We shouldn’t worry when a virus mutates during disease outbreaks View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-02-18

AUTHORS

Nathan D. Grubaugh, Mary E. Petrone, Edward C. Holmes

ABSTRACT

Mutation. The word naturally conjures fears of unexpected and freakish changes. Ill-informed discussions of mutations thrive during virus outbreaks, including the ongoing spread of SARS-CoV-2. In reality, mutations are a natural part of the virus life cycle and rarely impact outbreaks dramatically.

PAGES

529-530

References to SciGraph publications

  • 2018-12-13. Tracking virus outbreaks in the twenty-first century in NATURE MICROBIOLOGY
  • 2018-12-10. Origin and evolution of pathogenic coronaviruses in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-020-0690-4

    DOI

    http://dx.doi.org/10.1038/s41564-020-0690-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1124934783

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32071422


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptation, Physiological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Betacoronavirus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "COVID-19", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronavirus Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Evolution, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Host-Pathogen Interactions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pandemics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumonia, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "SARS-CoV-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Selection, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spike Glycoprotein, Coronavirus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Virulence", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Yale Institute for Global Health, Yale University, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA", 
                "Yale Institute for Global Health, Yale University, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grubaugh", 
            "givenName": "Nathan D.", 
            "id": "sg:person.0764330450.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764330450.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petrone", 
            "givenName": "Mary E.", 
            "id": "sg:person.015255357631.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015255357631.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1013.3", 
              "name": [
                "Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holmes", 
            "givenName": "Edward C.", 
            "id": "sg:person.012501436222.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012501436222.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41579-018-0118-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110510319", 
              "https://doi.org/10.1038/s41579-018-0118-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41564-018-0296-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110346428", 
              "https://doi.org/10.1038/s41564-018-0296-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-02-18", 
        "datePublishedReg": "2020-02-18", 
        "description": "Mutation. The word naturally conjures fears of unexpected and freakish changes. Ill-informed discussions of mutations thrive during virus outbreaks, including the ongoing spread of SARS-CoV-2. In reality, mutations are a natural part of the virus life cycle and rarely impact outbreaks dramatically.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41564-020-0690-4", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5476135", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5475983", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1052984", 
            "issn": [
              "2058-5276"
            ], 
            "name": "Nature Microbiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "keywords": [
          "SARS-CoV-2", 
          "virus life cycle", 
          "virus mutates", 
          "virus outbreak", 
          "ongoing spread", 
          "disease outbreaks", 
          "outbreak", 
          "mutations", 
          "fear", 
          "natural part", 
          "spread", 
          "changes", 
          "ills", 
          "life cycle", 
          "mutate", 
          "cycle", 
          "part", 
          "discussion", 
          "words", 
          "reality"
        ], 
        "name": "We shouldn\u2019t worry when a virus mutates during disease outbreaks", 
