ESR1 mutations in metastatic lobular breast cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Christine Desmedt, Julien Pingitore, Françoise Rothé, Caterina Marchio, Florian Clatot, Ghizlane Rouas, François Richard, François Bertucci, Odette Mariani, Christine Galant, Charlotte Fribbens, Ben O’Leary, Gert van den Eynden, Roberto Salgado, Nicholas C. Turner, Martine Piccart, Anne Vincent-Salomon, Giancarlo Pruneri, Denis Larsimont, Christos Sotiriou

ABSTRACT

Invasive lobular breast cancer (ILC) represents the second most common histology of breast cancer after invasive ductal breast cancer (IDC), accounts for up to 15% of all invasive cases and generally express the estrogen receptor (ER, coded by the ESR1 gene). ESR1 mutations have been associated with resistance to endocrine therapy, however these have not been specifically evaluated in ILC. We assessed the frequency of ESR1 mutations by droplet digital PCR in a retrospective multi-centric series of matched primary tumor and recurrence samples (n = 279) from 80 metastatic ER-positive ILC patients. We further compared ESR1 mutations between IDC and ILC patients in metastatic samples from MSKCC-IMPACT (n = 595 IDC and 116 ILC) and in ctDNA from the SoFEA and PALOMA-3 trials (n = 416 IDC and 76 ILC). In the retrospective series, the metastases from seven patients (9%) harbored ESR1 mutations, which were absent from the interrogated primary samples. Five patients (6%) had a mutation in the primary tumor or axillary metastasis, which could not be detected in the matched distant metastasis. In the MSKCC-IMPACT cohort, as well as in the SoFEA and PALOMA-3 trials, there were no differences in prevalence and distribution of the mutations between IDC and ILC, with D538G being the most frequent mutation in both histological subtypes. To conclude, no patient had an identical ESR1 mutation in the early and metastatic disease in the retrospective ILC series. In the external series, there was no difference in terms of prevalence and type of ESR1 mutations between ILC and IDC. More... »

PAGES

9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41523-019-0104-z

DOI

http://dx.doi.org/10.1038/s41523-019-0104-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112308286

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30820448


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Universit\u00e9 Libre de Bruxelles, 1000, Brussels, Belgium", 
            "Laboratory for Translational Breast Cancer Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desmedt", 
        "givenName": "Christine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Laboratory for Translational Breast Cancer Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pingitore", 
        "givenName": "Julien", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Universit\u00e9 Libre de Bruxelles, 1000, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth\u00e9", 
        "givenName": "Fran\u00e7oise", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, 26 Rue d\u2019Ulm, 75248, Paris C\u00e9dex05, France", 
            "Department of Medical Sciences, FPO-IRCCS Candiolo Cancer Institute, University of Turin, SP 142 Km3.95, 10060, Candiolo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchio", 
        "givenName": "Caterina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire De Rouen", 
          "id": "https://www.grid.ac/institutes/grid.41724.34", 
          "name": [
            "Department of Medical Oncology, Centre Henri-Becquerel, CS11516 rue d\u2019Amiens, 76000, Rouen, France", 
            "IRON/Inserm U1245, Rouen University Hospital, 22, boulevard Gambetta, 76183, Rouen, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clatot", 
        "givenName": "Florian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Universit\u00e9 Libre de Bruxelles, 1000, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rouas", 
        "givenName": "Ghizlane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Universit\u00e9 Libre de Bruxelles, 1000, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Richard", 
        "givenName": "Fran\u00e7ois", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherche en Canc\u00e9rologie de Marseille", 
          "id": "https://www.grid.ac/institutes/grid.463833.9", 
          "name": [
            "Predictive Oncology Laboratory, Institut Paoli-Calmettes, Centre de Recherche en Canc\u00e9rologie de Marseille, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertucci", 
        "givenName": "Fran\u00e7ois", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, 26 Rue d\u2019Ulm, 75248, Paris C\u00e9dex05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mariani", 
        "givenName": "Odette", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cliniques Universitaires Saint-Luc", 
          "id": "https://www.grid.ac/institutes/grid.48769.34", 
          "name": [
            "Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galant", 
        "givenName": "Christine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Breast Unit, Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK", 
            "The Breast Cancer Now Research Centre, The Institute of Cancer Research, SW3 6JB, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fribbens", 
        "givenName": "Charlotte", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Breast Unit, Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK", 
