Bright sub-20-nm cathodoluminescent nanoprobes for electron microscopy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-04

AUTHORS

Maxim B. Prigozhin, Peter C. Maurer, Alexandra M. Courtis, Nian Liu, Michael D. Wisser, Chris Siefe, Bining Tian, Emory Chan, Guosheng Song, Stefan Fischer, Shaul Aloni, D. Frank Ogletree, Edward S. Barnard, Lydia-Marie Joubert, Jianghong Rao, A. Paul Alivisatos, Roger M. Macfarlane, Bruce E. Cohen, Yi Cui, Jennifer A. Dionne, Steven Chu

ABSTRACT

Electron microscopy has been instrumental in our understanding of complex biological systems. Although electron microscopy reveals cellular morphology with nanoscale resolution, it does not provide information on the location of different types of proteins. An electron-microscopy-based bioimaging technology capable of localizing individual proteins and resolving protein-protein interactions with respect to cellular ultrastructure would provide important insights into the molecular biology of a cell. Here, we synthesize small lanthanide-doped nanoparticles and measure the absolute photon emission rate of individual nanoparticles resulting from a given electron excitation flux (cathodoluminescence). Our results suggest that the optimization of nanoparticle composition, synthesis protocols and electron imaging conditions can lead to sub-20-nm nanolabels that would enable high signal-to-noise localization of individual biomolecules within a cellular context. In ensemble measurements, these labels exhibit narrow spectra of nine distinct colours, so the imaging of biomolecules in a multicolour electron microscopy modality may be possible. More... »

PAGES

1-6

References to SciGraph publications

  • 2015-01. Directed evolution of APEX2 for electron microscopy and proximity labeling in NATURE METHODS
  • 2015-04. Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics in NATURE METHODS
  • 2014-07. Preparation of core-shell NaGdF4 nanoparticles doped with luminescent lanthanide ions to be used as upconversion-based probes in NATURE PROTOCOLS
  • 2015-10. Ultrahigh-throughput single-molecule spectroscopy and spectrally resolved super-resolution microscopy in NATURE METHODS
  • 2014-03. Correlative super-resolution fluorescence and metal-replica transmission electron microscopy in NATURE METHODS
  • 2014-04. Multiplexed ion beam imaging of human breast tumors in NATURE MEDICINE
  • 2014-04. Engineering bright sub-10-nm upconverting nanocrystals for single-molecule imaging in NATURE NANOTECHNOLOGY
  • 2014-01. Tunable lifetime multiplexing using luminescent nanocrystals in NATURE PHOTONICS
  • 2013-09-26. Upconversion luminescence imaging of cells and small animals in NATURE PROTOCOLS
  • 2017-12. High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling in SCIENTIFIC REPORTS
  • 2013-12. Recent advances in the optimization and functionalization of upconversion nanomaterials for in vivo bioapplications in NPG ASIA MATERIALS
  • 2005-10. Correlated light and electron microscopic imaging of multiple endogenous proteins using Quantum dots in NATURE METHODS
  • 2012-12. Correlative light and electron microscopy using cathodoluminescence from nanoparticles with distinguishable colours in SCIENTIFIC REPORTS
  • 2012-11. Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41565-019-0395-0

    DOI

    http://dx.doi.org/10.1038/s41565-019-0395-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112508968

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30833691


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Other Physical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physical Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Physics, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prigozhin", 
            "givenName": "Maxim B.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Physics, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maurer", 
            "givenName": "Peter C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Berkeley", 
              "id": "https://www.grid.ac/institutes/grid.47840.3f", 
              "name": [
                "Department of Chemistry, University of California at Berkeley, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Courtis", 
            "givenName": "Alexandra M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Georgia Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.213917.f", 
              "name": [
                "Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA", 
                "School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Nian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wisser", 
            "givenName": "Michael D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siefe", 
            "givenName": "Chris", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tian", 
            "givenName": "Bining", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "Emory", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hunan University", 
              "id": "https://www.grid.ac/institutes/grid.67293.39", 
              "name": [
                "Department of Radiology, Stanford University, Stanford, CA, USA", 
                "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Guosheng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fischer", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aloni", 
            "givenName": "Shaul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogletree", 
            "givenName": "D. Frank", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barnard", 
            "givenName": "Edward S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stellenbosch University", 
              "id": "https://www.grid.ac/institutes/grid.11956.3a", 
              "name": [
                "CSIF Beckman Center, Stanford University, Stanford, CA, USA", 
                "EM Unit, Central Analytical Facilities, Stellenbosch University, Stellenbosch, South Africa"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Joubert", 
            "givenName": "Lydia-Marie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Radiology, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rao", 
            "givenName": "Jianghong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kavli Energy NanoScience Institute", 
              "id": "https://www.grid.ac/institutes/grid.494610.e", 
              "name": [
                "Department of Chemistry, University of California at Berkeley, Berkeley, CA, USA", 
                "Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA", 
                "Department of Materials Science and Engineering, University of California, Berkeley, CA, USA", 
                "Kavli Energy NanoScience Institute, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alivisatos", 
