName": "Gioele", 
        "id": "sg:person.01257762472.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257762472.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soldatov", 
        "givenName": "Ruslan", 
        "id": "sg:person.010170410702.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010170410702.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeisel", 
        "givenName": "Amit", 
        "id": "sg:person.01106137556.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106137556.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braun", 
        "givenName": "Emelie", 
        "id": "sg:person.014177605310.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014177605310.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hochgerner", 
        "givenName": "Hannah", 
        "id": "sg:person.01237626470.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237626470.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Saint Petersburg State Polytechnical University", 
          "id": "https://www.grid.ac/institutes/grid.32495.39", 
          "name": [
            "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA", 
            "Department of Applied Mathematics, Peter The Great St. Petersburg Polytechnic University, St, Petersburg, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petukhov", 
        "givenName": "Viktor", 
        "id": "sg:person.016326567162.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016326567162.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lidschreiber", 
        "givenName": "Katja", 
        "id": "sg:person.07444151750.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07444151750.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kastriti", 
        "givenName": "Maria E.", 
        "id": "sg:person.01173467530.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173467530.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f6nnerberg", 
        "givenName": "Peter", 
        "id": "sg:person.0673507140.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673507140.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furlan", 
        "givenName": "Alessandro", 
        "id": "sg:person.0634267263.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634267263.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Jean", 
        "id": "sg:person.010662025035.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010662025035.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borm", 
        "givenName": "Lars E.", 
        "id": "sg:person.01074622007.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074622007.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Zehua", 
        "id": "sg:person.012475160702.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012475160702.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Bruggen", 
        "givenName": "David", 
        "id": "sg:person.0626012473.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626012473.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Jimin", 
        "id": "sg:person.01242124632.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242124632.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Xiaoling", 
        "id": "sg:person.0704320270.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704320270.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barker", 
        "givenName": "Roger", 
        "id": "sg:person.01104460675.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104460675.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sundstr\u00f6m", 
        "givenName": "Erik", 
        "id": "sg:person.01237560305.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237560305.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castelo-Branco", 
        "givenName": "Gon\u00e7alo", 
        "id": "sg:person.01056076404.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056076404.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Biophysical Chemistry", 
          "id": "https://www.grid.ac/institutes/grid.418140.8", 
          "name": [
            "Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden", 
            "Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cramer", 
        "givenName": "Patrick", 
        "id": "sg:person.01045113153.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045113153.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adameyko", 
        "givenName": "Igor", 
        "id": "sg:person.01055155570.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055155570.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Science for Life Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.452834.c", 
          "name": [
            "Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden", 
            "Science for Life Laboratory, Solna, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linnarsson", 
        "givenName": "Sten", 
        "id": "sg:person.0762434635.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762434635.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA", 
            "Harvard Stem Cell Institute, Cambridge, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kharchenko", 
        "givenName": "Peter V.", 
        "id": "sg:person.01050662451.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050662451.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cmet.2012.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002097536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aad9841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003127075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006291172", 
