Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-27

AUTHORS

Anjelique F. Schulfer, Thomas Battaglia, Yelina Alvarez, Luc Bijnens, Victoria E. Ruiz, Melody Ho, Serina Robinson, Tonya Ward, Laura M. Cox, Arlin B. Rogers, Dan Knights, R. Balfour Sartor, Martin J. Blaser

ABSTRACT

Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here we demonstrate that germ-free adult pregnant mice inoculated with a gut microbial community shaped by antibiotic exposure transmitted their perturbed microbiota to their offspring with high fidelity. Without any direct or continued exposure to antibiotics, this dysbiotic microbiota in the offspring remained distinct from controls for at least 21 weeks. By using both IL-10-deficient and wild-type mothers, we showed that both inoculum and genotype shape microbiota populations in the offspring. Because IL10-/- mice are genetically susceptible to colitis, we could assess the risk due to maternal transmission of an antibiotic-perturbed microbiota. We found that the IL10-/- offspring that had received the perturbed gut microbiota developed markedly increased colitis. Taken together, our findings indicate that antibiotic exposure shaping the maternal gut microbiota has effects that extend to the offspring, with both ecological and long-term disease consequences. More... »

PAGES

234-242

References to SciGraph publications

  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2016-07-13. Human gut microbes impact host serum metabolome and insulin sensitivity in NATURE
  • 2014-07-11. Infant antibiotic exposure and the development of childhood overweight and central adiposity in INTERNATIONAL JOURNAL OF OBESITY
  • 2011-12-01. An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2016-08-22. Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice in NATURE MICROBIOLOGY
  • 2009. Helicobacter -Based Mouse Models of Digestive System Carcinogenesis in INFLAMMATION AND CANCER
  • 2014-10-07. Branched-chain amino acids in metabolic signalling and insulin resistance in NATURE REVIEWS ENDOCRINOLOGY
  • 2016-01-13. Diet-induced extinction in the gut microbiota compounds over generations in NATURE
  • 2011-06-24. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2011-09-13. Association Between the Use of Antibiotics and New Diagnoses of Crohn's Disease and Ulcerative Colitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2016-04-27. Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet in GENOME MEDICINE
  • 2015-05-11. IL-10 producing intestinal macrophages prevent excessive anti-bacterial innate immunity by limiting IL-23 synthesis in NATURE COMMUNICATIONS
  • 2009-04-14. Prescription of drugs during pregnancy: a study using EFEMERIS, the new French database in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 2007-05-01. Long-term ecological impacts of antibiotic administration on the human intestinal microbiota in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2017-02-13. Dynamics of the human gut microbiome in Inflammatory Bowel Disease in NATURE MICROBIOLOGY
  • Journal

    TITLE

    Nature Microbiology

    ISSUE

    2

    VOLUME

    3

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-017-0075-5

    DOI

    http://dx.doi.org/10.1038/s41564-017-0075-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092999920