            "givenName": "A. Paul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IBM Research - Almaden", 
              "id": "https://www.grid.ac/institutes/grid.481551.c", 
              "name": [
                "IBM Research \u2013 Almaden, San Jose, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Macfarlane", 
            "givenName": "Roger M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lawrence Berkeley National Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.184769.5", 
              "name": [
                "Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cohen", 
            "givenName": "Bruce E.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cui", 
            "givenName": "Yi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dionne", 
            "givenName": "Jennifer A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Physics, Stanford University, Stanford, CA, USA", 
                "Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chu", 
            "givenName": "Steven", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1063/1.4936119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002002071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0020329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007086000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007446959", 
              "https://doi.org/10.1038/nmeth.3292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nphoton.2013.322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008203004", 
              "https://doi.org/10.1038/nphoton.2013.322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chembiol.2016.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011317326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja108948z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012210950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja108948z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012210950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014061671", 
              "https://doi.org/10.1038/nbt.2375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c4cs00205a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015248853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.aca.2014.04.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015434277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2014.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016071843", 
              "https://doi.org/10.1038/nprot.2014.111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016276879", 
              "https://doi.org/10.1038/nmeth791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016276879", 
              "https://doi.org/10.1038/nmeth791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016848253", 
              "https://doi.org/10.1038/nprot.2013.114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201405735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022941828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/smll.200900404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028606026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/smll.200900404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028606026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/revmodphys.82.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028649416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/revmodphys.82.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028649416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033631778", 
              "https://doi.org/10.1038/nmeth.3179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0957-4484/19/34/345606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033702915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep00865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034723466", 
              "https://doi.org/10.1038/srep00865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.optcom.2007.04.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034738391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.nanolett.5b00716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035199580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.06.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035956846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038928421", 
              "https://doi.org/10.1038/nmeth.3528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/36.1.3335766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040800833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/36.1.3335766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040800833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/am.2013.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044642006", 
              "https://doi.org/10.1038/am.2013.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/26.12.366014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046770501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/26.12.366014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046770501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047301596", 
              "https://doi.org/10.1038/nm.3488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048345698", 
              "https://doi.org/10.1038/nmeth.2816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nnano.2014.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053502599", 
              "https://doi.org/10.1038/nnano.2014.29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jz402233x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056135384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nn3000737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056224136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.1701366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057771721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrev.127.750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060425848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrev.127.750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060425848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1143/apex.4.112402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063031669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1364/boe.5.000378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065138027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/smll.201700543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084898616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.nanolett.6b05331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085305165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.25916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085402603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2017.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085596350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-07694-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090957114", 
