NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Elisa H F Jandrey, Ricardo P Moura, Luciana N S Andrade, Camila L Machado, Luiz Felipe Campesato, Katia Ramos M Leite, Lilian T Inoue, Paula F Asprino, Ana Paula M da Silva, Alfredo Carlos S D de Barros, Andre Carvalho, Vladmir C de Lima, Dirce M Carraro, Helena P Brentani, Isabela W da Cunha, Fernando A Soares, Raphael B Parmigiani, Roger Chammas, Anamaria A Camargo, Érico T Costa

ABSTRACT

The risk of developing metastatic disease in breast cancer patients is traditionally predictable based on the number of positive axillary lymph nodes, complemented with additional clinicopathological factors. However, since lymph node-negative patients have a 20-30% probability of developing metastatic disease, lymph node information alone is insufficient to accurately assess individual risk. Molecular approaches, such as multigene expression panels, analyze a set of cancer-related genes that more accurately predict the early risk of metastasis and the treatment response. Here, we present N-Myc downstream-regulated gene 4 (NDRG4) epigenetic silencing as a mechanistic biomarker of metastasis in ductal invasive breast tumors. While aberrant NDRG4 DNA hypermethylation is significantly associated with the development of metastatic disease, downregulation of NDRG4 transcription and protein expression is functionally associated with enhanced lymph node adhesion and cell mobility. Here, we show that epigenetic silencing of NDRG4 modulates integrin signaling by assembling β1-integrins into large punctate clusters at the leading edge of tumor cells to promote an "adhesive switch," decreasing cell adhesion to fibronectin and increasing cell adhesion and migration towards vitronectin, an important component of human lymph nodes. Taken together, our functional and clinical observations suggest that NDRG4 is a potential mechanistic biomarker in breast cancer that is functionally associated with metastatic disease. More... »

PAGES

11

References to SciGraph publications

  • 1998-02. Expression of αv integrins and vitronectin receptor identity in breast cancer cells in BRITISH JOURNAL OF CANCER
  • 2003-05. Integrin adhesion receptors in tumor metastasis in CLINICAL & EXPERIMENTAL METASTASIS
  • 2011-12. Differences in integrin expression and signaling within human breast cancer cells in BMC CANCER
  • 2011-12. β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer in BREAST CANCER RESEARCH
  • 1989-05. Tumor cell adhesion to frozen lymph node sections—anin vitro correlate of lymphatic metastasis in CLINICAL & EXPERIMENTAL METASTASIS
  • 2013-05. Mechanistic biomarkers for clinical decision making in rheumatic diseases in NATURE REVIEWS RHEUMATOLOGY
  • 2014-11. Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients in GENETICS IN MEDICINE
  • 2016-04. Targeting metastasis in NATURE REVIEWS CANCER
  • 1988-05. Basement-membrane components associated with the extracellular matrix of the lymph node in CELL AND TISSUE RESEARCH
  • 1990-12. Tumor cell adhesion to frozen lymph node sections — a correlate of lymphatic metastasis in breast carcinoma models of human and rat origin in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-11. Breast cancer cell adhesome and degradome interact to drive metastasis in NPJ BREAST CANCER
  • 2013-01. Downregulation of N-Myc downstream-regulated gene 4 influences patient survival in gliomas in BRAIN TUMOR PATHOLOGY
  • 2010-01. Integrins in cancer: biological implications and therapeutic opportunities in NATURE REVIEWS CANCER
  • 2003-10. Integrins in Mammary Gland Development and Differentiation of Mammary Epithelium in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41523-019-0106-x

    DOI

    http://dx.doi.org/10.1038/s41523-019-0106-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113266978

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30963110


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "1Centro de Oncologia Molecular, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jandrey", 
            "givenName": "Elisa H F", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "2Ludwig Institute for Cancer Research (LICR), S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moura", 
            "givenName": "Ricardo P", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo", 
              "id": "https://www.grid.ac/institutes/grid.488702.1", 
              "name": [
                "3Laborat\u00f3rio de Oncologia Experimental, Centro de Investiga\u00e7\u00e3o Translacional em Oncologia, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andrade", 
            "givenName": "Luciana N S", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo", 
              "id": "https://www.grid.ac/institutes/grid.488702.1", 
              "name": [
                "3Laborat\u00f3rio de Oncologia Experimental, Centro de Investiga\u00e7\u00e3o Translacional em Oncologia, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Machado", 
            "givenName": "Camila L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "1Centro de Oncologia Molecular, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campesato", 
            "givenName": "Luiz Felipe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "4Laborat\u00f3rio de Patologia, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leite", 
            "givenName": "Katia Ramos M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "1Centro de Oncologia Molecular, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Inoue", 
            "givenName": "Lilian T", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "1Centro de Oncologia Molecular, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asprino", 
            "givenName": "Paula F", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "2Ludwig Institute for Cancer Research (LICR), S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "da Silva", 
            "givenName": "Ana Paula M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "5Departamento de Mastologia, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Barros", 
            "givenName": "Alfredo Carlos S D", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital de C\u00e2ncer de Barretos", 
              "id": "https://www.grid.ac/institutes/grid.427783.d", 
              "name": [
                "6Hospital do C\u00e2ncer de Barretos, Barretos, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carvalho", 
