Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Saumel Ahmadi, Zoltan Bozoky, Michelle Di Paola, Sunny Xia, Canhui Li, Amy P. Wong, Leigh Wellhauser, Steven V. Molinski, Wan Ip, Hong Ouyang, Julie Avolio, Julie D. Forman-Kay, Felix Ratjen, Jeremy A. Hirota, Johanna Rommens, Janet Rossant, Tanja Gonska, Theo J. Moraes, Christine E. Bear

ABSTRACT

Pulmonary disease is the major cause of morbidity and mortality in patients with cystic fibrosis, a disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Heterogeneity in CFTR genotype-phenotype relationships in affected individuals plus the escalation of drug discovery targeting specific mutations highlights the need to develop robust in vitro platforms with which to stratify therapeutic options using relevant tissue. Toward this goal, we adapted a fluorescence plate reader assay of apical CFTR-mediated chloride conductance to enable profiling of a panel of modulators on primary nasal epithelial cultures derived from patients bearing different CFTR mutations. This platform faithfully recapitulated patient-specific responses previously observed in the "gold-standard" but relatively low-throughput Ussing chamber. Moreover, using this approach, we identified a novel strategy with which to augment the response to an approved drug in specific patients. In proof of concept studies, we also validated the use of this platform in measuring drug responses in lung cultures differentiated from cystic fibrosis iPS cells. Taken together, we show that this medium throughput assay of CFTR activity has the potential to stratify cystic fibrosis patient-specific responses to approved drugs and investigational compounds in vitro in primary and iPS cell-derived airway cultures. More... »

PAGES

12

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41525-017-0015-6

DOI

http://dx.doi.org/10.1038/s41525-017-0015-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084782251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28649446


