Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Jiangsheng Xu, Yunhua Liu, Yujing Li, Hai Wang, Samantha Stewart, Kevin Van der Jeught, Pranay Agarwal, Yuntian Zhang, Sheng Liu, Gang Zhao, Jun Wan, Xiongbin Lu, Xiaoming He

ABSTRACT

TP53 is the most frequently mutated or deleted gene in triple negative breast cancer (TNBC). Both the loss of TP53 and the lack of targeted therapy are significantly correlated with poor clinical outcomes, making TNBC the only type of breast cancer that has no approved targeted therapies. Through in silico analysis, we identified POLR2A in the TP53-neighbouring region as a collateral vulnerability target in TNBC tumours, suggesting that its inhibition via small interfering RNA (siRNA) may be an amenable approach for TNBC targeted treatment. To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delivery of POLR2A siRNA (siPol2). Suppression of POLR2A expression with the siPol2-laden nanoparticles leads to enhanced growth reduction of tumours characterized by hemizygous POLR2A loss. These results demonstrate the potential of the pH-responsive nanoparticle and the precise POLR2A targeted therapy in TNBC harbouring the common TP53 genomic alteration. More... »

PAGES

1-10

References to SciGraph publications

  • 2007-07. Transvascular delivery of small interfering RNA to the central nervous system in NATURE
  • 2013-05. Extracellular vesicles: biology and emerging therapeutic opportunities in NATURE REVIEWS DRUG DISCOVERY
  • 2017-01. Bioresponsive materials in NATURE REVIEWS MATERIALS
  • 2012-01. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery in NATURE MATERIALS
  • 2011-04. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes in NATURE BIOTECHNOLOGY
  • 2016-05. Analysis of nanoparticle delivery to tumours in NATURE REVIEWS MATERIALS
  • 2014-11. Drugging the undruggable RAS: Mission Possible? in NATURE REVIEWS DRUG DISCOVERY
  • 2017-12. Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells in NATURE COMMUNICATIONS
  • 2007-02. Restoration of p53 function leads to tumour regression in vivo in NATURE
  • 2016-05-10. The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes in NATURE COMMUNICATIONS
  • 2015-03. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy in NATURE MEDICINE
  • 2016-11. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2002-05. Effective expression of small interfering RNA in human cells in NATURE BIOTECHNOLOGY
  • 2012-06. The clonal and mutational evolution spectrum of primary triple-negative breast cancers in NATURE
  • 2016-10. Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas in NATURE GENETICS
  • 2012-06. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery in NATURE NANOTECHNOLOGY
  • 2016-05. Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology in MODERN PATHOLOGY
  • 2015-09. Knocking down disease: a progress report on siRNA therapeutics in NATURE REVIEWS GENETICS
  • 2007-06. Microenvironmental regulation of biomacromolecular therapies in NATURE REVIEWS DRUG DISCOVERY
  • 2015-12. Clinical experiences with systemically administered siRNA-based therapeutics in cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2014-08. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight in NATURE NANOTECHNOLOGY
  • 2015-04. TP53 loss creates therapeutic vulnerability in colorectal cancer in NATURE
  • 2016-06-06. PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery in NATURE COMMUNICATIONS
  • 2012-06. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups in NATURE
  • 2004-07. The RNAi revolution in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41565-019-0381-6

    DOI

    http://dx.doi.org/10.1038/s41565-019-0381-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112363480

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30804480


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA", 
                "Comprehensive Cancer Centre, The Ohio State University, Columbus, OH, USA", 
                "Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Jiangsheng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA", 
                "Melvin and Bren Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Yunhua", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA", 
                "Melvin and Bren Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Yujing", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA", 
                "Comprehensive Cancer Centre, The Ohio State University, Columbus, OH, USA", 
                "Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Hai", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Maryland, College Park", 
              "id": "https://www.grid.ac/institutes/grid.164295.d", 
              "name": [
                "Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stewart", 
            "givenName": "Samantha", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA", 
                "Melvin and Bren Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van der Jeught", 
            "givenName": "Kevin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agarwal", 
            "givenName": "Pranay", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Science and Technology of China", 
              "id": "https://www.grid.ac/institutes/grid.59053.3a", 
              "name": [
                "Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA", 
                "Department of Electronics Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Yuntian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Sheng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Science and Technology of China", 
              "id": "https://www.grid.ac/institutes/grid.59053.3a", 
              "name": [
                "Department of Electronics Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Gang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wan", 
            "givenName": "Jun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA", 
                "Melvin and Bren Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Xiongbin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Maryland, College Park", 
              "id": "https://www.grid.ac/institutes/grid.164295.d", 
              "name": [
                "Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA", 
                "Comprehensive Cancer Centre, The Ohio State University, Columbus, OH, USA", 
                "Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA", 
