Zika virus vaccines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-19

AUTHORS

Peter Abbink, Kathryn E. Stephenson, Dan H. Barouch

ABSTRACT

The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating consequences of ZIKV infection, particularly in pregnant women. Congenital Zika syndrome, characterized by malformations and microcephaly in neonates as well as developmental challenges in children, highlights the need for the development of a safe and effective vaccine. Multiple vaccine candidates have been developed and have shown promising results in both animal models and phase I clinical trials. However, important challenges remain for the clinical development of these vaccines. In this Progress article, we discuss recent preclinical studies and lessons learned from first-in-human clinical trials with ZIKV vaccines. More... »

PAGES

594-600

References to SciGraph publications

  • 2015-11-26. A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014 in ARCHIVES OF VIROLOGY
  • 2018-01-29. AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling in NATURE MICROBIOLOGY
  • 2017-01-23. A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus in NPJ VACCINES
  • 2017-11-17. Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis in SCIENTIFIC REPORTS
  • 2018-02-14. Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone in NATURE COMMUNICATIONS
  • 2016-11-10. Zika vaccine candidates progress through nonclinical development and enter clinical trials in NPJ VACCINES
  • 2017-11-01. Zika Virus Infects Intermediate Progenitor Cells and Post-mitotic Committed Neurons in Human Fetal Brain Tissues in SCIENTIFIC REPORTS
  • 2016-04-18. Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2017-09-22. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage in NATURE COMMUNICATIONS
  • 2016-05-11. The Brazilian Zika virus strain causes birth defects in experimental models in NATURE
  • 2017-04-10. A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models in NATURE MEDICINE
  • 2016-10-03. Zika viral dynamics and shedding in rhesus and cynomolgus macaques in NATURE MEDICINE
  • 2017-03-13. Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8+ T cells in NATURE MICROBIOLOGY
  • 2016-04-18. Prenatal brain MRI of fetuses with Zika virus infection in PEDIATRIC RADIOLOGY
  • 2016-04-19. Structure of the thermally stable Zika virus in NATURE
  • 2017-02-02. Zika virus protection by a single low dose nucleoside modified mRNA vaccination in NATURE
  • 2016-06-28. Vaccine Protection Against Zika Virus from Brazil in NATURE
  • 2016-10-19. ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy in SCIENTIFIC REPORTS
  • 2018-03-12. A systematic approach to the development of a safe live attenuated Zika vaccine in NATURE COMMUNICATIONS
  • 2016-08-25. First vaccine approval under the FDA Animal Rule in NPJ VACCINES
  • 2018-01-12. mRNA vaccines — a new era in vaccinology in NATURE REVIEWS DRUG DISCOVERY
  • 2017-11-07. A Zika Vaccine Targeting NS1 Protein Protects Immunocompetent Adult Mice in a Lethal Challenge Model in SCIENTIFIC REPORTS
  • 2017-02-21. Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes in NATURE COMMUNICATIONS
  • 2016-09-12. Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41579-018-0039-7

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