          "https://doi.org/10.1038/nmeth.2639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-cellbio-100109-104113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011401541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(03)00116-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012847809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0089673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017367979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms14049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019155899", 
          "https://doi.org/10.1038/ncomms14049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.051508.135600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023484284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.110882.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024095958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029706604", 
          "https://doi.org/10.1038/nmeth.2772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.04.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029937786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.080002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036639630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037343636", 
          "https://doi.org/10.1038/nature05453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037343636", 
          "https://doi.org/10.1038/nature05453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-016-0960-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038317037", 
          "https://doi.org/10.1186/s13059-016-0960-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.3269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042523106", 
          "https://doi.org/10.1038/nbt.3269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2011.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042971792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2011.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042971792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aal3753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090396081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aal3753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090396081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature24489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092574210", 
          "https://doi.org/10.1038/nature24489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature24489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092574210", 
          "https://doi.org/10.1038/nature24489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41593-017-0029-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099718517", 
          "https://doi.org/10.1038/s41593-017-0029-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/237446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099907099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/237446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099907099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/237446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099907099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41593-017-0056-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100351865", 
          "https://doi.org/10.1038/s41593-017-0056-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaq1723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103463932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-018-1449-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104989805", 
          "https://doi.org/10.1186/s13059-018-1449-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2018.06.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106053369"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08", 
    "datePublishedReg": "2018-08-01", 
    "description": "RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and throughput1. However, this approach captures only a static snapshot at a point in time, posing a challenge for the analysis of time-resolved phenomena such as embryogenesis or tissue regeneration. Here we show that RNA velocity-the time derivative of the gene expression state-can be directly estimated by distinguishing between unspliced and spliced mRNAs in common single-cell RNA sequencing protocols. RNA velocity is a high-dimensional vector that predicts the future state of individual cells on a timescale of hours. We validate its accuracy in the neural crest lineage, demonstrate its use on multiple published datasets and technical platforms, reveal the branching lineage tree of the developing mouse hippocampus, and examine the kinetics of transcription in human embryonic brain. We expect RNA velocity to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41586-018-0414-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6384432", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4243783", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3042228", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3498582", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7099039", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4579833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3780942", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7719", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "560"
      }
    ], 
    "name": "RNA velocity of single cells", 