                "Robert E. Fischell Institute for Biomedical Devices, University of Maryland, College Park, MD, USA", 
                "Marlene and Stewart Greenebaum Comprehensive Cancer Centre, University of Maryland, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "He", 
            "givenName": "Xiaoming", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nnano.2014.84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001710843", 
              "https://doi.org/10.1038/nnano.2014.84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c5cc01833a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004257737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/natrevmats.2016.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004594619", 
              "https://doi.org/10.1038/natrevmats.2016.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005736302", 
              "https://doi.org/10.1038/ng.3651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007363608", 
              "https://doi.org/10.1038/nrg3978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/nn900002m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007726710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007839694", 
              "https://doi.org/10.1038/nature14418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-060815-014710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008029800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nnano.2012.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009035919", 
              "https://doi.org/10.1038/nnano.2012.73"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/natrevmats.2016.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010697489", 
              "https://doi.org/10.1038/natrevmats.2016.75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2016.66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011587927", 
              "https://doi.org/10.1038/nrclinonc.2016.66"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar200151m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013721634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014607335", 
              "https://doi.org/10.1038/nature10983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/nnm.15.166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014975535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2016.11.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015153159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017651463", 
              "https://doi.org/10.1038/nrd4389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019185606", 
              "https://doi.org/10.1038/nrd4685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2016.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022263509", 
              "https://doi.org/10.1038/modpathol.2016.39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.09.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023699296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201610916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024919609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat3187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025699959", 
              "https://doi.org/10.1038/nmat3187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1001389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025958385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027457561", 
              "https://doi.org/10.1038/nature10933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027869587", 
              "https://doi.org/10.1038/nrd3978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.05.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028349062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.2017311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029404270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032452479", 
              "https://doi.org/10.1038/ncomms11822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032921883", 
              "https://doi.org/10.1038/nbt0502-505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032921883", 
              "https://doi.org/10.1038/nbt0502-505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032997417", 
              "https://doi.org/10.1038/nature05541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032997417", 
              "https://doi.org/10.1038/nature05541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.68.4068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033489195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033882648", 
              "https://doi.org/10.1038/nm.3791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2016.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035604938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2016.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035604938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2016.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035604938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1235122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035954369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036478917", 
              "https://doi.org/10.1038/nbt.1807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2818.1993.tb03313.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037201678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/humu.10081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041992681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adma.201504263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042684143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043277214", 
              "https://doi.org/10.1038/nature05901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsnano.5b02471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045260879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046336552", 
              "https://doi.org/10.1038/nrd2309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pharmtox-010715-103633", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046684814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1101372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047322703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-3045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048367977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050455938", 
