Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-11

AUTHORS

Xionghui Lin, Benjamin Swedlund, Mai-Linh N. Ton, Shila Ghazanfar, Carolina Guibentif, Catherine Paulissen, Elodie Baudelet, Elise Plaindoux, Younes Achouri, Emilie Calonne, Christine Dubois, William Mansfield, Stéphane Zaffran, John C. Marioni, Francois Fuks, Berthold Göttgens, Fabienne Lescroart, Cédric Blanpain

ABSTRACT

The mammalian heart arises from various populations of Mesp1-expressing cardiovascular progenitors (CPs) that are specified during the early stages of gastrulation. Mesp1 is a transcription factor that acts as a master regulator of CP specification and differentiation. However, how Mesp1 regulates the chromatin landscape of nascent mesodermal cells to define the temporal and spatial patterning of the distinct populations of CPs remains unknown. Here, by combining ChIP–seq, RNA-seq and ATAC-seq during mouse pluripotent stem cell differentiation, we defined the dynamic remodelling of the chromatin landscape mediated by Mesp1. We identified different enhancers that are temporally regulated to erase the pluripotent state and specify the pools of CPs that mediate heart development. We identified Zic2 and Zic3 as essential cofactors that act with Mesp1 to regulate its transcription-factor activity at key mesodermal enhancers, thereby regulating the chromatin remodelling and gene expression associated with the specification of the different populations of CPs in vivo. Our study identifies the dynamics of the chromatin landscape and enhancer remodelling associated with temporal patterning of early mesodermal cells into the distinct populations of CPs that mediate heart development. More... »

PAGES

1114-1128

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41556-022-00947-3

    DOI

    http://dx.doi.org/10.1038/s41556-022-00947-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149374997

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35817961


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