HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Yonatan Ganor, Fernando Real, Alexis Sennepin, Charles-Antoine Dutertre, Lisa Prevedel, Lin Xu, Daniela Tudor, Bénédicte Charmeteau, Anne Couedel-Courteille, Sabrina Marion, Ali-Redha Zenak, Jean-Pierre Jourdain, Zhicheng Zhou, Alain Schmitt, Claude Capron, Eliseo A Eugenin, Rémi Cheynier, Marc Revol, Sarra Cristofari, Anne Hosmalin, Morgane Bomsel

ABSTRACT

Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital mucosal tissues (the main HIV-1 entry portal on sexual transmission). Here, we show, using penile tissues from HIV-1-infected individuals under suppressive combination antiretroviral therapy, that urethral macrophages contain integrated HIV-1 DNA, RNA, proteins and intact virions in virus-containing compartment-like structures, whereas viral components remain undetectable in urethral T cells. Moreover, urethral cells specifically release replication-competent infectious HIV-1 following reactivation with the macrophage activator lipopolysaccharide, while the T-cell activator phytohaemagglutinin is ineffective. HIV-1 urethral reservoirs localize preferentially in a subset of polarized macrophages that highly expresses the interleukin-1 receptor, CD206 and interleukin-4 receptor, but not CD163. To our knowledge, these results are the first evidence that human urethral tissue macrophages constitute a principal HIV-1 reservoir. Such findings are determinant for therapeutic strategies aimed at HIV-1 eradication. More... »

PAGES

633-644

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-018-0335-z

    DOI

    http://dx.doi.org/10.1038/s41564-018-0335-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111908170

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30718846


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