              "https://doi.org/10.1038/ncomms11479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/430161a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051698033", 
              "https://doi.org/10.1038/430161a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/430161a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051698033", 
              "https://doi.org/10.1038/430161a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(16)32454-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053231706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-2321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-00297-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090952715", 
              "https://doi.org/10.1038/s41467-017-00297-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04", 
        "datePublishedReg": "2019-04-01", 
        "description": "TP53 is the most frequently mutated or deleted gene in triple negative breast cancer (TNBC). Both the loss of TP53 and the lack of targeted therapy are significantly correlated with poor clinical outcomes, making TNBC the only type of breast cancer that has no approved targeted therapies. Through in silico analysis, we identified POLR2A in the TP53-neighbouring region as a collateral vulnerability target in TNBC tumours, suggesting that its inhibition via small interfering RNA (siRNA) may be an amenable approach for TNBC targeted treatment. To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delivery of POLR2A siRNA (siPol2). Suppression of POLR2A expression with the siPol2-laden nanoparticles leads to enhanced growth reduction of tumours characterized by hemizygous POLR2A loss. These results demonstrate the potential of the pH-responsive nanoparticle and the precise POLR2A targeted therapy in TNBC harbouring the common TP53 genomic alteration.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41565-019-0381-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5476206", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1037429", 
            "issn": [
              "1748-3387", 
              "1748-3395"
            ], 
            "name": "Nature Nanotechnology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer", 
        "pagination": "1-10", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "38ef37b1ea0cbfaa83581084d2cff53061d72748a71ee91d1089d39ddd48a42d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30804480"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101283273"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41565-019-0381-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112363480"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41565-019-0381-6", 
          "https://app.dimensions.ai/details/publication/pub.1112363480"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T14:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117103_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41565-019-0381-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0381-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0381-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0381-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41565-019-0381-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    328 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41565-019-0381-6 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Ne4c4172baf6f4318a16cff778c181ed4
    4 schema:citation sg:pub.10.1038/430161a
    5 sg:pub.10.1038/modpathol.2016.39
    6 sg:pub.10.1038/natrevmats.2016.14
    7 sg:pub.10.1038/natrevmats.2016.75
    8 sg:pub.10.1038/nature05541
    9 sg:pub.10.1038/nature05901
    10 sg:pub.10.1038/nature10933
    11 sg:pub.10.1038/nature10983
    12 sg:pub.10.1038/nature14418
    13 sg:pub.10.1038/nbt.1807
    14 sg:pub.10.1038/nbt0502-505
    15 sg:pub.10.1038/ncomms11479
    16 sg:pub.10.1038/ncomms11822
    17 sg:pub.10.1038/ng.3651
    18 sg:pub.10.1038/nm.3791
    19 sg:pub.10.1038/nmat3187
    20 sg:pub.10.1038/nnano.2012.73
    21 sg:pub.10.1038/nnano.2014.84
    22 sg:pub.10.1038/nrclinonc.2016.66
    23 sg:pub.10.1038/nrd2309
    24 sg:pub.10.1038/nrd3978
    25 sg:pub.10.1038/nrd4389
    26 sg:pub.10.1038/nrd4685
    27 sg:pub.10.1038/nrg3978
    28 sg:pub.10.1038/s41467-017-00297-x
    29 https://doi.org/10.1002/adma.201504263
    30 https://doi.org/10.1002/anie.201610916
    31 https://doi.org/10.1002/humu.10081
    32 https://doi.org/10.1016/j.addr.2016.06.011
    33 https://doi.org/10.1016/j.ccr.2010.05.026
    34 https://doi.org/10.1016/j.cell.2015.09.033
    35 https://doi.org/10.1016/j.tcb.2016.11.003
    36 https://doi.org/10.1016/s0140-6736(16)32454-0
    37 https://doi.org/10.1021/acsnano.5b02471
    38 https://doi.org/10.1021/ar200151m
    39 https://doi.org/10.1021/nn900002m
    40 https://doi.org/10.1039/c5cc01833a
    41 https://doi.org/10.1056/nejmra1001389
    42 https://doi.org/10.1101/gad.2017311
    43 https://doi.org/10.1111/j.1365-2818.1993.tb03313.x
    44 https://doi.org/10.1126/science.1101372
    45 https://doi.org/10.1126/science.1235122
    46 https://doi.org/10.1146/annurev-biochem-060815-014710
    47 https://doi.org/10.1146/annurev-pharmtox-010715-103633
    48 https://doi.org/10.1158/0008-5472.can-15-2321
    49 https://doi.org/10.1158/1078-0432.ccr-06-3045
    50 https://doi.org/10.1200/jco.2016.68.4068
    51 https://doi.org/10.2217/nnm.15.166
    52 schema:datePublished 2019-04
    53 schema:datePublishedReg 2019-04-01
    54 schema:description TP53 is the most frequently mutated or deleted gene in triple negative breast cancer (TNBC). Both the loss of TP53 and the lack of targeted therapy are significantly correlated with poor clinical outcomes, making TNBC the only type of breast cancer that has no approved targeted therapies. Through in silico analysis, we identified POLR2A in the TP53-neighbouring region as a collateral vulnerability target in TNBC tumours, suggesting that its inhibition via small interfering RNA (siRNA) may be an amenable approach for TNBC targeted treatment. To enhance bioavailability and improve endo/lysosomal escape of siRNA, we designed pH-activated nanoparticles for augmented cytosolic delivery of POLR2A siRNA (siPol2). Suppression of POLR2A expression with the siPol2-laden nanoparticles leads to enhanced growth reduction of tumours characterized by hemizygous POLR2A loss. These results demonstrate the potential of the pH-responsive nanoparticle and the precise POLR2A targeted therapy in TNBC harbouring the common TP53 genomic alteration.
