Repetitive transcranial magnetic stimulation improves Parkinson’s freezing of gait via normalizing brain connectivity View Full Text


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Article Info

DATE

2020-07-17

AUTHORS

Tao-Mian Mi, Saurabh Garg, Fang Ba, Ai-Ping Liu, Pei-Peng Liang, Lin-Lin Gao, Qian Jia, Er-He Xu, Kun-Cheng Li, Piu Chan, Martin J. McKeown

ABSTRACT

Robust, effective treatments for Parkinson’s freezing of gait remain elusive. Our previous study revealed beneficial effects of high-frequency rTMS over the supplementary motor area. The present study aims to explore the neural mechanisms of rTMS treatments utilizing novel exploratory multivariate approaches. We first conducted a resting-state functional MRI study with a group of 40 Parkinson’s disease patients with freezing of gait, 31 without freezing of gait, and 30 normal controls. A subset of 30 patients with freezing of gait (verum group: N = 20; sham group: N = 10) who participated the aforementioned rTMS study underwent another scan after the treatments. Using the baseline scans, the imaging biomarkers for freezing of gait and Parkinson’s disease were developed by contrasting the connectivity profiles of patients with freezing of gait to those without freezing of gait and normal controls, respectively. These two biomarkers were then interrogated to assess the rTMS effects on connectivity patterns. Results showed that the freezing of gait biomarker was negatively correlated with Freezing of Gait Questionnaire score (r = −0.6723, p < 0.0001); while the Parkinson’s disease biomarker was negatively correlated with MDS-UPDRS motor score (r = −0.7281, p < 0.0001). After the rTMS treatment, both the freezing of gait biomarker (0.326 ± 0.125 vs. 0.486 ± 0.193, p = 0.0071) and Parkinson’s disease biomarker (0.313 ± 0.126 vs. 0.379 ± 0.155, p = 0.0378) were significantly improved in the verum group; whereas no significant biomarker changes were found in the sham group. Our findings indicate that high-frequency rTMS over the supplementary motor area confers the beneficial effect jointly through normalizing abnormal brain functional connectivity patterns specifically associated with freezing of gait, in addition to normalizing overall disrupted connectivity patterns seen in Parkinson’s disease. More... »

PAGES

16

References to SciGraph publications

  • 2016-10-28. The study of brain functional connectivity in Parkinson’s disease in TRANSLATIONAL NEURODEGENERATION
  • 1993. Causation, Prediction, and Search in NONE
  • 2010-10-24. Resting developments: a review of fMRI post-processing methodologies for spontaneous brain activity in MAGNETIC RESONANCE MATERIALS IN PHYSICS, BIOLOGY AND MEDICINE
  • 2007-07. Is there a future for therapeutic use of transcranial magnetic stimulation? in NATURE REVIEWS NEUROSCIENCE
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    URI

    http://scigraph.springernature.com/pub.10.1038/s41531-020-0118-0

    DOI

    http://dx.doi.org/10.1038/s41531-020-0118-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1129414758

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32699818


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