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Physiology, University of Toronto, Toronto, ON, Canada", 
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahmadi", 
        "givenName": "Saumel", 
        "id": "sg:person.0621440004.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621440004.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada", 
            "Department of Biochemistry, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bozoky", 
        "givenName": "Zoltan", 
        "id": "sg:person.01014306716.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014306716.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada", 
            "Department of Biochemistry, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Paola", 
        "givenName": "Michelle", 
        "id": "sg:person.016112505243.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016112505243.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Physiology, University of Toronto, Toronto, ON, Canada", 
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xia", 
        "givenName": "Sunny", 
        "id": "sg:person.01213072700.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213072700.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Canhui", 
        "id": "sg:person.01175351322.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175351322.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Programme in Developmental and Stem Cell Biology, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Amy P.", 
        "id": "sg:person.0676753750.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676753750.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wellhauser", 
        "givenName": "Leigh", 
        "id": "sg:person.01017365746.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017365746.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada", 
            "Department of Biochemistry, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Molinski", 
        "givenName": "Steven V.", 
        "id": "sg:person.01233401121.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233401121.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ip", 
        "givenName": "Wan", 
        "id": "sg:person.0600006247.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600006247.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ouyang", 
        "givenName": "Hong", 
        "id": "sg:person.013176557543.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013176557543.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avolio", 
        "givenName": "Julie", 
        "id": "sg:person.01157316334.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157316334.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada", 
            "Department of Biochemistry, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forman-Kay", 
        "givenName": "Julie D.", 
        "id": "sg:person.01036040176.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036040176.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Paediatrics, University of Toronto, Toronto, ON, Canada", 
            "Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ratjen", 
        "givenName": "Felix", 
        "id": "sg:person.01232113335.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232113335.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McMaster University", 
          "id": "https://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Firestone Institute for Respiratory Health, Division of Respirology, McMaster University, Hamilton, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirota", 
        "givenName": "Jeremy A.", 
        "id": "sg:person.01162077340.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162077340.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada", 
            "Programme in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rommens", 
        "givenName": "Johanna", 
        "id": "sg:person.01355172356.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355172356.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada", 
            "Programme in Developmental and Stem Cell Biology, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossant", 
        "givenName": "Janet", 
        "id": "sg:person.012701055245.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012701055245.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Paediatrics, University of Toronto, Toronto, ON, Canada", 
            "Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonska", 
        "givenName": "Tanja", 
        "id": "sg:person.01231272634.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231272634.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Department of Paediatrics, University of Toronto, Toronto, ON, Canada", 
            "Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moraes", 
        "givenName": "Theo J.", 
        "id": "sg:person.01121342625.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121342625.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Physiology, University of Toronto, Toronto, ON, Canada", 
            "Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada", 
            "Department of Biochemistry, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bear", 
        "givenName": "Christine E.", 
        "id": "sg:person.01251134606.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251134606.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2007.09.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000738859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90498-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001366314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/ajrcmb/8.5.522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005496523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aad8278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005661272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/358761a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009186996", 
          "https://doi.org/10.1038/358761a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcf.2014.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010395869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcf.2011.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010446987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2003.50331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011687727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0904709106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012506625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcf.2005.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012814495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199011293232203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014822459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057113488420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016322003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057113488420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016322003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2012.00160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017573205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2014.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019725816", 
          "https://doi.org/10.1038/clpt.2014.54"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/joim.12314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020340942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-61779-120-8_15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022785519", 
          "https://doi.org/10.1007/978-1-61779-120-8_15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-61779-120-8_15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022785519", 
          "https://doi.org/10.1007/978-1-61779-120-8_15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200312018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025704988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00035.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026460526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2008.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026600869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029517960", 
          "https://doi.org/10.1038/nrg3849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029844928", 
          "https://doi.org/10.1038/sj.onc.1206953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029844928", 
          "https://doi.org/10.1038/sj.onc.1206953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.393637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030011371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1105787108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030045105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e14-04-0935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030084864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030938455", 
          "https://doi.org/10.1038/nbt.2754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2634339100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032010126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s2213-2600(14)70132-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034540669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035253501", 
          "https://doi.org/10.1038/nbt.2328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m800268-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035440877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00340.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036145029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057115605834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036558118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057115605834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036558118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.201400218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038536976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2014.02.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042273954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042334899", 
          "https://doi.org/10.1038/nm.3201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201601-0154oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043149146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1105185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044458961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/352628a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044633103", 
          "https://doi.org/10.1038/352628a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20080029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045393905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20080029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045393905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2015.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045538010", 
          "https://doi.org/10.1038/mi.2015.104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2015.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046055100", 
          "https://doi.org/10.1038/nprot.2015.021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90155-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047418822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1409547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049294600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.3294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049442174", 
          "https://doi.org/10.1038/nbt.3294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00169.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049936464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.096669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050166980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2005.096669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050166980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2007.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052732616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mtm.2015.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053357744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053380687", 
          "https://doi.org/10.1038/nsmb882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053380687", 
          "https://doi.org/10.1038/nsmb882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jmedchem.6b01539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055100472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3008889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062688362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00085.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063195105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.2001.281.5.c1734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074893649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.4.10.2197151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078458745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2016-0276ma", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079379273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00119.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082411583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082467505", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083034293", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.1998.275.5.l917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083346902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.1998.275.5.l917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083346902"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Pulmonary disease is the major cause of morbidity and mortality in patients with cystic fibrosis, a disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Heterogeneity in CFTR genotype-phenotype relationships in affected individuals plus the escalation of drug discovery targeting specific mutations highlights the need to develop robust in vitro platforms with which to stratify therapeutic options using relevant tissue. Toward this goal, we adapted a fluorescence plate reader assay of apical CFTR-mediated chloride conductance to enable profiling of a panel of modulators on primary nasal epithelial cultures derived from patients bearing different CFTR mutations. This platform faithfully recapitulated patient-specific responses previously observed in the \"gold-standard\" but relatively low-throughput Ussing chamber. Moreover, using this approach, we identified a novel strategy with which to augment the response to an approved drug in specific patients. In proof of concept studies, we also validated the use of this platform in measuring drug responses in lung cultures differentiated from cystic fibrosis iPS cells. Taken together, we show that this medium throughput assay of CFTR activity has the potential to stratify cystic fibrosis patient-specific responses to approved drugs and investigational compounds in vitro in primary and iPS cell-derived airway cultures.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41525-017-0015-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1053748", 
        "issn": [
          "2056-7944"
        ], 
        "name": "npj Genomic Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia", 
    "pagination": "12", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ce61ac7a35fcd113d50d23a73a075684a364909e64832e5a6247fa83bb0bd20e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28649446"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101685193"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41525-017-0015-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084782251"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41525-017-0015-6", 
      "https://app.dimensions.ai/details/publication/pub.1084782251"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000492.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41525-017-0015-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41525-017-0015-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41525-017-0015-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41525-017-0015-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41525-017-0015-6'


 

This table displays all metadata directly associated to this object as RDF triples.

