Culturing the human microbiota and culturomics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Jean-Christophe Lagier, Grégory Dubourg, Matthieu Million, Frédéric Cadoret, Melhem Bilen, Florence Fenollar, Anthony Levasseur, Jean-Marc Rolain, Pierre-Edouard Fournier, Didier Raoult

ABSTRACT

The gut microbiota has an important role in the maintenance of human health and in disease pathogenesis. This importance was realized through the advent of omics technologies and their application to improve our knowledge of the gut microbial ecosystem. In particular, the use of metagenomics has revealed the diversity of the gut microbiota, but it has also highlighted that the majority of bacteria in the gut remain uncultured. Culturomics was developed to culture and identify unknown bacteria that inhabit the human gut as a part of the rebirth of culture techniques in microbiology. Consisting of multiple culture conditions combined with the rapid identification of bacteria, the culturomic approach has enabled the culture of hundreds of new microorganisms that are associated with humans, providing exciting new perspectives on host-bacteria relationships. In this Review, we discuss why and how culturomics was developed. We describe how culturomics has extended our understanding of bacterial diversity and then explore how culturomics can be applied to the study of the human microbiota and the potential implications for human health. More... »

PAGES

540-550

References to SciGraph publications

  • 2016-07-27. Human commensals producing a novel antibiotic impair pathogen colonization in NATURE
  • 2015-02. The microbiome of the urinary tract—a role beyond infection in NATURE REVIEWS UROLOGY
  • 2015-01. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile in NATURE
  • 2014-10. Aerobic culture of anaerobic bacteria using antioxidants: a preliminary report in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2016-06. Aerobic culture of methanogenic archaea without an external source of hydrogen in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2012-06. Human gut microbiome viewed across age and geography in NATURE
  • 2014-08. Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection in THE ISME JOURNAL
  • 2016-09. Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition in SCIENTIFIC REPORTS
  • 2016-02-02. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis in NATURE COMMUNICATIONS
  • 2017-12. Surface properties of SAR11 bacteria facilitate grazing avoidance in NATURE MICROBIOLOGY
  • 2015-04. Ecology and exploration of the rare biosphere in NATURE REVIEWS MICROBIOLOGY
  • 2015-10. Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning in NATURE BIOTECHNOLOGY
  • 2002-08. Cultivation of the ubiquitous SAR11 marine bacterioplankton clade in NATURE
  • 2013-12. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut in MICROBIOME
  • 2010-05. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2013-07. Insights into the phylogeny and coding potential of microbial dark matter in NATURE
  • 2016-05. Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation in NATURE
  • 2016-10. Gut microbiome and dietary patterns in different Saudi populations and monkeys in SCIENTIFIC REPORTS
  • 2009-01-22. A core gut microbiome in obese and lean twins in NATURE
  • 2017-03. Carcinogenesis and therapeutics: the microbiota perspective in NATURE MICROBIOLOGY
  • 2014-06. Persistent gut microbiota immaturity in malnourished Bangladeshi children in NATURE
  • 2017-03. Is there a link between urinary microbiota and bladder cancer? in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2016-12. Culture of previously uncultured members of the human gut microbiota by culturomics in NATURE MICROBIOLOGY
  • 2011-06. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2008-12. The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes in BMC BIOINFORMATICS
  • 2017-05-22. Anticancer effects of the microbiome and its products in NATURE REVIEWS MICROBIOLOGY
  • 2017-12. We are not alone: a case for the human microbiome in extra intestinal diseases in GUT PATHOGENS
  • 2018-12. In-depth resistome analysis by targeted metagenomics in MICROBIOME
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41579-018-0041-0

    DOI

    http://dx.doi.org/10.1038/s41579-018-0041-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105089803

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29937540


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lagier", 
            "givenName": "Jean-Christophe", 
            "id": "sg:person.01004721606.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004721606.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dubourg", 
            "givenName": "Gr\u00e9gory", 
            "id": "sg:person.01155653140.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155653140.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Million", 
            "givenName": "Matthieu", 
            "id": "sg:person.01351547462.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351547462.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Marseille Public University Hospital System", 
              "id": "https://www.grid.ac/institutes/grid.414336.7", 
              "name": [
                "Assistance Publique-H\u00f4pitaux de Marseille, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cadoret", 
            "givenName": "Fr\u00e9d\u00e9ric", 
            "id": "sg:person.014042662405.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014042662405.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "M\u00e9diterran\u00e9e Infection Foundation", 
              "id": "https://www.grid.ac/institutes/grid.483853.1", 
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France", 
                "Fondation M\u00e9diterran\u00e9e Infection, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bilen", 
            "givenName": "Melhem", 
            "id": "sg:person.010726140365.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010726140365.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, VITROME, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fenollar", 
            "givenName": "Florence", 
            "id": "sg:person.01335041505.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335041505.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Levasseur", 
            "givenName": "Anthony", 
            "id": "sg:person.0576321001.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576321001.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rolain", 
            "givenName": "Jean-Marc", 
            "id": "sg:person.0576561277.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576561277.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, VITROME, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fournier", 
            "givenName": "Pierre-Edouard", 
            "id": "sg:person.01056155042.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056155042.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Aix Marseille Universit\u00e9, IRD, AP-HM, MEPHI, IHU M\u00e9diterran\u00e9e Infection, Marseille, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raoult", 
