Clinical metagenomics View Full Text


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Article Info

DATE

2019-03-27

AUTHORS

Charles Y Chiu, Steven A Miller

ABSTRACT

Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly moving from research to clinical laboratories. This emerging approach is changing how physicians diagnose and treat infectious disease, with applications spanning a wide range of areas, including antimicrobial resistance, the microbiome, human host gene expression (transcriptomics) and oncology. Here, we focus on the challenges of implementing mNGS in the clinical laboratory and address potential solutions for maximizing its impact on patient care and public health. More... »

PAGES

1

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    N/A

    VOLUME

    N/A

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41576-019-0113-7

    DOI

    http://dx.doi.org/10.1038/s41576-019-0113-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113006301

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30918369


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