Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Masato Sato, Masayuki Yamato, Genya Mitani, Tomonori Takagaki, Kosuke Hamahashi, Yoshihiko Nakamura, Miya Ishihara, Ryo Matoba, Hiroyuki Kobayashi, Teruo Okano, Joji Mochida, Masahiko Watanabe

ABSTRACT

Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these in in vitro and in vivo preclinical studies, and have reported that the transplantation of chondrocyte sheets promoted hyaline cartilage repair in rat, rabbit, and minipig models. However, autologous transplantation of chondrocyte sheets has yet to be reported in humans. Here, we report our combination therapy in which conventional surgical treatment for OAK, is followed by autologous chondrocyte sheet transplantation for cartilage repair. Eight patients with OAK and cartilage defects categorized arthroscopically as Outerbridge grade III or IV receive the therapy. Patients are thoroughly assessed by preoperative and postoperative X-rays, magnetic resonance imaging (MRI), arthroscopy, Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score (LKS), and a laser-induced photoacoustic method to assess cartilage viscoelasticity. Arthroscopic biopsies of all patients are performed 12 months after transplantation for histological evaluation. The properties of the chondrocyte sheets are evaluated using gene expression analysis to investigate the ability to predict the clinical and structural outcomes of the therapy. For this small initial longitudinal series, combination therapy is effective, as assessed by MRI, arthroscopy, viscoelasticity, histology, and the clinical outcomes of KOOS and LKS. Gene marker sets identified in autologous chondrocyte sheets may be predictive of the overall KOOS, LKS, and histological scores after therapy. These predictive gene sets may be potential alternative markers for evaluating OAK treatment. More... »

PAGES

4

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41536-019-0069-4

DOI

http://dx.doi.org/10.1038/s41536-019-0069-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112285971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30820353


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Masato", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Institute of Advanced Biomedical Engineering and Science, Tokyo Women\u2019s Medical University, 8-1 Kawada-cho, Shinjuku, 162-8666, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamato", 
        "givenName": "Masayuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitani", 
        "givenName": "Genya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takagaki", 
        "givenName": "Tomonori", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamahashi", 
        "givenName": "Kosuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412767.1", 
          "name": [
            "Cell Processing Center, Tokai University Hospital, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Yoshihiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishihara", 
        "givenName": "Miya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DNA Chip Research (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.452377.0", 
          "name": [
            "DNA Chip Research Inc., 1-15-1 Kaigan, Suzue Baydium 5F Minato-ku, 105-0022, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matoba", 
        "givenName": "Ryo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Clinical Pharmacology, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "Hiroyuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Women's Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Institute of Advanced Biomedical Engineering and Science, Tokyo Women\u2019s Medical University, 8-1 Kawada-cho, Shinjuku, 162-8666, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okano", 
        "givenName": "Teruo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochida", 
        "givenName": "Joji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokai University", 
          "id": "https://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Masahiko", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archinte.166.6.651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000106164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2014.200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001446469", 
          "https://doi.org/10.1038/nrrheum.2014.200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1301-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003080790", 
          "https://doi.org/10.1007/s10067-009-1301-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1301-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003080790", 
          "https://doi.org/10.1007/s10067-009-1301-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1301-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003080790", 
          "https://doi.org/10.1007/s10067-009-1301-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.reth.2015.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004209990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.22829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006746775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2012.03.073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007015586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00595-011-0106-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007195225", 