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29180726


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Bacterial Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colitis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet, High-Fat", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Susceptibility", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dysbiosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Feces", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammatory Bowel Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-10", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metagenome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pathology, NYU Langone Medical Center, New York, New York, USA, 10016", 
              "id": "http://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Department of Microbiology, NYU Langone Medical Center, New York, New York, USA, 10016", 
                "Department of Pathology, NYU Langone Medical Center, New York, New York, USA, 10016"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schulfer", 
            "givenName": "Anjelique F.", 
            "id": "sg:person.01254370327.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254370327.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016", 
              "id": "http://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Battaglia", 
            "givenName": "Thomas", 
            "id": "sg:person.01116676571.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116676571.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016", 
              "id": "http://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alvarez", 
            "givenName": "Yelina", 
            "id": "sg:person.01015326712.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015326712.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bijnens", 
            "givenName": "Luc", 
            "id": "sg:person.01130440000.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130440000.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016", 
              "id": "http://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruiz", 
            "givenName": "Victoria E.", 
            "id": "sg:person.01176034505.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176034505.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016", 
              "id": "http://www.grid.ac/institutes/grid.240324.3", 
              "name": [
                "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ho", 
            "givenName": "Melody", 
            "id": "sg:person.013117772626.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013117772626.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA, 55455", 
              "id": "http://www.grid.ac/institutes/grid.17635.36", 
              "name": [
                "Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA, 55455"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robinson", 
            "givenName": "Serina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biotechnology Institute, University of Minnesota, Minneapolis, Minnesota, USA, 55455", 
              "id": "http://www.grid.ac/institutes/grid.17635.36", 
              "name": [
                "Biotechnology Institute, University of Minnesota, Minneapolis, Minnesota, USA, 55455"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ward", 
            "givenName": "Tonya", 
            "id": "sg:person.0602226221.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602226221.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston, MA, USA, 02115", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016", 
                "Department of Neurology, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston, MA, USA, 02115"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cox", 
            "givenName": "Laura M.", 
            "id": "sg:person.0704534574.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704534574.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA, 01536", 
              "id": "http://www.grid.ac/institutes/grid.429997.8", 
              "name": [
                "Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA, 01536"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rogers", 
            "givenName": "Arlin B.", 
            "id": "sg:person.016146304737.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016146304737.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA, 55455", 
              "id": "http://www.grid.ac/institutes/grid.17635.36", 
              "name": [
                "Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA, 55455"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knights", 
            "givenName": "Dan", 
            "id": "sg:person.01054701157.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054701157.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA, 27599", 
              "id": "http://www.grid.ac/institutes/grid.410711.2", 
              "name": [
                "Departments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA, 27599"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sartor", 
            "givenName": "R. Balfour", 
