An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Lauren M. Moore, Rachel Wilkinson, Mehmet Altan, Maria Toki, Daniel E. Carvajal-Hausdorf, John McGuire, Barbara E. Ehrlich, David L. Rimm

ABSTRACT

Neuronal calcium sensor-1 (NCS-1) has been identified as a binding partner of the taxane, paclitaxel. Our previous study showed that overexpression of NCS-1 increased the efficacy of paclitaxel in vitro, but was associated with poor clinical outcome. Here, we determine if NCS-1 expression is associated with pathological complete response (pCR) to taxane-based neoadjuvant chemotherapy in 105 pre-treatment breast cancer biopsies. Elevated expression of NCS-1 was found to be positively associated with pCR. These results suggest that NCS-1 may be a predictive biomarker for response to taxane-based neoadjuvant chemotherapy in breast cancer. More... »

PAGES

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41523-018-0057-7

DOI

http://dx.doi.org/10.1038/s41523-018-0057-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101436487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29560416


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