            "The Breast Cancer Now Research Centre, The Institute of Cancer Research, SW3 6JB, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Leary", 
        "givenName": "Ben", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GZA Ziekenhuizen campus Sint-Augustinus", 
          "id": "https://www.grid.ac/institutes/grid.428965.4", 
          "name": [
            "Department of Pathology, Sint Augustinus, Wilrijk, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Eynden", 
        "givenName": "Gert", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GZA Ziekenhuizen campus Sint-Augustinus", 
          "id": "https://www.grid.ac/institutes/grid.428965.4", 
          "name": [
            "Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Universit\u00e9 Libre de Bruxelles, 1000, Brussels, Belgium", 
            "Department of Pathology, Sint Augustinus, Wilrijk, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salgado", 
        "givenName": "Roberto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Breast Unit, Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK", 
            "The Breast Cancer Now Research Centre, The Institute of Cancer Research, SW3 6JB, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "Nicholas C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Jules Bordet", 
          "id": "https://www.grid.ac/institutes/grid.418119.4", 
          "name": [
            "Institut Jules Bordet, Boulevard de Waterloo 121, 1000, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piccart", 
        "givenName": "Martine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, 26 Rue d\u2019Ulm, 75248, Paris C\u00e9dex05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vincent-Salomon", 
        "givenName": "Anne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan", 
          "id": "https://www.grid.ac/institutes/grid.4708.b", 
          "name": [
            "Division of Pathology, European Institute of Oncology, University of Milan, Milan, Italy", 
            "Division of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133, Milan, Italy", 
            "School of Medicine, University of Milan, via Festa del Perdono 7, 20122, Milan, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pruneri", 
        "givenName": "Giancarlo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Jules Bordet", 
          "id": "https://www.grid.ac/institutes/grid.418119.4", 
          "name": [
            "Department of Pathology, Institut Jules Bordet, Boulevard de Waterloo 121, 1000, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larsimont", 
        "givenName": "Denis", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Universit\u00e9 Libre de Bruxelles, 1000, Brussels, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sotiriou", 
        "givenName": "Christos", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13058-015-0519-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000913518", 
          "https://doi.org/10.1186/s13058-015-0519-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0519-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000913518", 
          "https://doi.org/10.1186/s13058-015-0519-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0519-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000913518", 
          "https://doi.org/10.1186/s13058-015-0519-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2016.67.3061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003114495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.12792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004708788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010041153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011043290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011831914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms11579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013557158", 
          "https://doi.org/10.1038/ncomms11579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep18517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019178552", 
          "https://doi.org/10.1038/srep18517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019741899", 
          "https://doi.org/10.1038/ng.2822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.09.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023699296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2015.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025992588", 
          "https://doi.org/10.1038/nrclinonc.2015.99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2015.238717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027641776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0542-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028241679", 
          "https://doi.org/10.1186/s13058-015-0542-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0542-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028241679", 
          "https://doi.org/10.1186/s13058-015-0542-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0542-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028241679", 
          "https://doi.org/10.1186/s13058-015-0542-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032167006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scisignal.2004088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033807182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-016-3829-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040536389", 