            "id": "sg:person.012300373417.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012300373417.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York Harbor Veterans Affairs Medical Center, New York, New York, USA, 10010", 
              "id": "http://www.grid.ac/institutes/grid.274295.f", 
              "name": [
                "Department of Microbiology, NYU Langone Medical Center, New York, New York, USA, 10016", 
                "Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016", 
                "New York Harbor Veterans Affairs Medical Center, New York, New York, USA, 10010"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blaser", 
            "givenName": "Martin J.", 
            "id": "sg:person.01013345173.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013345173.52"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature18646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017924056", 
              "https://doi.org/10.1038/nature18646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033784361", 
              "https://doi.org/10.1038/ajg.2011.304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033081104", 
              "https://doi.org/10.1038/ncomms8055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2007.3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049335767", 
              "https://doi.org/10.1038/ismej.2007.3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ismej.2011.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051863807", 
              "https://doi.org/10.1038/ismej.2011.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-016-0297-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028545434", 
              "https://doi.org/10.1186/s13073-016-0297-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2017.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083801915", 
              "https://doi.org/10.1038/nmicrobiol.2017.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00228-009-0647-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012738735", 
              "https://doi.org/10.1007/s00228-009-0647-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-447-6_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035567877", 
              "https://doi.org/10.1007/978-1-59745-447-6_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmicrobiol.2016.140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022996683", 
              "https://doi.org/10.1038/nmicrobiol.2016.140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2014.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042102254", 
              "https://doi.org/10.1038/ijo.2014.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrendo.2014.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012805361", 
              "https://doi.org/10.1038/nrendo.2014.171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048142283", 
              "https://doi.org/10.1038/nature16504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-6-r60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000243423", 
              "https://doi.org/10.1186/gb-2011-12-6-r60"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-11-27", 
        "datePublishedReg": "2017-11-27", 
        "description": "Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here we demonstrate that germ-free adult pregnant mice inoculated with a gut microbial community shaped by antibiotic exposure transmitted their perturbed microbiota to their offspring with high fidelity. Without any direct or continued exposure to antibiotics, this dysbiotic microbiota in the offspring remained distinct from controls for at least 21 weeks. By using both IL-10-deficient and wild-type mothers, we showed that both inoculum and genotype shape microbiota populations in the offspring. Because IL10-/- mice are genetically susceptible to colitis, we could assess the risk due to maternal transmission of an antibiotic-perturbed microbiota. We found that the IL10-/- offspring that had received the perturbed gut microbiota developed markedly increased colitis. Taken together, our findings indicate that antibiotic exposure shaping the maternal gut microbiota has effects that extend to the offspring, with both ecological and long-term disease consequences.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41564-017-0075-5", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438821", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2436207", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2500335", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438822", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439546", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438988", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1052984", 
            "issn": [
              "2058-5276"
            ], 
            "name": "Nature Microbiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "3"
          }
        ], 
        "keywords": [
          "inflammatory bowel disease", 
          "antibiotic exposure", 
          "gut microbiota", 
          "perturbed gut microbiota", 
          "maternal gut microbiota", 
          "wild-type mothers", 
          "perturbed microbiota", 
          "dysbiotic microbiota", 
          "bowel disease", 
          "susceptible mice", 
          "pregnant mothers", 
          "pregnant mice", 
