Emerging connections between cerebellar development, behaviour and complex brain disorders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-28

AUTHORS

Aaron Sathyanesan, Joy Zhou, Joseph Scafidi, Detlef H Heck, Roy V Sillitoe, Vittorio Gallo

ABSTRACT

The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders share motor deficits as a common sequela. However, evidence gathered since the late 1980s suggests that the cerebellum is involved in motor and non-motor function, including cognition and emotion. More recently, evidence indicates that major neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, attention-deficit hyperactivity disorder and Down syndrome have potential links to abnormal cerebellar development. Out of recent findings from clinical and preclinical studies, the concept of the 'cerebellar connectome' has emerged that can be used as a framework to link the role of cerebellar development to human behaviour, disease states and the design of better therapeutic strategies. More... »

PAGES

1

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    http://scigraph.springernature.com/pub.10.1038/s41583-019-0152-2

    DOI

    http://dx.doi.org/10.1038/s41583-019-0152-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113046812

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30923348


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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    916 Department of Pathology and Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, Houston, TX, USA.
    917 Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
    918 rdf:type schema:Organization
     




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