393 TRIPLES      21 PREDICATES      87 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41525-017-0015-6 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author Na4ada6269b924577990e237ba1fdc8fc
4 schema:citation sg:pub.10.1007/978-1-61779-120-8_15
5 sg:pub.10.1038/352628a0
6 sg:pub.10.1038/358761a0
7 sg:pub.10.1038/clpt.2014.54
8 sg:pub.10.1038/mi.2015.104
9 sg:pub.10.1038/nbt.2328
10 sg:pub.10.1038/nbt.2754
11 sg:pub.10.1038/nbt.3294
12 sg:pub.10.1038/nm.3201
13 sg:pub.10.1038/nprot.2015.021
14 sg:pub.10.1038/nrg3849
15 sg:pub.10.1038/nsmb882
16 sg:pub.10.1038/sj.onc.1206953
17 https://app.dimensions.ai/details/publication/pub.1082467505
18 https://app.dimensions.ai/details/publication/pub.1083034293
19 https://doi.org/10.1002/j.1460-2075.1995.tb00119.x
20 https://doi.org/10.1002/pmic.201400218
21 https://doi.org/10.1016/0092-8674(91)90498-n
22 https://doi.org/10.1016/0092-8674(92)90155-6
23 https://doi.org/10.1016/j.cell.2007.09.037
24 https://doi.org/10.1016/j.chembiol.2014.02.021
25 https://doi.org/10.1016/j.jcf.2005.05.005
26 https://doi.org/10.1016/j.jcf.2011.12.005
27 https://doi.org/10.1016/j.jcf.2014.04.003
28 https://doi.org/10.1016/j.molmed.2007.05.001
29 https://doi.org/10.1016/j.tips.2008.01.006
30 https://doi.org/10.1016/s2213-2600(14)70132-8
31 https://doi.org/10.1021/acs.jmedchem.6b01539
32 https://doi.org/10.1038/mtm.2015.34
33 https://doi.org/10.1042/bj20080029
34 https://doi.org/10.1053/jhep.2003.50331
35 https://doi.org/10.1056/nejm199011293232203
36 https://doi.org/10.1056/nejmoa1105185
37 https://doi.org/10.1056/nejmoa1409547
38 https://doi.org/10.1073/pnas.0904709106
39 https://doi.org/10.1073/pnas.1105787108
40 https://doi.org/10.1073/pnas.2634339100
41 https://doi.org/10.1074/jbc.m112.393637
42 https://doi.org/10.1074/mcp.m800268-mcp200
43 https://doi.org/10.1083/jcb.200312018
44 https://doi.org/10.1091/mbc.e14-04-0935
45 https://doi.org/10.1096/fasebj.4.10.2197151
46 https://doi.org/10.1111/joim.12314
47 https://doi.org/10.1113/jphysiol.2005.096669
48 https://doi.org/10.1126/scitranslmed.3008889
49 https://doi.org/10.1126/scitranslmed.aad8278
50 https://doi.org/10.1152/ajpcell.2001.281.5.c1734
51 https://doi.org/10.1152/ajplung.00085.2001
52 https://doi.org/10.1152/ajplung.00169.2005
53 https://doi.org/10.1152/ajplung.00340.2003
54 https://doi.org/10.1152/ajplung.1998.275.5.l917
55 https://doi.org/10.1152/physrev.00035.2005
56 https://doi.org/10.1164/rccm.201601-0154oc
57 https://doi.org/10.1165/ajrcmb/8.5.522
58 https://doi.org/10.1165/rcmb.2016-0276ma
59 https://doi.org/10.1177/1087057113488420
60 https://doi.org/10.1177/1087057115605834
61 https://doi.org/10.3389/fphar.2012.00160
62 schema:datePublished 2017-12
63 schema:datePublishedReg 2017-12-01
64 schema:description Pulmonary disease is the major cause of morbidity and mortality in patients with cystic fibrosis, a disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. Heterogeneity in CFTR genotype-phenotype relationships in affected individuals plus the escalation of drug discovery targeting specific mutations highlights the need to develop robust in vitro platforms with which to stratify therapeutic options using relevant tissue. Toward this goal, we adapted a fluorescence plate reader assay of apical CFTR-mediated chloride conductance to enable profiling of a panel of modulators on primary nasal epithelial cultures derived from patients bearing different CFTR mutations. This platform faithfully recapitulated patient-specific responses previously observed in the "gold-standard" but relatively low-throughput Ussing chamber. Moreover, using this approach, we identified a novel strategy with which to augment the response to an approved drug in specific patients. In proof of concept studies, we also validated the use of this platform in measuring drug responses in lung cultures differentiated from cystic fibrosis iPS cells. Taken together, we show that this medium throughput assay of CFTR activity has the potential to stratify cystic fibrosis patient-specific responses to approved drugs and investigational compounds in vitro in primary and iPS cell-derived airway cultures.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N3b32d8c76d494f12b2b88a9fcbe9e240
69 Nd5cf0d0369c5438592774f72356cb041
70 sg:journal.1053748
71 schema:name Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia
72 schema:pagination 12
73 schema:productId N08ff57f687a5466ab3e3d5168fd0252a
74 N1f64ec4e551344e1ad42918827a2a853
75 N5eb7505b8d494fd086dab4b9e1bf39b7
76 N94a8b402197d4469b935fac8fed415ee
77 Nda66cc0967ea497289e7db399c517223
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084782251
79 https://doi.org/10.1038/s41525-017-0015-6
80 schema:sdDatePublished 2019-04-10T14:05
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N4ed30eb42a0a4a53be387b6d8a9cd3a0
83 schema:url https://www.nature.com/articles/s41525-017-0015-6
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N01d0ae700775427db7f5d093e259774f rdf:first sg:person.01251134606.39
88 rdf:rest rdf:nil
89 N08ff57f687a5466ab3e3d5168fd0252a schema:name readcube_id
90 schema:value ce61ac7a35fcd113d50d23a73a075684a364909e64832e5a6247fa83bb0bd20e
91 rdf:type schema:PropertyValue
92 N0b0eafc0a53344d9a166d13902b0f2b1 rdf:first sg:person.01017365746.34
93 rdf:rest Ne8e40d3a8b2c4e3b96d6f427214ac90f
94 N10ff356b30764d7495aa28aa5085f56d rdf:first sg:person.01232113335.80
95 rdf:rest Nb725b06064674781916c17123938e306
96 N1ed63330e512450fba352243218287d3 rdf:first sg:person.0600006247.76