        "pagination": "529-530", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1124934783"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41564-020-0690-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32071422"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41564-020-0690-4", 
          "https://app.dimensions.ai/details/publication/pub.1124934783"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_848.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41564-020-0690-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41564-020-0690-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41564-020-0690-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41564-020-0690-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41564-020-0690-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    175 TRIPLES      21 PREDICATES      63 URIs      53 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41564-020-0690-4 schema:about N4dc35444cd964c51ae18a9e97b4ee7bd
    2 N58d841cc0b48478abbba696d094efb3b
    3 N5e92fba4b7db4ac5859b13db1af58193
    4 N645e6cd38b7e4b508cebaf20e3d33f5e
    5 N66e578f88f90461f8947c1dcde804866
    6 N681c8119dbe04da2b79c1b9e80b2e042
    7 N69f5f6b7e54146ce812d0408ef521293
    8 N7154b29044a34c31b14c699b07a793f4
    9 N79b72a1e129c4c9fba1c57131e4900b8
    10 N79eb6bacdf964f53ba85e94945f15083
    11 N9a0bbc578fda4e3abd94ef3ec7b7a7c5
    12 Na943534ce158415a96ab173d821af4dc
    13 Nb5bf2f9dedf54103ad49bcde0dbd3951
    14 Nc84392e7f2474617852948f53c8b7241
    15 Nf0a2a21224fe4ee1be2bdefba3347a5d
    16 Nfb5601d78c6d43148ef8e79104ae75b1
    17 anzsrc-for:11
    18 anzsrc-for:1108
    19 schema:author Ne3e1c18ebc644eb7970c768ae9be1f7e
    20 schema:citation sg:pub.10.1038/s41564-018-0296-2
    21 sg:pub.10.1038/s41579-018-0118-9
    22 schema:datePublished 2020-02-18
    23 schema:datePublishedReg 2020-02-18
    24 schema:description Mutation. The word naturally conjures fears of unexpected and freakish changes. Ill-informed discussions of mutations thrive during virus outbreaks, including the ongoing spread of SARS-CoV-2. In reality, mutations are a natural part of the virus life cycle and rarely impact outbreaks dramatically.
    25 schema:genre article
    26 schema:isAccessibleForFree true
    27 schema:isPartOf N36aad4322e2549fd863a42b67b10587f
    28 N3ef465a067cd46d8a9f62b1a769feea6
    29 sg:journal.1052984
    30 schema:keywords SARS-CoV-2
    31 changes
    32 cycle
    33 discussion
    34 disease outbreaks
    35 fear
    36 ills
    37 life cycle
    38 mutate
    39 mutations
    40 natural part
    41 ongoing spread
    42 outbreak
    43 part
    44 reality
    45 spread
    46 virus life cycle
    47 virus mutates
    48 virus outbreak
    49 words
    50 schema:name We shouldn’t worry when a virus mutates during disease outbreaks
    51 schema:pagination 529-530
    52 schema:productId N0651090b812446a180f0b7939e79075b
    53 N5af353f376fe4cb78524f7ad33dab380
    54 Nd0e1a775afef4ad4bf6a1bddc02e0118
    55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124934783
    56 https://doi.org/10.1038/s41564-020-0690-4
    57 schema:sdDatePublished 2022-08-04T17:08
    58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    59 schema:sdPublisher Ndd0d5fcbd38b458483ba1497f7fc1b7f
    60 schema:url https://doi.org/10.1038/s41564-020-0690-4
    61 sgo:license sg:explorer/license/
    62 sgo:sdDataset articles
    63 rdf:type schema:ScholarlyArticle
    64 N0651090b812446a180f0b7939e79075b schema:name dimensions_id
    65 schema:value pub.1124934783
    66 rdf:type schema:PropertyValue
    67 N36aad4322e2549fd863a42b67b10587f schema:issueNumber 4
    68 rdf:type schema:PublicationIssue
    69 N3ed42da88050471883f5b25f7fb95e71 rdf:first sg:person.012501436222.04
    70 rdf:rest rdf:nil
    71 N3ef465a067cd46d8a9f62b1a769feea6 schema:volumeNumber 5
    72 rdf:type schema:PublicationVolume
    73 N4dc35444cd964c51ae18a9e97b4ee7bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Host-Pathogen Interactions
    75 rdf:type schema:DefinedTerm
    76 N58d841cc0b48478abbba696d094efb3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Pneumonia, Viral
    78 rdf:type schema:DefinedTerm
    79 N5af353f376fe4cb78524f7ad33dab380 schema:name pubmed_id
    80 schema:value 32071422
    81 rdf:type schema:PropertyValue
    82 N5e92fba4b7db4ac5859b13db1af58193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Virulence
    84 rdf:type schema:DefinedTerm
    85 N645e6cd38b7e4b508cebaf20e3d33f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Selection, Genetic
    87 rdf:type schema:DefinedTerm
    88 N66e578f88f90461f8947c1dcde804866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Animals
