P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-06-13

AUTHORS

Davide Capodanno, Usman Baber, Deepak L. Bhatt, Jean-Philippe Collet, George Dangas, Francesco Franchi, C. Michael Gibson, Hyeon-Cheol Gwon, Adnan Kastrati, Takeshi Kimura, Pedro A. Lemos, Renato D. Lopes, Roxana Mehran, Michelle L. O’Donoghue, Sunil V. Rao, Fabiana Rollini, Patrick W. Serruys, Philippe G. Steg, Robert F. Storey, Marco Valgimigli, Pascal Vranckx, Hirotoshi Watanabe, Stephan Windecker, Dominick J. Angiolillo

ABSTRACT

For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic pharmacology after percutaneous coronary intervention (PCI). In the past 5 years, several investigations have challenged this paradigm by testing the efficacy and safety of P2Y12 inhibitor monotherapy (that is, without aspirin) following a short course of DAPT. Collectively, these studies suggested a reduction in the risk of major bleeding and no significant increase in thrombotic or ischaemic events compared with guideline-recommended DAPT. Current recommendations are evolving to inform clinical practice on the ideal candidates for P2Y12 inhibitor monotherapy after PCI. Generalizing the results of studies of P2Y12 inhibitor monotherapy requires a thorough understanding of their design, populations, interventions, comparators and results. In this Review, we provide an up-to-date overview on the use of P2Y12 inhibitor monotherapy after PCI, including supporting pharmacodynamic and clinical evidence, practical recommendations and future directions. More... »

PAGES

829-844

Journal

TITLE

Nature Reviews Cardiology

ISSUE

12

VOLUME

19

Author Affiliations

  • Cardio-Thoracic-Vascular and Transplant Department, Azienda Ospedaliero-Universitaria Policlinico “Gaspare Rodolico – San Marco”, University of Catania, Catania, Italy
  • University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
  • Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • ACTION Group, Sorbonne Université, INSERM UMRS1166, Hôpital Pitié-Salpêtrière (AP-HP), Institut de Cardiologie, Paris, France
  • Icahn School of Medicine at Mount Sinai, Cardiovascular Institute, New York, NY, USA
  • University of Florida College of Medicine, Jacksonville, FL, USA
  • Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
  • Department of Cardiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • Deutsches Herzzentrum München, Cardiology and Technische Universität München, Munich, Germany
  • Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Hospital Israelita Albert Einstein and Heart Institute (InCor) University of São Paulo Medical School, São Paulo, Brazil
  • Duke University Medical Center, The Duke Clinical Research Institute, Durham, NC, USA
  • TIMI Study Group, Brigham and Women’s Hospital, Boston, MA, USA
  • The Lambe Institute for Translational Medicine and Curam, National University of Ireland Galway, Galway, Ireland
  • Université de Paris, INSERM U-1148, AP-HP, Hôpital Bichat, Paris, France
  • Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
  • Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano and Bern University Hospital, Bern, Switzerland
  • Department of Cardiology and Critical Care Medicine, Jessaziekenhuis, Faculty of Medicine and Life Sciences, University of Hasselt, Hasselt, Belgium
  • Department of Cardiology, Bern University Hospital, Inselspital, Bern, Switzerland
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41569-022-00725-6

    DOI

    http://dx.doi.org/10.1038/s41569-022-00725-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1148617855

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35697777


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