97 rdf:rest N829084cc0c44468f872b9d2bb79ef14e
98 N1f64ec4e551344e1ad42918827a2a853 schema:name pubmed_id
99 schema:value 28649446
100 rdf:type schema:PropertyValue
101 N20d2424ab14a4366bdf61a87af2ca994 rdf:first sg:person.01175351322.43
102 rdf:rest N8b277cc6c0dd4b54a4c0e2b7eb07966d
103 N30b05ebd38a545ffa1ac20dd3e67b916 rdf:first sg:person.012701055245.28
104 rdf:rest N552ef5ab2af5478fa783856e29247a1b
105 N38355c4f4d8849b389b7c49a03e0416b rdf:first sg:person.01036040176.43
106 rdf:rest N10ff356b30764d7495aa28aa5085f56d
107 N3b32d8c76d494f12b2b88a9fcbe9e240 schema:volumeNumber 2
108 rdf:type schema:PublicationVolume
109 N4ca5b2908c764319966382113c6e6f00 rdf:first sg:person.01157316334.15
110 rdf:rest N38355c4f4d8849b389b7c49a03e0416b
111 N4ed30eb42a0a4a53be387b6d8a9cd3a0 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N552ef5ab2af5478fa783856e29247a1b rdf:first sg:person.01231272634.68
114 rdf:rest N7d2ce74f1570427caabaa79eeaf61d7f
115 N5eb7505b8d494fd086dab4b9e1bf39b7 schema:name doi
116 schema:value 10.1038/s41525-017-0015-6
117 rdf:type schema:PropertyValue
118 N68bf2474bcc24a7ea791d2960e023e55 rdf:first sg:person.01014306716.17
119 rdf:rest Nb6073086b0c248099220b4df98ae0155
120 N7d2ce74f1570427caabaa79eeaf61d7f rdf:first sg:person.01121342625.84
121 rdf:rest N01d0ae700775427db7f5d093e259774f
122 N829084cc0c44468f872b9d2bb79ef14e rdf:first sg:person.013176557543.90
123 rdf:rest N4ca5b2908c764319966382113c6e6f00
124 N8b277cc6c0dd4b54a4c0e2b7eb07966d rdf:first sg:person.0676753750.51
125 rdf:rest N0b0eafc0a53344d9a166d13902b0f2b1
126 N94a8b402197d4469b935fac8fed415ee schema:name nlm_unique_id
127 schema:value 101685193
128 rdf:type schema:PropertyValue
129 Na4ada6269b924577990e237ba1fdc8fc rdf:first sg:person.0621440004.13
130 rdf:rest N68bf2474bcc24a7ea791d2960e023e55
131 Nb2a5d0679c21485ead514c6befd3cf29 rdf:first sg:person.01213072700.04
132 rdf:rest N20d2424ab14a4366bdf61a87af2ca994
133 Nb6073086b0c248099220b4df98ae0155 rdf:first sg:person.016112505243.45
134 rdf:rest Nb2a5d0679c21485ead514c6befd3cf29
135 Nb725b06064674781916c17123938e306 rdf:first sg:person.01162077340.24
136 rdf:rest Nf9dc637c5a124410a1e1fd246d91cfd4
137 Nd5cf0d0369c5438592774f72356cb041 schema:issueNumber 1
138 rdf:type schema:PublicationIssue
139 Nda66cc0967ea497289e7db399c517223 schema:name dimensions_id
140 schema:value pub.1084782251
141 rdf:type schema:PropertyValue
142 Ne8e40d3a8b2c4e3b96d6f427214ac90f rdf:first sg:person.01233401121.32
143 rdf:rest N1ed63330e512450fba352243218287d3
144 Nf9dc637c5a124410a1e1fd246d91cfd4 rdf:first sg:person.01355172356.46
145 rdf:rest N30b05ebd38a545ffa1ac20dd3e67b916
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
150 schema:name Cardiorespiratory Medicine and Haematology
151 rdf:type schema:DefinedTerm
152 sg:journal.1053748 schema:issn 2056-7944
153 schema:name npj Genomic Medicine
154 rdf:type schema:Periodical
155 sg:person.01014306716.17 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
156 schema:familyName Bozoky
157 schema:givenName Zoltan
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014306716.17
159 rdf:type schema:Person
160 sg:person.01017365746.34 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
161 schema:familyName Wellhauser
162 schema:givenName Leigh
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017365746.34
164 rdf:type schema:Person
165 sg:person.01036040176.43 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
166 schema:familyName Forman-Kay
167 schema:givenName Julie D.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036040176.43
169 rdf:type schema:Person
170 sg:person.01121342625.84 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
171 schema:familyName Moraes
172 schema:givenName Theo J.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121342625.84
174 rdf:type schema:Person
175 sg:person.01157316334.15 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
176 schema:familyName Avolio
177 schema:givenName Julie
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157316334.15
179 rdf:type schema:Person
180 sg:person.01162077340.24 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
181 schema:familyName Hirota
182 schema:givenName Jeremy A.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162077340.24
184 rdf:type schema:Person
185 sg:person.01175351322.43 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
186 schema:familyName Li
187 schema:givenName Canhui
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175351322.43
189 rdf:type schema:Person
190 sg:person.01213072700.04 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
191 schema:familyName Xia
192 schema:givenName Sunny
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213072700.04
194 rdf:type schema:Person
195 sg:person.01231272634.68 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
196 schema:familyName Gonska
197 schema:givenName Tanja
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231272634.68
199 rdf:type schema:Person
200 sg:person.01232113335.80 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
201 schema:familyName Ratjen
202 schema:givenName Felix
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232113335.80
204 rdf:type schema:Person
205 sg:person.01233401121.32 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
206 schema:familyName Molinski
207 schema:givenName Steven V.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233401121.32
209 rdf:type schema:Person
210 sg:person.01251134606.39 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