            "givenName": "Didier", 
            "id": "sg:person.013145671557.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013145671557.48"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/gb-2011-12-6-r60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000243423", 
              "https://doi.org/10.1186/gb-2011-12-6-r60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/apt.13344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000317583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/apt.13344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000317583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/apt.13344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000317583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.16.4.318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001719399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cmr.00110-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002947830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mbio.00893-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002966451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004780748", 
              "https://doi.org/10.1038/nature13828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmi.2014.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005137918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mas.10004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006023216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006083026", 
              "https://doi.org/10.1186/1471-2105-9-386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.01763-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006225500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2016.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006392325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2015.3725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007009668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6941.2007.00314.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007046076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1110591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008274652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jcm.00492-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008594040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000104752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009409814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009705339", 
              "https://doi.org/10.1038/nature17645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.mi.39.100185.001541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009812939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.micpath.2016.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010419496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-016-2627-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010587211", 
              "https://doi.org/10.1007/s10096-016-2627-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jcm.43.10.4993-5002.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011741159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nmni.2016.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012537096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1462-2920.2007.01369.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014119468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1462-2920.12662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014266489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1462-2920.12662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014266489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6941.2002.tb00904.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014657893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6941.2002.tb00904.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014657893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.10.5.334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014873762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1469-0691.12181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015051883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.71.7.3692-3700.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015058825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad1329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016080692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad1329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016080692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1240527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016546887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep32191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017421449", 
              "https://doi.org/10.1038/srep32191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijantimicag.2016.11.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018828071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019299949", 
              "https://doi.org/10.1038/nature12352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2014.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022221209", 
              "https://doi.org/10.1038/ismej.2014.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-micro-091014-104115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022371522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.01754-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022593521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1469-0691.12023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024329137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/cmr.00014-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024764492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-014-2137-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026371934", 
              "https://doi.org/10.1007/s10096-014-2137-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-014-2137-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026371934", 
              "https://doi.org/10.1007/s10096-014-2137-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1202851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027839530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1070633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027888193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jcm.02876-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028332893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2672.2007.03583.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028714759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030170002", 
