A physical biomarker of the quality of cultured corneal endothelial cells and of the long-term prognosis of corneal restoration in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-22

AUTHORS

Akihisa Yamamoto, Hiroshi Tanaka, Munetoyo Toda, Chie Sotozono, Junji Hamuro, Shigeru Kinoshita, Morio Ueno, Motomu Tanaka

ABSTRACT

Dysfunction of the corneal endothelium reduces the transparency of the cornea and can cause blindness. Because corneal endothelial cells have an extremely limited proliferative ability in vivo, treatment for corneal endothelial dysfunction involves the transplantation of donor corneal tissue. Corneal endothelium can also be restored via intraocular injection of endothelial cells in suspension after their expansion in vitro. Yet, because quality assessment during the expansion of the cells is a destructive process, a substantial number of the cultured cells are lost. Here, we show that the ‘spring constant’ of the effective interaction potential between endothelial cells in a confluent monolayer serves as a biomarker of the quality of corneal endothelial cells in vitro and of the long-term prognosis of corneal restoration in patients treated with culture-expanded endothelial cells or with transplanted corneas. The biomarker can be measured from phase contrast imaging in vitro and from specular microscopy in vivo, and may enable a shift from passive monitoring to pre-emptive intervention in patients with severe corneal disorders. More... »

PAGES

953-960

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41551-019-0429-9

DOI

http://dx.doi.org/10.1038/s41551-019-0429-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1118151736

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31332343


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