A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-28

AUTHORS

Yizhi Qi, Antonina Simakova, Nancy J Ganson, Xinghai Li, Kelli M Luginbuhl, Imran Özer, Wenge Liu, Michael S Hershfield, Krzysztof Matyjaszewski, Ashutosh Chilkoti

ABSTRACT

The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneous injection of site-specific (C-terminal) conjugates of exendin-4 (exendin) - a therapeutic peptide that is clinically used to treat type 2 diabetes - and poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) with precisely controlled molecular weights lowered blood glucose for up to 120 h in fed mice. Most notably, we show that an exendin-C-POEGMA conjugate with an average of 9 side-chain ethylene glycol (EG) repeats exhibits significantly lower reactivity towards patient-derived anti-poly(ethylene glycol) (PEG) antibodies than two FDA-approved PEGylated drugs, and that reducing the side-chain length to 3 EG repeats completely eliminates PEG antigenicity without compromising in vivo efficacy. Our findings establish the site-specific conjugation of POEGMA as a next-generation PEGylation technology for improving the pharmacological performance of traditional PEGylated drugs, whose safety and efficacy are hindered by pre-existing anti-PEG antibodies in patients. More... »

PAGES

0002

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41551-016-0002

DOI

http://dx.doi.org/10.1038/s41551-016-0002

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053436990

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28989813


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biomedical Engineering, Duke University, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Yizhi", 
        "id": "sg:person.01226337743.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226337743.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Carnegie Mellon University", 
          "id": "https://www.grid.ac/institutes/grid.147455.6", 
          "name": [
            "Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simakova", 
        "givenName": "Antonina", 
        "id": "sg:person.011070564715.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011070564715.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganson", 
        "givenName": "Nancy J", 
        "id": "sg:person.01012525437.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012525437.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biomedical Engineering, Duke University, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xinghai", 
        "id": "sg:person.01123070242.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123070242.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biomedical Engineering, Duke University, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luginbuhl", 
        "givenName": "Kelli M", 
        "id": "sg:person.0757651732.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757651732.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biomedical Engineering, Duke University, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00d6zer", 
        "givenName": "Imran", 
        "id": "sg:person.011631725505.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011631725505.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biomedical Engineering, Duke University, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Wenge", 
        "id": "sg:person.0612112655.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612112655.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC, USA.", 
            "Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hershfield", 
        "givenName": "Michael S", 
        "id": "sg:person.0645324745.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645324745.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Carnegie Mellon University", 
          "id": "https://www.grid.ac/institutes/grid.147455.6", 
          "name": [
            "Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matyjaszewski", 
        "givenName": "Krzysztof", 
        "id": "sg:person.0652352360.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652352360.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Department of Biomedical Engineering, Duke University, Durham, NC, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chilkoti", 
        "givenName": "Ashutosh", 
        "id": "sg:person.01051674744.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051674744.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.10.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000725462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr940534g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000997076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr940534g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000997076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(08)60065-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001186244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.101064198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001255813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(03)00108-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002304749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(03)00108-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002304749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eurpolymj.2013.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003536875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0803284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006319517", 
          "https://doi.org/10.1038/sj.ijo.0803284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0803284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006319517", 
          "https://doi.org/10.1038/sj.ijo.0803284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.187.14.4928-4934.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006329014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2006.11.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007144941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1472-8206.2008.00633.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007410708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar1861", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007745350", 
          "https://doi.org/10.1186/ar1861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000233512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007979869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m401374200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010585954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cbdd.12055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010931251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar4500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011531053", 
          "https://doi.org/10.1186/ar4500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200600272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013086299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja104493d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013100889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja104493d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013100889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm050428w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014424997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm050428w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014424997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-005-0289-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015176207", 
          "https://doi.org/10.1007/s00726-005-0289-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-005-0289-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015176207", 