              "https://doi.org/10.1038/nature07540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1102938108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030806330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.00345-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031113017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1404753111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032155404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1473-3099(15)00293-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032469302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200003023420903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033457372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmi.2015.10.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033655031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2014.03.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033993678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mbio.01021-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034081947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcimb.2012.00136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034936308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2016.00459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036852547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037507717", 
              "https://doi.org/10.1038/ncomms10391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.01541-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038354310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/525047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038623122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrurol.2014.361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040273906", 
              "https://doi.org/10.1038/nrurol.2014.361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.02006-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040808242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.01309-07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041067003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.00393-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041494592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep26051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042643376", 
              "https://doi.org/10.1038/srep26051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/ijs.0.02873-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043660988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044309870", 
              "https://doi.org/10.1038/nbt.3329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac4255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044673480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2016.203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044832209", 
              "https://doi.org/10.1038/nmicrobiol.2016.203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.06221-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044888064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature18634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046106649", 
              "https://doi.org/10.1038/nature18634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro3400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046380461", 
              "https://doi.org/10.1038/nrmicro3400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/1462-2920.13158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046471739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046723721", 
              "https://doi.org/10.1038/nature00917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046723721", 
              "https://doi.org/10.1038/nature00917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cid/civ468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047319460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-016-0213-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048130394", 
              "https://doi.org/10.1007/s10654-016-0213-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-016-0213-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048130394", 
              "https://doi.org/10.1007/s10654-016-0213-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/600885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050165478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-2618-1-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050628435", 
              "https://doi.org/10.1186/2049-2618-1-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms160816897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051016509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052356500", 
              "https://doi.org/10.1038/nature13421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052378845", 
              "https://doi.org/10.1038/nature11053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.120618.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052850693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/jiv766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052874622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/apt.13616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053442705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac60352a007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055066710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/jiw472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059710420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00207713-52-6-2141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060350966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/ijs.0.026989-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060383814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1093857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062449306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aah4669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062689247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1874285801610010057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069230337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3201/eid0701.010112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071122367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074543223", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077158954", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/27.12.1456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080342012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080465753", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080656128", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082420273", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.216242.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083687629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/19490976.2017.1290757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083779017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2017.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083855807", 
              "https://doi.org/10.1038/nmicrobiol.2017.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2017.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083855807", 
