Cytokinesis defects and cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-06

AUTHORS

Susanne M. A. Lens, René H. Medema

ABSTRACT

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is in fact an important cause of human cancers has remained unclear. In this Review, we summarize evidence that whole-genome-doubling events are frequently observed in human cancers and discuss the contribution that cytokinesis defects can make to tumorigenesis. We provide an overview of the potential causes of cytokinesis failure and discuss how tetraploid cells that are generated through cytokinesis defects are used in cancer as a transitory state on the route to aneuploidy. Finally, we discuss how cytokinesis defects can facilitate genetic diversification within the tumour to promote cancer development and could constitute the path of least resistance in tumour evolution. More... »

PAGES

32-45

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41568-018-0084-6

    DOI

    http://dx.doi.org/10.1038/s41568-018-0084-6

    DIMENSIONS

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    PUBMED

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