    "pagination": "494-498", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "420962c54af9a72846b2282deba2345d3a10c35b62e62e329352810a42fbecf8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30089906"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41586-018-0414-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106054982"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41586-018-0414-6", 
      "https://app.dimensions.ai/details/publication/pub.1106054982"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000370_0000000370/records_46751_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41586-018-0414-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0414-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0414-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0414-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41586-018-0414-6'


 

This table displays all metadata directly associated to this object as RDF triples.

421 TRIPLES      21 PREDICATES      73 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41586-018-0414-6 schema:about N019389c75a2d4f37929ec3e4fbd7a6a9
2 N1c12e85cf1bd42748a891455a4e0c29d
3 N1c12ea59b1da4cb58bd84acca9c5660d
4 N1d3b40474de945c7afa366cb6206be48
5 N23d7b79addf042e9988209939a2e73ca
6 N2411459aabdf42c9a47e614db1ec5065
7 N39a5dc4d0b7d48058e15429dce55a2ba
8 N3b111a63aab04a41b22c12dd333ce105
9 N4186e2777bfb453f99fdf5a6ecfb0483
10 N488f053d219c462b9f2660f6e8bf6036
11 N4eaf816842f0493981ced0380d57cde6
12 N532da94301aa4d75b030cbfa600afaef
13 N5532edb1ba894de8bd18253585560fe0
14 N63bca85c29a64d21941a70e523790e48
15 N8618581079f34daba1fa2d8fb7e1ca16
16 N9cd4dcc321534b3cb0e2d0b5a426a34d
17 Na654475a511d44e99708770be86f7e39
18 Nacdd652c6f304d39ad00017730c5eb3d
19 Ndceb3e7e64c649f489f3dfd43744fe6d
20 Nea68b9a879a440079b2627ea496fa7f8
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author Nd4ee13414bd54624be82f7dddd6625f4
24 schema:citation sg:pub.10.1038/nature05453
25 sg:pub.10.1038/nature24489
26 sg:pub.10.1038/nbt.3269
27 sg:pub.10.1038/ncomms14049
28 sg:pub.10.1038/nmeth.2639
29 sg:pub.10.1038/nmeth.2772
30 sg:pub.10.1038/s41593-017-0029-5
31 sg:pub.10.1038/s41593-017-0056-2
32 sg:pub.10.1186/s13059-016-0960-x
33 sg:pub.10.1186/s13059-018-1449-6
34 https://doi.org/10.1016/j.cell.2015.04.044
35 https://doi.org/10.1016/j.cell.2018.06.021
36 https://doi.org/10.1016/j.cmet.2012.11.004
37 https://doi.org/10.1016/s0896-6273(03)00116-8
38 https://doi.org/10.1038/msb.2011.62
39 https://doi.org/10.1101/237446
40 https://doi.org/10.1101/gr.110882.110
41 https://doi.org/10.1126/science.aad9841
42 https://doi.org/10.1126/science.aal3753
43 https://doi.org/10.1126/science.aaq1723
44 https://doi.org/10.1146/annurev-cellbio-100109-104113
45 https://doi.org/10.1146/annurev.neuro.051508.135600
46 https://doi.org/10.1242/dev.080002
47 https://doi.org/10.1371/journal.pone.0089673
48 schema:datePublished 2018-08
49 schema:datePublishedReg 2018-08-01
50 schema:description RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and throughput<sup>1</sup>. However, this approach captures only a static snapshot at a point in time, posing a challenge for the analysis of time-resolved phenomena such as embryogenesis or tissue regeneration. Here we show that RNA velocity-the time derivative of the gene expression state-can be directly estimated by distinguishing between unspliced and spliced mRNAs in common single-cell RNA sequencing protocols. RNA velocity is a high-dimensional vector that predicts the future state of individual cells on a timescale of hours. We validate its accuracy in the neural crest lineage, demonstrate its use on multiple published datasets and technical platforms, reveal the branching lineage tree of the developing mouse hippocampus, and examine the kinetics of transcription in human embryonic brain. We expect RNA velocity to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N60fcb72594784779b2a6a4e2e811f205
55 Nc5937644e615485081a7dc5ec76e9d68
56 sg:journal.1018957
57 schema:name RNA velocity of single cells
58 schema:pagination 494-498
59 schema:productId N4fab6eccdea34f86bb3990146a11e7d3
60 N5d57ec3dd4cc4f099ef80f6594c046bd
61 N9509f100914e46b98ac733da9cf3b920
62 Na2d4498ab8974565a1dc4b75c8c14032
63 Nda4eec00af1d4556b180c8ee6da8eb9a
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106054982
65 https://doi.org/10.1038/s41586-018-0414-6
66 schema:sdDatePublished 2019-04-11T13:30
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N775634a09e1e4ca7ac243b2979807a81
69 schema:url https://www.nature.com/articles/s41586-018-0414-6
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N019389c75a2d4f37929ec3e4fbd7a6a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Cell Lineage
75 rdf:type schema:DefinedTerm
76 N0f94a45bf3bd4466b76fe38591397e12 rdf:first sg:person.016326567162.44
77 rdf:rest Nc704f524759c4403a33a751a684f42ab
78 N126376c0834b4ab89ad16d78dcdf111d rdf:first sg:person.01045113153.17
79 rdf:rest N1e81e37efb1e4c1aad6cdb62014d5ffb
80 N140aa4bf601740d68833a3c04b31cd4f rdf:first sg:person.01237560305.02
81 rdf:rest Ndf97e31260594b0ba2939029b2122a52
82 N17deb15caeeb439d80ff3aa0e85d9a9c rdf:first sg:person.010662025035.63
83 rdf:rest N90be597342c249eeb0fceb46f4933516
84 N1c12e85cf1bd42748a891455a4e0c29d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Female
86 rdf:type schema:DefinedTerm
87 N1c12ea59b1da4cb58bd84acca9c5660d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Chromaffin Cells
89 rdf:type schema:DefinedTerm
90 N1d3b40474de945c7afa366cb6206be48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Reproducibility of Results
