piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03-16

AUTHORS

Feng Li, Peng Yuan, Ming Rao, Chun-Hui Jin, Wei Tang, Ye-Fei Rong, Yun-Ping Hu, Fengjuan Zhang, Tao Wei, Qi Yin, Tingbo Liang, Ligang Wu, Jinsong Li, Dangsheng Li, Yingbin Liu, Wenhui Lou, Shuang Zhao, Mo-Fang Liu

ABSTRACT

Piwi proteins are normally restricted in germ cells to suppress transposons through associations with Piwi-interacting RNAs (piRNAs), but they are also frequently activated in many types of human cancers. A great puzzle is the lack of significant induction of corresponding piRNAs in cancer cells, as we document here in human pancreatic ductal adenocarcinomas (PDACs), which implies that such germline-specific proteins are somehow hijacked to promote tumorigenesis through a different mode of action. Here, we show that in the absence of piRNAs, human PIWIL1 in PDAC functions as an oncoprotein by activating the anaphase promoting complex/cyclosome (APC/C) E3 complex, which then targets a critical cell adhesion-related protein, Pinin, to enhance PDAC metastasis. This is in contrast to piRNA-dependent PIWIL1 ubiquitination and removal by APC/C during late spermiogenesis. These findings unveil a piRNA-dependent mechanism to switch PIWIL1 from a substrate in spermatids to a co-activator of APC/C in human cancer cells. More... »

PAGES

425-438

References to SciGraph publications

  • 2006-06-04. A novel class of small RNAs bind to MILI protein in mouse testes in NATURE
  • 2006-06-04. A germline-specific class of small RNAs binds mammalian Piwi proteins in NATURE
  • 2011-03-23. PIWI-interacting small RNAs: the vanguard of genome defence in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-10-07. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25 in NATURE IMMUNOLOGY
  • 2016-01-15. Piwi-interacting RNAs in cancer: emerging functions and clinical utility in MOLECULAR CANCER
  • 1991-01. Cyclin is degraded by the ubiquitin pathway in NATURE
  • 2019-07-29. Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes in NATURE COMMUNICATIONS
  • 2009-04-30. Preparation of Synchronized Human Cell Extracts to Study Ubiquitination and Degradation in MITOSIS
  • 2005-07-20. Cancer/testis antigens, gametogenesis and cancer in NATURE REVIEWS CANCER
  • 2016-03-07. Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm in NATURE
  • 2014-05-02. Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis in CELL RESEARCH
  • 2015-01-13. MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes in CELL RESEARCH
  • 2011-06-02. Cubism and the cell cycle: the many faces of the APC/C in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2018-11-20. New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2000-01-13. Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function in ONCOGENE
  • 2009-04-19. Universal sample preparation method for proteome analysis in NATURE METHODS
  • 2018-11-16. PIWI-interacting RNAs: small RNAs with big functions in NATURE REVIEWS GENETICS
  • 2020-01-21. A dual role of the PIWI/piRNA machinery in regulating mRNAs during mouse spermiogenesis in SCIENCE CHINA LIFE SCIENCES
  • 2017-08-10. Human PIWI (HIWI) is an azoospermia factor in SCIENCE CHINA LIFE SCIENCES
  • 2006-08-09. The anaphase promoting complex/cyclosome: a machine designed to destroy in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Journal

    TITLE

    Nature Cell Biology

    ISSUE

    4

    VOLUME

    22

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41556-020-0486-z

    DOI

    http://dx.doi.org/10.1038/s41556-020-0486-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1125672541

