Enterotypes in the landscape of gut microbial community composition View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01

AUTHORS

Paul I. Costea, Falk Hildebrand, Manimozhiyan Arumugam, Fredrik Bäckhed, Martin J. Blaser, Frederic D. Bushman, Willem M. de Vos, S. Dusko Ehrlich, Claire M. Fraser, Masahira Hattori, Curtis Huttenhower, Ian B. Jeffery, Dan Knights, James D. Lewis, Ruth E. Ley, Howard Ochman, Paul W. O’Toole, Christopher Quince, David A. Relman, Fergus Shanahan, Shinichi Sunagawa, Jun Wang, George M. Weinstock, Gary D. Wu, Georg Zeller, Liping Zhao, Jeroen Raes, Rob Knight, Peer Bork

ABSTRACT

Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept. More... »

PAGES

8-16

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-017-0072-8

    DOI

    http://dx.doi.org/10.1038/s41564-017-0072-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1099697363

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29255284


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