          "https://doi.org/10.1007/s00595-011-0106-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2005.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008149203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0033-8389(03)00161-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008775187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7525-1-64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018618871", 
          "https://doi.org/10.1186/1477-7525-1-64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2012.01.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019178092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/joca.2001.0504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019809801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021668866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-9-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024480137", 
          "https://doi.org/10.1186/1472-6750-9-17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.arthro.2008.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024988420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.08.096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028511880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2013.11.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032378924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.820271005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036758756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11999-015-4324-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037500340", 
          "https://doi.org/10.1007/s11999-015-4324-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s11999-015-4324-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037500340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eats.2014.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040001004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0142-9612(95)93257-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040951601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lsm.21065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042211291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/keh411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044384488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13075-015-0899-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045179125", 
          "https://doi.org/10.1186/s13075-015-0899-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.088518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047958555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lsm.20285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050662221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lsm.20285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050662221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/term.1610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050901920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/term.1764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051294694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.joca.2010.04.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052246941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10763270152436517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059205982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tec.2015.0254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059314714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tec.2015.0254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059314714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198509000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198509000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198509000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200108000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200108000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-200108000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060168795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-197153030-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068885070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/term.2257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083839379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s41232-017-0053-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092264605", 
          "https://doi.org/10.1186/s41232-017-0053-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these in in vitro and in vivo preclinical studies, and have reported that the transplantation of chondrocyte sheets promoted hyaline cartilage repair in rat, rabbit, and minipig models. However, autologous transplantation of chondrocyte sheets has yet to be reported in humans. Here, we report our combination therapy in which conventional surgical treatment for OAK, is followed by autologous chondrocyte sheet transplantation for cartilage repair. Eight patients with OAK and cartilage defects categorized arthroscopically as Outerbridge grade III or IV receive the therapy. Patients are thoroughly assessed by preoperative and postoperative X-rays, magnetic resonance imaging (MRI), arthroscopy, Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score (LKS), and a laser-induced photoacoustic method to assess cartilage viscoelasticity. Arthroscopic biopsies of all patients are performed 12 months after transplantation for histological evaluation. The properties of the chondrocyte sheets are evaluated using gene expression analysis to investigate the ability to predict the clinical and structural outcomes of the therapy. For this small initial longitudinal series, combination therapy is effective, as assessed by MRI, arthroscopy, viscoelasticity, histology, and the clinical outcomes of KOOS and LKS. Gene marker sets identified in autologous chondrocyte sheets may be predictive of the overall KOOS, LKS, and histological scores after therapy. These predictive gene sets may be potential alternative markers for evaluating OAK treatment.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41536-019-0069-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1284500", 