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32203416


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anaphase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anaphase-Promoting Complex-Cyclosome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Argonaute Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Pancreatic Ductal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Adhesion Molecules", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spermatogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitination", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenograft Model Antitumor Assays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Feng", 
            "id": "sg:person.013046606227.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046606227.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yuan", 
            "givenName": "Peng", 
            "id": "sg:person.012377030325.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012377030325.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rao", 
            "givenName": "Ming", 
            "id": "sg:person.015252026221.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015252026221.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Life Science and Technology, Shanghai Tech University, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.440637.2", 
              "name": [
                "School of Life Science and Technology, Shanghai Tech University, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jin", 
            "givenName": "Chun-Hui", 
            "id": "sg:person.016047406621.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016047406621.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Animal Core Facility, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "The Animal Core Facility, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Wei", 
            "id": "sg:person.012525265665.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525265665.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.413087.9", 
              "name": [
                "Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rong", 
            "givenName": "Ye-Fei", 
            "id": "sg:person.0632242751.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632242751.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.412987.1", 
              "name": [
                "Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Yun-Ping", 
            "id": "sg:person.0774405706.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774405706.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Fengjuan", 
            "id": "sg:person.01341666411.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341666411.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.452661.2", 
              "name": [
                "Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wei", 
            "givenName": "Tao", 
            "id": "sg:person.01103351641.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103351641.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yin", 
            "givenName": "Qi", 
            "id": "sg:person.01157361270.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157361270.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.452661.2", 
              "name": [
                "Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liang", 
            "givenName": "Tingbo", 
            "id": "sg:person.016502045317.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016502045317.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Ligang", 
            "id": "sg:person.01062154530.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062154530.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "School of Life Science and Technology, Shanghai Tech University, Shanghai, China", 
                "State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Jinsong", 
            "id": "sg:person.01321141144.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321141144.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Dangsheng", 
            "id": "sg:person.0735132435.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735132435.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.412987.1", 
              "name": [
                "Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Yingbin", 
            "id": "sg:person.0740657664.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740657664.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.413087.9", 
              "name": [
                "Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lou", 
            "givenName": "Wenhui", 
            "id": "sg:person.01014604551.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014604551.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.507739.f", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Shuang", 
