Growth effects of N-acylethanolamines on gut bacteria reflect altered bacterial abundances in inflammatory bowel disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-20

AUTHORS

Nadine Fornelos, Eric A. Franzosa, Jason Bishai, John W. Annand, Akihiko Oka, Jason Lloyd-Price, Timothy D. Arthur, Ashley Garner, Julian Avila-Pacheco, Henry J. Haiser, Andrew C. Tolonen, Jeffrey A. Porter, Clary B. Clish, R. Balfour Sartor, Curtis Huttenhower, Hera Vlamakis, Ramnik J. Xavier

ABSTRACT

Inflammatory bowel diseases (IBD) are associated with alterations in gut microbial abundances and lumenal metabolite concentrations, but the effects of specific metabolites on the gut microbiota in health and disease remain largely unknown. Here, we analysed the influences of metabolites that are differentially abundant in IBD on the growth and physiology of gut bacteria that are also differentially abundant in IBD. We found that N-acylethanolamines (NAEs), a class of endogenously produced signalling lipids elevated in the stool of IBD patients and a T-cell transfer model of colitis, stimulated growth of species over-represented in IBD and inhibited that of species depleted in IBD in vitro. Using metagenomic sequencing, we recapitulated the effects of NAEs in complex microbial communities ex vivo, with Proteobacteria blooming and Bacteroidetes declining in the presence of NAEs. Metatranscriptomic analysis of the same communities identified components of the respiratory chain as important for the metabolism of NAEs, and this was verified using a mutant deficient for respiratory complex I. In this study, we identified NAEs as a class of metabolites that are elevated in IBD and have the potential to shift gut microbiota towards an IBD-like composition. More... »

PAGES

486-497

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-019-0655-7

    DOI

    http://dx.doi.org/10.1038/s41564-019-0655-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1124191048

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31959971


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