A framework for the development of effective anti-metastatic agents View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03

AUTHORS

Robin L Anderson, Theo Balasas, Juliana Callaghan, R Charles Coombes, Jeff Evans, Jacqueline A Hall, Sally Kinrade, David Jones, Paul S Jones, Rob Jones, John F Marshall, Maria Beatrice Panico, Jacqui A Shaw, Patricia S Steeg, Mark Sullivan, Warwick Tong, Andrew D Westwell, James W A Ritchie

ABSTRACT

Most cancer-related deaths are a result of metastasis, and thus the importance of this process as a target of therapy cannot be understated. By asking 'how can we effectively treat cancer?', we do not capture the complexity of a disease encompassing >200 different cancer types - many consisting of multiple subtypes - with considerable intratumoural heterogeneity, which can result in variable responses to a specific therapy. Moreover, we have much less information on the pathophysiological characteristics of metastases than is available for the primary tumour. Most disseminated tumour cells that arrive in distant tissues, surrounded by unfamiliar cells and a foreign microenvironment, are likely to die; however, those that survive can generate metastatic tumours with a markedly different biology from that of the primary tumour. To treat metastasis effectively, we must inhibit fundamental metastatic processes and develop specific preclinical and clinical strategies that do not rely on primary tumour responses. To address this crucial issue, Cancer Research UK and Cancer Therapeutics CRC Australia formed a Metastasis Working Group with representatives from not-for-profit, academic, government, industry and regulatory bodies in order to develop recommendations on how to tackle the challenges associated with treating (micro)metastatic disease. Herein, we describe the challenges identified as well as the proposed approaches for discovering and developing anticancer agents designed specifically to prevent or delay the metastatic outgrowth of cancer. More... »

PAGES

1

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41571-018-0134-8

    DOI

    http://dx.doi.org/10.1038/s41571-018-0134-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110363365

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30514977


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