Individual immune selection pressure has limited impact on seasonal influenza virus evolution View Full Text


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Article Info

DATE

2018-12-03

AUTHORS

Alvin X. Han, Sebastian Maurer-Stroh, Colin A. Russell

ABSTRACT

Seasonal influenza viruses are subjected to strong selection as seen by the sequential replacement of existing viral populations on the emergence of new antigenic variants. However, the process of within-host de novo mutant generation and evolutionary selection that underlies these antigenic sweeps is poorly understood. Here, we investigate mutational patterns between evolutionarily closely related human seasonal influenza viruses using host age as a proxy for immune experience. The systematic analysis of >25,000 virus sequences showed that individuals with substantially differing immune histories were frequently (30-62%) infected by viruses with identical amino acid sequences. Viruses from immunologically inexperienced individuals were as likely to possess substitutions with potential phenotypic relevance as highly experienced individuals. Mutations likely to cause antigenic changes were rare among closely related viruses and not associated with extent of host immune experience. These findings suggest that individual immune positive selection plays a limited role in the evolution of seasonal influenza viruses. More... »

PAGES

1-10

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41559-018-0741-x

    DOI

    http://dx.doi.org/10.1038/s41559-018-0741-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110134173

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30510176


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41559-018-0741-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41559-018-0741-x'

    RDF/XML is a standard XML format for linked data.

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