92 rdf:type schema:DefinedTerm
93 N1e81e37efb1e4c1aad6cdb62014d5ffb rdf:first sg:person.01055155570.19
94 rdf:rest Nee4dac9eb6144f1db9478cfa4bc7bb49
95 N23d7b79addf042e9988209939a2e73ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name RNA Splicing
97 rdf:type schema:DefinedTerm
98 N2411459aabdf42c9a47e614db1ec5065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Brain
100 rdf:type schema:DefinedTerm
101 N28e2d23f7054462d840a3bcf5cd53805 rdf:first sg:person.012475160702.79
102 rdf:rest N931627fa7cc94433aed6b161c9d591c7
103 N2a3ac1851cf94fed8b3a015bbecfa1db rdf:first sg:person.0673507140.84
104 rdf:rest N4a78e4c66715429591eafe5cc93455c2
105 N39a5dc4d0b7d48058e15429dce55a2ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Neural Crest
107 rdf:type schema:DefinedTerm
108 N3b111a63aab04a41b22c12dd333ce105 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name RNA
110 rdf:type schema:DefinedTerm
111 N4186e2777bfb453f99fdf5a6ecfb0483 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Male
113 rdf:type schema:DefinedTerm
114 N4878d2d1841c48e598a7ef3c41f6022f rdf:first sg:person.01050662451.08
115 rdf:rest rdf:nil
116 N488f053d219c462b9f2660f6e8bf6036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Transcription, Genetic
118 rdf:type schema:DefinedTerm
119 N4a78e4c66715429591eafe5cc93455c2 rdf:first sg:person.0634267263.96
120 rdf:rest N17deb15caeeb439d80ff3aa0e85d9a9c
121 N4eaf816842f0493981ced0380d57cde6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Time Factors
123 rdf:type schema:DefinedTerm
124 N4fab6eccdea34f86bb3990146a11e7d3 schema:name readcube_id
125 schema:value 420962c54af9a72846b2282deba2345d3a10c35b62e62e329352810a42fbecf8
126 rdf:type schema:PropertyValue
127 N532da94301aa4d75b030cbfa600afaef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Datasets as Topic
129 rdf:type schema:DefinedTerm
130 N5532edb1ba894de8bd18253585560fe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Kinetics
132 rdf:type schema:DefinedTerm
133 N5d57ec3dd4cc4f099ef80f6594c046bd schema:name nlm_unique_id
134 schema:value 0410462
135 rdf:type schema:PropertyValue
136 N60fcb72594784779b2a6a4e2e811f205 schema:volumeNumber 560
137 rdf:type schema:PublicationVolume
138 N63bca85c29a64d21941a70e523790e48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Glutamic Acid
140 rdf:type schema:DefinedTerm
141 N775634a09e1e4ca7ac243b2979807a81 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N832dbf11e4d840d8b38ccec914c77b8b rdf:first sg:person.0704320270.05
144 rdf:rest Ne36700626c694be691991af85536c043
145 N8618581079f34daba1fa2d8fb7e1ca16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Neurons
147 rdf:type schema:DefinedTerm
148 N8cb33a3074c84cc0bd21d27b35d08cf0 rdf:first sg:person.01173467530.79
149 rdf:rest N2a3ac1851cf94fed8b3a015bbecfa1db
150 N90be597342c249eeb0fceb46f4933516 rdf:first sg:person.01074622007.21
151 rdf:rest N28e2d23f7054462d840a3bcf5cd53805
152 N931627fa7cc94433aed6b161c9d591c7 rdf:first sg:person.0626012473.69
153 rdf:rest Nbe5bd7a6a5074ba1bddb205d343537bb
154 N9509f100914e46b98ac733da9cf3b920 schema:name doi
155 schema:value 10.1038/s41586-018-0414-6
156 rdf:type schema:PropertyValue
157 N9cd4dcc321534b3cb0e2d0b5a426a34d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Animals
159 rdf:type schema:DefinedTerm
160 Na2d4498ab8974565a1dc4b75c8c14032 schema:name pubmed_id
161 schema:value 30089906
162 rdf:type schema:PropertyValue
163 Na654475a511d44e99708770be86f7e39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Sequence Analysis, RNA
165 rdf:type schema:DefinedTerm
166 Na6db288d483a489b979db1e3a5ebd8f7 rdf:first sg:person.010170410702.13
167 rdf:rest Ne8fffdca904e41a2a4a2ab710a87f853
168 Nacdd652c6f304d39ad00017730c5eb3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Hippocampus
170 rdf:type schema:DefinedTerm
171 Nb167556987fa4ee083ac595daa11d324 rdf:first sg:person.014177605310.04
172 rdf:rest Nd934bd31d9464f209cd6dca7d8277a86
173 Nbe5bd7a6a5074ba1bddb205d343537bb rdf:first sg:person.01242124632.08
174 rdf:rest N832dbf11e4d840d8b38ccec914c77b8b
175 Nc5937644e615485081a7dc5ec76e9d68 schema:issueNumber 7719
176 rdf:type schema:PublicationIssue
177 Nc704f524759c4403a33a751a684f42ab rdf:first sg:person.07444151750.17
178 rdf:rest N8cb33a3074c84cc0bd21d27b35d08cf0
179 Nd4ee13414bd54624be82f7dddd6625f4 rdf:first sg:person.01257762472.48
180 rdf:rest Na6db288d483a489b979db1e3a5ebd8f7
181 Nd934bd31d9464f209cd6dca7d8277a86 rdf:first sg:person.01237626470.41
182 rdf:rest N0f94a45bf3bd4466b76fe38591397e12
183 Nda4eec00af1d4556b180c8ee6da8eb9a schema:name dimensions_id
184 schema:value pub.1106054982
185 rdf:type schema:PropertyValue
186 Ndceb3e7e64c649f489f3dfd43744fe6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Single-Cell Analysis
188 rdf:type schema:DefinedTerm
189 Ndf97e31260594b0ba2939029b2122a52 rdf:first sg:person.01056076404.43
190 rdf:rest N126376c0834b4ab89ad16d78dcdf111d
191 Ne36700626c694be691991af85536c043 rdf:first sg:person.01104460675.05
192 rdf:rest N140aa4bf601740d68833a3c04b31cd4f
193 Ne8fffdca904e41a2a4a2ab710a87f853 rdf:first sg:person.01106137556.69
194 rdf:rest Nb167556987fa4ee083ac595daa11d324
195 Nea68b9a879a440079b2627ea496fa7f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Mice
197 rdf:type schema:DefinedTerm
198 Nee4dac9eb6144f1db9478cfa4bc7bb49 rdf:first sg:person.0762434635.03
199 rdf:rest N4878d2d1841c48e598a7ef3c41f6022f
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
204 schema:name Genetics
205 rdf:type schema:DefinedTerm
206 sg:grant.3042228 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