          "https://doi.org/10.1007/s10549-016-3829-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2014.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042208245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-2332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044209610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms11479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050455938", 
          "https://doi.org/10.1038/ncomms11479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdw286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059394804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aac7551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062688860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-1534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063225044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-15-1523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063281040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.64.0334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11912-017-0591-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084510893", 
          "https://doi.org/10.1007/s11912-017-0591-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11912-017-0591-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084510893", 
          "https://doi.org/10.1007/s11912-017-0591-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085214027", 
          "https://doi.org/10.1038/nm.4333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085214027", 
          "https://doi.org/10.1038/nm.4333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/po.17.00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085426344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0043-109374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090287090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2017.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091159111", 
          "https://doi.org/10.1038/modpathol.2017.95"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091213415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdx490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091457978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djx268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092960408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2018.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101004622"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Invasive lobular breast cancer (ILC) represents the second most common histology of breast cancer after invasive ductal breast cancer (IDC), accounts for up to 15% of all invasive cases and generally express the estrogen receptor (ER, coded by the ESR1 gene). ESR1 mutations have been associated with resistance to endocrine therapy, however these have not been specifically evaluated in ILC. We assessed the frequency of ESR1 mutations by droplet digital PCR in a retrospective multi-centric series of matched primary tumor and recurrence samples (n\u2009=\u2009279) from 80 metastatic ER-positive ILC patients. We further compared ESR1 mutations between IDC and ILC patients in metastatic samples from MSKCC-IMPACT (n\u2009=\u2009595 IDC and 116 ILC) and in ctDNA from the SoFEA and PALOMA-3 trials (n\u2009=\u2009416 IDC and 76 ILC). In the retrospective series, the metastases from seven patients (9%) harbored ESR1 mutations, which were absent from the interrogated primary samples. Five patients (6%) had a mutation in the primary tumor or axillary metastasis, which could not be detected in the matched distant metastasis. In the MSKCC-IMPACT cohort, as well as in the SoFEA and PALOMA-3 trials, there were no differences in prevalence and distribution of the mutations between IDC and ILC, with D538G being the most frequent mutation in both histological subtypes. To conclude, no patient had an identical ESR1 mutation in the early and metastatic disease in the retrospective ILC series. In the external series, there was no difference in terms of prevalence and type of ESR1 mutations between ILC and IDC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41523-019-0104-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1052988", 
        "issn": [
          "2374-4677"
        ], 
        "name": "npj Breast Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "ESR1 mutations in metastatic lobular breast cancer patients", 
    "pagination": "9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3056c8b9586c32510a715e37c7534e863d98c6b8001fd349619647507d719909"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30820448"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101674891"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41523-019-0104-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112308286"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41523-019-0104-z", 
      "https://app.dimensions.ai/details/publication/pub.1112308286"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11719_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41523-019-0104-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0104-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0104-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0104-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41523-019-0104-z'


 