            "givenName": "Andre", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AC Camargo Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413320.7", 
              "name": [
                "7Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, Funda\u00e7\u00e3o Ant\u00f4nio Prudente, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Lima", 
            "givenName": "Vladmir C", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AC Camargo Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413320.7", 
              "name": [
                "7Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, Funda\u00e7\u00e3o Ant\u00f4nio Prudente, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carraro", 
            "givenName": "Dirce M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Sao Paulo", 
              "id": "https://www.grid.ac/institutes/grid.11899.38", 
              "name": [
                "8LIM23-Instituto de Psiquiatria, Faculdade de Medicina da Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brentani", 
            "givenName": "Helena P", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rede D'OR, Hospital S\u00e3o Luis, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "da Cunha", 
            "givenName": "Isabela W", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Rede D'OR, Hospital S\u00e3o Luis, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soares", 
            "givenName": "Fernando A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "2Ludwig Institute for Cancer Research (LICR), S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parmigiani", 
            "givenName": "Raphael B", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo", 
              "id": "https://www.grid.ac/institutes/grid.488702.1", 
              "name": [
                "3Laborat\u00f3rio de Oncologia Experimental, Centro de Investiga\u00e7\u00e3o Translacional em Oncologia, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, S\u00e3o Paulo, SP Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chammas", 
            "givenName": "Roger", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "1Centro de Oncologia Molecular, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil.", 
                "2Ludwig Institute for Cancer Research (LICR), S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Camargo", 
            "givenName": "Anamaria A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "1Centro de Oncologia Molecular, Hospital S\u00edrio-Liban\u00eas, S\u00e3o Paulo, SP Brazil.", 
                "2Ludwig Institute for Cancer Research (LICR), S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Costa", 
            "givenName": "\u00c9rico T", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.3892/ol.2014.2815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002009437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002009437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.256446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002554522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2016.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004660332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2016.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004660332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2016.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004660332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005473659", 
              "https://doi.org/10.1186/bcr2905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-11-293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008537337", 
              "https://doi.org/10.1186/1471-2407-11-293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gim.2014.40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008544192", 
              "https://doi.org/10.1038/gim.2014.40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e12-07-0539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008589522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1006459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009918781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00214379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011713530", 
              "https://doi.org/10.1007/bf00214379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00214379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011713530", 
              "https://doi.org/10.1007/bf00214379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0017911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012826110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013028814", 
              "https://doi.org/10.1038/nrc2748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013028814", 
              "https://doi.org/10.1038/nrc2748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-2469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013955205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci116007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016061509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017098641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017098641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mex.2014.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018019424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.26558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018405265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1022983000355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022174695", 
              "https://doi.org/10.1023/a:1022983000355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.41.12.1269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024320219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:jomg.0000017426.74915.b9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028686975", 
              "https://doi.org/10.1023/b:jomg.0000017426.74915.b9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r000003200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029173915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.9.e45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030834024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0103896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031778769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ydbio.2008.02.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031866225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4172/1948-5956.1000407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032005218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01806291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032031807", 