          "antibiotic use", 
          "intestinal microbiome", 
          "microbiota populations", 
          "gut microbial community", 
          "disease consequences", 
          "mice", 
          "continued exposure", 
          "microbiota", 
          "IL10", 
          "maternal transmission", 
          "mothers", 
          "children", 
          "risk", 
          "exposure", 
          "offspring", 
          "colitis", 
          "disease", 
          "weeks", 
          "antibiotics", 
          "microbiome", 
          "population", 
          "findings", 
          "control", 
          "effect", 
          "transmission", 
          "use", 
          "consequences", 
          "inoculum", 
          "community", 
          "transfer", 
          "high fidelity", 
          "microbial communities", 
          "fidelity", 
          "intergenerational transfers", 
          "antibiotic-perturbed microbiota", 
          "germ-free adult pregnant mice", 
          "adult pregnant mice", 
          "genotype shape microbiota populations", 
          "shape microbiota populations", 
          "long-term disease consequences"
        ], 
        "name": "Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice", 
        "pagination": "234-242", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092999920"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41564-017-0075-5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29180726"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41564-017-0075-5", 
          "https://app.dimensions.ai/details/publication/pub.1092999920"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_722.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41564-017-0075-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41564-017-0075-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41564-017-0075-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41564-017-0075-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41564-017-0075-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    368 TRIPLES      22 PREDICATES      111 URIs      88 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41564-017-0075-5 schema:about N06a5c716ef274d05b1e5aa1510de665c
    2 N2c200dd737c9418f9f05d33b7fab7acd
    3 N2d1b6af0faf34ffa8ad49ba76091dce5
    4 N39fb75b39dac4f2bb9d2eafdcf12fba4
    5 N3ee63b17a05d4ced8d075bfbd9849132
    6 N585caa4372c7438190fdfbb0c0d194bd
    7 N5a122c38f4d5430fa39366659ed90258
    8 N6b5fe7755b424ffea788c37eeac0aa84
    9 N76773381e3a64061ab08e88b78a39e0d
    10 N867242b8000b4df6bd7e5aab8a914f32
    11 N8a71c335313046ea984280ae7672f431
    12 N8e448c2fbeb94bcaba4efca2034ecbd7
    13 N922cca97de84442fa17738739a6fb68c
    14 Na85d91511c714d47bb3f9e60e00e515f
    15 Nb318f72d51934609ac8d524585598117
    16 Nc691df2c4c984adc92a52091cdb93365
    17 Nc6c53a3235824b9cbae88e4cbb4c9217
    18 Nde14bbafcd4a445db68050f86d6fb94a
    19 anzsrc-for:11
    20 anzsrc-for:1114
    21 schema:author N10e38c28443c483f8dc717f960d7dc71
    22 schema:citation sg:pub.10.1007/978-1-59745-447-6_11
    23 sg:pub.10.1007/s00228-009-0647-2
    24 sg:pub.10.1038/ajg.2011.304
    25 sg:pub.10.1038/ijo.2014.119
    26 sg:pub.10.1038/ismej.2007.3
    27 sg:pub.10.1038/ismej.2011.139
    28 sg:pub.10.1038/nature16504
    29 sg:pub.10.1038/nature18646
    30 sg:pub.10.1038/ncomms8055
    31 sg:pub.10.1038/nmeth.f.303
    32 sg:pub.10.1038/nmicrobiol.2016.140
    33 sg:pub.10.1038/nmicrobiol.2017.4
    34 sg:pub.10.1038/nrendo.2014.171
    35 sg:pub.10.1186/gb-2011-12-6-r60
    36 sg:pub.10.1186/s13073-016-0297-9
    37 schema:datePublished 2017-11-27
    38 schema:datePublishedReg 2017-11-27
    39 schema:description Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here we demonstrate that germ-free adult pregnant mice inoculated with a gut microbial community shaped by antibiotic exposure transmitted their perturbed microbiota to their offspring with high fidelity. Without any direct or continued exposure to antibiotics, this dysbiotic microbiota in the offspring remained distinct from controls for at least 21 weeks. By using both IL-10-deficient and wild-type mothers, we showed that both inoculum and genotype shape microbiota populations in the offspring. Because IL10<sup>-/-</sup> mice are genetically susceptible to colitis, we could assess the risk due to maternal transmission of an antibiotic-perturbed microbiota. We found that the IL10<sup>-/-</sup> offspring that had received the perturbed gut microbiota developed markedly increased colitis. Taken together, our findings indicate that antibiotic exposure shaping the maternal gut microbiota has effects that extend to the offspring, with both ecological and long-term disease consequences.
    40 schema:genre article
    41 schema:inLanguage en
    42 schema:isAccessibleForFree true
    43 schema:isPartOf N9c45e091ece64c02b5764a69c6ed443e
    44 Nee8b159c1ceb40f99847e283d73dc9d6
    45 sg:journal.1052984
    46 schema:keywords IL10
    47 adult pregnant mice
    48 antibiotic exposure
    49 antibiotic use
    50 antibiotic-perturbed microbiota
    51 antibiotics
    52 bowel disease
    53 children
    54 colitis
    55 community
    56 consequences
    57 continued exposure
    58 control
    59 disease
    60 disease consequences
    61 dysbiotic microbiota
    62 effect