              "https://doi.org/10.1038/nmicrobiol.2017.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2017.8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083855807", 
              "https://doi.org/10.1038/nmicrobiol.2017.8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmi.2017.02.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084066625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mbio.00093-17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084222269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13099-017-0163-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252301", 
              "https://doi.org/10.1186/s13099-017-0163-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13099-017-0163-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084252301", 
              "https://doi.org/10.1186/s13099-017-0163-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkx295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084786396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro.2017.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085463395", 
              "https://doi.org/10.1038/nrmicro.2017.44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2017.00899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085565376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20170495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085898877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2468-1253(17)30147-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091342226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41564-017-0030-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092034260", 
              "https://doi.org/10.1038/s41564-017-0030-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aan3706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092506295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aan3706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092506295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40168-017-0387-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100403575", 
              "https://doi.org/10.1186/s40168-017-0387-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jcm.01663-17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101276756"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-09", 
        "datePublishedReg": "2018-09-01", 
        "description": "The gut microbiota has an important role in the maintenance of human health and in disease pathogenesis. This importance was realized through the advent of omics technologies and their application to improve our knowledge of the gut microbial ecosystem. In particular, the use of metagenomics has revealed the diversity of the gut microbiota, but it has also highlighted that the majority of bacteria in the gut remain uncultured. Culturomics was developed to culture and identify unknown bacteria that inhabit the human gut as a part of the rebirth of culture techniques in microbiology. Consisting of multiple culture conditions combined with the rapid identification of bacteria, the culturomic approach has enabled the culture of hundreds of new microorganisms that are associated with humans, providing exciting new perspectives on host-bacteria relationships. In this Review, we discuss why and how culturomics was developed. We describe how culturomics has extended our understanding of bacterial diversity and then explore how culturomics can be applied to the study of the human microbiota and the potential implications for human health.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41579-018-0041-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1032854", 
            "issn": [
              "1740-1526", 
              "1740-1534"
            ], 
            "name": "Nature Reviews Microbiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "Culturing the human microbiota and culturomics", 
        "pagination": "540-550", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a9998935706163f7c6565e59d3e987b3505fd474b53e5aeb94a3d711a5090a7d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29937540"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101190261"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41579-018-0041-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1105089803"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41579-018-0041-0", 
          "https://app.dimensions.ai/details/publication/pub.1105089803"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000519.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41579-018-0041-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41579-018-0041-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41579-018-0041-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41579-018-0041-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41579-018-0041-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    508 TRIPLES      21 PREDICATES      140 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41579-018-0041-0 schema:about anzsrc-for:06
    2 anzsrc-for:0605
    3 schema:author Nf91ba55b667b412e800c638838a064a7
    4 schema:citation sg:pub.10.1007/s10096-014-2137-4
    5 sg:pub.10.1007/s10096-016-2627-7
    6 sg:pub.10.1007/s10654-016-0213-z
    7 sg:pub.10.1038/ismej.2014.13
    8 sg:pub.10.1038/nature00917
    9 sg:pub.10.1038/nature07540
    10 sg:pub.10.1038/nature11053
    11 sg:pub.10.1038/nature12352
    12 sg:pub.10.1038/nature13421
    13 sg:pub.10.1038/nature13828
    14 sg:pub.10.1038/nature17645
    15 sg:pub.10.1038/nature18634
    16 sg:pub.10.1038/nbt.3329
    17 sg:pub.10.1038/ncomms10391
    18 sg:pub.10.1038/nmeth.f.303
    19 sg:pub.10.1038/nmicrobiol.2016.203
    20 sg:pub.10.1038/nmicrobiol.2017.8
    21 sg:pub.10.1038/nrmicro.2017.44
    22 sg:pub.10.1038/nrmicro3400
    23 sg:pub.10.1038/nrurol.2014.361
    24 sg:pub.10.1038/s41564-017-0030-5
    25 sg:pub.10.1038/srep26051
    26 sg:pub.10.1038/srep32191
    27 sg:pub.10.1186/1471-2105-9-386
    28 sg:pub.10.1186/2049-2618-1-3
    29 sg:pub.10.1186/gb-2011-12-6-r60
    30 sg:pub.10.1186/s13099-017-0163-3
    31 sg:pub.10.1186/s40168-017-0387-y
    32 https://app.dimensions.ai/details/publication/pub.1074543223
    33 https://app.dimensions.ai/details/publication/pub.1077158954
    34 https://app.dimensions.ai/details/publication/pub.1080465753
    35 https://app.dimensions.ai/details/publication/pub.1080656128
    36 https://app.dimensions.ai/details/publication/pub.1082420273
    37 https://doi.org/10.1001/jama.2015.3725
    38 https://doi.org/10.1002/mas.10004
    39 https://doi.org/10.1016/j.cmi.2014.07.003
    40 https://doi.org/10.1016/j.cmi.2015.10.032
    41 https://doi.org/10.1016/j.cmi.2017.02.031
    42 https://doi.org/10.1016/j.ijantimicag.2016.11.015
    43 https://doi.org/10.1016/j.immuni.2016.09.009
    44 https://doi.org/10.1016/j.micpath.2016.02.003
    45 https://doi.org/10.1016/j.nmni.2016.04.006
    46 https://doi.org/10.1016/j.tim.2014.03.001
