Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Matthew A. Bochenek, Omid Veiseh, Arturo J. Vegas, James J. McGarrigle, Meirigeng Qi, Enza Marchese, Mustafa Omami, Joshua C. Doloff, Joshua Mendoza-Elias, Mohammad Nourmohammadzadeh, Arshad Khan, Chun-Chieh Yeh, Yuan Xing, Douglas Isa, Sofia Ghani, Jie Li, Casey Landry, Andrew R. Bader, Karsten Olejnik, Michael Chen, Jennifer Hollister-Lock, Yong Wang, Dale L. Greiner, Gordon C. Weir, Berit Løkensgard Strand, Anne Mari A. Rokstad, Igor Lacik, Robert Langer, Daniel G. Anderson, Jose Oberholzer

ABSTRACT

The transplantation of pancreatic islet cells could restore glycaemic control in patients with type-I diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic control in diabetic rodent models; yet human patients transplanted with equivalent microsphere formulations have experienced only transient islet-graft function, owing to a vigorous foreign-body reaction (FBR), to pericapsular fibrotic overgrowth (PFO) and, in upright bipedal species, to the sedimentation of the microspheres within the peritoneal cavity. Here, we report the results of the testing, in non-human primate (NHP) models, of seven alginate formulations that were efficacious in rodents, including three that led to transient islet-graft function in clinical trials. Although one month post-implantation all formulations elicited significant FBR and PFO, three chemically modified, immune-modulating alginate formulations elicited reduced FBR. In conjunction with a minimally invasive transplantation technique into the bursa omentalis of NHPs, the most promising chemically modified alginate derivative (Z1-Y15) protected viable and glucose-responsive allogeneic islets for 4 months without the need for immunosuppression. Chemically modified alginate formulations may enable the long-term transplantation of islets for the correction of insulin deficiency. More... »

PAGES

810-821

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41551-018-0275-1

    DOI

    http://dx.doi.org/10.1038/s41551-018-0275-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106070344

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30873298


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41551-018-0275-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41551-018-0275-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41551-018-0275-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41551-018-0275-1'


     

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