              "https://doi.org/10.1038/s41598-017-07694-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-07694-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090957114", 
              "https://doi.org/10.1038/s41598-017-07694-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2017.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092341244"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-04", 
        "datePublishedReg": "2019-03-04", 
        "description": "Electron microscopy has been instrumental in our understanding of complex biological systems. Although electron microscopy reveals cellular morphology with nanoscale resolution, it does not provide information on the location of different types of proteins. An electron-microscopy-based bioimaging technology capable of localizing individual proteins and resolving protein-protein interactions with respect to cellular ultrastructure would provide important insights into the molecular biology of a cell. Here, we synthesize small lanthanide-doped nanoparticles and measure the absolute photon emission rate of individual nanoparticles resulting from a given electron excitation flux (cathodoluminescence). Our results suggest that the optimization of nanoparticle composition, synthesis protocols and electron imaging conditions can lead to sub-20-nm nanolabels that would enable high signal-to-noise localization of individual biomolecules within a cellular context. In ensemble measurements, these labels exhibit narrow spectra of nine distinct colours, so the imaging of biomolecules in a multicolour electron microscopy modality may be possible.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41565-019-0395-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2675052", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4317598", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4319840", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7753294", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4318468", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1037429", 
            "issn": [
              "1748-3387", 
              "1748-3395"
            ], 
            "name": "Nature Nanotechnology", 
            "type": "Periodical"
          }
        ], 
        "name": "Bright sub-20-nm cathodoluminescent nanoprobes for electron microscopy", 
        "pagination": "1-6", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7e5096f0da3ae6d6b45b0443785338bf87d8a8a199f949b842be0ea5c53165ea"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30833691"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101283273"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41565-019-0395-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112508968"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41565-019-0395-0", 
          "https://app.dimensions.ai/details/publication/pub.1112508968"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60369_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41565-019-0395-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0395-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0395-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0395-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0395-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      21 PREDICATES      66 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41565-019-0395-0 schema:about anzsrc-for:02
    2 anzsrc-for:0299
    3 schema:author N8e71269ae68a4f90bbde68d155ad1e52
    4 schema:citation sg:pub.10.1038/am.2013.63
    5 sg:pub.10.1038/nbt.2375
    6 sg:pub.10.1038/nm.3488
    7 sg:pub.10.1038/nmeth.2816
    8 sg:pub.10.1038/nmeth.3179
    9 sg:pub.10.1038/nmeth.3292
    10 sg:pub.10.1038/nmeth.3528
    11 sg:pub.10.1038/nmeth791
    12 sg:pub.10.1038/nnano.2014.29
    13 sg:pub.10.1038/nphoton.2013.322
    14 sg:pub.10.1038/nprot.2013.114
    15 sg:pub.10.1038/nprot.2014.111
    16 sg:pub.10.1038/s41598-017-07694-8
    17 sg:pub.10.1038/srep00865
    18 https://doi.org/10.1002/anie.201405735
    19 https://doi.org/10.1002/smll.200900404
    20 https://doi.org/10.1002/smll.201700543
    21 https://doi.org/10.1016/j.aca.2014.04.030
    22 https://doi.org/10.1016/j.cell.2015.06.054
    23 https://doi.org/10.1016/j.chembiol.2016.10.006
    24 https://doi.org/10.1016/j.jsb.2017.05.008
    25 https://doi.org/10.1016/j.jsb.2017.10.009
    26 https://doi.org/10.1016/j.optcom.2007.04.069
    27 https://doi.org/10.1021/acs.nanolett.5b00716
    28 https://doi.org/10.1021/acs.nanolett.6b05331
    29 https://doi.org/10.1021/ja108948z
    30 https://doi.org/10.1021/jz402233x
    31 https://doi.org/10.1021/nn3000737
    32 https://doi.org/10.1039/c4cs00205a
    33 https://doi.org/10.1063/1.1701366
    34 https://doi.org/10.1063/1.4936119
    35 https://doi.org/10.1088/0957-4484/19/34/345606
    36 https://doi.org/10.1103/physrev.127.750
    37 https://doi.org/10.1103/revmodphys.82.209
    38 https://doi.org/10.1143/apex.4.112402
    39 https://doi.org/10.1177/26.12.366014
    40 https://doi.org/10.1177/36.1.3335766
    41 https://doi.org/10.1364/boe.5.000378
    42 https://doi.org/10.1371/journal.pbio.0020329
    43 https://doi.org/10.7554/elife.25916
    44 schema:datePublished 2019-03-04
    45 schema:datePublishedReg 2019-03-04
    46 schema:description Electron microscopy has been instrumental in our understanding of complex biological systems. Although electron microscopy reveals cellular morphology with nanoscale resolution, it does not provide information on the location of different types of proteins. An electron-microscopy-based bioimaging technology capable of localizing individual proteins and resolving protein-protein interactions with respect to cellular ultrastructure would provide important insights into the molecular biology of a cell. Here, we synthesize small lanthanide-doped nanoparticles and measure the absolute photon emission rate of individual nanoparticles resulting from a given electron excitation flux (cathodoluminescence). Our results suggest that the optimization of nanoparticle composition, synthesis protocols and electron imaging conditions can lead to sub-20-nm nanolabels that would enable high signal-to-noise localization of individual biomolecules within a cellular context. In ensemble measurements, these labels exhibit narrow spectra of nine distinct colours, so the imaging of biomolecules in a multicolour electron microscopy modality may be possible.