    47 https://doi.org/10.1016/s1473-3099(15)00293-5
    48 https://doi.org/10.1016/s2468-1253(17)30147-4
    49 https://doi.org/10.1021/ac60352a007
    50 https://doi.org/10.1056/nejm200003023420903
    51 https://doi.org/10.1056/nejmoa1202851
    52 https://doi.org/10.1073/pnas.1102938108
    53 https://doi.org/10.1073/pnas.1404753111
    54 https://doi.org/10.1080/19490976.2017.1290757
    55 https://doi.org/10.1084/jem.20170495
    56 https://doi.org/10.1086/525047
    57 https://doi.org/10.1086/600885
    58 https://doi.org/10.1093/ajcn/27.12.1456
    59 https://doi.org/10.1093/cid/civ468
    60 https://doi.org/10.1093/infdis/jiv766
    61 https://doi.org/10.1093/infdis/jiw472
    62 https://doi.org/10.1093/nar/gkx295
    63 https://doi.org/10.1099/00207713-52-6-2141
    64 https://doi.org/10.1099/ijs.0.026989-0
    65 https://doi.org/10.1099/ijs.0.02873-0
    66 https://doi.org/10.1101/gr.120618.111
    67 https://doi.org/10.1101/gr.216242.116
    68 https://doi.org/10.1111/1462-2920.12662
    69 https://doi.org/10.1111/1462-2920.13158
    70 https://doi.org/10.1111/1469-0691.12023
    71 https://doi.org/10.1111/1469-0691.12181
    72 https://doi.org/10.1111/apt.13344
    73 https://doi.org/10.1111/apt.13616
    74 https://doi.org/10.1111/j.1365-2672.2007.03583.x
    75 https://doi.org/10.1111/j.1462-2920.2007.01369.x
    76 https://doi.org/10.1111/j.1574-6941.2002.tb00904.x
    77 https://doi.org/10.1111/j.1574-6941.2007.00314.x
    78 https://doi.org/10.1126/science.1070633
    79 https://doi.org/10.1126/science.1093857
    80 https://doi.org/10.1126/science.1110591
    81 https://doi.org/10.1126/science.1240527
    82 https://doi.org/10.1126/science.aac4255
    83 https://doi.org/10.1126/science.aad1329
    84 https://doi.org/10.1126/science.aan3706
    85 https://doi.org/10.1126/scitranslmed.aah4669
    86 https://doi.org/10.1128/aem.00393-08
    87 https://doi.org/10.1128/aem.01309-07
    88 https://doi.org/10.1128/aem.01541-09
    89 https://doi.org/10.1128/aem.01754-09
    90 https://doi.org/10.1128/aem.01763-14
    91 https://doi.org/10.1128/aem.02006-15
    92 https://doi.org/10.1128/aem.71.7.3692-3700.2005
    93 https://doi.org/10.1128/cmr.00014-14
    94 https://doi.org/10.1128/cmr.00110-14
    95 https://doi.org/10.1128/jb.00345-12
    96 https://doi.org/10.1128/jb.06221-11
    97 https://doi.org/10.1128/jcm.00492-13
    98 https://doi.org/10.1128/jcm.01663-17
    99 https://doi.org/10.1128/jcm.02876-13
    100 https://doi.org/10.1128/jcm.43.10.4993-5002.2005
    101 https://doi.org/10.1128/mbio.00093-17
    102 https://doi.org/10.1128/mbio.00893-14
    103 https://doi.org/10.1128/mbio.01021-14
    104 https://doi.org/10.1136/gut.10.5.334
    105 https://doi.org/10.1136/gut.16.4.318
    106 https://doi.org/10.1146/annurev-micro-091014-104115
    107 https://doi.org/10.1146/annurev.mi.39.100185.001541
    108 https://doi.org/10.1159/000104752
    109 https://doi.org/10.2174/1874285801610010057
    110 https://doi.org/10.3201/eid0701.010112
    111 https://doi.org/10.3389/fcimb.2012.00136
    112 https://doi.org/10.3389/fmicb.2016.00459
    113 https://doi.org/10.3389/fmicb.2017.00899
    114 https://doi.org/10.3390/ijms160816897
    115 schema:datePublished 2018-09
    116 schema:datePublishedReg 2018-09-01
    117 schema:description The gut microbiota has an important role in the maintenance of human health and in disease pathogenesis. This importance was realized through the advent of omics technologies and their application to improve our knowledge of the gut microbial ecosystem. In particular, the use of metagenomics has revealed the diversity of the gut microbiota, but it has also highlighted that the majority of bacteria in the gut remain uncultured. Culturomics was developed to culture and identify unknown bacteria that inhabit the human gut as a part of the rebirth of culture techniques in microbiology. Consisting of multiple culture conditions combined with the rapid identification of bacteria, the culturomic approach has enabled the culture of hundreds of new microorganisms that are associated with humans, providing exciting new perspectives on host-bacteria relationships. In this Review, we discuss why and how culturomics was developed. We describe how culturomics has extended our understanding of bacterial diversity and then explore how culturomics can be applied to the study of the human microbiota and the potential implications for human health.
    118 schema:genre research_article
    119 schema:inLanguage en
    120 schema:isAccessibleForFree false
    121 schema:isPartOf N77e9d765df3e4a5da86aaa7012993944
    122 Nd977b7dc57f64230b759e7e68f8d03a2
    123 sg:journal.1032854
    124 schema:name Culturing the human microbiota and culturomics
    125 schema:pagination 540-550
    126 schema:productId N444f4bdbe589438fa7fc2938f0d08a12
    127 N4d362240b76d49beb7717eb4e072c6d0
    128 Ncdf21940e4d04c2791874fe455a2fdfe
    129 Ne8bf36b8d02f4f519e08a5ca058228d6
    130 Nf6043c7258e44a74aa6ddcba40494e32
    131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105089803
    132 https://doi.org/10.1038/s41579-018-0041-0
    133 schema:sdDatePublished 2019-04-10T20:48
    134 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    135 schema:sdPublisher N645ac053226c45878ad2f41d48507e47
    136 schema:url https://www.nature.com/articles/s41579-018-0041-0
    137 sgo:license sg:explorer/license/
    138 sgo:sdDataset articles
    139 rdf:type schema:ScholarlyArticle
    140 N101aa24ac70242fc88a54c2767dc5e1b rdf:first sg:person.01155653140.28
    141 rdf:rest N496899d4ab8240778d2da5c2f60c8cb7
    142 N1328596c45ef480fbebdd45e5b6deaf4 schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    143 rdf:type schema:Organization
    144 N20248f776b2d4f45bc0d45625dfdc740 rdf:first sg:person.01335041505.52
    145 rdf:rest N346560bae4144314b4fbddda883037d9
    146 N2821efec148743299cfb238b2b2e55a3 rdf:first sg:person.014042662405.36
    147 rdf:rest Na7ae08d17a3049d1aa6a5fef616211de
    148 N346560bae4144314b4fbddda883037d9 rdf:first sg:person.0576321001.81
    149 rdf:rest N8190eef7d8cd4737a82d6296067748c2
    150 N3656318d495d485e8ae3b9805d56bef3 schema:name Aix Marseille Université, IRD, AP-HM, VITROME, IHU Méditerranée Infection, Marseille, France
    151 rdf:type schema:Organization
    152 N3d6a2e8c947b463a9df25454e7c715ec rdf:first sg:person.013145671557.48
    153 rdf:rest rdf:nil
    154 N444f4bdbe589438fa7fc2938f0d08a12 schema:name doi
    155 schema:value 10.1038/s41579-018-0041-0
    156 rdf:type schema:PropertyValue
    157 N496899d4ab8240778d2da5c2f60c8cb7 rdf:first sg:person.01351547462.11
    158 rdf:rest N2821efec148743299cfb238b2b2e55a3
    159 N4d362240b76d49beb7717eb4e072c6d0 schema:name nlm_unique_id
    160 schema:value 101190261
    161 rdf:type schema:PropertyValue
    162 N501195c18a8a463c9714536be0c6a519 schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    163 rdf:type schema:Organization
    164 N59bc3b0b691243b39807233ad81e053b schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    165 rdf:type schema:Organization