            "id": "sg:person.0671022567.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671022567.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "School of Life Science and Technology, Shanghai Tech University, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.440637.2", 
              "name": [
                "State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences\u2013University of Chinese Academy of Sciences, Shanghai, China", 
                "School of Life Science and Technology, Shanghai Tech University, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Mo-Fang", 
            "id": "sg:person.01005774441.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005774441.81"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature04916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001506500", 
              "https://doi.org/10.1038/nature04916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60327-993-2_19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008617652", 
              "https://doi.org/10.1007/978-1-60327-993-2_19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2014.41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038086302", 
              "https://doi.org/10.1038/cr.2014.41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017306261", 
              "https://doi.org/10.1038/ni.2427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/349132a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013684407", 
              "https://doi.org/10.1038/349132a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11427-017-9149-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091160799", 
              "https://doi.org/10.1007/s11427-017-9149-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41580-018-0080-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110036840", 
              "https://doi.org/10.1038/s41580-018-0080-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052146030", 
              "https://doi.org/10.1038/nrm3089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029225241", 
              "https://doi.org/10.1038/nature04917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2015.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048200072", 
              "https://doi.org/10.1038/cr.2015.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-019-11312-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1119949700", 
              "https://doi.org/10.1038/s41467-019-11312-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019623495", 
              "https://doi.org/10.1038/nrc1669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040289272", 
              "https://doi.org/10.1038/sj.onc.1203328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41576-018-0073-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109911273", 
              "https://doi.org/10.1038/s41576-018-0073-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047379825", 
              "https://doi.org/10.1038/nmeth.1322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11427-020-1632-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1124282310", 
              "https://doi.org/10.1007/s11427-020-1632-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-016-0491-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002928423", 
              "https://doi.org/10.1186/s12943-016-0491-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053705055", 
              "https://doi.org/10.1038/nrm1988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034050231", 
              "https://doi.org/10.1038/nature17150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036650576", 
              "https://doi.org/10.1038/nrm3132"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-03-16", 
        "datePublishedReg": "2020-03-16", 
        "description": "Piwi proteins are normally restricted in germ cells to suppress transposons through associations with Piwi-interacting RNAs (piRNAs), but they are also frequently activated in many types of human cancers. A great puzzle is the lack of significant induction of corresponding piRNAs in cancer cells, as we document here in human pancreatic ductal adenocarcinomas (PDACs), which implies that such germline-specific proteins are somehow hijacked to promote tumorigenesis through a different mode of action. Here, we show that in the absence of piRNAs, human PIWIL1 in PDAC functions as an oncoprotein by activating the anaphase promoting complex/cyclosome (APC/C) E3 complex, which then targets a critical cell adhesion-related protein, Pinin, to enhance PDAC metastasis. This is in contrast to piRNA-dependent PIWIL1 ubiquitination and removal by APC/C during late spermiogenesis. These findings unveil a piRNA-dependent mechanism to switch PIWIL1 from a substrate in spermatids to a co-activator of APC/C in human cancer cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41556-020-0486-z", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8374014", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8909368", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8909197", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1021344", 
