Metatranscriptome of human faecal microbial communities in a cohort of adult men View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-15

AUTHORS

Galeb S. Abu-Ali, Raaj S. Mehta, Jason Lloyd-Price, Himel Mallick, Tobyn Branck, Kerry L. Ivey, David A. Drew, Casey DuLong, Eric Rimm, Jacques Izard, Andrew T. Chan, Curtis Huttenhower

ABSTRACT

The gut microbiome is intimately related to human health, but it is not yet known which functional activities are driven by specific microorganisms' ecological configurations or transcription. We report a large-scale investigation of 372 human faecal metatranscriptomes and 929 metagenomes from a subset of 308 men in the Health Professionals Follow-Up Study. We identified a metatranscriptomic 'core' universally transcribed over time and across participants, often by different microorganisms. In contrast to the housekeeping functions enriched in this core, a 'variable' metatranscriptome included specialized pathways that were differentially expressed both across participants and among microorganisms. Finally, longitudinal metagenomic profiles allowed ecological interaction network reconstruction, which remained stable over the six-month timespan, as did strain tracking within and between participants. These results provide an initial characterization of human faecal microbial ecology into core, subject-specific, microorganism-specific and temporally variable transcription, and they differentiate metagenomically versus metatranscriptomically informative aspects of the human faecal microbiome. More... »

PAGES

356-366

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-017-0084-4

    DOI

    http://dx.doi.org/10.1038/s41564-017-0084-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100404462

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29335555


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    357 Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    358 The Broad Institute, Cambridge, MA, USA
    359 rdf:type schema:Organization
    360 grid-institutes:grid.66859.34 schema:alternateName The Broad Institute, Cambridge, MA, USA
    361 schema:name Biostatistics Department, Harvard T. H. Chan School of Public Health, Boston, MA, USA
    362 The Broad Institute, Cambridge, MA, USA
    363 rdf:type schema:Organization
     




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