        "issn": [
          "2057-3995"
        ], 
        "name": "npj Regenerative Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis", 
    "pagination": "4", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "348d433b53cfb0ea86c38dd683dfa49263250f264cddaad418af0edfc3a079c0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30820353"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101699846"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41536-019-0069-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112285971"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41536-019-0069-4", 
      "https://app.dimensions.ai/details/publication/pub.1112285971"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11692_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41536-019-0069-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41536-019-0069-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41536-019-0069-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41536-019-0069-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41536-019-0069-4'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      66 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41536-019-0069-4 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nae72662bfd464d09b9d571761929c2d0
4 schema:citation sg:pub.10.1007/s00595-011-0106-4
5 sg:pub.10.1007/s10067-009-1301-1
6 sg:pub.10.1007/s11999-015-4324-8
7 sg:pub.10.1038/nrrheum.2014.200
8 sg:pub.10.1186/1472-6750-9-17
9 sg:pub.10.1186/1477-7525-1-64
10 sg:pub.10.1186/s13075-015-0899-4
11 sg:pub.10.1186/s41232-017-0053-6
12 https://doi.org/10.1001/archinte.166.6.651
13 https://doi.org/10.1002/ar.22829
14 https://doi.org/10.1002/jbm.820271005
15 https://doi.org/10.1002/lsm.20285
16 https://doi.org/10.1002/lsm.21065
17 https://doi.org/10.1002/term.1610
18 https://doi.org/10.1002/term.1764
19 https://doi.org/10.1002/term.2257
20 https://doi.org/10.1007/s11999-015-4324-8
21 https://doi.org/10.1016/0142-9612(95)93257-e
22 https://doi.org/10.1016/j.arthro.2008.08.015
23 https://doi.org/10.1016/j.bbrc.2006.08.096
24 https://doi.org/10.1016/j.biomaterials.2012.01.056
25 https://doi.org/10.1016/j.biomaterials.2012.03.073
26 https://doi.org/10.1016/j.biomaterials.2013.11.071
27 https://doi.org/10.1016/j.eats.2014.05.009
28 https://doi.org/10.1016/j.ejrad.2005.08.007
29 https://doi.org/10.1016/j.joca.2010.04.016
30 https://doi.org/10.1016/j.reth.2015.06.003
31 https://doi.org/10.1016/s0033-8389(03)00161-1
32 https://doi.org/10.1053/joca.2001.0504
33 https://doi.org/10.1056/nejmoa040455
34 https://doi.org/10.1089/10763270152436517
35 https://doi.org/10.1089/ten.tec.2015.0254
36 https://doi.org/10.1093/rheumatology/keh411
37 https://doi.org/10.1097/00003086-198509000-00007
38 https://doi.org/10.1097/00003086-200108000-00002
39 https://doi.org/10.1136/gut.2005.088518
40 https://doi.org/10.2106/00004623-197153030-00009
41 schema:datePublished 2019-12
42 schema:datePublishedReg 2019-12-01
43 schema:description Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these in in vitro and in vivo preclinical studies, and have reported that the transplantation of chondrocyte sheets promoted hyaline cartilage repair in rat, rabbit, and minipig models. However, autologous transplantation of chondrocyte sheets has yet to be reported in humans. Here, we report our combination therapy in which conventional surgical treatment for OAK, is followed by autologous chondrocyte sheet transplantation for cartilage repair. Eight patients with OAK and cartilage defects categorized arthroscopically as Outerbridge grade III or IV receive the therapy. Patients are thoroughly assessed by preoperative and postoperative X-rays, magnetic resonance imaging (MRI), arthroscopy, Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score (LKS), and a laser-induced photoacoustic method to assess cartilage viscoelasticity. Arthroscopic biopsies of all patients are performed 12 months after transplantation for histological evaluation. The properties of the chondrocyte sheets are evaluated using gene expression analysis to investigate the ability to predict the clinical and structural outcomes of the therapy. For this small initial longitudinal series, combination therapy is effective, as assessed by MRI, arthroscopy, viscoelasticity, histology, and the clinical outcomes of KOOS and LKS. Gene marker sets identified in autologous chondrocyte sheets may be predictive of the overall KOOS, LKS, and histological scores after therapy. These predictive gene sets may be potential alternative markers for evaluating OAK treatment.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf Nc8d3767e3936431386f48657980bfbe8
48 Ne2f858dc9fd3480cbbae8a0f71789377
49 sg:journal.1284500
50 schema:name Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis
51 schema:pagination 4
52 schema:productId N09ae169c9cc742aaa1feccaf8500af4a
53 N77613ff156624f3980c9e264c139c9b4
54 Na748371b6ca345d2ad0a3049f76abbc9
55 Nb64c9855b4234610af83c3715fdf8cbf
56 Nb67ea24a06054bc988045d044cf33a95
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112285971
58 https://doi.org/10.1038/s41536-019-0069-4
59 schema:sdDatePublished 2019-04-11T11:17
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N5900310b1057411fadb1c4226969f21f
