Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Nicoletta I. Petridou, Silvia Grigolon, Guillaume Salbreux, Edouard Hannezo, Carl-Philipp Heisenberg

ABSTRACT

Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shape and motion. The extent by which forces deform tissues critically depends on the rheological properties of the recipient tissue. Yet, whether and how dynamic changes in tissue rheology affect tissue morphogenesis and how they are regulated within the developing organism remain unclear. Here, we show that blastoderm spreading at the onset of zebrafish morphogenesis relies on a rapid, pronounced and spatially patterned tissue fluidization. Blastoderm fluidization is temporally controlled by mitotic cell rounding-dependent cell-cell contact disassembly during the last rounds of cell cleavages. Moreover, fluidization is spatially restricted to the central blastoderm by local activation of non-canonical Wnt signalling within the blastoderm margin, increasing cell cohesion and thereby counteracting the effect of mitotic rounding on contact disassembly. Overall, our results identify a fluidity transition mediated by loss of cell cohesion as a critical regulator of embryo morphogenesis. More... »

PAGES

169-178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41556-018-0247-4

DOI

http://dx.doi.org/10.1038/s41556-018-0247-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110346421

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30559456


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Science and Technology Austria", 
          "id": "https://www.grid.ac/institutes/grid.33565.36", 
          "name": [
            "Institute of Science and Technology Austria, Klosterneuburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petridou", 
        "givenName": "Nicoletta I.", 
        "id": "sg:person.0727066765.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727066765.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grigolon", 
        "givenName": "Silvia", 
        "id": "sg:person.07361443321.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07361443321.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "The Francis Crick Institute, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salbreux", 
        "givenName": "Guillaume", 
        "id": "sg:person.012345044027.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012345044027.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Science and Technology Austria", 
          "id": "https://www.grid.ac/institutes/grid.33565.36", 
          "name": [
            "Institute of Science and Technology Austria, Klosterneuburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hannezo", 
        "givenName": "Edouard", 
        "id": "sg:person.01321470664.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321470664.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Science and Technology Austria", 
          "id": "https://www.grid.ac/institutes/grid.33565.36", 
          "name": [
            "Institute of Science and Technology Austria, Klosterneuburg, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heisenberg", 
        "givenName": "Carl-Philipp", 
        "id": "sg:person.0750434541.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750434541.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncomms9872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002201891", 
          "https://doi.org/10.1038/ncomms9872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003215518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200606017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003308669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1226418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003543676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.090381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005107622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0052554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007282691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008263031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/bs.mcb.2016.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012865283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2008.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012911400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2010.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013130294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.24353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015392733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1224143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016124803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/aja.1002030302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017782944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019312574", 
          "https://doi.org/10.1038/nmeth.4101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2016.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019421644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-385065-2.00007-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019958565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0099116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021458408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1225399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023485437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diff.2013.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024218128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-30406-4_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024474651", 
          "https://doi.org/10.1007/978-3-642-30406-4_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2013.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024619913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2009.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026004906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(98)77932-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026252028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2010.07.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027025402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevx.6.021011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028156542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevx.6.021011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028156542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2976/1.2895661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030180004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1010059108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030650357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033195161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1006591107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033770447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.22692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034972805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036016570", 