          "https://doi.org/10.1007/s00726-005-0289-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-005-0289-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015176207", 
          "https://doi.org/10.1007/s00726-005-0289-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(00)00193-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020015933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm901387t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020914636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm901387t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020914636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja408069v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021861508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0904378106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021925885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022421691", 
          "https://doi.org/10.1038/nbt.1588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022421691", 
          "https://doi.org/10.1038/nbt.1588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69705-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022756080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.9.2492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022950121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2009.48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023258232", 
          "https://doi.org/10.1038/nrendo.2009.48"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2011.12.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024184520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2010.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024853807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201408126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024882202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja042230+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032227744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja042230+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032227744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b719689j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032675870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3py01089a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034138507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425247.2012.720969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035823459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc900468v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036084167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc900468v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036084167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/marc.201300460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041153758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.suppl_3.s215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041970513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379113", 
          "https://doi.org/10.1038/15100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/15100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379113", 
          "https://doi.org/10.1038/15100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.04679104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042434380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1006044107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042742812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000233309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043690317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja039915e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044596906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja039915e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044596906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c1py00034a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046592378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-409x(91)90037-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050509794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-409x(91)90037-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050509794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051687311", 
          "https://doi.org/10.1038/nrd2399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052175453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1214518110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053135604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi010902s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055193961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi010902s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055193961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ma048438x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056189711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ma048438x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056189711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156720107780362339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069186511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.37.9.1163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076153877", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077609258", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082789141", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9781420039832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1095904015"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11-28", 
    "datePublishedReg": "2016-11-28", 
    "description": "The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneous injection of site-specific (C-terminal) conjugates of exendin-4 (exendin) - a therapeutic peptide that is clinically used to treat type 2 diabetes - and poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) with precisely controlled molecular weights lowered blood glucose for up to 120 h in fed mice. Most notably, we show that an exendin-C-POEGMA conjugate with an average of 9 side-chain ethylene glycol (EG) repeats exhibits significantly lower reactivity towards patient-derived anti-poly(ethylene glycol) (PEG) antibodies than two FDA-approved PEGylated drugs, and that reducing the side-chain length to 3 EG repeats completely eliminates PEG antigenicity without compromising in vivo efficacy. Our findings establish the site-specific conjugation of POEGMA as a next-generation PEGylation technology for improving the pharmacological performance of traditional PEGylated drugs, whose safety and efficacy are hindered by pre-existing anti-PEG antibodies in patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41551-016-0002", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2500476", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1284437", 
        "issn": [
          "2157-846X"
        ], 
        "name": "Nature Biomedical Engineering", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity", 
    "pagination": "0002", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fe86e4f4d74ee5a1ab42f05ef991be1911db0a4a4bcff852ebc10d77da78a229"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28989813"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101696896"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41551-016-0002"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053436990"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41551-016-0002", 
      "https://app.dimensions.ai/details/publication/pub.1053436990"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41551-016-0002"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41551-016-0002'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41551-016-0002'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41551-016-0002'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41551-016-0002'