62 schema:url https://www.nature.com/articles/s41536-019-0069-4
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N093d31916fa74683b71f580b7ed1f0dd rdf:first N4f30049c24444300aaaf658cc22ec1a4
67 rdf:rest rdf:nil
68 N09ae169c9cc742aaa1feccaf8500af4a schema:name pubmed_id
69 schema:value 30820353
70 rdf:type schema:PropertyValue
71 N0bd34712adb34e7c971578d032af12dc rdf:first Nc8a6677d70f64d40bb5b2fa5fba71e0b
72 rdf:rest N093d31916fa74683b71f580b7ed1f0dd
73 N1bae7e93fa6c41bd92d346c0129c4ed3 schema:affiliation https://www.grid.ac/institutes/grid.410818.4
74 schema:familyName Okano
75 schema:givenName Teruo
76 rdf:type schema:Person
77 N2810c8d43e7641a094d384dfcb1cf831 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
78 schema:familyName Sato
79 schema:givenName Masato
80 rdf:type schema:Person
81 N2c1511e8b0c943e19760bb74e478dbc3 rdf:first N2c4d4f5845a54c979efcc8e3006b6c43
82 rdf:rest N48f39952fc414ac3a1ac4c63750ea987
83 N2c4d4f5845a54c979efcc8e3006b6c43 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
84 schema:familyName Takagaki
85 schema:givenName Tomonori
86 rdf:type schema:Person
87 N327142564e324fbcb817c49434c2c4ff rdf:first Nae81b41594eb4df29a706b94b0eba501
88 rdf:rest N33a2daedb3f340429343527c84831e7a
89 N33a2daedb3f340429343527c84831e7a rdf:first N536457109b2c4d9b82a50acbfb89f2c8
90 rdf:rest Nabb3cb4546f7470c862a6d262b0476e8
91 N48f39952fc414ac3a1ac4c63750ea987 rdf:first Nb9a31b9fd87147458802f02549e8898b
92 rdf:rest N327142564e324fbcb817c49434c2c4ff
93 N4f30049c24444300aaaf658cc22ec1a4 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
94 schema:familyName Watanabe
95 schema:givenName Masahiko
96 rdf:type schema:Person
97 N536457109b2c4d9b82a50acbfb89f2c8 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
98 schema:familyName Ishihara
99 schema:givenName Miya
100 rdf:type schema:Person
101 N5900310b1057411fadb1c4226969f21f schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N609513d98d6b4939bfb48ca4ce0ca75a schema:affiliation https://www.grid.ac/institutes/grid.410818.4
104 schema:familyName Yamato
105 schema:givenName Masayuki
106 rdf:type schema:Person
107 N77613ff156624f3980c9e264c139c9b4 schema:name readcube_id
108 schema:value 348d433b53cfb0ea86c38dd683dfa49263250f264cddaad418af0edfc3a079c0
109 rdf:type schema:PropertyValue
110 N7adfa52d3c61490788b27de08695b6d4 rdf:first Nf5b87bb317d54df2bed7afaf77f097b0
111 rdf:rest N2c1511e8b0c943e19760bb74e478dbc3
112 N8b6c79716ee940599b7d4d947a839992 schema:affiliation https://www.grid.ac/institutes/grid.452377.0
113 schema:familyName Matoba
114 schema:givenName Ryo
115 rdf:type schema:Person
116 N8e1fa457de32461f96f0e5e21585c514 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
117 schema:familyName Kobayashi
118 schema:givenName Hiroyuki
119 rdf:type schema:Person
120 Na748371b6ca345d2ad0a3049f76abbc9 schema:name dimensions_id
121 schema:value pub.1112285971
122 rdf:type schema:PropertyValue
123 Nabb3cb4546f7470c862a6d262b0476e8 rdf:first N8b6c79716ee940599b7d4d947a839992
124 rdf:rest Nd4efbb33a15042bdb9f4ba3115bb3e84
125 Nae72662bfd464d09b9d571761929c2d0 rdf:first N2810c8d43e7641a094d384dfcb1cf831
126 rdf:rest Nde47fff1303b4a9c8217fd39c9ce0556
127 Nae81b41594eb4df29a706b94b0eba501 schema:affiliation https://www.grid.ac/institutes/grid.412767.1
128 schema:familyName Nakamura
129 schema:givenName Yoshihiko
130 rdf:type schema:Person
131 Nb64c9855b4234610af83c3715fdf8cbf schema:name doi
132 schema:value 10.1038/s41536-019-0069-4
133 rdf:type schema:PropertyValue
134 Nb67ea24a06054bc988045d044cf33a95 schema:name nlm_unique_id
135 schema:value 101699846
136 rdf:type schema:PropertyValue
137 Nb9a31b9fd87147458802f02549e8898b schema:affiliation https://www.grid.ac/institutes/grid.265061.6
138 schema:familyName Hamahashi
139 schema:givenName Kosuke
140 rdf:type schema:Person
141 Nbd76e67fe44e45fb87a796d768dafbae rdf:first N1bae7e93fa6c41bd92d346c0129c4ed3
142 rdf:rest N0bd34712adb34e7c971578d032af12dc
143 Nc8a6677d70f64d40bb5b2fa5fba71e0b schema:affiliation https://www.grid.ac/institutes/grid.265061.6
144 schema:familyName Mochida
145 schema:givenName Joji
146 rdf:type schema:Person
147 Nc8d3767e3936431386f48657980bfbe8 schema:volumeNumber 4
148 rdf:type schema:PublicationVolume
149 Nd4efbb33a15042bdb9f4ba3115bb3e84 rdf:first N8e1fa457de32461f96f0e5e21585c514
150 rdf:rest Nbd76e67fe44e45fb87a796d768dafbae
151 Nde47fff1303b4a9c8217fd39c9ce0556 rdf:first N609513d98d6b4939bfb48ca4ce0ca75a
152 rdf:rest N7adfa52d3c61490788b27de08695b6d4
153 Ne2f858dc9fd3480cbbae8a0f71789377 schema:issueNumber 1
154 rdf:type schema:PublicationIssue
155 Nf5b87bb317d54df2bed7afaf77f097b0 schema:affiliation https://www.grid.ac/institutes/grid.265061.6
156 schema:familyName Mitani
157 schema:givenName Genya
158 rdf:type schema:Person
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
163 schema:name Clinical Sciences
164 rdf:type schema:DefinedTerm
165 sg:journal.1284500 schema:issn 2057-3995
166 schema:name npj Regenerative Medicine
167 rdf:type schema:Periodical
168 sg:pub.10.1007/s00595-011-0106-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007195225
169 https://doi.org/10.1007/s00595-011-0106-4
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/s10067-009-1301-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003080790
172 https://doi.org/10.1007/s10067-009-1301-1
173 rdf:type schema:CreativeWork
174 sg:pub.10.1007/s11999-015-4324-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037500340
175 https://doi.org/10.1007/s11999-015-4324-8
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/nrrheum.2014.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001446469
178 https://doi.org/10.1038/nrrheum.2014.200