    47 schema:genre research_article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf sg:journal.1037429
    51 schema:name Bright sub-20-nm cathodoluminescent nanoprobes for electron microscopy
    52 schema:pagination 1-6
    53 schema:productId N7966dad9c7394ddc87e835e5ec4391c3
    54 Na20a88f1efa047d9ab516263eaf761ca
    55 Ncf449d3ac2f44547a93afbf0308c582c
    56 Nef9e1b2435554795a813d2480668f929
    57 Nfd9723c3fdcd4e329210c49aa07ffbe3
    58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112508968
    59 https://doi.org/10.1038/s41565-019-0395-0
    60 schema:sdDatePublished 2019-04-11T11:05
    61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    62 schema:sdPublisher N5e0db47d741442c38448254980d8387a
    63 schema:url https://www.nature.com/articles/s41565-019-0395-0
    64 sgo:license sg:explorer/license/
    65 sgo:sdDataset articles
    66 rdf:type schema:ScholarlyArticle
    67 N02f7c9ac381f4008bce0e60117d16840 rdf:first N17526f09444c4d8da9523bd00ac4c06c
    68 rdf:rest N460899f838a444169b682fa7af343373
    69 N0461742d4d9b4fd0be0abf7e184c541a rdf:first Nb49c9924774141c9afb91caa8232ff8b
    70 rdf:rest Nbcf136b4cbab4a7e876e8319ceb00bdd
    71 N04ab2b1d188644b58a6e51960f09ceea rdf:first Nf2f603db5cf64f4fa30c1aae634bda6d
    72 rdf:rest N02f7c9ac381f4008bce0e60117d16840
    73 N0eea9977614944049556dcd2bfc33f74 rdf:first Nf711f470d3974c37afc845a80fb92d4c
    74 rdf:rest Na6e0186999a440fba290a5b6d4d29185
    75 N17526f09444c4d8da9523bd00ac4c06c schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    76 schema:familyName Siefe
    77 schema:givenName Chris
    78 rdf:type schema:Person
    79 N275326f8b2e84c008517797a55b29a4c schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    80 schema:familyName Dionne
    81 schema:givenName Jennifer A.
    82 rdf:type schema:Person
    83 N3cc59ff8399546b89c1049d300514f44 rdf:first Nd69b025ddb3249d2a56fc5b617c6f425
    84 rdf:rest N95b13823028843a9a1c1bbd46cd1432c
    85 N425bc9e65bfd4750baa896b71f6aff22 rdf:first N275326f8b2e84c008517797a55b29a4c
    86 rdf:rest N98a29e258a0d4361b2ab0b00e8a3a2d5
    87 N460899f838a444169b682fa7af343373 rdf:first N478a7212f10742d8a277eaf05ba4b0df
    88 rdf:rest N60e99f67954442ad98d21fb537c19fab
    89 N478a7212f10742d8a277eaf05ba4b0df schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    90 schema:familyName Tian
    91 schema:givenName Bining
    92 rdf:type schema:Person
    93 N4a1602a2fb564df19dbe13d649742e36 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    94 schema:familyName Cohen
    95 schema:givenName Bruce E.
    96 rdf:type schema:Person
    97 N4efb256af49141d98859cafbf9de45b9 schema:affiliation https://www.grid.ac/institutes/grid.494610.e
    98 schema:familyName Alivisatos
    99 schema:givenName A. Paul
    100 rdf:type schema:Person
    101 N4fbbca80489f45ab8be7251a735c7eb7 rdf:first N980ed80067bc4169936e1ca93b62d0d9
    102 rdf:rest N04ab2b1d188644b58a6e51960f09ceea
    103 N54b99a6fcbb24db594c161e1bca1fdc0 rdf:first N7d91d4b946424f218ce5bce0ff792fbe
    104 rdf:rest Nb4daeadc7cc94fa9aa315b53a48392a9
    105 N5e0db47d741442c38448254980d8387a schema:name Springer Nature - SN SciGraph project
    106 rdf:type schema:Organization
    107 N600faa496cac4082bbd361f386539b37 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
    108 schema:familyName Courtis
    109 schema:givenName Alexandra M.