          "https://doi.org/10.1038/nature09642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038256555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200310027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038274785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-384892-5.00010-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039007085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(98)00013-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039152685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2004.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039593160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2005.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041713272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2005.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041713272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rsif.2013.0726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041737387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mod.2005.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042292289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2009.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042613811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1994.1212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042776613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1011086107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045300665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.104315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047331432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nphys3471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047923366", 
          "https://doi.org/10.1038/nphys3471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200709161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048518262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1162493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050946491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2009.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051694207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevlett.104.218101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052451694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/physrevlett.104.218101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052451694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(85)90010-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052601127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35011068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053242271", 
          "https://doi.org/10.1038/35011068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35011068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053242271", 
          "https://doi.org/10.1038/35011068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/19336918.2015.1113366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058412406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1387/ijdb.093028sl", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067191155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082425450", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2017.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083849409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.144964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085419399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085722638", 
          "https://doi.org/10.1038/ncb3524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085722638", 
          "https://doi.org/10.1038/ncb3524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.26944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101524454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.26944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101524454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0479-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106613357", 
          "https://doi.org/10.1038/s41586-018-0479-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0479-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106613357", 
          "https://doi.org/10.1038/s41586-018-0479-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0479-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106613357", 
          "https://doi.org/10.1038/s41586-018-0479-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41586-018-0479-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106613357", 
          "https://doi.org/10.1038/s41586-018-0479-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shape and motion. The extent by which forces deform tissues critically depends on the rheological properties of the recipient tissue. Yet, whether and how dynamic changes in tissue rheology affect tissue morphogenesis and how they are regulated within the developing organism remain unclear. Here, we show that blastoderm spreading at the onset of zebrafish morphogenesis relies on a rapid, pronounced and spatially patterned tissue fluidization. Blastoderm fluidization is temporally controlled by mitotic cell rounding-dependent cell-cell contact disassembly during the last rounds of cell cleavages. Moreover, fluidization is spatially restricted to the central blastoderm by local activation of non-canonical Wnt signalling within the blastoderm margin, increasing cell cohesion and thereby counteracting the effect of mitotic rounding on contact disassembly. Overall, our results identify a fluidity transition mediated by loss of cell cohesion as a critical regulator of embryo morphogenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41556-018-0247-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6798244", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021344", 
        "issn": [
          "1465-7392", 
          "1476-4679"
        ], 
        "name": "Nature Cell Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling", 
    "pagination": "169-178", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fdd18b990610e00f252a98acceddc7472dd59361ddc1e3df0045ff6aa5086be6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30559456"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100890575"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41556-018-0247-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110346421"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41556-018-0247-4", 
      "https://app.dimensions.ai/details/publication/pub.1110346421"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000369_0000000369/records_68943_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41556-018-0247-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41556-018-0247-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41556-018-0247-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41556-018-0247-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41556-018-0247-4'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41556-018-0247-4 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N5dbe41e662c64d48ae8f9a2a929a4ad9
4 schema:citation sg:pub.10.1007/978-3-642-30406-4_10
5 sg:pub.10.1038/35011068
6 sg:pub.10.1038/nature09642
7 sg:pub.10.1038/ncb3524
8 sg:pub.10.1038/ncomms9872
9 sg:pub.10.1038/nmeth.4101
10 sg:pub.10.1038/nphys3471
11 sg:pub.10.1038/s41586-018-0479-2
12 https://app.dimensions.ai/details/publication/pub.1082425450
13 https://doi.org/10.1002/aja.1002030302
14 https://doi.org/10.1002/ar.22692
15 https://doi.org/10.1002/dvdy.24353
16 https://doi.org/10.1006/dbio.1994.1212
17 https://doi.org/10.1016/0012-1606(85)90010-7
18 https://doi.org/10.1016/b978-0-12-384892-5.00010-4
19 https://doi.org/10.1016/b978-0-12-385065-2.00007-4
20 https://doi.org/10.1016/bs.mcb.2016.11.012
21 https://doi.org/10.1016/j.cell.2013.05.008
22 https://doi.org/10.1016/j.cell.2015.01.008
23 https://doi.org/10.1016/j.cub.2008.02.013
24 https://doi.org/10.1016/j.cub.2009.11.036
25 https://doi.org/10.1016/j.cub.2010.10.009