    166 N5abd269416b2436593ef2d0495413de7 schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    167 rdf:type schema:Organization
    168 N645ac053226c45878ad2f41d48507e47 schema:name Springer Nature - SN SciGraph project
    169 rdf:type schema:Organization
    170 N6b9c19786d8c4d0fb27d353077478130 schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    171 rdf:type schema:Organization
    172 N77e9d765df3e4a5da86aaa7012993944 schema:issueNumber 9
    173 rdf:type schema:PublicationIssue
    174 N8190eef7d8cd4737a82d6296067748c2 rdf:first sg:person.0576561277.28
    175 rdf:rest Nf373a376d7224ff98ba071eb999ad198
    176 N897e1af917cc4740bbc97403aa4fce15 schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    177 rdf:type schema:Organization
    178 Na7ae08d17a3049d1aa6a5fef616211de rdf:first sg:person.010726140365.39
    179 rdf:rest N20248f776b2d4f45bc0d45625dfdc740
    180 Ncdf21940e4d04c2791874fe455a2fdfe schema:name readcube_id
    181 schema:value a9998935706163f7c6565e59d3e987b3505fd474b53e5aeb94a3d711a5090a7d
    182 rdf:type schema:PropertyValue
    183 Nd977b7dc57f64230b759e7e68f8d03a2 schema:volumeNumber 16
    184 rdf:type schema:PublicationVolume
    185 Ne8bf36b8d02f4f519e08a5ca058228d6 schema:name pubmed_id
    186 schema:value 29937540
    187 rdf:type schema:PropertyValue
    188 Nf373a376d7224ff98ba071eb999ad198 rdf:first sg:person.01056155042.95
    189 rdf:rest N3d6a2e8c947b463a9df25454e7c715ec
    190 Nf40eac15d3c94eed9bad08abf1727601 schema:name Aix Marseille Université, IRD, AP-HM, VITROME, IHU Méditerranée Infection, Marseille, France
    191 rdf:type schema:Organization
    192 Nf6043c7258e44a74aa6ddcba40494e32 schema:name dimensions_id
    193 schema:value pub.1105089803
    194 rdf:type schema:PropertyValue
    195 Nf91ba55b667b412e800c638838a064a7 rdf:first sg:person.01004721606.00
    196 rdf:rest N101aa24ac70242fc88a54c2767dc5e1b
    197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Biological Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Microbiology
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1032854 schema:issn 1740-1526
    204 1740-1534
    205 schema:name Nature Reviews Microbiology
    206 rdf:type schema:Periodical
    207 sg:person.01004721606.00 schema:affiliation N897e1af917cc4740bbc97403aa4fce15
    208 schema:familyName Lagier
    209 schema:givenName Jean-Christophe
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004721606.00
    211 rdf:type schema:Person
    212 sg:person.01056155042.95 schema:affiliation N3656318d495d485e8ae3b9805d56bef3
    213 schema:familyName Fournier
    214 schema:givenName Pierre-Edouard
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056155042.95
    216 rdf:type schema:Person
    217 sg:person.010726140365.39 schema:affiliation https://www.grid.ac/institutes/grid.483853.1
    218 schema:familyName Bilen
    219 schema:givenName Melhem
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010726140365.39
    221 rdf:type schema:Person
    222 sg:person.01155653140.28 schema:affiliation N1328596c45ef480fbebdd45e5b6deaf4
    223 schema:familyName Dubourg
    224 schema:givenName Grégory
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155653140.28
    226 rdf:type schema:Person
    227 sg:person.013145671557.48 schema:affiliation N5abd269416b2436593ef2d0495413de7
    228 schema:familyName Raoult
    229 schema:givenName Didier
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013145671557.48
    231 rdf:type schema:Person
    232 sg:person.01335041505.52 schema:affiliation Nf40eac15d3c94eed9bad08abf1727601
    233 schema:familyName Fenollar
    234 schema:givenName Florence
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335041505.52
    236 rdf:type schema:Person
    237 sg:person.01351547462.11 schema:affiliation N501195c18a8a463c9714536be0c6a519
    238 schema:familyName Million
    239 schema:givenName Matthieu
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351547462.11
    241 rdf:type schema:Person
    242 sg:person.014042662405.36 schema:affiliation https://www.grid.ac/institutes/grid.414336.7
    243 schema:familyName Cadoret
    244 schema:givenName Frédéric
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014042662405.36
    246 rdf:type schema:Person
    247 sg:person.0576321001.81 schema:affiliation N6b9c19786d8c4d0fb27d353077478130
    248 schema:familyName Levasseur
    249 schema:givenName Anthony
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576321001.81
    251 rdf:type schema:Person
    252 sg:person.0576561277.28 schema:affiliation N59bc3b0b691243b39807233ad81e053b
    253 schema:familyName Rolain
    254 schema:givenName Jean-Marc
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576561277.28
    256 rdf:type schema:Person
    257 sg:pub.10.1007/s10096-014-2137-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026371934
    258 https://doi.org/10.1007/s10096-014-2137-4
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s10096-016-2627-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010587211
    261 https://doi.org/10.1007/s10096-016-2627-7
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s10654-016-0213-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1048130394
    264 https://doi.org/10.1007/s10654-016-0213-z
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/ismej.2014.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022221209
    267 https://doi.org/10.1038/ismej.2014.13
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature00917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046723721
    270 https://doi.org/10.1038/nature00917
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature07540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030170002
    273 https://doi.org/10.1038/nature07540
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature11053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052378845
    276 https://doi.org/10.1038/nature11053
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature12352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019299949
    279 https://doi.org/10.1038/nature12352
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nature13421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052356500
    282 https://doi.org/10.1038/nature13421
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nature13828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004780748
    285 https://doi.org/10.1038/nature13828
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nature17645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009705339
    288 https://doi.org/10.1038/nature17645
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nature18634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046106649
    291 https://doi.org/10.1038/nature18634
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nbt.3329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044309870
    294 https://doi.org/10.1038/nbt.3329