              "https://doi.org/10.1007/bf01806291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01806291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032031807", 
              "https://doi.org/10.1007/bf01806291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku1151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033224422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.012484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035114773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrrheum.2013.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035116479", 
              "https://doi.org/10.1038/nrrheum.2013.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.12003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036060122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2014.15746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037083200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.15.5758-5765.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038578144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.14099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038676057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btr260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039284123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000155210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039434640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djp131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040523303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040586971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3001875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041074347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1311194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043151806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1003034107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043718703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01753685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044301266", 
              "https://doi.org/10.1007/bf01753685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01753685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044301266", 
              "https://doi.org/10.1007/bf01753685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044649302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.critrevonc.2004.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047583081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npjbcancer.2015.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049891695", 
              "https://doi.org/10.1038/npjbcancer.2015.17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19960529)66:5<703::aid-ijc20>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050309538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.27819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050363363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc.2016.25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050875196", 
              "https://doi.org/10.1038/nrc.2016.25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0925-4439(03)00059-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051705978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0925-4439(03)00059-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051705978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.03460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052559928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10014-012-0092-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052733491", 
              "https://doi.org/10.1007/s10014-012-0092-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052888200", 
              "https://doi.org/10.1038/bjc.1998.86"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1998.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052888200", 
              "https://doi.org/10.1038/bjc.1998.86"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archotol.130.1.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053099225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.2000.6496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053445556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/omi.2011.0146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059303959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v21.i35.10057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079154704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0174230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084305362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2017.0424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084922420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14343/jcscr.2016.4e1005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085269371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi-2017-0118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099910096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/epi-2017-0118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099910096"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "The risk of developing metastatic disease in breast cancer patients is traditionally predictable based on the number of positive axillary lymph nodes, complemented with additional clinicopathological factors. However, since lymph node-negative patients have a 20-30% probability of developing metastatic disease, lymph node information alone is insufficient to accurately assess individual risk. Molecular approaches, such as multigene expression panels, analyze a set of cancer-related genes that more accurately predict the early risk of metastasis and the treatment response. Here, we present N-Myc downstream-regulated gene 4 (NDRG4) epigenetic silencing as a mechanistic biomarker of metastasis in ductal invasive breast tumors. While aberrant NDRG4 DNA hypermethylation is significantly associated with the development of metastatic disease, downregulation of NDRG4 transcription and protein expression is functionally associated with enhanced lymph node adhesion and cell mobility. Here, we show that epigenetic silencing of NDRG4 modulates integrin signaling by assembling \u03b21-integrins into large punctate clusters at the leading edge of tumor cells to promote an \"adhesive switch,\" decreasing cell adhesion to fibronectin and increasing cell adhesion and migration towards vitronectin, an important component of human lymph nodes. Taken together, our functional and clinical observations suggest that NDRG4 is a potential mechanistic biomarker in breast cancer that is functionally associated with metastatic disease.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41523-019-0106-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4541725", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1052988", 