    110 rdf:type schema:Person
    111 N60e99f67954442ad98d21fb537c19fab rdf:first N7516f1290c3741858ce3eac92d4af96d
    112 rdf:rest N54b99a6fcbb24db594c161e1bca1fdc0
    113 N7516f1290c3741858ce3eac92d4af96d schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    114 schema:familyName Chan
    115 schema:givenName Emory
    116 rdf:type schema:Person
    117 N7966dad9c7394ddc87e835e5ec4391c3 schema:name nlm_unique_id
    118 schema:value 101283273
    119 rdf:type schema:PropertyValue
    120 N7d91d4b946424f218ce5bce0ff792fbe schema:affiliation https://www.grid.ac/institutes/grid.67293.39
    121 schema:familyName Song
    122 schema:givenName Guosheng
    123 rdf:type schema:Person
    124 N819ee23908bd4740b85328e7413f216e rdf:first Ndce54b50f9384412b60d4df501f1ea06
    125 rdf:rest N0461742d4d9b4fd0be0abf7e184c541a
    126 N8e71269ae68a4f90bbde68d155ad1e52 rdf:first N96a0028b8be94ef495c0b654306a1371
    127 rdf:rest N0eea9977614944049556dcd2bfc33f74
    128 N95b13823028843a9a1c1bbd46cd1432c rdf:first N4a1602a2fb564df19dbe13d649742e36
    129 rdf:rest Ne75bbde692b8442b8e2def73fb8917e3
    130 N96a0028b8be94ef495c0b654306a1371 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    131 schema:familyName Prigozhin
    132 schema:givenName Maxim B.
    133 rdf:type schema:Person
    134 N980ed80067bc4169936e1ca93b62d0d9 schema:affiliation https://www.grid.ac/institutes/grid.213917.f
    135 schema:familyName Liu
    136 schema:givenName Nian
    137 rdf:type schema:Person
    138 N98a29e258a0d4361b2ab0b00e8a3a2d5 rdf:first Ne3e3f613aec44dab8a613a2f18fbb694
    139 rdf:rest rdf:nil
    140 Na20a88f1efa047d9ab516263eaf761ca schema:name pubmed_id
    141 schema:value 30833691
    142 rdf:type schema:PropertyValue
    143 Na62e9872b4c844d39ff2517db0011b5c rdf:first Ncdf1b3393b0346eab8eee76615d37ca2
    144 rdf:rest Nbf90564a51a4426590a55a96b58e58c8
    145 Na6e0186999a440fba290a5b6d4d29185 rdf:first N600faa496cac4082bbd361f386539b37
    146 rdf:rest N4fbbca80489f45ab8be7251a735c7eb7
    147 Naa0973e0f9574d8d987dc9f05bc29764 rdf:first N4efb256af49141d98859cafbf9de45b9
    148 rdf:rest N3cc59ff8399546b89c1049d300514f44
    149 Nb49c9924774141c9afb91caa8232ff8b schema:affiliation https://www.grid.ac/institutes/grid.11956.3a
    150 schema:familyName Joubert
    151 schema:givenName Lydia-Marie
    152 rdf:type schema:Person
    153 Nb4daeadc7cc94fa9aa315b53a48392a9 rdf:first Nc6d805b873624d7f8470833b6038557b
    154 rdf:rest Na62e9872b4c844d39ff2517db0011b5c
    155 Nbcf136b4cbab4a7e876e8319ceb00bdd rdf:first Neaf9a368916c4ed49e31e036e431d0bc
    156 rdf:rest Naa0973e0f9574d8d987dc9f05bc29764
    157 Nbf90564a51a4426590a55a96b58e58c8 rdf:first Nd60b33467aff433e95fcc97bda9c0660
    158 rdf:rest N819ee23908bd4740b85328e7413f216e
    159 Nc6d805b873624d7f8470833b6038557b schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    160 schema:familyName Fischer
    161 schema:givenName Stefan
    162 rdf:type schema:Person
    163 Ncdf1b3393b0346eab8eee76615d37ca2 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    164 schema:familyName Aloni
    165 schema:givenName Shaul
    166 rdf:type schema:Person
    167 Ncf449d3ac2f44547a93afbf0308c582c schema:name readcube_id
    168 schema:value 7e5096f0da3ae6d6b45b0443785338bf87d8a8a199f949b842be0ea5c53165ea
    169 rdf:type schema:PropertyValue
    170 Nd60b33467aff433e95fcc97bda9c0660 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    171 schema:familyName Ogletree
    172 schema:givenName D. Frank
    173 rdf:type schema:Person
    174 Nd69b025ddb3249d2a56fc5b617c6f425 schema:affiliation https://www.grid.ac/institutes/grid.481551.c
    175 schema:familyName Macfarlane
    176 schema:givenName Roger M.
