The metabolic nature of inflammatory bowel diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-29

AUTHORS

Timon E. Adolph, Moritz Meyer, Julian Schwärzler, Lisa Mayr, Felix Grabherr, Herbert Tilg

ABSTRACT

Crohn’s disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary habits over the past few decades. Here, we review experimental and clinical evidence for the metabolic nature of gut inflammation in IBD and delineate distinct parallels to the inflammatory state in metabolic diseases. Experimental evidence indicates that excessive intake of specific macronutrients in a Western diet fuels an inflammatory response in the gut by exploiting sensors of innate immunity and perturbation of gut microbial metabolism. Genetic IBD risk partly affects metabolism and stress signalling of innate immunity, and immunometabolism controls susceptibility to gut inflammation. Epidemiological and clinical studies indicate that specific nutrients in the Western diet pose a risk for the development of IBD and a poor disease course. Translational studies in IBD indicate perturbation of energy metabolism in immune cells and perturbation of gut microbial metabolism, which can be shaped by diet. In turn, dietary restriction by exclusive enteral nutrition induces remission in patients with IBD. Collectively, these studies support a metabolic underpinning of gut inflammation in IBD as described for metabolic inflammation in obesity and related disorders. More... »

PAGES

753-767

References to SciGraph publications

  • 2017-02-09. Inflammation, metaflammation and immunometabolic disorders in NATURE
  • 2015-08-18. Biologic agents for IBD: practical insights in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2015-03-03. Epidemiology and risk factors for IBD in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2015-02-03. Dietary management of IBD—insights and advice in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2008-08-20. ATP drives lamina propria TH17 cell differentiation in NATURE
  • 2020-04-14. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease in NATURE COMMUNICATIONS
  • 2010-05-11. Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2019-08-23. A high-sugar diet rapidly enhances susceptibility to colitis via depletion of luminal short-chain fatty acids in mice in SCIENTIFIC REPORTS
  • 2019-02-27. Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn’s Disease in SCIENTIFIC REPORTS
  • 2016-11-30. Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2016-06-27. The unfolded protein response in immunity and inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2022-01-10. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques in MUCOSAL IMMUNOLOGY
  • 2020-03-19. JAK–STAT pathway targeting for the treatment of inflammatory bowel disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2013-10-02. Paneth cells as a site of origin for intestinal inflammation in NATURE
  • 2019-01-03. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response in NATURE COMMUNICATIONS
  • 2021-02-11. Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes in NATURE IMMUNOLOGY
  • 2002-11. A central role for JNK in obesity and insulin resistance in NATURE
  • 2013-12-11. Diet rapidly and reproducibly alters the human gut microbiome in NATURE
  • 2017-01-17. Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract in LIPIDS IN HEALTH AND DISEASE
  • 2015-02-25. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome in NATURE
  • 2019-05-29. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases in NATURE
  • 2021-09-21. Innate immune detection of lipid oxidation as a threat assessment strategy in NATURE REVIEWS IMMUNOLOGY
  • 2006-12-21. Human gut microbes associated with obesity in NATURE
  • 2020-03-09. Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2021-03-04. The food additive EDTA aggravates colitis and colon carcinogenesis in mouse models in SCIENTIFIC REPORTS
  • 2018-09-27. You are what you eat: diet, health and the gut microbiota in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2014-04-22. Cytokines in inflammatory bowel disease in NATURE REVIEWS IMMUNOLOGY
  • 2014-09-17. Artificial sweeteners induce glucose intolerance by altering the gut microbiota in NATURE
  • 2016-08-01. C13orf31 (FAMIN) is a central regulator of immunometabolic function in NATURE IMMUNOLOGY
  • 2014-02-25. Intestinal epithelial cells: regulators of barrier function and immune homeostasis in NATURE REVIEWS IMMUNOLOGY
  • 2018-11-26. IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2017-10-11. Environmental triggers in IBD: a review of progress and evidence in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2012-09-26. A metagenome-wide association study of gut microbiota in type 2 diabetes in NATURE
  • 2022-05-16. Dietary management of adults with IBD — the emerging role of dietary therapy in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2016-11-24. Persistent microbiome alterations modulate the rate of post-dieting weight regain in NATURE
  • 2019-06-27. Microbial genes and pathways in inflammatory bowel disease in NATURE REVIEWS MICROBIOLOGY
  • 2019-04-08. Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria in NATURE COMMUNICATIONS
  • 2006-12. An obesity-associated gut microbiome with increased capacity for energy harvest in NATURE
  • 2021-04-15. A guide to interrogating immunometabolism in NATURE REVIEWS IMMUNOLOGY
  • 2021-04-21. The changing landscape of atherosclerosis in NATURE
  • 2017-08-11. Adapting to obesity with adipose tissue inflammation in NATURE REVIEWS ENDOCRINOLOGY
  • 2020-04-02. Crohn’s disease in NATURE REVIEWS DISEASE PRIMERS
  • 2021-10-21. IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies in NATURE MEDICINE
  • 2013-04-07. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis in NATURE MEDICINE
