A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tiphany Chrun, Sandra Lacôte, Céline Urien, Luc Jouneau, Céline Barc, Edwige Bouguyon, Vanessa Contreras, Audrey Ferrier-Rembert, Christophe N. Peyrefitte, Nuria Busquets, Enric Vidal, Joan Pujols, Philippe Marianneau, Isabelle Schwartz-Cornil

ABSTRACT

Rift Valley fever virus, a phlebovirus endemic in Africa, causes serious diseases in ruminants and humans. Due to the high probability of new outbreaks and spread to other continents where competent vectors are present, vaccine development is an urgent priority as no licensed vaccines are available outside areas of endemicity. In this study, we evaluated in sheep the protective immunity induced by DNA vaccines encoding the extracellular portion of the Gn antigen which was either or not targeted to antigen-presenting cells. The DNA encoding untargeted antigen was the most potent at inducing IgG responses, although not neutralizing, and conferred a significant clinical and virological protection upon infectious challenge, superior to DNA vaccines encoding the targeted antigen. A statistical analysis of the challenge parameters supported that the anti-eGn IgG, rather than the T-cell response, was instrumental in protection. Altogether, this work shows that a DNA vaccine encoding the extracellular portion of the Gn antigen confers substantial-although incomplete-protective immunity in sheep, a natural host with high preclinical relevance, and provides some insights into key immune correlates useful for further vaccine improvements against the Rift Valley fever virus. More... »

PAGES

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41541-018-0052-x

DOI

http://dx.doi.org/10.1038/s41541-018-0052-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103491639

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29707242


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