            "issn": [
              "1465-7392", 
              "1476-4679"
            ], 
            "name": "Nature Cell Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "keywords": [
          "PIWI-interacting RNAs", 
          "APC/C", 
          "absence of piRNAs", 
          "cell adhesion-related proteins", 
          "germline-specific proteins", 
          "complex/cyclosome", 
          "adhesion-related proteins", 
          "cancer cells", 
          "PIWI proteins", 
          "human cancer cells", 
          "E3 complex", 
          "pancreatic cancer metastasis", 
          "late spermiogenesis", 
          "germ cells", 
          "human pancreatic ductal adenocarcinoma", 
          "PIWIL1", 
          "human cancers", 
          "pancreatic ductal adenocarcinoma", 
          "cancer metastasis", 
          "protein", 
          "anaphase", 
          "significant induction", 
          "PDAC metastasis", 
          "great puzzles", 
          "cells", 
          "cyclosome", 
          "ubiquitination", 
          "pinin", 
          "transposon", 
          "spermiogenesis", 
          "RNA", 
          "tumorigenesis", 
          "oncoprotein", 
          "spermatids", 
          "ductal adenocarcinoma", 
          "induction", 
          "function", 
          "complexes", 
          "different modes", 
          "metastasis", 
          "mechanism", 
          "substrate", 
          "absence", 
          "contrast", 
          "cancer", 
          "action", 
          "association", 
          "types", 
          "findings", 
          "lack", 
          "puzzle", 
          "removal", 
          "adenocarcinoma", 
          "mode"
        ], 
        "name": "piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis", 
        "pagination": "425-438", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1125672541"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41556-020-0486-z"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32203416"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41556-020-0486-z", 
          "https://app.dimensions.ai/details/publication/pub.1125672541"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_843.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41556-020-0486-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41556-020-0486-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41556-020-0486-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41556-020-0486-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41556-020-0486-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    442 TRIPLES      21 PREDICATES      125 URIs      95 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41556-020-0486-z schema:about N0c06967fff794402b01b47eb29faa284
    2 N1131f0868e7c4513b5940f5ba65c321e
    3 N2ee00d0f7bf7443aa98356ae15834f4d
    4 N3d82157701f14457a968284410473d8d
    5 N40460ca2ba894b6998842558e8737021
    6 N4e7e3e2c563543a3a016f450cf14eee3
    7 N5156a6227b984eb7807ea59ad0a8fac6
    8 N84620f2f0e694772abd27f2190e38e9a
    9 N906fa1be9df5483087d4392793c712cb
    10 N9d1f814300894ca89bd49d1ffaa457a1
    11 Nab54e044d6da4eef84057679c977efdf
    12 Nb5cd3903399a453688a8c088d27b0fa7
    13 Nbb07b1bd79474d2d9664fc9a02983dbf
    14 Nc0cfe2fc533e47d0be14757481abf689
    15 Nc6d3253e9afb439dbbb16efcf3e53e3e
    16 Nd8dccbffe6624c4cb388f8cc6217dfff
    17 Ndc4bbc584d4a4395b56b45818eee2e29
    18 Ne020e96940ca494eb7212e339e83c655
    19 Ne55813f1f2d6419facc0249d9b895a18
    20 Ne8132013ef864a099ead9e637ed390bb
    21 Nedf6a8bda6f94ac69b5b32aa142f1241
    22 Nf0da0678b9bf4291a500bac27a0e1c94
    23 Nf3bd8205c2d440eeb81001ecc6921e8a
    24 Nf780cbc3e18245ec8a183395681ebc58
    25 anzsrc-for:06
    26 anzsrc-for:0601
    27 anzsrc-for:11
    28 anzsrc-for:1112
    29 schema:author N74151bfe8a8e488b919d0062d06890f3
    30 schema:citation sg:pub.10.1007/978-1-60327-993-2_19
    31 sg:pub.10.1007/s11427-017-9149-0
    32 sg:pub.10.1007/s11427-020-1632-5
    33 sg:pub.10.1038/349132a0
    34 sg:pub.10.1038/cr.2014.41
    35 sg:pub.10.1038/cr.2015.4
    36 sg:pub.10.1038/nature04916
    37 sg:pub.10.1038/nature04917
    38 sg:pub.10.1038/nature17150
    39 sg:pub.10.1038/ni.2427
    40 sg:pub.10.1038/nmeth.1322
    41 sg:pub.10.1038/nrc1669
    42 sg:pub.10.1038/nrm1988
    43 sg:pub.10.1038/nrm3089
    44 sg:pub.10.1038/nrm3132
    45 sg:pub.10.1038/s41467-019-11312-8
    46 sg:pub.10.1038/s41576-018-0073-3
    47 sg:pub.10.1038/s41580-018-0080-4
    48 sg:pub.10.1038/sj.onc.1203328
    49 sg:pub.10.1186/s12943-016-0491-9
    50 schema:datePublished 2020-03-16
    51 schema:datePublishedReg 2020-03-16