207 rdf:type schema:MonetaryGrant
208 sg:grant.3498582 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
209 rdf:type schema:MonetaryGrant
210 sg:grant.3780942 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
211 rdf:type schema:MonetaryGrant
212 sg:grant.4243783 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
213 rdf:type schema:MonetaryGrant
214 sg:grant.4579833 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
215 rdf:type schema:MonetaryGrant
216 sg:grant.6384432 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
217 rdf:type schema:MonetaryGrant
218 sg:grant.7099039 http://pending.schema.org/fundedItem sg:pub.10.1038/s41586-018-0414-6
219 rdf:type schema:MonetaryGrant
220 sg:journal.1018957 schema:issn 0090-0028
221 1476-4687
222 schema:name Nature
223 rdf:type schema:Periodical
224 sg:person.010170410702.13 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
225 schema:familyName Soldatov
226 schema:givenName Ruslan
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010170410702.13
228 rdf:type schema:Person
229 sg:person.01045113153.17 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
230 schema:familyName Cramer
231 schema:givenName Patrick
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045113153.17
233 rdf:type schema:Person
234 sg:person.01050662451.08 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
235 schema:familyName Kharchenko
236 schema:givenName Peter V.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050662451.08
238 rdf:type schema:Person
239 sg:person.01055155570.19 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
240 schema:familyName Adameyko
241 schema:givenName Igor
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055155570.19
243 rdf:type schema:Person
244 sg:person.01056076404.43 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
245 schema:familyName Castelo-Branco
246 schema:givenName Gonçalo
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056076404.43
248 rdf:type schema:Person
249 sg:person.010662025035.63 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
250 schema:familyName Fan
251 schema:givenName Jean
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010662025035.63
253 rdf:type schema:Person
254 sg:person.01074622007.21 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
255 schema:familyName Borm
256 schema:givenName Lars E.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074622007.21
258 rdf:type schema:Person
259 sg:person.01104460675.05 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
260 schema:familyName Barker
261 schema:givenName Roger
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104460675.05
263 rdf:type schema:Person
264 sg:person.01106137556.69 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
265 schema:familyName Zeisel
266 schema:givenName Amit
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106137556.69
268 rdf:type schema:Person
269 sg:person.01173467530.79 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
270 schema:familyName Kastriti
271 schema:givenName Maria E.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173467530.79
273 rdf:type schema:Person
274 sg:person.01237560305.02 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
275 schema:familyName Sundström
276 schema:givenName Erik
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237560305.02
278 rdf:type schema:Person
279 sg:person.01237626470.41 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
280 schema:familyName Hochgerner
281 schema:givenName Hannah
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237626470.41
283 rdf:type schema:Person
284 sg:person.01242124632.08 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
285 schema:familyName Guo
286 schema:givenName Jimin
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242124632.08
288 rdf:type schema:Person
289 sg:person.012475160702.79 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
290 schema:familyName Liu
291 schema:givenName Zehua
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012475160702.79
293 rdf:type schema:Person
294 sg:person.01257762472.48 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
295 schema:familyName La Manno
296 schema:givenName Gioele
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257762472.48
298 rdf:type schema:Person
299 sg:person.014177605310.04 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
300 schema:familyName Braun
301 schema:givenName Emelie
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014177605310.04
303 rdf:type schema:Person
304 sg:person.016326567162.44 schema:affiliation https://www.grid.ac/institutes/grid.32495.39
305 schema:familyName Petukhov
306 schema:givenName Viktor
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016326567162.44
308 rdf:type schema:Person
309 sg:person.0626012473.69 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
310 schema:familyName van Bruggen
311 schema:givenName David
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626012473.69
313 rdf:type schema:Person
314 sg:person.0634267263.96 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
315 schema:familyName Furlan
316 schema:givenName Alessandro
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634267263.96
318 rdf:type schema:Person
319 sg:person.0673507140.84 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
320 schema:familyName Lönnerberg
321 schema:givenName Peter
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673507140.84
323 rdf:type schema:Person
324 sg:person.0704320270.05 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