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/ncomms10391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037507717
    297 https://doi.org/10.1038/ncomms10391
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nmeth.f.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009032055
    300 https://doi.org/10.1038/nmeth.f.303
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nmicrobiol.2016.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044832209
    303 https://doi.org/10.1038/nmicrobiol.2016.203
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nmicrobiol.2017.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083855807
    306 https://doi.org/10.1038/nmicrobiol.2017.8
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nrmicro.2017.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085463395
    309 https://doi.org/10.1038/nrmicro.2017.44
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nrmicro3400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046380461
    312 https://doi.org/10.1038/nrmicro3400
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nrurol.2014.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040273906
    315 https://doi.org/10.1038/nrurol.2014.361
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/s41564-017-0030-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092034260
    318 https://doi.org/10.1038/s41564-017-0030-5
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/srep26051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042643376
    321 https://doi.org/10.1038/srep26051
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/srep32191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017421449
    324 https://doi.org/10.1038/srep32191
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1186/1471-2105-9-386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006083026
    327 https://doi.org/10.1186/1471-2105-9-386
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1186/2049-2618-1-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050628435
    330 https://doi.org/10.1186/2049-2618-1-3
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1186/gb-2011-12-6-r60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000243423
    333 https://doi.org/10.1186/gb-2011-12-6-r60
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1186/s13099-017-0163-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084252301
    336 https://doi.org/10.1186/s13099-017-0163-3
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1186/s40168-017-0387-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1100403575
    339 https://doi.org/10.1186/s40168-017-0387-y
    340 rdf:type schema:CreativeWork
    341 https://app.dimensions.ai/details/publication/pub.1074543223 schema:CreativeWork
    342 https://app.dimensions.ai/details/publication/pub.1077158954 schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1080465753 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1080656128 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1082420273 schema:CreativeWork
    346 https://doi.org/10.1001/jama.2015.3725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007009668
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1002/mas.10004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006023216
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.cmi.2014.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005137918
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.cmi.2015.10.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033655031
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.cmi.2017.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084066625
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.ijantimicag.2016.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018828071
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/j.immuni.2016.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006392325
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/j.micpath.2016.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419496
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/j.nmni.2016.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012537096
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/j.tim.2014.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033993678
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/s1473-3099(15)00293-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032469302
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/s2468-1253(17)30147-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091342226
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1021/ac60352a007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055066710
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1056/nejm200003023420903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033457372
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1056/nejmoa1202851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027839530
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1073/pnas.1102938108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030806330
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1073/pnas.1404753111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032155404
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1080/19490976.2017.1290757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083779017
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1084/jem.20170495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085898877
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1086/525047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038623122
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1086/600885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050165478
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1093/ajcn/27.12.1456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080342012
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1093/cid/civ468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047319460
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1093/infdis/jiv766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052874622
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1093/infdis/jiw472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059710420
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1093/nar/gkx295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084786396
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1099/00207713-52-6-2141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060350966
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1099/ijs.0.026989-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060383814
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1099/ijs.0.02873-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043660988
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1101/gr.120618.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052850693