    90 rdf:type schema:DefinedTerm
    91 N681c8119dbe04da2b79c1b9e80b2e042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Spike Glycoprotein, Coronavirus
    93 rdf:type schema:DefinedTerm
    94 N69f5f6b7e54146ce812d0408ef521293 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Gene Expression
    96 rdf:type schema:DefinedTerm
    97 N7154b29044a34c31b14c699b07a793f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Pandemics
    99 rdf:type schema:DefinedTerm
    100 N79b72a1e129c4c9fba1c57131e4900b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Mutation
    102 rdf:type schema:DefinedTerm
    103 N79eb6bacdf964f53ba85e94945f15083 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Evolution, Molecular
    105 rdf:type schema:DefinedTerm
    106 N9a0bbc578fda4e3abd94ef3ec7b7a7c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Adaptation, Physiological
    108 rdf:type schema:DefinedTerm
    109 Na943534ce158415a96ab173d821af4dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name COVID-19
    111 rdf:type schema:DefinedTerm
    112 Nb5bf2f9dedf54103ad49bcde0dbd3951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Betacoronavirus
    114 rdf:type schema:DefinedTerm
    115 Nc84392e7f2474617852948f53c8b7241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name SARS-CoV-2
    117 rdf:type schema:DefinedTerm
    118 Nd0e1a775afef4ad4bf6a1bddc02e0118 schema:name doi
    119 schema:value 10.1038/s41564-020-0690-4
    120 rdf:type schema:PropertyValue
    121 Ndd0d5fcbd38b458483ba1497f7fc1b7f schema:name Springer Nature - SN SciGraph project
    122 rdf:type schema:Organization
    123 Ne16174e6a1994c919e12b9f2fc60aa10 rdf:first sg:person.015255357631.94
    124 rdf:rest N3ed42da88050471883f5b25f7fb95e71
    125 Ne3e1c18ebc644eb7970c768ae9be1f7e rdf:first sg:person.0764330450.63
    126 rdf:rest Ne16174e6a1994c919e12b9f2fc60aa10
    127 Nf0a2a21224fe4ee1be2bdefba3347a5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Coronavirus Infections
    129 rdf:type schema:DefinedTerm
    130 Nfb5601d78c6d43148ef8e79104ae75b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Humans
    132 rdf:type schema:DefinedTerm
    133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    134 schema:name Medical and Health Sciences
    135 rdf:type schema:DefinedTerm
    136 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Medical Microbiology
    138 rdf:type schema:DefinedTerm
    139 sg:grant.5475983 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-020-0690-4
    140 rdf:type schema:MonetaryGrant
    141 sg:grant.5476135 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-020-0690-4
    142 rdf:type schema:MonetaryGrant
    143 sg:journal.1052984 schema:issn 2058-5276
    144 schema:name Nature Microbiology
    145 schema:publisher Springer Nature
    146 rdf:type schema:Periodical
    147 sg:person.012501436222.04 schema:affiliation grid-institutes:grid.1013.3
    148 schema:familyName Holmes
    149 schema:givenName Edward C.
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012501436222.04
    151 rdf:type schema:Person
    152 sg:person.015255357631.94 schema:affiliation grid-institutes:grid.47100.32
    153 schema:familyName Petrone
    154 schema:givenName Mary E.
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015255357631.94
    156 rdf:type schema:Person
    157 sg:person.0764330450.63 schema:affiliation grid-institutes:grid.47100.32
    158 schema:familyName Grubaugh
    159 schema:givenName Nathan D.
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764330450.63
    161 rdf:type schema:Person
    162 sg:pub.10.1038/s41564-018-0296-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110346428
    163 https://doi.org/10.1038/s41564-018-0296-2
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1038/s41579-018-0118-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110510319
    166 https://doi.org/10.1038/s41579-018-0118-9
    167 rdf:type schema:CreativeWork
    168 grid-institutes:grid.1013.3 schema:alternateName Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia
    169 schema:name Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, New South Wales, Australia
    170 rdf:type schema:Organization
    171 grid-institutes:grid.47100.32 schema:alternateName Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA
    172 Yale Institute for Global Health, Yale University, New Haven, CT, USA
    173 schema:name Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA
    174 Yale Institute for Global Health, Yale University, New Haven, CT, USA
    175 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...