Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Joy Feld, Vinod Chandran, Nigil Haroon, Robert Inman, Dafna Gladman

ABSTRACT

Ankylosing spondylitis (AS) was first identified in the late 17th century. 250 years later, inflammatory spine disease was recognized to be one of the patterns of psoriatic arthritis (PsA). Isolated spondylitis is rare among patients with PsA, occurring in less than 5% of patients; however, many patients with PsA have axial disease that is concurrent with peripheral arthritis. At the other end of the spondyloarthritis spectrum, psoriasis is observed in 10% of patients with AS. Although axial involvement in PsA can be indistinguishable from axial disease in AS, it can also differ in several respects, raising the question of whether axial PsA and AS (with or without psoriasis) are different clinical presentations of the same disease, or whether they are separate diseases that have overlapping features. In this Review, the clinical presentation, metrology, radiographic characteristics, genetic factors, treatment options and axial prognosis of the two diseases are addressed. The aim of this Review is to capture all available comparisons made to date, to highlight the similarities and differences between AS and axial PsA and to propose a research agenda. More... »

PAGES

363-371

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41584-018-0006-8

    DOI

    http://dx.doi.org/10.1038/s41584-018-0006-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103945125

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29752461


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