Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-02-05

AUTHORS

Yu Toyoda, Tappei Takada, Hiroki Saito, Hiroshi Hirata, Ami Ota-Kontani, Naoyuki Kobayashi, Youichi Tsuchiya, Hiroshi Suzuki

ABSTRACT

As hyperuricemia is a cause of urate-related diseases such as gout, the anti-hyperuricemic and/or uricosuric activity of food ingredients is receiving increased attention. Here, we examined the inhibitory activities of seven Citrus flavonoids against URAT1, a renal transporter involved in urate re-uptake from urine. We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases. More... »

PAGES

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41538-020-0063-7

DOI

http://dx.doi.org/10.1038/s41538-020-0063-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1124593876

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32047858


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