            "issn": [
              "2374-4677"
            ], 
            "name": "npj Breast Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "name": "NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients.", 
        "pagination": "11", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41523-019-0106-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113266978"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101674891"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30963110"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41523-019-0106-x", 
          "https://app.dimensions.ai/details/publication/pub.1113266978"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56158_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/s41523-019-0106-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0106-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0106-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0106-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0106-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    389 TRIPLES      21 PREDICATES      87 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41523-019-0106-x schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N0683c2cc8316403a9416da022f21a8e7
    4 schema:citation sg:pub.10.1007/bf00214379
    5 sg:pub.10.1007/bf01753685
    6 sg:pub.10.1007/bf01806291
    7 sg:pub.10.1007/s10014-012-0092-2
    8 sg:pub.10.1023/a:1022983000355
    9 sg:pub.10.1023/b:jomg.0000017426.74915.b9
    10 sg:pub.10.1038/bjc.1998.86
    11 sg:pub.10.1038/gim.2014.40
    12 sg:pub.10.1038/npjbcancer.2015.17
    13 sg:pub.10.1038/nrc.2016.25
    14 sg:pub.10.1038/nrc2748
    15 sg:pub.10.1038/nrrheum.2013.14
    16 sg:pub.10.1186/1471-2407-11-293
    17 sg:pub.10.1186/bcr2905
    18 https://doi.org/10.1001/archotol.130.1.39
    19 https://doi.org/10.1001/jama.2014.15746
    20 https://doi.org/10.1001/jamaoncol.2017.0424
    21 https://doi.org/10.1002/(sici)1097-0215(19960529)66:5<703::aid-ijc20>3.0.co;2-3
    22 https://doi.org/10.1002/cncr.26558
    23 https://doi.org/10.1002/cncr.27819
    24 https://doi.org/10.1006/geno.2000.6496
    25 https://doi.org/10.1016/j.ccr.2006.10.008
    26 https://doi.org/10.1016/j.critrevonc.2004.12.006
    27 https://doi.org/10.1016/j.mex.2014.06.004
    28 https://doi.org/10.1016/j.molonc.2016.09.008
    29 https://doi.org/10.1016/j.ydbio.2008.02.044
    30 https://doi.org/10.1016/s0925-4439(03)00059-0
    31 https://doi.org/10.1056/nejmoa1311194
    32 https://doi.org/10.1073/pnas.0506580102
    33 https://doi.org/10.1073/pnas.1003034107
    34 https://doi.org/10.1074/jbc.m109.012484
    35 https://doi.org/10.1074/jbc.m111.256446
    36 https://doi.org/10.1074/jbc.r000003200
    37 https://doi.org/10.1089/omi.2011.0146
    38 https://doi.org/10.1091/mbc.e12-07-0539
    39 https://doi.org/10.1093/bioinformatics/btr260
    40 https://doi.org/10.1093/jnci/djp131
    41 https://doi.org/10.1093/nar/29.9.e45
    42 https://doi.org/10.1093/nar/gku1151
    43 https://doi.org/10.1126/scitranslmed.3001875
    44 https://doi.org/10.1128/mcb.20.15.5758-5765.2000
    45 https://doi.org/10.1136/jcp.41.12.1269
    46 https://doi.org/10.1158/1078-0432.ccr-14-2469
    47 https://doi.org/10.1159/000155210
    48 https://doi.org/10.1172/jci116007
    49 https://doi.org/10.1172/jci119298
    50 https://doi.org/10.1242/jcs.03460
    51 https://doi.org/10.1371/journal.pgen.1006459
    52 https://doi.org/10.1371/journal.pone.0017911
    53 https://doi.org/10.1371/journal.pone.0103896
    54 https://doi.org/10.1371/journal.pone.0174230
    55 https://doi.org/10.14343/jcscr.2016.4e1005
    56 https://doi.org/10.18632/oncotarget.12003
    57 https://doi.org/10.18632/oncotarget.14099
    58 https://doi.org/10.2217/epi-2017-0118
    59 https://doi.org/10.3748/wjg.v21.i35.10057
    60 https://doi.org/10.3892/ol.2014.2413
    61 https://doi.org/10.3892/ol.2014.2815
    62 https://doi.org/10.4172/1948-5956.1000407
    63 schema:datePublished 2019-12
    64 schema:datePublishedReg 2019-12-01
    65 schema:description The risk of developing metastatic disease in breast cancer patients is traditionally predictable based on the number of positive axillary lymph nodes, complemented with additional clinicopathological factors. However, since lymph node-negative patients have a 20-30% probability of developing metastatic disease, lymph node information alone is insufficient to accurately assess individual risk. Molecular approaches, such as multigene expression panels, analyze a set of cancer-related genes that more accurately predict the early risk of metastasis and the treatment response. Here, we present N-Myc downstream-regulated gene 4 (NDRG4) epigenetic silencing as a mechanistic biomarker of metastasis in ductal invasive breast tumors. While aberrant NDRG4 DNA hypermethylation is significantly associated with the development of metastatic disease, downregulation of NDRG4 transcription and protein expression is functionally associated with enhanced lymph node adhesion and cell mobility. Here, we show that epigenetic silencing of NDRG4 modulates integrin signaling by assembling β1-integrins into large punctate clusters at the leading edge of tumor cells to promote an "adhesive switch," decreasing cell adhesion to fibronectin and increasing cell adhesion and migration towards vitronectin, an important component of human lymph nodes. Taken together, our functional and clinical observations suggest that NDRG4 is a potential mechanistic biomarker in breast cancer that is functionally associated with metastatic disease.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree false
    69 schema:isPartOf N1944a241f63a40a69188956439201d03
    70 N98f765ffccf241978b76a4db53cf6abc
    71 sg:journal.1052988
    72 schema:name NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients.