    63 exposure
    64 fidelity
    65 findings
    66 genotype shape microbiota populations
    67 germ-free adult pregnant mice
    68 gut microbial community
    69 gut microbiota
    70 high fidelity
    71 inflammatory bowel disease
    72 inoculum
    73 intergenerational transfers
    74 intestinal microbiome
    75 long-term disease consequences
    76 maternal gut microbiota
    77 maternal transmission
    78 mice
    79 microbial communities
    80 microbiome
    81 microbiota
    82 microbiota populations
    83 mothers
    84 offspring
    85 perturbed gut microbiota
    86 perturbed microbiota
    87 population
    88 pregnant mice
    89 pregnant mothers
    90 risk
    91 shape microbiota populations
    92 susceptible mice
    93 transfer
    94 transmission
    95 use
    96 weeks
    97 wild-type mothers
    98 schema:name Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice
    99 schema:pagination 234-242
    100 schema:productId N1b8f2714e0f04768bc9022139eae03d5
    101 N3645a046225045079e09d00a870767bc
    102 N7043a9f549c446a68eae2d3b42c022d8
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092999920
    104 https://doi.org/10.1038/s41564-017-0075-5
    105 schema:sdDatePublished 2021-12-01T19:39
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher N625b113d166a4d0eabe6b6a1f37a0b66
    108 schema:url https://doi.org/10.1038/s41564-017-0075-5
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N06a5c716ef274d05b1e5aa1510de665c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Feces
    114 rdf:type schema:DefinedTerm
    115 N10e38c28443c483f8dc717f960d7dc71 rdf:first sg:person.01254370327.89
    116 rdf:rest N95a636907c6b4b498dd2118f7d1b37a3
    117 N1b8f2714e0f04768bc9022139eae03d5 schema:name dimensions_id
    118 schema:value pub.1092999920
    119 rdf:type schema:PropertyValue
    120 N205d69e245974a1dba39cca2df124c51 rdf:first N6ef716b19e674c88be575ee24ab15f97
    121 rdf:rest N3aeec0dadefb4d9cbd674a723c7fb1ef
    122 N2251d9fd94944c38b4c983ead99a11fb rdf:first sg:person.013117772626.50
    123 rdf:rest N205d69e245974a1dba39cca2df124c51
    124 N23ec23ae7b5b47a5992272ee28463340 rdf:first sg:person.01130440000.56
    125 rdf:rest N3280cf2e35774e1590f0ef95ad4f2b21
    126 N260ec863004645aa9af3d930afce27d7 rdf:first sg:person.01054701157.41
    127 rdf:rest N56422c5d891845b69e8b2f7ea84c6c74
    128 N2c200dd737c9418f9f05d33b7fab7acd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Pregnancy
    130 rdf:type schema:DefinedTerm
    131 N2d1b6af0faf34ffa8ad49ba76091dce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Interleukin-10
    133 rdf:type schema:DefinedTerm
    134 N3280cf2e35774e1590f0ef95ad4f2b21 rdf:first sg:person.01176034505.50
    135 rdf:rest N2251d9fd94944c38b4c983ead99a11fb
    136 N3645a046225045079e09d00a870767bc schema:name doi
    137 schema:value 10.1038/s41564-017-0075-5
    138 rdf:type schema:PropertyValue
    139 N39fb75b39dac4f2bb9d2eafdcf12fba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Dysbiosis
    141 rdf:type schema:DefinedTerm
    142 N3aeec0dadefb4d9cbd674a723c7fb1ef rdf:first sg:person.0602226221.92
    143 rdf:rest N444e0d2900154489af8afc78e0ee28ed
    144 N3ee63b17a05d4ced8d075bfbd9849132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Anti-Bacterial Agents
    146 rdf:type schema:DefinedTerm
    147 N444e0d2900154489af8afc78e0ee28ed rdf:first sg:person.0704534574.51
    148 rdf:rest N84661140cb844e79a3fd4b0f59dcea57
    149 N56422c5d891845b69e8b2f7ea84c6c74 rdf:first sg:person.012300373417.42
    150 rdf:rest Nf60f80c78e424e55a7ab91ea62480bda
    151 N585caa4372c7438190fdfbb0c0d194bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Colon
    153 rdf:type schema:DefinedTerm
    154 N5a122c38f4d5430fa39366659ed90258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Diet, High-Fat
    156 rdf:type schema:DefinedTerm
    157 N5c84170b72844a6f936befda5046588f rdf:first sg:person.01015326712.91
    158 rdf:rest N23ec23ae7b5b47a5992272ee28463340
    159 N625b113d166a4d0eabe6b6a1f37a0b66 schema:name Springer Nature - SN SciGraph project
    160 rdf:type schema:Organization
    161 N6b5fe7755b424ffea788c37eeac0aa84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Animals
    163 rdf:type schema:DefinedTerm
    164 N6ef716b19e674c88be575ee24ab15f97 schema:affiliation grid-institutes:grid.17635.36
    165 schema:familyName Robinson
    166 schema:givenName Serina
    167 rdf:type schema:Person
    168 N7043a9f549c446a68eae2d3b42c022d8 schema:name pubmed_id
    169 schema:value 29180726
    170 rdf:type schema:PropertyValue
    171 N76773381e3a64061ab08e88b78a39e0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Metagenome
    173 rdf:type schema:DefinedTerm
    174 N84661140cb844e79a3fd4b0f59dcea57 rdf:first sg:person.016146304737.46
    175 rdf:rest N260ec863004645aa9af3d930afce27d7
    176 N867242b8000b4df6bd7e5aab8a914f32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Phenotype
    178 rdf:type schema:DefinedTerm
    179 N8a71c335313046ea984280ae7672f431 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Mice, Inbred C57BL
    181 rdf:type schema:DefinedTerm
    182 N8e448c2fbeb94bcaba4efca2034ecbd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Disease Models, Animal
    184 rdf:type schema:DefinedTerm