211 schema:familyName Bear
212 schema:givenName Christine E.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251134606.39
214 rdf:type schema:Person
215 sg:person.012701055245.28 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
216 schema:familyName Rossant
217 schema:givenName Janet
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012701055245.28
219 rdf:type schema:Person
220 sg:person.013176557543.90 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
221 schema:familyName Ouyang
222 schema:givenName Hong
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013176557543.90
224 rdf:type schema:Person
225 sg:person.01355172356.46 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
226 schema:familyName Rommens
227 schema:givenName Johanna
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355172356.46
229 rdf:type schema:Person
230 sg:person.016112505243.45 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
231 schema:familyName Di Paola
232 schema:givenName Michelle
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016112505243.45
234 rdf:type schema:Person
235 sg:person.0600006247.76 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
236 schema:familyName Ip
237 schema:givenName Wan
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600006247.76
239 rdf:type schema:Person
240 sg:person.0621440004.13 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
241 schema:familyName Ahmadi
242 schema:givenName Saumel
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621440004.13
244 rdf:type schema:Person
245 sg:person.0676753750.51 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
246 schema:familyName Wong
247 schema:givenName Amy P.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676753750.51
249 rdf:type schema:Person
250 sg:pub.10.1007/978-1-61779-120-8_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022785519
251 https://doi.org/10.1007/978-1-61779-120-8_15
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/352628a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044633103
254 https://doi.org/10.1038/352628a0
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/358761a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009186996
257 https://doi.org/10.1038/358761a0
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/clpt.2014.54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019725816
260 https://doi.org/10.1038/clpt.2014.54
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/mi.2015.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045538010
263 https://doi.org/10.1038/mi.2015.104
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nbt.2328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035253501
266 https://doi.org/10.1038/nbt.2328
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nbt.2754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030938455
269 https://doi.org/10.1038/nbt.2754
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nbt.3294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049442174
272 https://doi.org/10.1038/nbt.3294
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nm.3201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042334899
275 https://doi.org/10.1038/nm.3201
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nprot.2015.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046055100
278 https://doi.org/10.1038/nprot.2015.021
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nrg3849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029517960
281 https://doi.org/10.1038/nrg3849
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nsmb882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053380687
284 https://doi.org/10.1038/nsmb882
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/sj.onc.1206953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029844928
287 https://doi.org/10.1038/sj.onc.1206953
288 rdf:type schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1082467505 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1083034293 schema:CreativeWork
291 https://doi.org/10.1002/j.1460-2075.1995.tb00119.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082411583
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/pmic.201400218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038536976
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/0092-8674(91)90498-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1001366314
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/0092-8674(92)90155-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047418822
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.cell.2007.09.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000738859
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.chembiol.2014.02.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042273954
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.jcf.2005.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012814495
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.jcf.2011.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010446987
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jcf.2014.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010395869
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.molmed.2007.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052732616
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.tips.2008.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026600869