    52 schema:description Piwi proteins are normally restricted in germ cells to suppress transposons through associations with Piwi-interacting RNAs (piRNAs), but they are also frequently activated in many types of human cancers. A great puzzle is the lack of significant induction of corresponding piRNAs in cancer cells, as we document here in human pancreatic ductal adenocarcinomas (PDACs), which implies that such germline-specific proteins are somehow hijacked to promote tumorigenesis through a different mode of action. Here, we show that in the absence of piRNAs, human PIWIL1 in PDAC functions as an oncoprotein by activating the anaphase promoting complex/cyclosome (APC/C) E3 complex, which then targets a critical cell adhesion-related protein, Pinin, to enhance PDAC metastasis. This is in contrast to piRNA-dependent PIWIL1 ubiquitination and removal by APC/C during late spermiogenesis. These findings unveil a piRNA-dependent mechanism to switch PIWIL1 from a substrate in spermatids to a co-activator of APC/C in human cancer cells.
    53 schema:genre article
    54 schema:isAccessibleForFree false
    55 schema:isPartOf N1a0fd635d73142f79988365056f6d814
    56 Nda4532ff248a4bd7977cb7de685184ec
    57 sg:journal.1021344
    58 schema:keywords APC/C
    59 E3 complex
    60 PDAC metastasis
    61 PIWI proteins
    62 PIWI-interacting RNAs
    63 PIWIL1
    64 RNA
    65 absence
    66 absence of piRNAs
    67 action
    68 adenocarcinoma
    69 adhesion-related proteins
    70 anaphase
    71 association
    72 cancer
    73 cancer cells
    74 cancer metastasis
    75 cell adhesion-related proteins
    76 cells
    77 complex/cyclosome
    78 complexes
    79 contrast
    80 cyclosome
    81 different modes
    82 ductal adenocarcinoma
    83 findings
    84 function
    85 germ cells
    86 germline-specific proteins
    87 great puzzles
    88 human cancer cells
    89 human cancers
    90 human pancreatic ductal adenocarcinoma
    91 induction
    92 lack
    93 late spermiogenesis
    94 mechanism
    95 metastasis
    96 mode
    97 oncoprotein
    98 pancreatic cancer metastasis
    99 pancreatic ductal adenocarcinoma
    100 pinin
    101 protein
    102 puzzle
    103 removal
    104 significant induction
    105 spermatids
    106 spermiogenesis
    107 substrate
    108 transposon
    109 tumorigenesis
    110 types
    111 ubiquitination
    112 schema:name piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis
    113 schema:pagination 425-438
    114 schema:productId N400636a6c0e145fead9998a2df54810e
    115 N41560f20a9ef4767a262f7c0c71a327f
    116 N9b37af0188b04d1a9552d7ed7cd073bd
    117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125672541
    118 https://doi.org/10.1038/s41556-020-0486-z
    119 schema:sdDatePublished 2022-09-02T16:05
    120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    121 schema:sdPublisher Nc192a63a8cc64c2183da63306878e597
    122 schema:url https://doi.org/10.1038/s41556-020-0486-z
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset articles
    125 rdf:type schema:ScholarlyArticle
    126 N0c06967fff794402b01b47eb29faa284 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Pancreatic Neoplasms
    128 rdf:type schema:DefinedTerm
    129 N1131f0868e7c4513b5940f5ba65c321e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Animals
    131 rdf:type schema:DefinedTerm
    132 N1a0fd635d73142f79988365056f6d814 schema:volumeNumber 22
    133 rdf:type schema:PublicationVolume
    134 N1bdaae37d10041438ab0e95f3ee24c8f rdf:first sg:person.0632242751.52
    135 rdf:rest N5767be878ea643d88507e6d16152194b
    136 N1d9b758ba4be47458447805f9902e3f6 rdf:first sg:person.012525265665.38
    137 rdf:rest N1bdaae37d10041438ab0e95f3ee24c8f
    138 N1f8586dc9e2e40efa6e135c725e17bf8 rdf:first sg:person.01005774441.81
    139 rdf:rest rdf:nil
    140 N2096c00875c84f90bba9068a5618c8f5 rdf:first sg:person.01014604551.20
    141 rdf:rest Nf247bfa27c004e248f7b49c04d1ee5e7
    142 N2ee00d0f7bf7443aa98356ae15834f4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Argonaute Proteins
    144 rdf:type schema:DefinedTerm
    145 N352e3cbaa92d4ec0a05155ee1d93e133 rdf:first sg:person.015252026221.18
    146 rdf:rest Nb38881b7bc4d48d3821eb46516f08c97
    147 N3d7683464fb44d7baad359b7d34974e1 rdf:first sg:person.01341666411.48
    148 rdf:rest N9c76db51c7024261ba92948eedd79aca
    149 N3d82157701f14457a968284410473d8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Humans
    151 rdf:type schema:DefinedTerm
    152 N400636a6c0e145fead9998a2df54810e schema:name dimensions_id
    153 schema:value pub.1125672541
    154 rdf:type schema:PropertyValue
    155 N40460ca2ba894b6998842558e8737021 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Mice, Knockout
    157 rdf:type schema:DefinedTerm
    158 N41560f20a9ef4767a262f7c0c71a327f schema:name pubmed_id
    159 schema:value 32203416
    160 rdf:type schema:PropertyValue
    161 N4e7e3e2c563543a3a016f450cf14eee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Xenograft Model Antitumor Assays
    163 rdf:type schema:DefinedTerm
    164 N5156a6227b984eb7807ea59ad0a8fac6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Male
    166 rdf:type schema:DefinedTerm
    167 N5767be878ea643d88507e6d16152194b rdf:first sg:person.0774405706.48
    168 rdf:rest N3d7683464fb44d7baad359b7d34974e1
    169 N74151bfe8a8e488b919d0062d06890f3 rdf:first sg:person.013046606227.22
    170 rdf:rest N8a3fbd4180244890945f330f6b234b82