    55 schema:genre research_article
    56 schema:inLanguage en
    57 schema:isAccessibleForFree false
    58 schema:isPartOf N2c8fa4a071254b52bffe2280e9154d32
    59 Nceb4b7f1cb3743e494c09e12a7af2909
    60 sg:journal.1037429
    61 schema:name Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer
    62 schema:pagination 1-10
    63 schema:productId N4ecece4e2cfc4590a7beaf957f1459b3
    64 N6cd96fe7b0e44678bc2ba4645db3a755
    65 N7f961f6fbb42473f83f73a4d58c9b2ba
    66 Nd9a0f3d0f72445daa8fc72a929db9030
    67 Nf55f37c4bb6c4e9487c8d7f37739b74d
    68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112363480
    69 https://doi.org/10.1038/s41565-019-0381-6
    70 schema:sdDatePublished 2019-04-11T14:18
    71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    72 schema:sdPublisher Na37c0df0f65c4b339999366d41c65597
    73 schema:url https://www.nature.com/articles/s41565-019-0381-6
    74 sgo:license sg:explorer/license/
    75 sgo:sdDataset articles
    76 rdf:type schema:ScholarlyArticle
    77 N0624a4be4e3649dcb03df04f68089006 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    78 schema:familyName Wang
    79 schema:givenName Hai
    80 rdf:type schema:Person
    81 N1941479717dd492184289a87e02f4745 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    82 schema:familyName Liu
    83 schema:givenName Sheng
    84 rdf:type schema:Person
    85 N1dddcf606a58475aa6e1f5be87a275e4 schema:affiliation https://www.grid.ac/institutes/grid.164295.d
    86 schema:familyName Stewart
    87 schema:givenName Samantha
    88 rdf:type schema:Person
    89 N2229bd894eee4c0c87e353f0a3fc311b schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    90 schema:familyName Van der Jeught
    91 schema:givenName Kevin
    92 rdf:type schema:Person
    93 N2c8fa4a071254b52bffe2280e9154d32 schema:volumeNumber 14
    94 rdf:type schema:PublicationVolume
    95 N4ecece4e2cfc4590a7beaf957f1459b3 schema:name doi
    96 schema:value 10.1038/s41565-019-0381-6
    97 rdf:type schema:PropertyValue
    98 N5147819e22964685a2cc799f95d85844 rdf:first N2229bd894eee4c0c87e353f0a3fc311b
    99 rdf:rest Nbaedb90e611442dda19dcef899dcfd42
    100 N5fef86119ff84aeb964aaac0a767eb06 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    101 schema:familyName Liu
    102 schema:givenName Yunhua
    103 rdf:type schema:Person
    104 N6a85e9059a0340efa311fc2cc0c98a95 rdf:first N79cf02c9e4b4441a8e37513fc57b1a9c
    105 rdf:rest rdf:nil
    106 N6cd96fe7b0e44678bc2ba4645db3a755 schema:name readcube_id
    107 schema:value 38ef37b1ea0cbfaa83581084d2cff53061d72748a71ee91d1089d39ddd48a42d
    108 rdf:type schema:PropertyValue
    109 N7503cb29241f4e7985c402fe27b0450c schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    110 schema:familyName Agarwal
    111 schema:givenName Pranay
    112 rdf:type schema:Person
    113 N761ebad7f87446b495da1d508a6901f4 rdf:first N1941479717dd492184289a87e02f4745
    114 rdf:rest Nb722339a98df4527b87921d84b915245
    115 N79b0e086f51e471f810b6be074bc8965 rdf:first Nb472acd1c95d4145865cb2076121f60a
    116 rdf:rest N9cff8cfd4f294992b8824d54f6330131
    117 N79cf02c9e4b4441a8e37513fc57b1a9c schema:affiliation https://www.grid.ac/institutes/grid.164295.d
    118 schema:familyName He
    119 schema:givenName Xiaoming
    120 rdf:type schema:Person
    121 N7f961f6fbb42473f83f73a4d58c9b2ba schema:name dimensions_id
    122 schema:value pub.1112363480
    123 rdf:type schema:PropertyValue
    124 N80b281a3b0544c12b883c1ff53435d70 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    125 schema:familyName Wan
    126 schema:givenName Jun
    127 rdf:type schema:Person
    128 N8329d94ceb7745dca091e3cdb518c594 rdf:first Ne5a5f5bc1ff3455da420da51179c91cd
    129 rdf:rest N761ebad7f87446b495da1d508a6901f4
    130 N83669868d290433d8a3f3d936f4e0145 rdf:first N80b281a3b0544c12b883c1ff53435d70
    131 rdf:rest Naa6ab37c0ceb4b81aedca5467cd7f05e
    132 N8ee7098c56524bf1bc596a1fbca308ff schema:affiliation https://www.grid.ac/institutes/grid.59053.3a
    133 schema:familyName Zhao
    134 schema:givenName Gang
    135 rdf:type schema:Person
    136 N9cff8cfd4f294992b8824d54f6330131 rdf:first N0624a4be4e3649dcb03df04f68089006
    137 rdf:rest Nf3904bee837444d7953f0c8f16f96e54
    138 Na37c0df0f65c4b339999366d41c65597 schema:name Springer Nature - SN SciGraph project
    139 rdf:type schema:Organization
    140 Naa6ab37c0ceb4b81aedca5467cd7f05e rdf:first Ndbf8d3f8c3b64005aa8627ae3dbdc216
    141 rdf:rest N6a85e9059a0340efa311fc2cc0c98a95
    142 Nad80563227264f638a198f8109f082d2 rdf:first N5fef86119ff84aeb964aaac0a767eb06
    143 rdf:rest N79b0e086f51e471f810b6be074bc8965
    144 Nb1076275b92e4abc80fd1761a18c92cf schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    145 schema:familyName Xu
    146 schema:givenName Jiangsheng
    147 rdf:type schema:Person
    148 Nb472acd1c95d4145865cb2076121f60a schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    149 schema:familyName Li
    150 schema:givenName Yujing
    151 rdf:type schema:Person
    152 Nb722339a98df4527b87921d84b915245 rdf:first N8ee7098c56524bf1bc596a1fbca308ff
    153 rdf:rest N83669868d290433d8a3f3d936f4e0145
    154 Nbaedb90e611442dda19dcef899dcfd42 rdf:first N7503cb29241f4e7985c402fe27b0450c