This table displays all metadata directly associated to this object as RDF triples.

334 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41523-019-0104-z schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nf523e606050d4fac9a3973c048d0ad3c
4 schema:citation sg:pub.10.1007/s10549-016-3829-5
5 sg:pub.10.1007/s11912-017-0591-8
6 sg:pub.10.1038/modpathol.2017.95
7 sg:pub.10.1038/ncomms11479
8 sg:pub.10.1038/ncomms11579
9 sg:pub.10.1038/ng.2822
10 sg:pub.10.1038/nm.4333
11 sg:pub.10.1038/nrclinonc.2015.99
12 sg:pub.10.1038/srep18517
13 sg:pub.10.1186/s13058-015-0519-x
14 sg:pub.10.1186/s13058-015-0542-y
15 https://doi.org/10.1001/jamaoncol.2016.1279
16 https://doi.org/10.1016/j.ccell.2017.07.005
17 https://doi.org/10.1016/j.ccell.2018.01.004
18 https://doi.org/10.1016/j.cell.2014.08.027
19 https://doi.org/10.1016/j.cell.2015.09.033
20 https://doi.org/10.1016/j.critrevonc.2014.07.003
21 https://doi.org/10.1016/j.ejca.2010.05.013
22 https://doi.org/10.1055/s-0043-109374
23 https://doi.org/10.1093/annonc/mdw286
24 https://doi.org/10.1093/annonc/mdx490
25 https://doi.org/10.1093/jnci/djx268
26 https://doi.org/10.1126/scisignal.2004088
27 https://doi.org/10.1126/scitranslmed.aac7551
28 https://doi.org/10.1158/1078-0432.ccr-13-2332
29 https://doi.org/10.1158/1078-0432.ccr-15-1534
30 https://doi.org/10.1158/2159-8290.cd-12-0095
31 https://doi.org/10.1158/2159-8290.cd-15-1523
32 https://doi.org/10.1200/jco.2015.64.0334
33 https://doi.org/10.1200/jco.2016.67.3061
34 https://doi.org/10.1200/po.17.00011
35 https://doi.org/10.1373/clinchem.2015.238717
36 https://doi.org/10.7554/elife.12792
37 schema:datePublished 2019-12
38 schema:datePublishedReg 2019-12-01
39 schema:description Invasive lobular breast cancer (ILC) represents the second most common histology of breast cancer after invasive ductal breast cancer (IDC), accounts for up to 15% of all invasive cases and generally express the estrogen receptor (ER, coded by the <i>ESR1</i> gene). <i>ESR1</i> mutations have been associated with resistance to endocrine therapy, however these have not been specifically evaluated in ILC. We assessed the frequency of <i>ESR1</i> mutations by droplet digital PCR in a retrospective multi-centric series of matched primary tumor and recurrence samples (<i>n</i> = 279) from 80 metastatic ER-positive ILC patients. We further compared <i>ESR1</i> mutations between IDC and ILC patients in metastatic samples from MSKCC-IMPACT (<i>n</i> = 595 IDC and 116 ILC) and in ctDNA from the SoFEA and PALOMA-3 trials (<i>n</i> = 416 IDC and 76 ILC). In the retrospective series, the metastases from seven patients (9%) harbored <i>ESR1</i> mutations, which were absent from the interrogated primary samples. Five patients (6%) had a mutation in the primary tumor or axillary metastasis, which could not be detected in the matched distant metastasis. In the MSKCC-IMPACT cohort, as well as in the SoFEA and PALOMA-3 trials, there were no differences in prevalence and distribution of the mutations between IDC and ILC, with D538G being the most frequent mutation in both histological subtypes. To conclude, no patient had an identical <i>ESR1</i> mutation in the early and metastatic disease in the retrospective ILC series. In the external series, there was no difference in terms of prevalence and type of ESR1 mutations between ILC and IDC.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf N3cf47041f8764da5bca9ea5d6e875b9e
44 N655ca0ee849e4d979e20eb47d4e0c6c5
45 sg:journal.1052988
46 schema:name ESR1 mutations in metastatic lobular breast cancer patients
47 schema:pagination 9
48 schema:productId N3207327061d94b66acc425a54b1b1d70
49 N7266601210d6436b84c85c706f33356c
50 Nc69d4ee7ab81499fa498773eefc6c251
51 Nde0e98fd3fac4f96a72264e4f8c0c122
52 Ne8f26dbd17414938b05678aa75acf7cd
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112308286
54 https://doi.org/10.1038/s41523-019-0104-z
55 schema:sdDatePublished 2019-04-11T11:20
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Nb16379641d374a85acf61525eebdd1dc
58 schema:url https://www.nature.com/articles/s41523-019-0104-z
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N00db6cbde3874f88af9ebac774aa7cc5 rdf:first N1eb42e266cf141569a2ee66bab49cf06
63 rdf:rest Na079e07683f945e6ab65714d49f382ba
64 N01ee0a58314d4e1aae5f41ff7c0c7015 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
65 schema:familyName Fribbens
66 schema:givenName Charlotte
67 rdf:type schema:Person
68 N04ed40a64df149d19854f6db1f625d3a rdf:first Ne3bb20ff8a7a49b788c551f34932eed3
69 rdf:rest Na2559f1e40b849dd9645a628325fd262
70 N0682936049714adeb4b501426524d488 rdf:first N3f123f42a4e44508b24faebc364d70b1
71 rdf:rest N9b99a6e5be644cda80d1fdf417bdd7a1
72 N081fc190898b4fe1ad173054f2fb3bb6 rdf:first N3d98afcad4fb4cd1ad83e20a8b7ef46c
73 rdf:rest N35af66a33fd840bb808126be9f242128
74 N1281023d0f7b4d728ccfeaf24c5c20a9 rdf:first N14d6d0d1cd1c4ec2b814f0df7ad4c515
75 rdf:rest rdf:nil
76 N14d6d0d1cd1c4ec2b814f0df7ad4c515 schema:affiliation N73d70ca0ad5f4eb0b106138125b5de6e
77 schema:familyName Sotiriou
78 schema:givenName Christos
79 rdf:type schema:Person
80 N1eb42e266cf141569a2ee66bab49cf06 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
81 schema:familyName Vincent-Salomon
82 schema:givenName Anne
83 rdf:type schema:Person
84 N21dbd22fea3f413ea5081a6207016ff3 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
85 schema:familyName Turner
86 schema:givenName Nicholas C.
