Circular RNAs open a new chapter in cardiovascular biology. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-05

AUTHORS

Simona Aufiero, Yolan J Reckman, Yigal M Pinto, Esther E Creemers

ABSTRACT

Circular RNAs (circRNAs) are emerging as a new class of non-coding RNA molecules. This unusual class of RNA species is generated by a back-splicing event of one or two exons, resulting in a covalently closed circRNA molecule. Owing to their circular form, circRNAs are protected from degradation by exonucleases and have greater stability than linear RNA. Advances in computational analysis of RNA sequencing have revealed that thousands of different circRNAs are expressed in a wide range of mammalian tissues, including the cardiovascular system. Moreover, numerous circRNAs are expressed in a disease-specific manner. A great deal of progress has been made in understanding the biogenesis and function of these circRNAs. In this Review, we discuss the current understanding of circRNA biogenesis and function, with a particular emphasis on the cardiovascular system. More... »

Journal

TITLE

Nature Reviews Cardiology

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41569-019-0185-2

DOI

http://dx.doi.org/10.1038/s41569-019-0185-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113261601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30952956


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