Enterotypes in the landscape of gut microbial community composition View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-18

AUTHORS

Paul I. Costea, Falk Hildebrand, Manimozhiyan Arumugam, Fredrik Bäckhed, Martin J. Blaser, Frederic D. Bushman, Willem M. de Vos, S. Dusko Ehrlich, Claire M. Fraser, Masahira Hattori, Curtis Huttenhower, Ian B. Jeffery, Dan Knights, James D. Lewis, Ruth E. Ley, Howard Ochman, Paul W. O’Toole, Christopher Quince, David A. Relman, Fergus Shanahan, Shinichi Sunagawa, Jun Wang, George M. Weinstock, Gary D. Wu, Georg Zeller, Liping Zhao, Jeroen Raes, Rob Knight, Peer Bork

ABSTRACT

Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept. More... »

PAGES

8-16

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  • Journal

    TITLE

    Nature Microbiology

    ISSUE

    1

    VOLUME

    3

    Author Affiliations

  • European Molecular Biology Laboratory, Heidelberg, Germany
  • Laboratory of Microbiology, Vrije Universiteit Brussel, Brussels, Belgium
  • The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  • Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
  • New York University Langone Medical Center, New York, NY, USA
  • Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
  • Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands
  • King’s College London, Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital, London, UK
  • Institute for Genome Sciences at the University of Maryland School of Medicine, Baltimore, MD, USA
  • Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
  • Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
  • APC Microbiome Institute, University College Cork, Cork, Ireland
  • Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA
  • Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  • MPI Department of Microbiome Science, Tübingen, Germany
  • Department of Integrative Biology, University of Texas, Austin, TX, USA
  • Warwick Medical School, University of Warwick, Coventry, UK
  • Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
  • Department of Biology, Institute of Microbiology, ETH Zurich, Zurich, Switzerland
  • Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Pokfulam, Hong Kong
  • The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
  • Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  • Ministry of Education Key Laboratory for Systems Biomedicine, Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
  • Department of Microbiology and Immunology, Rega Institute KU Leuven, Leuven, Belgium
  • Howard Hughes Medical Institute, University of Colorado, Boulder, CO, USA
  • Molecular Medicine Partnership Unit, Heidelberg, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41564-017-0072-8

    DOI

    http://dx.doi.org/10.1038/s41564-017-0072-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1099697363

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29255284


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