Rapeseed protein-derived peptides, LY, RALP, and GHS, modulates key enzymes and intermediate products of renin–angiotensin system pathway in spontaneously hypertensive ... View Full Text


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Article Info

DATE

2019-12

AUTHORS

Rong He, Yi-Jie Yang, Zhigao Wang, Chang-rui Xing, Jian Yuan, Li-Feng Wang, Chibuike Udenigwe, Xing-Rong Ju

ABSTRACT

Rapeseed proteins are a rich source of bioactive peptides. LY, RALP and GHS were previously identified from rapeseed protein hydrolysates as potent ACE and renin inhibiting peptides. In this study, the rapeseed peptides were individually evaluated for their molecular mechanisms and regulatory effects on components of the renin–angiotensin system in spontaneously hypertensive rats (SHR), including the mRNA and/or protein levels of angiotensin-converting enzyme (ACE), renin, ACE2, angiotensin II and angiotensin-(1–7) in myocardial tissues. Oral administration of 30 mg peptides/kg body weight every 2 days for five weeks significantly decreased the systolic blood pressure and the myocardial mRNA and protein levels of ACE and renin in SHR. LY, RALP and GHS also increased the expression of ACE2, angiotensin-(1-7) and Mas receptor levels, which may have mediated their antihypertensive activity. Dipeptide LY also inhibited angiotensin II protein expression in the heart tissue. Taken together, the finding demonstrates the multi-target physiological effects of the rapeseed peptides, beyond ACE and renin inhibition, which enhances knowledge of the antihypertensive mechanisms of food protein-derived peptides. There is growing interest in developing food originating antihypertensive peptides. The rapeseed protein hydrolysates LY, RALP and GHS are known as inhibitory peptides, capable of lowering the blood pressure. Now Xing-Rong Ju from Nanjing University of Finance and Economics and coworkers evaluated their regulatory effects from the molecular level. And they found the inhibitory roles of LY, RALP and GHS were multi-targeted at gene and/or protein levels. The decrease of the systolic blood pressure after their five weeks’ oral administration might be attributed to the increased expression of ACE2. Among these three peptides, LY was found to exhibit the most effect which may be due to its stronger inhibition on the expression of Ang II protein in the heart tissue. These remain to be further explored. More... »

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http://scigraph.springernature.com/pub.10.1038/s41538-018-0033-5

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http://dx.doi.org/10.1038/s41538-018-0033-5

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https://app.dimensions.ai/details/publication/pub.1111375489


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40 schema:description Rapeseed proteins are a rich source of bioactive peptides. LY, RALP and GHS were previously identified from rapeseed protein hydrolysates as potent ACE and renin inhibiting peptides. In this study, the rapeseed peptides were individually evaluated for their molecular mechanisms and regulatory effects on components of the renin–angiotensin system in spontaneously hypertensive rats (SHR), including the mRNA and/or protein levels of angiotensin-converting enzyme (ACE), renin, ACE2, angiotensin II and angiotensin-(1–7) in myocardial tissues. Oral administration of 30 mg peptides/kg body weight every 2 days for five weeks significantly decreased the systolic blood pressure and the myocardial mRNA and protein levels of ACE and renin in SHR. LY, RALP and GHS also increased the expression of ACE2, angiotensin-(1-7) and Mas receptor levels, which may have mediated their antihypertensive activity. Dipeptide LY also inhibited angiotensin II protein expression in the heart tissue. Taken together, the finding demonstrates the multi-target physiological effects of the rapeseed peptides, beyond ACE and renin inhibition, which enhances knowledge of the antihypertensive mechanisms of food protein-derived peptides. There is growing interest in developing food originating antihypertensive peptides. The rapeseed protein hydrolysates LY, RALP and GHS are known as inhibitory peptides, capable of lowering the blood pressure. Now Xing-Rong Ju from Nanjing University of Finance and Economics and coworkers evaluated their regulatory effects from the molecular level. And they found the inhibitory roles of LY, RALP and GHS were multi-targeted at gene and/or protein levels. The decrease of the systolic blood pressure after their five weeks’ oral administration might be attributed to the increased expression of ACE2. Among these three peptides, LY was found to exhibit the most effect which may be due to its stronger inhibition on the expression of Ang II protein in the heart tissue. These remain to be further explored.
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