87 rdf:type schema:Person
88 N3207327061d94b66acc425a54b1b1d70 schema:name dimensions_id
89 schema:value pub.1112308286
90 rdf:type schema:PropertyValue
91 N331cda2bc44546b0b2fa55520477be7e rdf:first Nebfdeacf3b0f4b60a1f22d57386c8500
92 rdf:rest N1281023d0f7b4d728ccfeaf24c5c20a9
93 N35af66a33fd840bb808126be9f242128 rdf:first N88eb87065f4d4383a582ac618c5c817f
94 rdf:rest Nf00e4abb64784e99a9e40b8b05b4f864
95 N3bf3d157f6ba48a3a6be0c27f9dfdcba schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
96 schema:familyName O’Leary
97 schema:givenName Ben
98 rdf:type schema:Person
99 N3cf47041f8764da5bca9ea5d6e875b9e schema:volumeNumber 5
100 rdf:type schema:PublicationVolume
101 N3d1c693f31a74f7092188161bedca82f schema:affiliation https://www.grid.ac/institutes/grid.418596.7
102 schema:familyName Mariani
103 schema:givenName Odette
104 rdf:type schema:Person
105 N3d98afcad4fb4cd1ad83e20a8b7ef46c schema:affiliation https://www.grid.ac/institutes/grid.428965.4
106 schema:familyName van den Eynden
107 schema:givenName Gert
108 rdf:type schema:Person
109 N3f123f42a4e44508b24faebc364d70b1 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
110 schema:familyName Pingitore
111 schema:givenName Julien
112 rdf:type schema:Person
113 N431d367b00be44ea9b71a828d124e75e rdf:first N572bce2d82804299ae5e17907632c2c6
114 rdf:rest Nb66881dfaf9b4681b0a638a518f73c05
115 N4411ba33803a442e93368c701ed683de schema:name Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Université Libre de Bruxelles, 1000, Brussels, Belgium
116 rdf:type schema:Organization
117 N4429636e426544878add13ce9d63d9f0 rdf:first Ndc06be9923774c87a3559d59aae0e870
118 rdf:rest N00db6cbde3874f88af9ebac774aa7cc5
119 N55d5d7cf6ce848008888ab8a3eaf7728 rdf:first N7d94fc1c4f644e7e91875c62f8c1a4ac
120 rdf:rest Na604e2faa3c140508beb74ecf26e2905
121 N56164ee8f6ea4913b4e13497185ae29c rdf:first Naa8d494e63404ade96ea6be9aea9a200
122 rdf:rest N04ed40a64df149d19854f6db1f625d3a
123 N572bce2d82804299ae5e17907632c2c6 schema:affiliation https://www.grid.ac/institutes/grid.48769.34
124 schema:familyName Galant
125 schema:givenName Christine
126 rdf:type schema:Person
127 N602f743e5d6f4080b087a324dd23b2ad schema:name Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Université Libre de Bruxelles, 1000, Brussels, Belgium
128 rdf:type schema:Organization
129 N655ca0ee849e4d979e20eb47d4e0c6c5 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N695a67defcf5499dae1bea5e7cce918f schema:name Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Université Libre de Bruxelles, 1000, Brussels, Belgium
132 rdf:type schema:Organization
133 N7266601210d6436b84c85c706f33356c schema:name doi
134 schema:value 10.1038/s41523-019-0104-z
135 rdf:type schema:PropertyValue
136 N73d70ca0ad5f4eb0b106138125b5de6e schema:name Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Université Libre de Bruxelles, 1000, Brussels, Belgium
137 rdf:type schema:Organization
138 N7a845e11133b45cc8503d6a3270e90e6 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
139 schema:familyName Marchio
140 schema:givenName Caterina
141 rdf:type schema:Person
142 N7d94fc1c4f644e7e91875c62f8c1a4ac schema:affiliation https://www.grid.ac/institutes/grid.463833.9
143 schema:familyName Bertucci
144 schema:givenName François
145 rdf:type schema:Person
146 N88eb87065f4d4383a582ac618c5c817f schema:affiliation https://www.grid.ac/institutes/grid.428965.4
147 schema:familyName Salgado
148 schema:givenName Roberto
149 rdf:type schema:Person
150 N947420c12ba84a7d9adbb18208a6bb22 schema:affiliation N4411ba33803a442e93368c701ed683de
151 schema:familyName Rothé
152 schema:givenName Françoise
153 rdf:type schema:Person
154 N9b99a6e5be644cda80d1fdf417bdd7a1 rdf:first N947420c12ba84a7d9adbb18208a6bb22
155 rdf:rest Nfd91d42657c548d09105c3b899b8f89a
156 Na079e07683f945e6ab65714d49f382ba rdf:first Nc7d860b1804c4063a03624009c4ca02f
157 rdf:rest N331cda2bc44546b0b2fa55520477be7e
158 Na2559f1e40b849dd9645a628325fd262 rdf:first Nd7fff304802149acb8d8ca11fe49ac56
159 rdf:rest N55d5d7cf6ce848008888ab8a3eaf7728
160 Na604e2faa3c140508beb74ecf26e2905 rdf:first N3d1c693f31a74f7092188161bedca82f
161 rdf:rest N431d367b00be44ea9b71a828d124e75e
162 Naa8d494e63404ade96ea6be9aea9a200 schema:affiliation https://www.grid.ac/institutes/grid.41724.34
163 schema:familyName Clatot
164 schema:givenName Florian
165 rdf:type schema:Person
166 Nb16379641d374a85acf61525eebdd1dc schema:name Springer Nature - SN SciGraph project
167 rdf:type schema:Organization
168 Nb66881dfaf9b4681b0a638a518f73c05 rdf:first N01ee0a58314d4e1aae5f41ff7c0c7015
169 rdf:rest Nbe48826304c34b24908b578550cd9fb3
170 Nb7c65da7a6494c4d95274e0d8d8bbacf schema:affiliation https://www.grid.ac/institutes/grid.5596.f
171 schema:familyName Desmedt
172 schema:givenName Christine