26 https://doi.org/10.1016/j.devcel.2004.04.001
27 https://doi.org/10.1016/j.devcel.2005.08.011
28 https://doi.org/10.1016/j.devcel.2009.01.008
29 https://doi.org/10.1016/j.devcel.2013.01.016
30 https://doi.org/10.1016/j.devcel.2016.01.007
31 https://doi.org/10.1016/j.devcel.2017.01.010
32 https://doi.org/10.1016/j.diff.2013.02.005
33 https://doi.org/10.1016/j.mod.2005.03.008
34 https://doi.org/10.1016/j.ydbio.2009.04.036
35 https://doi.org/10.1016/j.ydbio.2010.07.037
36 https://doi.org/10.1016/s0006-3495(98)77932-9
37 https://doi.org/10.1016/s0925-4773(98)00013-6
38 https://doi.org/10.1038/sj.embor.7400386
39 https://doi.org/10.1073/pnas.1006591107
40 https://doi.org/10.1073/pnas.1010059108
41 https://doi.org/10.1073/pnas.1011086107
42 https://doi.org/10.1080/19336918.2015.1113366
43 https://doi.org/10.1083/jcb.200310027
44 https://doi.org/10.1083/jcb.200606017
45 https://doi.org/10.1083/jcb.200709161
46 https://doi.org/10.1098/rsif.2013.0726
47 https://doi.org/10.1103/physrevlett.104.218101
48 https://doi.org/10.1103/physrevx.6.021011
49 https://doi.org/10.1126/science.1162493
50 https://doi.org/10.1126/science.1224143
51 https://doi.org/10.1126/science.1225399
52 https://doi.org/10.1126/science.1226418
53 https://doi.org/10.1242/dev.00758
54 https://doi.org/10.1242/dev.090381
55 https://doi.org/10.1242/dev.104315
56 https://doi.org/10.1242/dev.144964
57 https://doi.org/10.1371/journal.pone.0052554
58 https://doi.org/10.1371/journal.pone.0099116
59 https://doi.org/10.1387/ijdb.093028sl
60 https://doi.org/10.2976/1.2895661
61 https://doi.org/10.7554/elife.26944
62 schema:datePublished 2019-02
63 schema:datePublishedReg 2019-02-01
64 schema:description Tissue morphogenesis is driven by mechanical forces that elicit changes in cell size, shape and motion. The extent by which forces deform tissues critically depends on the rheological properties of the recipient tissue. Yet, whether and how dynamic changes in tissue rheology affect tissue morphogenesis and how they are regulated within the developing organism remain unclear. Here, we show that blastoderm spreading at the onset of zebrafish morphogenesis relies on a rapid, pronounced and spatially patterned tissue fluidization. Blastoderm fluidization is temporally controlled by mitotic cell rounding-dependent cell-cell contact disassembly during the last rounds of cell cleavages. Moreover, fluidization is spatially restricted to the central blastoderm by local activation of non-canonical Wnt signalling within the blastoderm margin, increasing cell cohesion and thereby counteracting the effect of mitotic rounding on contact disassembly. Overall, our results identify a fluidity transition mediated by loss of cell cohesion as a critical regulator of embryo morphogenesis.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree false
68 schema:isPartOf Ncd9b58d37cd94c1aaf526a8b530503a5
69 Ne943e50dedbf42be86582d15e834b22b
70 sg:journal.1021344
71 schema:name Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling
72 schema:pagination 169-178
73 schema:productId N21e154b284b3419ca6224dc4da19cd78
74 N8721073a711347c98bd1e30e33bb82b1
75 N92a1214b60394a9bba05dc43421a7515
76 Na810b926ffce4df3b1b3970361be79ef
77 Nd0b06677e99f4f058af2f2c18b8a032e
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110346421
79 https://doi.org/10.1038/s41556-018-0247-4
80 schema:sdDatePublished 2019-04-11T13:22
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N8a01e26af9694879972cb5fcf0edbe64
83 schema:url https://www.nature.com/articles/s41556-018-0247-4
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N21e154b284b3419ca6224dc4da19cd78 schema:name nlm_unique_id
88 schema:value 100890575
89 rdf:type schema:PropertyValue
90 N5004ba63ecca4b9e8f38f4d5c987b310 rdf:first sg:person.0750434541.99
91 rdf:rest rdf:nil
92 N5dbe41e662c64d48ae8f9a2a929a4ad9 rdf:first sg:person.0727066765.67
93 rdf:rest Ndc9660d4ef564040aadd7cdac0e4fed0
94 N60add7b03cb94d89affd7d4c0cfd349b rdf:first sg:person.012345044027.09
95 rdf:rest N91af252d2797415cb570d5d6a1ece497
96 N8721073a711347c98bd1e30e33bb82b1 schema:name pubmed_id
97 schema:value 30559456
98 rdf:type schema:PropertyValue
99 N8a01e26af9694879972cb5fcf0edbe64 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N91af252d2797415cb570d5d6a1ece497 rdf:first sg:person.01321470664.07
102 rdf:rest N5004ba63ecca4b9e8f38f4d5c987b310
103 N92a1214b60394a9bba05dc43421a7515 schema:name readcube_id
104 schema:value fdd18b990610e00f252a98acceddc7472dd59361ddc1e3df0045ff6aa5086be6
105 rdf:type schema:PropertyValue
106 Na810b926ffce4df3b1b3970361be79ef schema:name doi
107 schema:value 10.1038/s41556-018-0247-4
108 rdf:type schema:PropertyValue
109 Ncd9b58d37cd94c1aaf526a8b530503a5 schema:issueNumber 2
110 rdf:type schema:PublicationIssue
111 Nd0b06677e99f4f058af2f2c18b8a032e schema:name dimensions_id
112 schema:value pub.1110346421
113 rdf:type schema:PropertyValue
114 Ndc9660d4ef564040aadd7cdac0e4fed0 rdf:first sg:person.07361443321.23
115 rdf:rest N60add7b03cb94d89affd7d4c0cfd349b
116 Ne943e50dedbf42be86582d15e834b22b schema:volumeNumber 21
117 rdf:type schema:PublicationVolume
118 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
119 schema:name Biological Sciences
120 rdf:type schema:DefinedTerm
121 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
122 schema:name Biochemistry and Cell Biology
123 rdf:type schema:DefinedTerm
124 sg:grant.6798244 http://pending.schema.org/fundedItem sg:pub.10.1038/s41556-018-0247-4
125 rdf:type schema:MonetaryGrant
126 sg:journal.1021344 schema:issn 1465-7392
127 1476-4679
128 schema:name Nature Cell Biology
129 rdf:type schema:Periodical
130 sg:person.012345044027.09 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
131 schema:familyName Salbreux
132 schema:givenName Guillaume
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012345044027.09
134 rdf:type schema:Person
135 sg:person.01321470664.07 schema:affiliation https://www.grid.ac/institutes/grid.33565.36
136 schema:familyName Hannezo
137 schema:givenName Edouard
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321470664.07
139 rdf:type schema:Person
140 sg:person.0727066765.67 schema:affiliation https://www.grid.ac/institutes/grid.33565.36
141 schema:familyName Petridou
142 schema:givenName Nicoletta I.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727066765.67
144 rdf:type schema:Person
145 sg:person.07361443321.23 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
146 schema:familyName Grigolon
147 schema:givenName Silvia
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07361443321.23
149 rdf:type schema:Person
150 sg:person.0750434541.99 schema:affiliation https://www.grid.ac/institutes/grid.33565.36
151 schema:familyName Heisenberg
152 schema:givenName Carl-Philipp
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750434541.99
154 rdf:type schema:Person
155 sg:pub.10.1007/978-3-642-30406-4_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024474651
156 https://doi.org/10.1007/978-3-642-30406-4_10
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/35011068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053242271
159 https://doi.org/10.1038/35011068
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/nature09642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036016570
162 https://doi.org/10.1038/nature09642
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/ncb3524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085722638
165 https://doi.org/10.1038/ncb3524
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/ncomms9872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002201891