    171 N84620f2f0e694772abd27f2190e38e9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Ubiquitination
    173 rdf:type schema:DefinedTerm
    174 N8a3fbd4180244890945f330f6b234b82 rdf:first sg:person.012377030325.53
    175 rdf:rest N352e3cbaa92d4ec0a05155ee1d93e133
    176 N8ff3b5628d044577b4c1023b03de82b6 rdf:first sg:person.016502045317.57
    177 rdf:rest Na73e318babca4908b864e31a4118fe12
    178 N906fa1be9df5483087d4392793c712cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Carcinogenesis
    180 rdf:type schema:DefinedTerm
    181 N9b37af0188b04d1a9552d7ed7cd073bd schema:name doi
    182 schema:value 10.1038/s41556-020-0486-z
    183 rdf:type schema:PropertyValue
    184 N9c76db51c7024261ba92948eedd79aca rdf:first sg:person.01103351641.38
    185 rdf:rest N9d188200b2c446a0a898b8bcfac025c3
    186 N9cb516140596447a9289274f237d57bb rdf:first sg:person.01321141144.46
    187 rdf:rest Nddf119dad5a849678a19f037bc1a68ea
    188 N9d188200b2c446a0a898b8bcfac025c3 rdf:first sg:person.01157361270.50
    189 rdf:rest N8ff3b5628d044577b4c1023b03de82b6
    190 N9d1f814300894ca89bd49d1ffaa457a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Nuclear Proteins
    192 rdf:type schema:DefinedTerm
    193 Na73e318babca4908b864e31a4118fe12 rdf:first sg:person.01062154530.46
    194 rdf:rest N9cb516140596447a9289274f237d57bb
    195 Nab54e044d6da4eef84057679c977efdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Cell Line, Tumor
    197 rdf:type schema:DefinedTerm
    198 Nb38881b7bc4d48d3821eb46516f08c97 rdf:first sg:person.016047406621.13
    199 rdf:rest N1d9b758ba4be47458447805f9902e3f6
    200 Nb5a83098b33c43209cb23f02827a5195 rdf:first sg:person.0740657664.39
    201 rdf:rest N2096c00875c84f90bba9068a5618c8f5
    202 Nb5cd3903399a453688a8c088d27b0fa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Cell Adhesion Molecules
    204 rdf:type schema:DefinedTerm
    205 Nbb07b1bd79474d2d9664fc9a02983dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Mice, Nude
    207 rdf:type schema:DefinedTerm
    208 Nc0cfe2fc533e47d0be14757481abf689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Anaphase-Promoting Complex-Cyclosome
    210 rdf:type schema:DefinedTerm
    211 Nc192a63a8cc64c2183da63306878e597 schema:name Springer Nature - SN SciGraph project
    212 rdf:type schema:Organization
    213 Nc6d3253e9afb439dbbb16efcf3e53e3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Adenocarcinoma
    215 rdf:type schema:DefinedTerm
    216 Nd8dccbffe6624c4cb388f8cc6217dfff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Anaphase
    218 rdf:type schema:DefinedTerm
    219 Nda4532ff248a4bd7977cb7de685184ec schema:issueNumber 4
    220 rdf:type schema:PublicationIssue
    221 Ndc4bbc584d4a4395b56b45818eee2e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Lymphatic Metastasis
    223 rdf:type schema:DefinedTerm
    224 Nddf119dad5a849678a19f037bc1a68ea rdf:first sg:person.0735132435.05
    225 rdf:rest Nb5a83098b33c43209cb23f02827a5195
    226 Ne020e96940ca494eb7212e339e83c655 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Cell Proliferation
    228 rdf:type schema:DefinedTerm
    229 Ne55813f1f2d6419facc0249d9b895a18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Carcinoma, Pancreatic Ductal
    231 rdf:type schema:DefinedTerm
    232 Ne8132013ef864a099ead9e637ed390bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Gene Expression Regulation, Neoplastic
    234 rdf:type schema:DefinedTerm
    235 Nedf6a8bda6f94ac69b5b32aa142f1241 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name RNA, Small Interfering
    237 rdf:type schema:DefinedTerm
    238 Nf0da0678b9bf4291a500bac27a0e1c94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Mice
    240 rdf:type schema:DefinedTerm
    241 Nf247bfa27c004e248f7b49c04d1ee5e7 rdf:first sg:person.0671022567.52
    242 rdf:rest N1f8586dc9e2e40efa6e135c725e17bf8
    243 Nf3bd8205c2d440eeb81001ecc6921e8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    244 schema:name Signal Transduction
    245 rdf:type schema:DefinedTerm
    246 Nf780cbc3e18245ec8a183395681ebc58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Spermatogenesis
    248 rdf:type schema:DefinedTerm
    249 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    250 schema:name Biological Sciences
    251 rdf:type schema:DefinedTerm
    252 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    253 schema:name Biochemistry and Cell Biology
    254 rdf:type schema:DefinedTerm
    255 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    256 schema:name Medical and Health Sciences
    257 rdf:type schema:DefinedTerm
    258 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    259 schema:name Oncology and Carcinogenesis
    260 rdf:type schema:DefinedTerm
    261 sg:grant.8374014 http://pending.schema.org/fundedItem sg:pub.10.1038/s41556-020-0486-z
    262 rdf:type schema:MonetaryGrant
    263 sg:grant.8909197 http://pending.schema.org/fundedItem sg:pub.10.1038/s41556-020-0486-z
    264 rdf:type schema:MonetaryGrant