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1101/gr.216242.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083687629
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1111/1462-2920.12662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014266489
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1111/1462-2920.13158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046471739
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1111/1469-0691.12023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024329137
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1111/1469-0691.12181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015051883
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1111/apt.13344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000317583
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1111/apt.13616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053442705
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1111/j.1365-2672.2007.03583.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028714759
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1111/j.1462-2920.2007.01369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014119468
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1111/j.1574-6941.2002.tb00904.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014657893
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1111/j.1574-6941.2007.00314.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007046076
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1126/science.1070633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027888193
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1126/science.1093857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449306
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1126/science.1110591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008274652
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1126/science.1240527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016546887
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1126/science.aac4255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044673480
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1126/science.aad1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016080692
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1126/science.aan3706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092506295
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1126/scitranslmed.aah4669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062689247
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1128/aem.00393-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041494592
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1128/aem.01309-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041067003
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1128/aem.01541-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038354310
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1128/aem.01754-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022593521
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1128/aem.01763-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006225500
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1128/aem.02006-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040808242
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1128/aem.71.7.3692-3700.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015058825
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1128/cmr.00014-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024764492
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1128/cmr.00110-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002947830
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1128/jb.00345-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031113017
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1128/jb.06221-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044888064
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1128/jcm.00492-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008594040
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1128/jcm.01663-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101276756
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1128/jcm.02876-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028332893
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1128/jcm.43.10.4993-5002.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011741159
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1128/mbio.00093-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084222269
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1128/mbio.00893-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002966451
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1128/mbio.01021-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034081947
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1136/gut.10.5.334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014873762
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1136/gut.16.4.318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001719399
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1146/annurev-micro-091014-104115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022371522
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1146/annurev.mi.39.100185.001541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009812939
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1159/000104752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009409814
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.2174/1874285801610010057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069230337
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.3201/eid0701.010112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071122367
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.3389/fcimb.2012.00136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034936308
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.3389/fmicb.2016.00459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036852547
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.3389/fmicb.2017.00899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085565376
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.3390/ijms160816897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051016509
    501 rdf:type schema:CreativeWork
    502 https://www.grid.ac/institutes/grid.414336.7 schema:alternateName Marseille Public University Hospital System
    503 schema:name Assistance Publique-Hôpitaux de Marseille, IHU Méditerranée Infection, Marseille, France
    504 rdf:type schema:Organization
    505 https://www.grid.ac/institutes/grid.483853.1 schema:alternateName Méditerranée Infection Foundation
    506 schema:name Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France
    507 Fondation Méditerranée Infection, IHU Méditerranée Infection, Marseille, France
    508 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...