    177 rdf:type schema:Person
    178 Ndce54b50f9384412b60d4df501f1ea06 schema:affiliation https://www.grid.ac/institutes/grid.184769.5
    179 schema:familyName Barnard
    180 schema:givenName Edward S.
    181 rdf:type schema:Person
    182 Ne3e3f613aec44dab8a613a2f18fbb694 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    183 schema:familyName Chu
    184 schema:givenName Steven
    185 rdf:type schema:Person
    186 Ne75bbde692b8442b8e2def73fb8917e3 rdf:first Ned5eaa108320400c8867ce0401dd3b24
    187 rdf:rest N425bc9e65bfd4750baa896b71f6aff22
    188 Neaf9a368916c4ed49e31e036e431d0bc schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    189 schema:familyName Rao
    190 schema:givenName Jianghong
    191 rdf:type schema:Person
    192 Ned5eaa108320400c8867ce0401dd3b24 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    193 schema:familyName Cui
    194 schema:givenName Yi
    195 rdf:type schema:Person
    196 Nef9e1b2435554795a813d2480668f929 schema:name doi
    197 schema:value 10.1038/s41565-019-0395-0
    198 rdf:type schema:PropertyValue
    199 Nf2f603db5cf64f4fa30c1aae634bda6d schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    200 schema:familyName Wisser
    201 schema:givenName Michael D.
    202 rdf:type schema:Person
    203 Nf711f470d3974c37afc845a80fb92d4c schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    204 schema:familyName Maurer
    205 schema:givenName Peter C.
    206 rdf:type schema:Person
    207 Nfd9723c3fdcd4e329210c49aa07ffbe3 schema:name dimensions_id
    208 schema:value pub.1112508968
    209 rdf:type schema:PropertyValue
    210 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Physical Sciences
    212 rdf:type schema:DefinedTerm
    213 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
    214 schema:name Other Physical Sciences
    215 rdf:type schema:DefinedTerm
    216 sg:grant.2675052 http://pending.schema.org/fundedItem sg:pub.10.1038/s41565-019-0395-0
    217 rdf:type schema:MonetaryGrant
    218 sg:grant.4317598 http://pending.schema.org/fundedItem sg:pub.10.1038/s41565-019-0395-0
    219 rdf:type schema:MonetaryGrant
    220 sg:grant.4318468 http://pending.schema.org/fundedItem sg:pub.10.1038/s41565-019-0395-0
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.4319840 http://pending.schema.org/fundedItem sg:pub.10.1038/s41565-019-0395-0
    223 rdf:type schema:MonetaryGrant
    224 sg:grant.7753294 http://pending.schema.org/fundedItem sg:pub.10.1038/s41565-019-0395-0
    225 rdf:type schema:MonetaryGrant
    226 sg:journal.1037429 schema:issn 1748-3387
    227 1748-3395
    228 schema:name Nature Nanotechnology
    229 rdf:type schema:Periodical
    230 sg:pub.10.1038/am.2013.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044642006
    231 https://doi.org/10.1038/am.2013.63
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nbt.2375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014061671
    234 https://doi.org/10.1038/nbt.2375
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nm.3488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047301596
    237 https://doi.org/10.1038/nm.3488
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nmeth.2816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048345698
    240 https://doi.org/10.1038/nmeth.2816
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nmeth.3179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033631778
    243 https://doi.org/10.1038/nmeth.3179
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nmeth.3292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007446959
    246 https://doi.org/10.1038/nmeth.3292
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nmeth.3528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038928421
    249 https://doi.org/10.1038/nmeth.3528
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nmeth791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016276879
    252 https://doi.org/10.1038/nmeth791
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nnano.2014.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053502599
    255 https://doi.org/10.1038/nnano.2014.29
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nphoton.2013.322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008203004
    258 https://doi.org/10.1038/nphoton.2013.322
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nprot.2013.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016848253
    261 https://doi.org/10.1038/nprot.2013.114
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/nprot.2014.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016071843
    264 https://doi.org/10.1038/nprot.2014.111
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/s41598-017-07694-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090957114
    267 https://doi.org/10.1038/s41598-017-07694-8
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/srep00865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034723466
    270 https://doi.org/10.1038/srep00865
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1002/anie.201405735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022941828
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1002/smll.200900404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028606026
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/smll.201700543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084898616