    265 sg:grant.8909368 http://pending.schema.org/fundedItem sg:pub.10.1038/s41556-020-0486-z
    266 rdf:type schema:MonetaryGrant
    267 sg:journal.1021344 schema:issn 1465-7392
    268 1476-4679
    269 schema:name Nature Cell Biology
    270 schema:publisher Springer Nature
    271 rdf:type schema:Periodical
    272 sg:person.01005774441.81 schema:affiliation grid-institutes:grid.440637.2
    273 schema:familyName Liu
    274 schema:givenName Mo-Fang
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005774441.81
    276 rdf:type schema:Person
    277 sg:person.01014604551.20 schema:affiliation grid-institutes:grid.413087.9
    278 schema:familyName Lou
    279 schema:givenName Wenhui
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014604551.20
    281 rdf:type schema:Person
    282 sg:person.01062154530.46 schema:affiliation grid-institutes:grid.507739.f
    283 schema:familyName Wu
    284 schema:givenName Ligang
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062154530.46
    286 rdf:type schema:Person
    287 sg:person.01103351641.38 schema:affiliation grid-institutes:grid.452661.2
    288 schema:familyName Wei
    289 schema:givenName Tao
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103351641.38
    291 rdf:type schema:Person
    292 sg:person.01157361270.50 schema:affiliation grid-institutes:grid.507739.f
    293 schema:familyName Yin
    294 schema:givenName Qi
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157361270.50
    296 rdf:type schema:Person
    297 sg:person.012377030325.53 schema:affiliation grid-institutes:grid.507739.f
    298 schema:familyName Yuan
    299 schema:givenName Peng
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012377030325.53
    301 rdf:type schema:Person
    302 sg:person.012525265665.38 schema:affiliation grid-institutes:grid.507739.f
    303 schema:familyName Tang
    304 schema:givenName Wei
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012525265665.38
    306 rdf:type schema:Person
    307 sg:person.013046606227.22 schema:affiliation grid-institutes:grid.507739.f
    308 schema:familyName Li
    309 schema:givenName Feng
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013046606227.22
    311 rdf:type schema:Person
    312 sg:person.01321141144.46 schema:affiliation grid-institutes:grid.507739.f
    313 schema:familyName Li
    314 schema:givenName Jinsong
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321141144.46
    316 rdf:type schema:Person
    317 sg:person.01341666411.48 schema:affiliation grid-institutes:grid.507739.f
    318 schema:familyName Zhang
    319 schema:givenName Fengjuan
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341666411.48
    321 rdf:type schema:Person
    322 sg:person.015252026221.18 schema:affiliation grid-institutes:grid.507739.f
    323 schema:familyName Rao
    324 schema:givenName Ming
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015252026221.18
    326 rdf:type schema:Person
    327 sg:person.016047406621.13 schema:affiliation grid-institutes:grid.440637.2
    328 schema:familyName Jin
    329 schema:givenName Chun-Hui
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016047406621.13
    331 rdf:type schema:Person
    332 sg:person.016502045317.57 schema:affiliation grid-institutes:grid.452661.2
    333 schema:familyName Liang
    334 schema:givenName Tingbo
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016502045317.57
    336 rdf:type schema:Person
    337 sg:person.0632242751.52 schema:affiliation grid-institutes:grid.413087.9
    338 schema:familyName Rong
    339 schema:givenName Ye-Fei
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632242751.52
    341 rdf:type schema:Person
    342 sg:person.0671022567.52 schema:affiliation grid-institutes:grid.507739.f
    343 schema:familyName Zhao
    344 schema:givenName Shuang
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671022567.52
    346 rdf:type schema:Person
    347 sg:person.0735132435.05 schema:affiliation grid-institutes:grid.507739.f
    348 schema:familyName Li
    349 schema:givenName Dangsheng
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735132435.05
    351 rdf:type schema:Person
    352 sg:person.0740657664.39 schema:affiliation grid-institutes:grid.412987.1
    353 schema:familyName Liu
    354 schema:givenName Yingbin
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740657664.39
    356 rdf:type schema:Person
    357 sg:person.0774405706.48 schema:affiliation grid-institutes:grid.412987.1
    358 schema:familyName Hu
    359 schema:givenName Yun-Ping
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774405706.48
    361 rdf:type schema:Person
    362 sg:pub.10.1007/978-1-60327-993-2_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008617652
    363 https://doi.org/10.1007/978-1-60327-993-2_19
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1007/s11427-017-9149-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091160799
    366 https://doi.org/10.1007/s11427-017-9149-0