173 rdf:type schema:Person
174 Nbe48826304c34b24908b578550cd9fb3 rdf:first N3bf3d157f6ba48a3a6be0c27f9dfdcba
175 rdf:rest N081fc190898b4fe1ad173054f2fb3bb6
176 Nc69d4ee7ab81499fa498773eefc6c251 schema:name pubmed_id
177 schema:value 30820448
178 rdf:type schema:PropertyValue
179 Nc7d860b1804c4063a03624009c4ca02f schema:affiliation https://www.grid.ac/institutes/grid.4708.b
180 schema:familyName Pruneri
181 schema:givenName Giancarlo
182 rdf:type schema:Person
183 Nd7fff304802149acb8d8ca11fe49ac56 schema:affiliation N602f743e5d6f4080b087a324dd23b2ad
184 schema:familyName Richard
185 schema:givenName François
186 rdf:type schema:Person
187 Ndc06be9923774c87a3559d59aae0e870 schema:affiliation https://www.grid.ac/institutes/grid.418119.4
188 schema:familyName Piccart
189 schema:givenName Martine
190 rdf:type schema:Person
191 Nde0e98fd3fac4f96a72264e4f8c0c122 schema:name readcube_id
192 schema:value 3056c8b9586c32510a715e37c7534e863d98c6b8001fd349619647507d719909
193 rdf:type schema:PropertyValue
194 Ne3bb20ff8a7a49b788c551f34932eed3 schema:affiliation N695a67defcf5499dae1bea5e7cce918f
195 schema:familyName Rouas
196 schema:givenName Ghizlane
197 rdf:type schema:Person
198 Ne8f26dbd17414938b05678aa75acf7cd schema:name nlm_unique_id
199 schema:value 101674891
200 rdf:type schema:PropertyValue
201 Nebfdeacf3b0f4b60a1f22d57386c8500 schema:affiliation https://www.grid.ac/institutes/grid.418119.4
202 schema:familyName Larsimont
203 schema:givenName Denis
204 rdf:type schema:Person
205 Nf00e4abb64784e99a9e40b8b05b4f864 rdf:first N21dbd22fea3f413ea5081a6207016ff3
206 rdf:rest N4429636e426544878add13ce9d63d9f0
207 Nf523e606050d4fac9a3973c048d0ad3c rdf:first Nb7c65da7a6494c4d95274e0d8d8bbacf
208 rdf:rest N0682936049714adeb4b501426524d488
209 Nfd91d42657c548d09105c3b899b8f89a rdf:first N7a845e11133b45cc8503d6a3270e90e6
210 rdf:rest N56164ee8f6ea4913b4e13497185ae29c
211 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
212 schema:name Medical and Health Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
215 schema:name Oncology and Carcinogenesis
216 rdf:type schema:DefinedTerm
217 sg:journal.1052988 schema:issn 2374-4677
218 schema:name npj Breast Cancer
219 rdf:type schema:Periodical
220 sg:pub.10.1007/s10549-016-3829-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040536389
221 https://doi.org/10.1007/s10549-016-3829-5
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s11912-017-0591-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084510893
224 https://doi.org/10.1007/s11912-017-0591-8
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/modpathol.2017.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091159111
227 https://doi.org/10.1038/modpathol.2017.95
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/ncomms11479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050455938
230 https://doi.org/10.1038/ncomms11479
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/ncomms11579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013557158
233 https://doi.org/10.1038/ncomms11579
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/ng.2822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019741899
236 https://doi.org/10.1038/ng.2822
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nm.4333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085214027
239 https://doi.org/10.1038/nm.4333
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/nrclinonc.2015.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025992588
242 https://doi.org/10.1038/nrclinonc.2015.99
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/srep18517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019178552
245 https://doi.org/10.1038/srep18517
246 rdf:type schema:CreativeWork
247 sg:pub.10.1186/s13058-015-0519-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000913518
248 https://doi.org/10.1186/s13058-015-0519-x
249 rdf:type schema:CreativeWork
250 sg:pub.10.1186/s13058-015-0542-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028241679
251 https://doi.org/10.1186/s13058-015-0542-y
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1001/jamaoncol.2016.1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032167006
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.ccell.2017.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091213415
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.ccell.2018.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101004622
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.cell.2014.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010041153
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.cell.2015.09.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023699296
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.critrevonc.2014.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042208245