    185 N922cca97de84442fa17738739a6fb68c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Inflammatory Bowel Diseases
    187 rdf:type schema:DefinedTerm
    188 N95a636907c6b4b498dd2118f7d1b37a3 rdf:first sg:person.01116676571.96
    189 rdf:rest N5c84170b72844a6f936befda5046588f
    190 N9c45e091ece64c02b5764a69c6ed443e schema:volumeNumber 3
    191 rdf:type schema:PublicationVolume
    192 Na85d91511c714d47bb3f9e60e00e515f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Gastrointestinal Microbiome
    194 rdf:type schema:DefinedTerm
    195 Nb318f72d51934609ac8d524585598117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Female
    197 rdf:type schema:DefinedTerm
    198 Nc691df2c4c984adc92a52091cdb93365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Mice
    200 rdf:type schema:DefinedTerm
    201 Nc6c53a3235824b9cbae88e4cbb4c9217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Colitis
    203 rdf:type schema:DefinedTerm
    204 Nde14bbafcd4a445db68050f86d6fb94a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Disease Susceptibility
    206 rdf:type schema:DefinedTerm
    207 Nee8b159c1ceb40f99847e283d73dc9d6 schema:issueNumber 2
    208 rdf:type schema:PublicationIssue
    209 Nf60f80c78e424e55a7ab91ea62480bda rdf:first sg:person.01013345173.52
    210 rdf:rest rdf:nil
    211 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Medical and Health Sciences
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Paediatrics and Reproductive Medicine
    216 rdf:type schema:DefinedTerm
    217 sg:grant.2436207 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-017-0075-5
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2438821 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-017-0075-5
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2438822 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-017-0075-5
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.2438988 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-017-0075-5
    224 rdf:type schema:MonetaryGrant
    225 sg:grant.2439546 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-017-0075-5
    226 rdf:type schema:MonetaryGrant
    227 sg:grant.2500335 http://pending.schema.org/fundedItem sg:pub.10.1038/s41564-017-0075-5
    228 rdf:type schema:MonetaryGrant
    229 sg:journal.1052984 schema:issn 2058-5276
    230 schema:name Nature Microbiology
    231 schema:publisher Springer Nature
    232 rdf:type schema:Periodical
    233 sg:person.01013345173.52 schema:affiliation grid-institutes:grid.274295.f
    234 schema:familyName Blaser
    235 schema:givenName Martin J.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013345173.52
    237 rdf:type schema:Person
    238 sg:person.01015326712.91 schema:affiliation grid-institutes:grid.240324.3
    239 schema:familyName Alvarez
    240 schema:givenName Yelina
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015326712.91
    242 rdf:type schema:Person
    243 sg:person.01054701157.41 schema:affiliation grid-institutes:grid.17635.36
    244 schema:familyName Knights
    245 schema:givenName Dan
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054701157.41
    247 rdf:type schema:Person
    248 sg:person.01116676571.96 schema:affiliation grid-institutes:grid.240324.3
    249 schema:familyName Battaglia
    250 schema:givenName Thomas
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116676571.96
    252 rdf:type schema:Person
    253 sg:person.01130440000.56 schema:affiliation grid-institutes:None
    254 schema:familyName Bijnens
    255 schema:givenName Luc
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130440000.56
    257 rdf:type schema:Person
    258 sg:person.01176034505.50 schema:affiliation grid-institutes:grid.240324.3
    259 schema:familyName Ruiz
    260 schema:givenName Victoria E.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176034505.50
    262 rdf:type schema:Person
    263 sg:person.012300373417.42 schema:affiliation grid-institutes:grid.410711.2
    264 schema:familyName Sartor
    265 schema:givenName R. Balfour
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012300373417.42
    267 rdf:type schema:Person
    268 sg:person.01254370327.89 schema:affiliation grid-institutes:grid.240324.3
    269 schema:familyName Schulfer
    270 schema:givenName Anjelique F.
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254370327.89
    272 rdf:type schema:Person
    273 sg:person.013117772626.50 schema:affiliation grid-institutes:grid.240324.3
    274 schema:familyName Ho
    275 schema:givenName Melody
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013117772626.50
    277 rdf:type schema:Person
    278 sg:person.016146304737.46 schema:affiliation grid-institutes:grid.429997.8
    279 schema:familyName Rogers
    280 schema:givenName Arlin B.
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016146304737.46
    282 rdf:type schema:Person
    283 sg:person.0602226221.92 schema:affiliation grid-institutes:grid.17635.36
    284 schema:familyName Ward
    285 schema:givenName Tonya
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602226221.92
    287 rdf:type schema:Person
    288 sg:person.0704534574.51 schema:affiliation grid-institutes:grid.38142.3c
    289 schema:familyName Cox
    290 schema:givenName Laura M.
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704534574.51