179 rdf:type schema:CreativeWork
180 sg:pub.10.1186/1472-6750-9-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024480137
181 https://doi.org/10.1186/1472-6750-9-17
182 rdf:type schema:CreativeWork
183 sg:pub.10.1186/1477-7525-1-64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018618871
184 https://doi.org/10.1186/1477-7525-1-64
185 rdf:type schema:CreativeWork
186 sg:pub.10.1186/s13075-015-0899-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045179125
187 https://doi.org/10.1186/s13075-015-0899-4
188 rdf:type schema:CreativeWork
189 sg:pub.10.1186/s41232-017-0053-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092264605
190 https://doi.org/10.1186/s41232-017-0053-6
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1001/archinte.166.6.651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000106164
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/ar.22829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006746775
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/jbm.820271005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036758756
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/lsm.20285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050662221
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/lsm.21065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042211291
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/term.1610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050901920
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/term.1764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051294694
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/term.2257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083839379
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1007/s11999-015-4324-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037500340
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0142-9612(95)93257-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1040951601
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.arthro.2008.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024988420
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.bbrc.2006.08.096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028511880
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.biomaterials.2012.01.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019178092
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.biomaterials.2012.03.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007015586
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.biomaterials.2013.11.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032378924
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.eats.2014.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040001004
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.ejrad.2005.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008149203
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.joca.2010.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052246941
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.reth.2015.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004209990
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0033-8389(03)00161-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008775187
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1053/joca.2001.0504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019809801
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1056/nejmoa040455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021668866
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1089/10763270152436517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059205982
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1089/ten.tec.2015.0254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059314714
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/rheumatology/keh411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044384488
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/00003086-198509000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060161240
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/00003086-200108000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060168795
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1136/gut.2005.088518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047958555
247 rdf:type schema:CreativeWork
248 https://doi.org/10.2106/00004623-197153030-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068885070
249 rdf:type schema:CreativeWork
250 https://www.grid.ac/institutes/grid.265061.6 schema:alternateName Tokai University
251 schema:name Department of Clinical Pharmacology, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan
252 Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.410818.4 schema:alternateName Tokyo Women's Medical University
255 schema:name Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku, 162-8666, Tokyo, Japan
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.412767.1 schema:alternateName Tokai University Hospital
258 schema:name Cell Processing Center, Tokai University Hospital, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.416614.0 schema:alternateName National Defense Medical College
261 schema:name Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Saitama, Japan
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.452377.0 schema:alternateName DNA Chip Research (Japan)
264 schema:name DNA Chip Research Inc., 1-15-1 Kaigan, Suzue Baydium 5F Minato-ku, 105-0022, Tokyo, Japan
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...