  • 2020-01-31. Host–microbiota interactions in inflammatory bowel disease in NATURE REVIEWS IMMUNOLOGY
  • 2014-01-07. Tailoring anti-TNF therapy in IBD: drug levels and disease activity in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2021-07-13. Dietary carbohydrates and fats in nonalcoholic fatty liver disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2020-11-18. Dietary fibre in gastrointestinal health and disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2015-11-10. Regulation of metabolism by the innate immune system in NATURE REVIEWS ENDOCRINOLOGY
  • 2021-02-10. The metabolic impact of small intestinal nutrient sensing in NATURE COMMUNICATIONS
  • 2021-10-14. Metabolic Messengers: tumour necrosis factor in NATURE METABOLISM
  • 2020-12-14. The intestinal barrier, an arbitrator turned provocateur in IBD in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2021-03-24. Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH in NATURE
  • 2021-03-24. NASH limits anti-tumour surveillance in immunotherapy-treated HCC in NATURE
  • 2011-04-10. Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling in NATURE IMMUNOLOGY
  • 2016-05-09. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands in NATURE MEDICINE
  • 2015-09-01. The global burden of IBD: from 2015 to 2025 in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2019-04-29. The NLRP3 inflammasome: molecular activation and regulation to therapeutics in NATURE REVIEWS IMMUNOLOGY
  • 2022-01-05. Diet, lipids, and antitumor immunity in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2020-10-08. The four epidemiological stages in the global evolution of inflammatory bowel disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2011-04. Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2017-04-12. Inflammasomes and intestinal inflammation in MUCOSAL IMMUNOLOGY
  • 2019-08-06. The intestinal microbiota fuelling metabolic inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2020-07-10. Cell death in the gut epithelium and implications for chronic inflammation in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2021-07-30. Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer in PARTICLE AND FIBRE TOXICOLOGY
  • 2019-07-30. The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms in INFLAMMATION RESEARCH
  • 2021-06-28. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease in NATURE MEDICINE
  • 2017-06-28. Intestinal lymphatic vasculature: structure, mechanisms and functions in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2020-02-03. Regulation of intestinal lipid metabolism: current concepts and relevance to disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2016-07-11. A guide to immunometabolism for immunologists in NATURE REVIEWS IMMUNOLOGY
  • 2020-02-19. Gut microbiota-derived metabolites as key actors in inflammatory bowel disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2015-12-02. Immunopathogenesis of IBD: current state of the art in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2013-08-28. Richness of human gut microbiome correlates with metabolic markers in NATURE
  • 2021-10-15. Gut bacterial metabolites modulate endoplasmic reticulum stress in GENOME BIOLOGY
  • 2014-12-23. Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation in NATURE COMMUNICATIONS
  • 2019-01-02. Microbiota and metabolites in metabolic diseases in NATURE REVIEWS ENDOCRINOLOGY
  • 2019-03-01. The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2012-06-13. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice in NATURE
  • 2016-04-20. Impact of the gut microbiota on inflammation, obesity, and metabolic disease in GENOME MEDICINE
  • 2017-07-21. Regulation of hepatic glucose metabolism in health and disease in NATURE REVIEWS ENDOCRINOLOGY
  • 2020-09-10. Ulcerative colitis in NATURE REVIEWS DISEASE PRIMERS
  • 2022-05-25. Discovery of bioactive microbial gene products in inflammatory bowel disease in NATURE
  • 2018-05-22. The role of diet in the aetiopathogenesis of inflammatory bowel disease in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2011-09-14. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41575-022-00658-y

    DOI

    http://dx.doi.org/10.1038/s41575-022-00658-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149842786

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35906289


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    90 schema:description Crohn’s disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary habits over the past few decades. Here, we review experimental and clinical evidence for the metabolic nature of gut inflammation in IBD and delineate distinct parallels to the inflammatory state in metabolic diseases. Experimental evidence indicates that excessive intake of specific macronutrients in a Western diet fuels an inflammatory response in the gut by exploiting sensors of innate immunity and perturbation of gut microbial metabolism. Genetic IBD risk partly affects metabolism and stress signalling of innate immunity, and immunometabolism controls susceptibility to gut inflammation. Epidemiological and clinical studies indicate that specific nutrients in the Western diet pose a risk for the development of IBD and a poor disease course. Translational studies in IBD indicate perturbation of energy metabolism in immune cells and perturbation of gut microbial metabolism, which can be shaped by diet. In turn, dietary restriction by exclusive enteral nutrition induces remission in patients with IBD. Collectively, these studies support a metabolic underpinning of gut inflammation in IBD as described for metabolic inflammation in obesity and related disorders.
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