    155 rdf:rest N8329d94ceb7745dca091e3cdb518c594
    156 Nceb4b7f1cb3743e494c09e12a7af2909 schema:issueNumber 4
    157 rdf:type schema:PublicationIssue
    158 Nd9a0f3d0f72445daa8fc72a929db9030 schema:name nlm_unique_id
    159 schema:value 101283273
    160 rdf:type schema:PropertyValue
    161 Ndbf8d3f8c3b64005aa8627ae3dbdc216 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    162 schema:familyName Lu
    163 schema:givenName Xiongbin
    164 rdf:type schema:Person
    165 Ne4c4172baf6f4318a16cff778c181ed4 rdf:first Nb1076275b92e4abc80fd1761a18c92cf
    166 rdf:rest Nad80563227264f638a198f8109f082d2
    167 Ne5a5f5bc1ff3455da420da51179c91cd schema:affiliation https://www.grid.ac/institutes/grid.59053.3a
    168 schema:familyName Zhang
    169 schema:givenName Yuntian
    170 rdf:type schema:Person
    171 Nf3904bee837444d7953f0c8f16f96e54 rdf:first N1dddcf606a58475aa6e1f5be87a275e4
    172 rdf:rest N5147819e22964685a2cc799f95d85844
    173 Nf55f37c4bb6c4e9487c8d7f37739b74d schema:name pubmed_id
    174 schema:value 30804480
    175 rdf:type schema:PropertyValue
    176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Medical and Health Sciences
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Oncology and Carcinogenesis
    181 rdf:type schema:DefinedTerm
    182 sg:grant.5476206 http://pending.schema.org/fundedItem sg:pub.10.1038/s41565-019-0381-6
    183 rdf:type schema:MonetaryGrant
    184 sg:journal.1037429 schema:issn 1748-3387
    185 1748-3395
    186 schema:name Nature Nanotechnology
    187 rdf:type schema:Periodical
    188 sg:pub.10.1038/430161a schema:sameAs https://app.dimensions.ai/details/publication/pub.1051698033
    189 https://doi.org/10.1038/430161a
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/modpathol.2016.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022263509
    192 https://doi.org/10.1038/modpathol.2016.39
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/natrevmats.2016.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004594619
    195 https://doi.org/10.1038/natrevmats.2016.14
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/natrevmats.2016.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010697489
    198 https://doi.org/10.1038/natrevmats.2016.75
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/nature05541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032997417
    201 https://doi.org/10.1038/nature05541
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/nature05901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043277214
    204 https://doi.org/10.1038/nature05901
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/nature10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
    207 https://doi.org/10.1038/nature10933
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
    210 https://doi.org/10.1038/nature10983
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nature14418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007839694
    213 https://doi.org/10.1038/nature14418
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nbt.1807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036478917
    216 https://doi.org/10.1038/nbt.1807
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nbt0502-505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921883
    219 https://doi.org/10.1038/nbt0502-505
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/ncomms11479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050455938
    222 https://doi.org/10.1038/ncomms11479
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/ncomms11822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032452479
    225 https://doi.org/10.1038/ncomms11822
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/ng.3651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005736302
    228 https://doi.org/10.1038/ng.3651
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nm.3791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033882648
    231 https://doi.org/10.1038/nm.3791
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nmat3187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025699959
    234 https://doi.org/10.1038/nmat3187
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nnano.2012.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009035919
    237 https://doi.org/10.1038/nnano.2012.73
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nnano.2014.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001710843
    240 https://doi.org/10.1038/nnano.2014.84
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nrclinonc.2016.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011587927
    243 https://doi.org/10.1038/nrclinonc.2016.66
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nrd2309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046336552
    246 https://doi.org/10.1038/nrd2309
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nrd3978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027869587
    249 https://doi.org/10.1038/nrd3978
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nrd4389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017651463
    252 https://doi.org/10.1038/nrd4389