 

This table displays all metadata directly associated to this object as RDF triples.

311 TRIPLES      21 PREDICATES      83 URIs      20 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41551-016-0002 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N1818b8d666694ef5a13fc737da3541a3
4 schema:citation sg:pub.10.1007/s00726-005-0289-3
5 sg:pub.10.1038/15100
6 sg:pub.10.1038/nbt.1588
7 sg:pub.10.1038/nrd2399
8 sg:pub.10.1038/nrendo.2009.48
9 sg:pub.10.1038/sj.ijo.0803284
10 sg:pub.10.1186/ar1861
11 sg:pub.10.1186/ar4500
12 https://app.dimensions.ai/details/publication/pub.1076153877
13 https://app.dimensions.ai/details/publication/pub.1077609258
14 https://app.dimensions.ai/details/publication/pub.1082789141
15 https://doi.org/10.1002/anie.200600272
16 https://doi.org/10.1002/anie.201408126
17 https://doi.org/10.1002/cncr.22739
18 https://doi.org/10.1002/marc.201300460
19 https://doi.org/10.1016/0169-409x(91)90037-d
20 https://doi.org/10.1016/j.eurpolymj.2013.04.015
21 https://doi.org/10.1016/j.jaci.2015.10.034
22 https://doi.org/10.1016/j.jconrel.2006.11.013
23 https://doi.org/10.1016/j.jconrel.2010.10.004
24 https://doi.org/10.1016/j.neuropharm.2011.12.022
25 https://doi.org/10.1016/s0065-3233(08)60065-0
26 https://doi.org/10.1016/s0140-6736(06)69705-5
27 https://doi.org/10.1016/s0142-9612(00)00193-9
28 https://doi.org/10.1016/s0169-409x(03)00108-x
29 https://doi.org/10.1021/bc900468v
30 https://doi.org/10.1021/bi010902s
31 https://doi.org/10.1021/bm050428w
32 https://doi.org/10.1021/bm901387t
33 https://doi.org/10.1021/cr940534g
34 https://doi.org/10.1021/ja039915e
35 https://doi.org/10.1021/ja042230+
36 https://doi.org/10.1021/ja104493d
37 https://doi.org/10.1021/ja408069v
38 https://doi.org/10.1021/ma048438x
39 https://doi.org/10.1039/b719689j
40 https://doi.org/10.1039/c1py00034a
41 https://doi.org/10.1039/c3py01089a
42 https://doi.org/10.1073/pnas.0904378106
43 https://doi.org/10.1073/pnas.1006044107
44 https://doi.org/10.1073/pnas.101064198
45 https://doi.org/10.1073/pnas.1214518110
46 https://doi.org/10.1074/jbc.m401374200
47 https://doi.org/10.1110/ps.04679104
48 https://doi.org/10.1111/cbdd.12055
49 https://doi.org/10.1111/j.1472-8206.2008.00633.x
50 https://doi.org/10.1128/jb.187.14.4928-4934.2005
51 https://doi.org/10.1159/000233309
52 https://doi.org/10.1159/000233512
53 https://doi.org/10.1201/9781420039832
54 https://doi.org/10.1517/17425247.2012.720969
55 https://doi.org/10.2174/156720107780362339
56 https://doi.org/10.2337/diab.37.9.1163
57 https://doi.org/10.2337/diabetes.53.9.2492
58 https://doi.org/10.2337/diabetes.53.suppl_3.s215
59 schema:datePublished 2016-11-28
60 schema:datePublishedReg 2016-11-28
61 schema:description The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneous injection of site-specific (C-terminal) conjugates of exendin-4 (exendin) - a therapeutic peptide that is clinically used to treat type 2 diabetes - and poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) with precisely controlled molecular weights lowered blood glucose for up to 120 h in fed mice. Most notably, we show that an exendin-C-POEGMA conjugate with an average of 9 side-chain ethylene glycol (EG) repeats exhibits significantly lower reactivity towards patient-derived anti-poly(ethylene glycol) (PEG) antibodies than two FDA-approved PEGylated drugs, and that reducing the side-chain length to 3 EG repeats completely eliminates PEG antigenicity without compromising <i>in vivo</i> efficacy. Our findings establish the site-specific conjugation of POEGMA as a next-generation PEGylation technology for improving the pharmacological performance of traditional PEGylated drugs, whose safety and efficacy are hindered by pre-existing anti-PEG antibodies in patients.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf Nc7fc97bcfcd04619996587d2e26c74cc
66 Ndc86506aeed242378f244094180f6035
67 sg:journal.1284437
68 schema:name A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity
69 schema:pagination 0002
70 schema:productId N33348aa616c44fbcb57aab14d357d2ff
71 N38e2caed8ae24c7b938dd6f13ff5c20c
72 N60a0351a434e41a987952a63c9a755c6
73 Ncbb0550f804f4a94944f30440123a9eb
74 Nd35d65020f9347ff9fc13ae0b3130f4f
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053436990
76 https://doi.org/10.1038/s41551-016-0002
77 schema:sdDatePublished 2019-04-10T21:44
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N9743bb9483504159884f34a3184c39b5
80 schema:url http://www.nature.com/articles/s41551-016-0002
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N1818b8d666694ef5a13fc737da3541a3 rdf:first sg:person.01226337743.70
85 rdf:rest Ne893fae6e557421f9314cacc5fc2b6fe
86 N33348aa616c44fbcb57aab14d357d2ff schema:name doi
87 schema:value 10.1038/s41551-016-0002
88 rdf:type schema:PropertyValue
89 N38e2caed8ae24c7b938dd6f13ff5c20c schema:name nlm_unique_id
90 schema:value 101696896
91 rdf:type schema:PropertyValue
92 N41ce7f52a6ae427e8c19ff53ac99b187 rdf:first sg:person.01123070242.34
93 rdf:rest N59dcac0bcf844f1d9791ffbf0747ab42
94 N59dcac0bcf844f1d9791ffbf0747ab42 rdf:first sg:person.0757651732.68
95 rdf:rest N6a8727e0501e453abe621eba0549101c
96 N60a0351a434e41a987952a63c9a755c6 schema:name dimensions_id
97 schema:value pub.1053436990
98 rdf:type schema:PropertyValue
99 N6a8727e0501e453abe621eba0549101c rdf:first sg:person.011631725505.14
100 rdf:rest Nd9bcfb698e4c4951b3829f278442345c
101 N799c6fdc988747cfa039370d2fdfd525 rdf:first sg:person.01051674744.73
102 rdf:rest rdf:nil
103 N9743bb9483504159884f34a3184c39b5 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 Nb2397701712a42b489b0cf7785032105 rdf:first sg:person.01012525437.03
106 rdf:rest N41ce7f52a6ae427e8c19ff53ac99b187
107 Nc7fc97bcfcd04619996587d2e26c74cc schema:issueNumber 1
108 rdf:type schema:PublicationIssue
109 Ncbb0550f804f4a94944f30440123a9eb schema:name readcube_id