    292 rdf:type schema:Person
    293 sg:pub.10.1007/978-1-59745-447-6_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035567877
    294 https://doi.org/10.1007/978-1-59745-447-6_11
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s00228-009-0647-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012738735
    297 https://doi.org/10.1007/s00228-009-0647-2
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/ajg.2011.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033784361
    300 https://doi.org/10.1038/ajg.2011.304
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/ijo.2014.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042102254
    303 https://doi.org/10.1038/ijo.2014.119
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/ismej.2007.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049335767
    306 https://doi.org/10.1038/ismej.2007.3
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/ismej.2011.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051863807
    309 https://doi.org/10.1038/ismej.2011.139
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nature16504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048142283
    312 https://doi.org/10.1038/nature16504
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nature18646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017924056
    315 https://doi.org/10.1038/nature18646
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/ncomms8055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033081104
    318 https://doi.org/10.1038/ncomms8055
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nmeth.f.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009032055
    321 https://doi.org/10.1038/nmeth.f.303
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/nmicrobiol.2016.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022996683
    324 https://doi.org/10.1038/nmicrobiol.2016.140
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/nmicrobiol.2017.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083801915
    327 https://doi.org/10.1038/nmicrobiol.2017.4
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/nrendo.2014.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012805361
    330 https://doi.org/10.1038/nrendo.2014.171
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1186/gb-2011-12-6-r60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000243423
    333 https://doi.org/10.1186/gb-2011-12-6-r60
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1186/s13073-016-0297-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028545434
    336 https://doi.org/10.1186/s13073-016-0297-9
    337 rdf:type schema:CreativeWork
    338 grid-institutes:None schema:alternateName Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium
    339 schema:name Janssen R&D, Janssen Pharmaceutical Companies of J&J, Turnhoutseweg 30, Beerse, 2340, Belgium
    340 rdf:type schema:Organization
    341 grid-institutes:grid.17635.36 schema:alternateName Biotechnology Institute, University of Minnesota, Minneapolis, Minnesota, USA, 55455
    342 Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA, 55455
    343 Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA, 55455
    344 schema:name Biotechnology Institute, University of Minnesota, Minneapolis, Minnesota, USA, 55455
    345 Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA, 55455
    346 Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA, 55455
    347 rdf:type schema:Organization
    348 grid-institutes:grid.240324.3 schema:alternateName Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016
    349 Department of Pathology, NYU Langone Medical Center, New York, New York, USA, 10016
    350 schema:name Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016
    351 Department of Microbiology, NYU Langone Medical Center, New York, New York, USA, 10016
    352 Department of Pathology, NYU Langone Medical Center, New York, New York, USA, 10016
    353 rdf:type schema:Organization
    354 grid-institutes:grid.274295.f schema:alternateName New York Harbor Veterans Affairs Medical Center, New York, New York, USA, 10010
    355 schema:name Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016
    356 Department of Microbiology, NYU Langone Medical Center, New York, New York, USA, 10016
    357 New York Harbor Veterans Affairs Medical Center, New York, New York, USA, 10010
    358 rdf:type schema:Organization
    359 grid-institutes:grid.38142.3c schema:alternateName Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA, 02115
    360 schema:name Department of Medicine, NYU Langone Medical Center, New York, New York, USA, 10016
    361 Department of Neurology, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA, 02115
    362 rdf:type schema:Organization
    363 grid-institutes:grid.410711.2 schema:alternateName Departments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA, 27599
    364 schema:name Departments of Medicine, Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA, 27599
    365 rdf:type schema:Organization
    366 grid-institutes:grid.429997.8 schema:alternateName Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA, 01536
    367 schema:name Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA, 01536
    368 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...