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nrd4685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019185606
    255 https://doi.org/10.1038/nrd4685
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nrg3978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007363608
    258 https://doi.org/10.1038/nrg3978
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/s41467-017-00297-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1090952715
    261 https://doi.org/10.1038/s41467-017-00297-x
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/adma.201504263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042684143
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/anie.201610916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024919609
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/humu.10081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041992681
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.addr.2016.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035604938
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.ccr.2010.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028349062
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.cell.2015.09.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023699296
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.tcb.2016.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015153159
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0140-6736(16)32454-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053231706
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1021/acsnano.5b02471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045260879
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1021/ar200151m schema:sameAs https://app.dimensions.ai/details/publication/pub.1013721634
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1021/nn900002m schema:sameAs https://app.dimensions.ai/details/publication/pub.1007726710
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1039/c5cc01833a schema:sameAs https://app.dimensions.ai/details/publication/pub.1004257737
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1056/nejmra1001389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025958385
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1101/gad.2017311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029404270
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1111/j.1365-2818.1993.tb03313.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037201678
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1126/science.1101372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047322703
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1126/science.1235122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035954369
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1146/annurev-biochem-060815-014710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008029800
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1146/annurev-pharmtox-010715-103633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046684814
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1158/0008-5472.can-15-2321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215962
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1158/1078-0432.ccr-06-3045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048367977
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1200/jco.2016.68.4068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033489195
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.2217/nnm.15.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014975535
    308 rdf:type schema:CreativeWork
    309 https://www.grid.ac/institutes/grid.164295.d schema:alternateName University of Maryland, College Park
    310 schema:name Comprehensive Cancer Centre, The Ohio State University, Columbus, OH, USA
    311 Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
    312 Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA
    313 Marlene and Stewart Greenebaum Comprehensive Cancer Centre, University of Maryland, Baltimore, MD, USA
    314 Robert E. Fischell Institute for Biomedical Devices, University of Maryland, College Park, MD, USA
    315 rdf:type schema:Organization
    316 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
    317 schema:name Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    318 Melvin and Bren Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, IN, USA
    319 rdf:type schema:Organization
    320 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
    321 schema:name Comprehensive Cancer Centre, The Ohio State University, Columbus, OH, USA
    322 Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
    323 Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA
    324 rdf:type schema:Organization
    325 https://www.grid.ac/institutes/grid.59053.3a schema:alternateName University of Science and Technology of China
    326 schema:name Department of Electronics Science and Technology, University of Science and Technology of China, Hefei, Anhui, China
    327 Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA
    328 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...