110 schema:value fe86e4f4d74ee5a1ab42f05ef991be1911db0a4a4bcff852ebc10d77da78a229
111 rdf:type schema:PropertyValue
112 Nd35d65020f9347ff9fc13ae0b3130f4f schema:name pubmed_id
113 schema:value 28989813
114 rdf:type schema:PropertyValue
115 Nd9bcfb698e4c4951b3829f278442345c rdf:first sg:person.0612112655.11
116 rdf:rest Nfd6ce335ac77499ca698dbc73c0aa722
117 Ndc86506aeed242378f244094180f6035 schema:volumeNumber 1
118 rdf:type schema:PublicationVolume
119 Ne893fae6e557421f9314cacc5fc2b6fe rdf:first sg:person.011070564715.13
120 rdf:rest Nb2397701712a42b489b0cf7785032105
121 Ned3baee804954e93bbbf12f2d494f058 rdf:first sg:person.0652352360.72
122 rdf:rest N799c6fdc988747cfa039370d2fdfd525
123 Nfd6ce335ac77499ca698dbc73c0aa722 rdf:first sg:person.0645324745.16
124 rdf:rest Ned3baee804954e93bbbf12f2d494f058
125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
126 schema:name Medical and Health Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
129 schema:name Clinical Sciences
130 rdf:type schema:DefinedTerm
131 sg:grant.2500476 http://pending.schema.org/fundedItem sg:pub.10.1038/s41551-016-0002
132 rdf:type schema:MonetaryGrant
133 sg:journal.1284437 schema:issn 2157-846X
134 schema:name Nature Biomedical Engineering
135 rdf:type schema:Periodical
136 sg:person.01012525437.03 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
137 schema:familyName Ganson
138 schema:givenName Nancy J
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012525437.03
140 rdf:type schema:Person
141 sg:person.01051674744.73 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
142 schema:familyName Chilkoti
143 schema:givenName Ashutosh
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051674744.73
145 rdf:type schema:Person
146 sg:person.011070564715.13 schema:affiliation https://www.grid.ac/institutes/grid.147455.6
147 schema:familyName Simakova
148 schema:givenName Antonina
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011070564715.13
150 rdf:type schema:Person
151 sg:person.01123070242.34 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
152 schema:familyName Li
153 schema:givenName Xinghai
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123070242.34
155 rdf:type schema:Person
156 sg:person.011631725505.14 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
157 schema:familyName Özer
158 schema:givenName Imran
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011631725505.14
160 rdf:type schema:Person
161 sg:person.01226337743.70 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
162 schema:familyName Qi
163 schema:givenName Yizhi
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226337743.70
165 rdf:type schema:Person
166 sg:person.0612112655.11 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
167 schema:familyName Liu
168 schema:givenName Wenge
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612112655.11
170 rdf:type schema:Person
171 sg:person.0645324745.16 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
172 schema:familyName Hershfield
173 schema:givenName Michael S
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645324745.16
175 rdf:type schema:Person
176 sg:person.0652352360.72 schema:affiliation https://www.grid.ac/institutes/grid.147455.6
177 schema:familyName Matyjaszewski
178 schema:givenName Krzysztof
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652352360.72
180 rdf:type schema:Person
181 sg:person.0757651732.68 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
182 schema:familyName Luginbuhl
183 schema:givenName Kelli M
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757651732.68
185 rdf:type schema:Person
186 sg:pub.10.1007/s00726-005-0289-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015176207
187 https://doi.org/10.1007/s00726-005-0289-3
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/15100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379113
190 https://doi.org/10.1038/15100
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nbt.1588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022421691
193 https://doi.org/10.1038/nbt.1588
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nrd2399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051687311
196 https://doi.org/10.1038/nrd2399
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nrendo.2009.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023258232
199 https://doi.org/10.1038/nrendo.2009.48
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/sj.ijo.0803284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006319517
202 https://doi.org/10.1038/sj.ijo.0803284
203 rdf:type schema:CreativeWork
204 sg:pub.10.1186/ar1861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007745350
205 https://doi.org/10.1186/ar1861
206 rdf:type schema:CreativeWork
207 sg:pub.10.1186/ar4500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011531053
208 https://doi.org/10.1186/ar4500
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1076153877 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1077609258 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1082789141 schema:CreativeWork
213 https://doi.org/10.1002/anie.200600272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013086299
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/anie.201408126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024882202
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/cncr.22739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052175453
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/marc.201300460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041153758
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0169-409x(91)90037-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1050509794
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.eurpolymj.2013.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003536875