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/s2213-2600(14)70132-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034540669
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1021/acs.jmedchem.6b01539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055100472
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1038/mtm.2015.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053357744
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1042/bj20080029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045393905
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1053/jhep.2003.50331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011687727
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1056/nejm199011293232203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014822459
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1056/nejmoa1105185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044458961
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1056/nejmoa1409547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049294600
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.0904709106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012506625
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1073/pnas.1105787108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030045105
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1073/pnas.2634339100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032010126
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1074/jbc.m112.393637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030011371
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1074/mcp.m800268-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035440877
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1083/jcb.200312018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025704988
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1091/mbc.e14-04-0935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030084864
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1096/fasebj.4.10.2197151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078458745
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/joim.12314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020340942
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1113/jphysiol.2005.096669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050166980
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1126/scitranslmed.3008889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688362
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/scitranslmed.aad8278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005661272
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1152/ajpcell.2001.281.5.c1734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074893649
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1152/ajplung.00085.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063195105
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1152/ajplung.00169.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049936464
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1152/ajplung.00340.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036145029
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1152/ajplung.1998.275.5.l917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083346902
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1152/physrev.00035.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026460526
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1164/rccm.201601-0154oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1043149146
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1165/ajrcmb/8.5.522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005496523
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1165/rcmb.2016-0276ma schema:sameAs https://app.dimensions.ai/details/publication/pub.1079379273
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1177/1087057113488420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016322003
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1177/1087057115605834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036558118
374 rdf:type schema:CreativeWork
375 https://doi.org/10.3389/fphar.2012.00160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017573205
376 rdf:type schema:CreativeWork
377 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
378 schema:name Department of Biochemistry, University of Toronto, Toronto, ON, Canada
379 Department of Physiology, University of Toronto, Toronto, ON, Canada
380 Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.25073.33 schema:alternateName McMaster University
383 schema:name Firestone Institute for Respiratory Health, Division of Respirology, McMaster University, Hamilton, ON, Canada
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
386 schema:name Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
387 Department of Paediatrics, University of Toronto, Toronto, ON, Canada
388 Department of Physiology, University of Toronto, Toronto, ON, Canada
389 Programme in Developmental and Stem Cell Biology, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
390 Programme in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
391 Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
392 Programme in Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
393 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...