325 schema:familyName He
326 schema:givenName Xiaoling
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704320270.05
328 rdf:type schema:Person
329 sg:person.07444151750.17 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
330 schema:familyName Lidschreiber
331 schema:givenName Katja
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07444151750.17
333 rdf:type schema:Person
334 sg:person.0762434635.03 schema:affiliation https://www.grid.ac/institutes/grid.452834.c
335 schema:familyName Linnarsson
336 schema:givenName Sten
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762434635.03
338 rdf:type schema:Person
339 sg:pub.10.1038/nature05453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037343636
340 https://doi.org/10.1038/nature05453
341 rdf:type schema:CreativeWork
342 sg:pub.10.1038/nature24489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092574210
343 https://doi.org/10.1038/nature24489
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/nbt.3269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042523106
346 https://doi.org/10.1038/nbt.3269
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/ncomms14049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019155899
349 https://doi.org/10.1038/ncomms14049
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/nmeth.2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006291172
352 https://doi.org/10.1038/nmeth.2639
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/nmeth.2772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029706604
355 https://doi.org/10.1038/nmeth.2772
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/s41593-017-0029-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099718517
358 https://doi.org/10.1038/s41593-017-0029-5
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/s41593-017-0056-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100351865
361 https://doi.org/10.1038/s41593-017-0056-2
362 rdf:type schema:CreativeWork
363 sg:pub.10.1186/s13059-016-0960-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038317037
364 https://doi.org/10.1186/s13059-016-0960-x
365 rdf:type schema:CreativeWork
366 sg:pub.10.1186/s13059-018-1449-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104989805
367 https://doi.org/10.1186/s13059-018-1449-6
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/j.cell.2015.04.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029937786
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/j.cell.2018.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106053369
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/j.cmet.2012.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002097536
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1016/s0896-6273(03)00116-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012847809
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1038/msb.2011.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042971792
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1101/237446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099907099
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1101/gr.110882.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024095958
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1126/science.aad9841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003127075
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1126/science.aal3753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090396081
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1126/science.aaq1723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103463932
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1146/annurev-cellbio-100109-104113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011401541
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1146/annurev.neuro.051508.135600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023484284
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1242/dev.080002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036639630
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1371/journal.pone.0089673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017367979
396 rdf:type schema:CreativeWork
397 https://www.grid.ac/institutes/grid.32495.39 schema:alternateName Saint Petersburg State Polytechnical University
398 schema:name Department of Applied Mathematics, Peter The Great St. Petersburg Polytechnic University, St, Petersburg, Russia
399 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
402 schema:name Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
403 Harvard Stem Cell Institute, Cambridge, MA, USA
404 rdf:type schema:Organization
405 https://www.grid.ac/institutes/grid.418140.8 schema:alternateName Max Planck Institute for Biophysical Chemistry
406 schema:name Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
407 Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.452834.c schema:alternateName Science for Life Laboratory
410 schema:name Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
411 Science for Life Laboratory, Solna, Sweden
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
414 schema:name Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
415 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
416 Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
417 Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
420 schema:name John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
421 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...