    73 schema:pagination 11
    74 schema:productId N145a32fe0413405aa2244b4375a7f537
    75 Nd6416397631346268682a24aa53da88b
    76 Nf011a25d2ba04f3397fea4d558cffa99
    77 Nff83401342144438823db9cb50888af8
    78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113266978
    79 https://doi.org/10.1038/s41523-019-0106-x
    80 schema:sdDatePublished 2019-04-15T09:11
    81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    82 schema:sdPublisher N910e71220d3d4cfa86e569b92bd4f118
    83 schema:url http://www.nature.com/articles/s41523-019-0106-x
    84 sgo:license sg:explorer/license/
    85 sgo:sdDataset articles
    86 rdf:type schema:ScholarlyArticle
    87 N00c2466508f74a43a06b2cfedae31089 rdf:first Nccaaded8c9ec49a2a7e8eece77d61dc3
    88 rdf:rest Nff30f22fe7634827baaf17206c220472
    89 N0683c2cc8316403a9416da022f21a8e7 rdf:first N9d6c1257772c4330833809732510c243
    90 rdf:rest N8e11633e1b184ce69ff92afd1e09d21c
    91 N12662bc589f24920a009ce69a11d6699 schema:affiliation N564e79f95bd64fdbb3111a6521929ce8
    92 schema:familyName da Cunha
    93 schema:givenName Isabela W
    94 rdf:type schema:Person
    95 N145a32fe0413405aa2244b4375a7f537 schema:name dimensions_id
    96 schema:value pub.1113266978
    97 rdf:type schema:PropertyValue
    98 N1944a241f63a40a69188956439201d03 schema:issueNumber 1
    99 rdf:type schema:PublicationIssue
    100 N1f8d98aa6bb14aad8264a0731f87b504 rdf:first N12662bc589f24920a009ce69a11d6699
    101 rdf:rest Nb0d5e95bff874f0fba5b6157d43eeee0
    102 N21c4c4c132f347fa803e10d27506c1a8 rdf:first Nbf8ee8968b6142d1a444115e7a1210f3
    103 rdf:rest N290c9f9a23bd4ccb943513e24f66b4a3
    104 N290c9f9a23bd4ccb943513e24f66b4a3 rdf:first Nf959eec76f0b4a2e957faaded0bc6490
    105 rdf:rest Nff7a16da9821489b98e3140bd9a2cde1
    106 N2c98081701f349a6855137ea90084b91 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    107 schema:familyName Camargo
    108 schema:givenName Anamaria A
    109 rdf:type schema:Person
    110 N31c5502d50864d4796b425ebea069c47 rdf:first N849078a96ebc4c618def2490dd465a65
    111 rdf:rest Na0aaecc0f8ab4487b8a0578c760334ef
    112 N42b647613d5d4a7ebeffbf3c258c7cb2 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    113 schema:familyName Leite
    114 schema:givenName Katia Ramos M
    115 rdf:type schema:Person
    116 N479ffd17232b4a6c858ca1c3de47101e schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    117 schema:familyName Inoue
    118 schema:givenName Lilian T
    119 rdf:type schema:Person
    120 N4847e296ef5347cea4f7e8e49f9467f8 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
    121 schema:familyName Brentani
    122 schema:givenName Helena P
    123 rdf:type schema:Person
    124 N4de1b19631e14eaa9414bcab523c94cc schema:affiliation https://www.grid.ac/institutes/grid.413320.7
    125 schema:familyName Carraro
    126 schema:givenName Dirce M
    127 rdf:type schema:Person
    128 N55624af6f8434b2fa0c574916b0e1357 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    129 schema:familyName Moura