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.ejca.2010.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011043290
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1055/s-0043-109374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090287090
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/annonc/mdw286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059394804
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/annonc/mdx490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091457978
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1093/jnci/djx268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092960408
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1126/scitranslmed.aac7551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062688860
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/1078-0432.ccr-13-2332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044209610
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/1078-0432.ccr-15-1534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225044
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1158/2159-8290.cd-15-1523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281040
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1200/jco.2015.64.0334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204450
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.2016.67.3061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003114495
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1200/po.17.00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085426344
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1373/clinchem.2015.238717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027641776
294 rdf:type schema:CreativeWork
295 https://doi.org/10.7554/elife.12792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004708788
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
298 schema:name Breast Unit, Royal Marsden Hospital, Fulham Road, SW3 6JJ, London, UK
299 The Breast Cancer Now Research Centre, The Institute of Cancer Research, SW3 6JB, London, UK
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.41724.34 schema:alternateName Centre Hospitalier Universitaire De Rouen
302 schema:name Department of Medical Oncology, Centre Henri-Becquerel, CS11516 rue d’Amiens, 76000, Rouen, France
303 IRON/Inserm U1245, Rouen University Hospital, 22, boulevard Gambetta, 76183, Rouen, France
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.418119.4 schema:alternateName Institut Jules Bordet
306 schema:name Department of Pathology, Institut Jules Bordet, Boulevard de Waterloo 121, 1000, Brussels, Belgium
307 Institut Jules Bordet, Boulevard de Waterloo 121, 1000, Brussels, Belgium
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
310 schema:name Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, 26 Rue d’Ulm, 75248, Paris Cédex05, France
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.428965.4 schema:alternateName GZA Ziekenhuizen campus Sint-Augustinus
313 schema:name Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Université Libre de Bruxelles, 1000, Brussels, Belgium
314 Department of Pathology, Sint Augustinus, Wilrijk, Belgium
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.463833.9 schema:alternateName Centre de Recherche en Cancérologie de Marseille
317 schema:name Predictive Oncology Laboratory, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, Marseille, France
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.4708.b schema:alternateName University of Milan
320 schema:name Division of Pathology, European Institute of Oncology, University of Milan, Milan, Italy
321 Division of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133, Milan, Italy
322 School of Medicine, University of Milan, via Festa del Perdono 7, 20122, Milan, Milano, Italy
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.48769.34 schema:alternateName Cliniques Universitaires Saint-Luc
325 schema:name Department of Pathology, Cliniques Universitaires Saint Luc, Brussels, Belgium
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
328 schema:name Breast Cancer Translational Research Laboratory, Institut Jules Bordet, U-CRC, Université Libre de Bruxelles, 1000, Brussels, Belgium
329 Laboratory for Translational Breast Cancer Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
332 schema:name Department of Medical Sciences, FPO-IRCCS Candiolo Cancer Institute, University of Turin, SP 142 Km3.95, 10060, Candiolo, Italy
333 Department of Pathology, Institut Curie, Paris Sciences Lettres Research University, 26 Rue d’Ulm, 75248, Paris Cédex05, France
334 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...