168 https://doi.org/10.1038/ncomms9872
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/nmeth.4101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019312574
171 https://doi.org/10.1038/nmeth.4101
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/nphys3471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047923366
174 https://doi.org/10.1038/nphys3471
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/s41586-018-0479-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106613357
177 https://doi.org/10.1038/s41586-018-0479-2
178 rdf:type schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1082425450 schema:CreativeWork
180 https://doi.org/10.1002/aja.1002030302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017782944
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1002/ar.22692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034972805
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/dvdy.24353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015392733
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1006/dbio.1994.1212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042776613
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0012-1606(85)90010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052601127
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/b978-0-12-384892-5.00010-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039007085
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/b978-0-12-385065-2.00007-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019958565
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/bs.mcb.2016.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012865283
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.cell.2013.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008263031
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.cell.2015.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038256555
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.cub.2008.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012911400
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.cub.2009.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042613811
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.cub.2010.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013130294
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.devcel.2004.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039593160
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.devcel.2005.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041713272
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.devcel.2009.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051694207
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.devcel.2013.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024619913
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.devcel.2016.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019421644
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.devcel.2017.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083849409
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.diff.2013.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024218128
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.mod.2005.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042292289
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.ydbio.2009.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026004906
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.ydbio.2010.07.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027025402
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0006-3495(98)77932-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026252028
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0925-4773(98)00013-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039152685
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1038/sj.embor.7400386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003215518
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1073/pnas.1006591107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033770447
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1073/pnas.1010059108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030650357
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1073/pnas.1011086107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045300665
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1080/19336918.2015.1113366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058412406
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1083/jcb.200310027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038274785
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1083/jcb.200606017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003308669
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1083/jcb.200709161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048518262
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1098/rsif.2013.0726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041737387
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1103/physrevlett.104.218101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052451694
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1103/physrevx.6.021011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028156542
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1126/science.1162493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050946491
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1126/science.1224143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016124803
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1126/science.1225399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023485437
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1126/science.1226418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003543676
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1242/dev.00758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033195161
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1242/dev.090381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005107622
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1242/dev.104315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047331432
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1242/dev.144964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085419399
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1371/journal.pone.0052554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007282691
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1371/journal.pone.0099116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021458408
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1387/ijdb.093028sl schema:sameAs https://app.dimensions.ai/details/publication/pub.1067191155
273 rdf:type schema:CreativeWork
274 https://doi.org/10.2976/1.2895661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030180004
275 rdf:type schema:CreativeWork
276 https://doi.org/10.7554/elife.26944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101524454
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.33565.36 schema:alternateName Institute of Science and Technology Austria
279 schema:name Institute of Science and Technology Austria, Klosterneuburg, Austria
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
282 schema:name The Francis Crick Institute, London, UK
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...