    130 schema:givenName Ricardo P
    131 rdf:type schema:Person
    132 N564e79f95bd64fdbb3111a6521929ce8 schema:name Rede D'OR, Hospital São Luis, São Paulo, SP Brazil.
    133 rdf:type schema:Organization
    134 N5932780cce304a8198a2dd5465140c43 schema:name Rede D'OR, Hospital São Luis, São Paulo, SP Brazil.
    135 rdf:type schema:Organization
    136 N75221960b5d041d392ba438db8dfa495 schema:affiliation https://www.grid.ac/institutes/grid.488702.1
    137 schema:familyName Machado
    138 schema:givenName Camila L
    139 rdf:type schema:Person
    140 N849078a96ebc4c618def2490dd465a65 schema:affiliation https://www.grid.ac/institutes/grid.488702.1
    141 schema:familyName Andrade
    142 schema:givenName Luciana N S
    143 rdf:type schema:Person
    144 N8c19a10bcb0343eda2f9db2419148e7a rdf:first N479ffd17232b4a6c858ca1c3de47101e
    145 rdf:rest N944cd7f8c0694a3db85bebfe5dcbd5bc
    146 N8e11633e1b184ce69ff92afd1e09d21c rdf:first N55624af6f8434b2fa0c574916b0e1357
    147 rdf:rest N31c5502d50864d4796b425ebea069c47
    148 N910e71220d3d4cfa86e569b92bd4f118 schema:name Springer Nature - SN SciGraph project
    149 rdf:type schema:Organization
    150 N9211f18d0e3d4f428dc1ceb5ca4f81c6 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    151 schema:familyName Asprino
    152 schema:givenName Paula F
    153 rdf:type schema:Person
    154 N92a47af53d404f6d928e7dd029675cab rdf:first N4847e296ef5347cea4f7e8e49f9467f8
    155 rdf:rest N1f8d98aa6bb14aad8264a0731f87b504
    156 N92a5643583c0405f882e483aac0a90c1 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    157 schema:familyName Parmigiani
    158 schema:givenName Raphael B
    159 rdf:type schema:Person
    160 N9444f061e46742ef80fbbce47916cf20 schema:affiliation N5932780cce304a8198a2dd5465140c43
    161 schema:familyName Soares
    162 schema:givenName Fernando A
    163 rdf:type schema:Person
    164 N944cd7f8c0694a3db85bebfe5dcbd5bc rdf:first N9211f18d0e3d4f428dc1ceb5ca4f81c6
    165 rdf:rest N21c4c4c132f347fa803e10d27506c1a8
    166 N9451d04a254b451c9099f37a94c06c09 rdf:first Nce77ae780e7a41d89e1a1ca475d1b1bb
    167 rdf:rest rdf:nil
    168 N98f765ffccf241978b76a4db53cf6abc schema:volumeNumber 5
    169 rdf:type schema:PublicationVolume
    170 N9d6c1257772c4330833809732510c243 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    171 schema:familyName Jandrey
    172 schema:givenName Elisa H F
    173 rdf:type schema:Person
    174 Na0aaecc0f8ab4487b8a0578c760334ef rdf:first N75221960b5d041d392ba438db8dfa495
    175 rdf:rest Ne95336a8a41043db9f0335ddd9e97252
    176 Nb0d5e95bff874f0fba5b6157d43eeee0 rdf:first N9444f061e46742ef80fbbce47916cf20
    177 rdf:rest Nb4cc765e00cb437096d3b9d203861b80
    178 Nb4cc765e00cb437096d3b9d203861b80 rdf:first N92a5643583c0405f882e483aac0a90c1
    179 rdf:rest N00c2466508f74a43a06b2cfedae31089
    180 Nbf8ee8968b6142d1a444115e7a1210f3 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    181 schema:familyName da Silva
    182 schema:givenName Ana Paula M
    183 rdf:type schema:Person
    184 Nccaaded8c9ec49a2a7e8eece77d61dc3 schema:affiliation https://www.grid.ac/institutes/grid.488702.1
    185 schema:familyName Chammas
    186 schema:givenName Roger
    187 rdf:type schema:Person
    188 Nce77ae780e7a41d89e1a1ca475d1b1bb schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    189 schema:familyName Costa
    190 schema:givenName Érico T
    191 rdf:type schema:Person
    192 Nd330afbf98714d52a51b88c24a13a0e2 schema:affiliation https://www.grid.ac/institutes/grid.427783.d
    193 schema:familyName Carvalho
    194 schema:givenName Andre
    195 rdf:type schema:Person
    196 Nd6416397631346268682a24aa53da88b schema:name nlm_unique_id
    197 schema:value 101674891
    198 rdf:type schema:PropertyValue
    199 Nd7b465cbdf0549a8a2b93716fee3e7c6 rdf:first N4de1b19631e14eaa9414bcab523c94cc
    200 rdf:rest N92a47af53d404f6d928e7dd029675cab
    201 Nd97fd2a6e91f4fd0a79e603ff52714a9 rdf:first N42b647613d5d4a7ebeffbf3c258c7cb2
    202 rdf:rest N8c19a10bcb0343eda2f9db2419148e7a
    203 Nda99d291dfd44420b08749730ff1c42f schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    204 schema:familyName Campesato
    205 schema:givenName Luiz Felipe
    206 rdf:type schema:Person
    207 Ne95336a8a41043db9f0335ddd9e97252 rdf:first Nda99d291dfd44420b08749730ff1c42f
    208 rdf:rest Nd97fd2a6e91f4fd0a79e603ff52714a9
    209 Nec2e1417d8aa4fafb2111c4e0870e47e schema:affiliation https://www.grid.ac/institutes/grid.413320.7
    210 schema:familyName de Lima
    211 schema:givenName Vladmir C
    212 rdf:type schema:Person
    213 Nf011a25d2ba04f3397fea4d558cffa99 schema:name pubmed_id
    214 schema:value 30963110
    215 rdf:type schema:PropertyValue
    216 Nf959eec76f0b4a2e957faaded0bc6490 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    217 schema:familyName de Barros
    218 schema:givenName Alfredo Carlos S D
    219 rdf:type schema:Person
    220 Nfdab2ada91d7470e855d979a752770f3 rdf:first Nec2e1417d8aa4fafb2111c4e0870e47e
    221 rdf:rest Nd7b465cbdf0549a8a2b93716fee3e7c6
    222 Nff30f22fe7634827baaf17206c220472 rdf:first N2c98081701f349a6855137ea90084b91
    223 rdf:rest N9451d04a254b451c9099f37a94c06c09
    224 Nff7a16da9821489b98e3140bd9a2cde1 rdf:first Nd330afbf98714d52a51b88c24a13a0e2