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1007/s11427-020-1632-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1124282310
    369 https://doi.org/10.1007/s11427-020-1632-5
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/349132a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013684407
    372 https://doi.org/10.1038/349132a0
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/cr.2014.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038086302
    375 https://doi.org/10.1038/cr.2014.41
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/cr.2015.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048200072
    378 https://doi.org/10.1038/cr.2015.4
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/nature04916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001506500
    381 https://doi.org/10.1038/nature04916
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/nature04917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029225241
    384 https://doi.org/10.1038/nature04917
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nature17150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034050231
    387 https://doi.org/10.1038/nature17150
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/ni.2427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017306261
    390 https://doi.org/10.1038/ni.2427
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nmeth.1322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047379825
    393 https://doi.org/10.1038/nmeth.1322
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nrc1669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019623495
    396 https://doi.org/10.1038/nrc1669
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nrm1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705055
    399 https://doi.org/10.1038/nrm1988
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nrm3089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052146030
    402 https://doi.org/10.1038/nrm3089
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nrm3132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036650576
    405 https://doi.org/10.1038/nrm3132
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/s41467-019-11312-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1119949700
    408 https://doi.org/10.1038/s41467-019-11312-8
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/s41576-018-0073-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109911273
    411 https://doi.org/10.1038/s41576-018-0073-3
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/s41580-018-0080-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110036840
    414 https://doi.org/10.1038/s41580-018-0080-4
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/sj.onc.1203328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040289272
    417 https://doi.org/10.1038/sj.onc.1203328
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1186/s12943-016-0491-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002928423
    420 https://doi.org/10.1186/s12943-016-0491-9
    421 rdf:type schema:CreativeWork
    422 grid-institutes:grid.412987.1 schema:alternateName Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    423 schema:name Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    424 rdf:type schema:Organization
    425 grid-institutes:grid.413087.9 schema:alternateName Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China
    426 schema:name Department of Pancreatic Surgery, Zhong Shan Hospital, Shanghai, China
    427 rdf:type schema:Organization
    428 grid-institutes:grid.440637.2 schema:alternateName School of Life Science and Technology, Shanghai Tech University, Shanghai, China
    429 schema:name School of Life Science and Technology, Shanghai Tech University, Shanghai, China
    430 State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences–University of Chinese Academy of Sciences, Shanghai, China
    431 rdf:type schema:Organization
    432 grid-institutes:grid.452661.2 schema:alternateName Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
    433 schema:name Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
    434 rdf:type schema:Organization
    435 grid-institutes:grid.507739.f schema:alternateName State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences–University of Chinese Academy of Sciences, Shanghai, China
    436 State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences–University of Chinese Academy of Sciences, Shanghai, China
    437 The Animal Core Facility, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    438 schema:name School of Life Science and Technology, Shanghai Tech University, Shanghai, China
    439 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences–University of Chinese Academy of Sciences, Shanghai, China
    440 State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences–University of Chinese Academy of Sciences, Shanghai, China
    441 The Animal Core Facility, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    442 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...