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.aca.2014.04.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015434277
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.cell.2015.06.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035956846
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.chembiol.2016.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011317326
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.jsb.2017.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085596350
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.jsb.2017.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092341244
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.optcom.2007.04.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034738391
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1021/acs.nanolett.5b00716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035199580
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1021/acs.nanolett.6b05331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085305165
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1021/ja108948z schema:sameAs https://app.dimensions.ai/details/publication/pub.1012210950
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1021/jz402233x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056135384
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1021/nn3000737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056224136
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1039/c4cs00205a schema:sameAs https://app.dimensions.ai/details/publication/pub.1015248853
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1063/1.1701366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057771721
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1063/1.4936119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002002071
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1088/0957-4484/19/34/345606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033702915
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1103/physrev.127.750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060425848
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1103/revmodphys.82.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028649416
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1143/apex.4.112402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063031669
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1177/26.12.366014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046770501
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1177/36.1.3335766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040800833
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1364/boe.5.000378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065138027
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1371/journal.pbio.0020329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007086000
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.7554/elife.25916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085402603
    323 rdf:type schema:CreativeWork
    324 https://www.grid.ac/institutes/grid.11956.3a schema:alternateName Stellenbosch University
    325 schema:name CSIF Beckman Center, Stanford University, Stanford, CA, USA
    326 EM Unit, Central Analytical Facilities, Stellenbosch University, Stellenbosch, South Africa
    327 rdf:type schema:Organization
    328 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
    329 schema:name Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA
    330 Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA
    331 Department of Physics, Stanford University, Stanford, CA, USA
    332 Department of Radiology, Stanford University, Stanford, CA, USA
    333 rdf:type schema:Organization
    334 https://www.grid.ac/institutes/grid.184769.5 schema:alternateName Lawrence Berkeley National Laboratory
    335 schema:name Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    336 rdf:type schema:Organization
    337 https://www.grid.ac/institutes/grid.213917.f schema:alternateName Georgia Institute of Technology
    338 schema:name Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA
    339 School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    340 rdf:type schema:Organization
    341 https://www.grid.ac/institutes/grid.47840.3f schema:alternateName University of California, Berkeley
    342 schema:name Department of Chemistry, University of California at Berkeley, Berkeley, CA, USA
    343 rdf:type schema:Organization
    344 https://www.grid.ac/institutes/grid.481551.c schema:alternateName IBM Research - Almaden
    345 schema:name IBM Research – Almaden, San Jose, CA, USA
    346 rdf:type schema:Organization
    347 https://www.grid.ac/institutes/grid.494610.e schema:alternateName Kavli Energy NanoScience Institute
    348 schema:name Department of Chemistry, University of California at Berkeley, Berkeley, CA, USA
    349 Department of Materials Science and Engineering, University of California, Berkeley, CA, USA
    350 Kavli Energy NanoScience Institute, Berkeley, CA, USA
    351 Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    352 rdf:type schema:Organization
    353 https://www.grid.ac/institutes/grid.67293.39 schema:alternateName Hunan University
    354 schema:name Department of Radiology, Stanford University, Stanford, CA, USA
    355 State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...