    225 rdf:rest Nfdab2ada91d7470e855d979a752770f3
    226 Nff83401342144438823db9cb50888af8 schema:name doi
    227 schema:value 10.1038/s41523-019-0106-x
    228 rdf:type schema:PropertyValue
    229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    230 schema:name Medical and Health Sciences
    231 rdf:type schema:DefinedTerm
    232 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Oncology and Carcinogenesis
    234 rdf:type schema:DefinedTerm
    235 sg:grant.4541725 http://pending.schema.org/fundedItem sg:pub.10.1038/s41523-019-0106-x
    236 rdf:type schema:MonetaryGrant
    237 sg:journal.1052988 schema:issn 2374-4677
    238 schema:name npj Breast Cancer
    239 rdf:type schema:Periodical
    240 sg:pub.10.1007/bf00214379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011713530
    241 https://doi.org/10.1007/bf00214379
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/bf01753685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044301266
    244 https://doi.org/10.1007/bf01753685
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1007/bf01806291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032031807
    247 https://doi.org/10.1007/bf01806291
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s10014-012-0092-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052733491
    250 https://doi.org/10.1007/s10014-012-0092-2
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1023/a:1022983000355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022174695
    253 https://doi.org/10.1023/a:1022983000355
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1023/b:jomg.0000017426.74915.b9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028686975
    256 https://doi.org/10.1023/b:jomg.0000017426.74915.b9
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/bjc.1998.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052888200
    259 https://doi.org/10.1038/bjc.1998.86
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/gim.2014.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008544192
    262 https://doi.org/10.1038/gim.2014.40
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/npjbcancer.2015.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049891695
    265 https://doi.org/10.1038/npjbcancer.2015.17
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nrc.2016.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050875196
    268 https://doi.org/10.1038/nrc.2016.25
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nrc2748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013028814
    271 https://doi.org/10.1038/nrc2748
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nrrheum.2013.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035116479
    274 https://doi.org/10.1038/nrrheum.2013.14
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1186/1471-2407-11-293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008537337
    277 https://doi.org/10.1186/1471-2407-11-293
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1186/bcr2905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005473659
    280 https://doi.org/10.1186/bcr2905
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1001/archotol.130.1.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053099225
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1001/jama.2014.15746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037083200
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1001/jamaoncol.2017.0424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084922420
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1002/(sici)1097-0215(19960529)66:5<703::aid-ijc20>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050309538
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1002/cncr.26558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018405265
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1002/cncr.27819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050363363
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1006/geno.2000.6496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053445556
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.ccr.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040586971
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.critrevonc.2004.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047583081
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.mex.2014.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018019424
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.molonc.2016.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004660332
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.ydbio.2008.02.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031866225
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/s0925-4439(03)00059-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051705978
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1056/nejmoa1311194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043151806
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1073/pnas.1003034107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043718703
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1074/jbc.m109.012484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035114773