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jaci.2015.10.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000725462
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.jconrel.2006.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007144941
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.jconrel.2010.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024853807
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.neuropharm.2011.12.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024184520
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0065-3233(08)60065-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001186244
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0140-6736(06)69705-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022756080
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0142-9612(00)00193-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020015933
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0169-409x(03)00108-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002304749
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1021/bc900468v schema:sameAs https://app.dimensions.ai/details/publication/pub.1036084167
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1021/bi010902s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055193961
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1021/bm050428w schema:sameAs https://app.dimensions.ai/details/publication/pub.1014424997
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1021/bm901387t schema:sameAs https://app.dimensions.ai/details/publication/pub.1020914636
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1021/cr940534g schema:sameAs https://app.dimensions.ai/details/publication/pub.1000997076
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1021/ja039915e schema:sameAs https://app.dimensions.ai/details/publication/pub.1044596906
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1021/ja042230+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1032227744
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1021/ja104493d schema:sameAs https://app.dimensions.ai/details/publication/pub.1013100889
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1021/ja408069v schema:sameAs https://app.dimensions.ai/details/publication/pub.1021861508
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1021/ma048438x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056189711
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1039/b719689j schema:sameAs https://app.dimensions.ai/details/publication/pub.1032675870
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1039/c1py00034a schema:sameAs https://app.dimensions.ai/details/publication/pub.1046592378
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1039/c3py01089a schema:sameAs https://app.dimensions.ai/details/publication/pub.1034138507
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1073/pnas.0904378106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021925885
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.1006044107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042742812
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1073/pnas.101064198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001255813
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1073/pnas.1214518110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053135604
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1074/jbc.m401374200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010585954
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1110/ps.04679104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042434380
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1111/cbdd.12055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010931251
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1111/j.1472-8206.2008.00633.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007410708
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1128/jb.187.14.4928-4934.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006329014
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1159/000233309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043690317
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1159/000233512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007979869
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1201/9781420039832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1095904015
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1517/17425247.2012.720969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035823459
292 rdf:type schema:CreativeWork
293 https://doi.org/10.2174/156720107780362339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069186511
294 rdf:type schema:CreativeWork
295 https://doi.org/10.2337/diab.37.9.1163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735590
296 rdf:type schema:CreativeWork
297 https://doi.org/10.2337/diabetes.53.9.2492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022950121
298 rdf:type schema:CreativeWork
299 https://doi.org/10.2337/diabetes.53.suppl_3.s215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041970513
300 rdf:type schema:CreativeWork
301 https://www.grid.ac/institutes/grid.147455.6 schema:alternateName Carnegie Mellon University
302 schema:name Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA.
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
305 schema:name Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC, USA.
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
308 schema:name Department of Biochemistry, Duke University School of Medicine, Durham, NC, USA.
309 Department of Biomedical Engineering, Duke University, Durham, NC, USA.
310 Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC, USA.
311 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...