Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12-02

AUTHORS

Paul-Henri Prévot, Kevin Gehere, Fabrice Arcizet, Himanshu Akolkar, Mina A. Khoei, Kévin Blaize, Omar Oubari, Pierre Daye, Marion Lanoë, Manon Valet, Sami Dalouz, Paul Langlois, Elric Esposito, Valérie Forster, Elisabeth Dubus, Nicolas Wattiez, Elena Brazhnikova, Céline Nouvel-Jaillard, Yannick LeMer, Joanna Demilly, Claire-Maëlle Fovet, Philippe Hantraye, Morgane Weissenburger, Henri Lorach, Elodie Bouillet, Martin Deterre, Ralf Hornig, Guillaume Buc, José-Alain Sahel, Guillaume Chenegros, Pierre Pouget, Ryad Benosman, Serge Picaud

ABSTRACT

Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multipixel stimulation of the prosthesis within radiation safety limits enabled eye tracking in the animals, that they responded to stimulations directed at the implant with repeated saccades and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of the prosthesis in patients affected by dry atrophic age-related macular degeneration. More... »

PAGES

172-180

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41551-019-0484-2

DOI

http://dx.doi.org/10.1038/s41551-019-0484-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123048175

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31792423


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