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1074/jbc.m111.256446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002554522
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1074/jbc.r000003200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029173915
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1089/omi.2011.0146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059303959
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1091/mbc.e12-07-0539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008589522
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1093/bioinformatics/btr260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039284123
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1093/jnci/djp131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040523303
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1093/nar/29.9.e45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030834024
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1093/nar/gku1151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033224422
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1126/scitranslmed.3001875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041074347
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1128/mcb.20.15.5758-5765.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038578144
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1136/jcp.41.12.1269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024320219
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1158/1078-0432.ccr-14-2469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013955205
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1159/000155210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039434640
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1172/jci116007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016061509
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1172/jci119298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044649302
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1242/jcs.03460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052559928
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1371/journal.pgen.1006459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009918781
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1371/journal.pone.0017911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012826110
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1371/journal.pone.0103896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031778769
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1371/journal.pone.0174230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084305362
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.14343/jcscr.2016.4e1005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085269371
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.18632/oncotarget.12003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060122
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.18632/oncotarget.14099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038676057
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.2217/epi-2017-0118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099910096
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.3748/wjg.v21.i35.10057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079154704
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.3892/ol.2014.2413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017098641
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.3892/ol.2014.2815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002009437
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.4172/1948-5956.1000407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032005218
    371 rdf:type schema:CreativeWork
    372 https://www.grid.ac/institutes/grid.11899.38 schema:alternateName University of Sao Paulo
    373 schema:name 8LIM23-Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo (USP), São Paulo, Brazil.
    374 rdf:type schema:Organization
    375 https://www.grid.ac/institutes/grid.413320.7 schema:alternateName AC Camargo Hospital
    376 schema:name 7Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, Fundação Antônio Prudente, São Paulo, SP Brazil.
    377 rdf:type schema:Organization
    378 https://www.grid.ac/institutes/grid.413471.4 schema:alternateName Hospital Sírio-Libanês
    379 schema:name 1Centro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, SP Brazil.
    380 2Ludwig Institute for Cancer Research (LICR), São Paulo, Brazil.
    381 4Laboratório de Patologia, Hospital Sírio-Libanês, São Paulo, SP Brazil.
    382 5Departamento de Mastologia, Hospital Sírio-Libanês, São Paulo, Brazil.
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.427783.d schema:alternateName Hospital de Câncer de Barretos
    385 schema:name 6Hospital do Câncer de Barretos, Barretos, SP Brazil.
    386 rdf:type schema:Organization
    387 https://www.grid.ac/institutes/grid.488702.1 schema:alternateName Instituto do Câncer do Estado de São Paulo
    388 schema:name 3Laboratório de Oncologia Experimental, Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, São Paulo, SP Brazil.
    389 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...